Blocking CD40 Alleviates Th1 and Th17 Cell Responses in Elastin Peptide-Induced Murine Emphysema

References

• Ananth S, Hurst JR. ERJ advances: state of the art in definitions and diagnosis of COPD. Eur Respir J. 2023;61(4):2202318. doi:10.1183/13993003.02318-2022
   PubMed Web of Science ®Google Scholar
• Stolz D, Mkorombindo T, Schumann DM, et al. Towards the elimination of chronic obstructive pulmonary disease: a lancet commission. Lancet. 2022;400(10356):921–972. doi:10.1016/s0140-6736(22)01273-9
   PubMed Web of Science ®Google Scholar
• Rosenwasser Y, Berger I, Loewy ZG. Therapeutic approaches for Chronic Obstructive Pulmonary Disease (COPD) exacerbations. Pathogens. 2022;11(12):1513. doi:10.3390/pathogens11121513
   PubMed Web of Science ®Google Scholar
• Milara J, Peiró T, Serrano A, et al. Roflumilast N-oxide inhibits bronchial epithelial to mesenchymal transition induced by cigarette smoke in smokers with COPD. Pulm Pharmacol Ther. 2014;28(2):138–148. doi:10.1016/j.pupt.2014.02.001
   PubMed Web of Science ®Google Scholar
• Wen L, Krauss-Etschmann S, Petersen F, Yu X. Autoantibodies in chronic obstructive pulmonary disease. Front Immunol. 2018;9:66. doi:10.3389/fimmu.2018.00066
   PubMed Web of Science ®Google Scholar
• Jin Y, Wan Y, Chen G, et al. Treg/IL-17 ratio and treg differentiation in patients with COPD. PLoS One. 2014;9(10):e111044. doi:10.1371/journal.pone.0111044
   PubMed Web of Science ®Google Scholar
• Kheradmand F, Zhang Y, Corry DB. Contribution of adaptive immunity to human COPD and experimental models of emphysema. Physiol Rev. 2023;103(2):1059–1093. doi:10.1152/physrev.00036.2021
   PubMed Web of Science ®Google Scholar
• Pouwels SD, Hesse L, Faiz A, et al. Susceptibility for cigarette smoke-induced DAMP release and DAMP-induced inflammation in COPD. Am J Physiol Lung Cell Mol Physiol. 2016;311(5):L881–L892. doi:10.1152/ajplung.00135.2016
   PubMed Web of Science ®Google Scholar
• Pouwels SD, Zijlstra GJ, van der Toorn M, et al. Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice. Am J Physiol Lung Cell Mol Physiol. 2016;310(4):L377–L386. doi:10.1152/ajplung.00174.2015
   PubMed Web of Science ®Google Scholar
• Lee SH, Goswami S, Grudo A, et al. Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat Med. 2007;13(5):567–569. doi:10.1038/nm1583
   PubMed Web of Science ®Google Scholar
• Zhou JS, Li ZY, Xu XC, et al. Cigarette smoke-initiated autoimmunity facilitates sensitisation to elastin-induced COPD-like pathologies in mice. Eur Respir J. 2020;56(3). doi:10.1183/13993003.00404-2020
   Web of Science ®Google Scholar
• He J, Turino GM, Lin YY. Characterization of peptide fragments from lung elastin degradation in chronic obstructive pulmonary disease. Exp Lung Res. 2010;36(9):548–557. doi:10.3109/01902148.2010.489143
   PubMed Web of Science ®Google Scholar
• Luisetti M, Ma S, Iadarola P, et al. Desmosine as a biomarker of elastin degradation in COPD: current status and future directions. Eur Respir J. 2008;32(5):1146–1157. doi:10.1183/09031936.00174807
   PubMed Web of Science ®Google Scholar
• Sellami M, Meghraoui-Kheddar A, Terryn C, et al. Induction and regulation of murine emphysema by elastin peptides. Am J Physiol Lung Cell Mol Physiol. 2016;310(1):L8–L23. doi:10.1152/ajplung.00068.2015
   PubMed Web of Science ®Google Scholar
• Rønnow SR, Langholm LL, Sand JMB, et al. Specific elastin degradation products are associated with poor outcome in the ECLIPSE COPD cohort. Sci Rep. 2019;9(1):4064. doi:10.1038/s41598-019-40785-2
   PubMedGoogle Scholar
• Pierre A, Lemaire F, Meghraoui-Kheddar A, Audonnet S, Héry-Huynh S, Le Naour R. Impact of aging on inflammatory and immune responses during elastin peptide-induced murine emphysema. Am J Physiol Lung Cell Mol Physiol. 2019;316(4):L608–L620. doi:10.1152/ajplung.00402.2018
   PubMed Web of Science ®Google Scholar
• Tang S, Ma T, Zhang H, et al. Erythromycin prevents elastin peptide-induced emphysema and modulates CD4(+)T cell responses in mice. Int J Chron Obstruct Pulmon Dis. 2019;14:2697–2709. doi:10.2147/copd.S222195
   PubMed Web of Science ®Google Scholar
• Meghraoui-Kheddar A, Pierre A, Sellami M, Audonnet S, Lemaire F, Le Naour R. Elastin receptor (S-gal) occupancy by elastin peptides modulates T-cell response during murine emphysema. Am J Physiol Lung Cell Mol Physiol. 2017;313(3):L534–L547. doi:10.1152/ajplung.00465.2016
   PubMed Web of Science ®Google Scholar
• Liang Y, Shen Y, Kuang L, et al. Cigarette smoke exposure promotes differentiation of CD4(+) T cells toward Th17 cells by CD40-CD40L costimulatory pathway in mice. Int J Chron Obstruct Pulmon Dis. 2018;13:959–968. doi:10.2147/copd.S155754
   PubMed Web of Science ®Google Scholar
• Harding SA, Sarma J, Josephs DH, et al. Upregulation of the CD40/CD40 ligand dyad and platelet-monocyte aggregation in cigarette smokers. Circulation. 2004;109(16):1926–1929. doi:10.1161/01.Cir.0000127128.52679.E4
   PubMed Web of Science ®Google Scholar
• Ma DY, Clark EA. The role of CD40 and CD154/CD40L in dendritic cells. Semin Immunol. 2009;21(5):265–272. doi:10.1016/j.smim.2009.05.010
   PubMed Web of Science ®Google Scholar
• Sia JK, Bizzell E, Madan-Lala R, Rengarajan J, Salgame P. Engaging the CD40-CD40L pathway augments T-helper cell responses and improves control of Mycobacterium tuberculosis infection. PLoS Pathog. 2017;13(8):e1006530. doi:10.1371/journal.ppat.1006530
   PubMed Web of Science ®Google Scholar
• Iezzi G, Sonderegger I, Ampenberger F, Schmitz N, Marsland BJ, Kopf M. CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells. Proc Natl Acad Sci U S A. 2009;106(3):876–881. doi:10.1073/pnas.0810769106
   PubMed Web of Science ®Google Scholar
• Bruder D, Westendorf AM, Geffers R, et al. CD4 T lymphocyte-mediated lung disease: steady state between pathological and tolerogenic immune reactions. Am J Respir Crit Care Med. 2004;170(11):1145–1152. doi:10.1164/rccm.200404-464OC
   PubMed Web of Science ®Google Scholar
• Thurlbeck WM. Internal surface area and other measurements in emphysema. Thorax. 1967;22(6):483–496. doi:10.1136/thx.22.6.483
   PubMed Web of Science ®Google Scholar
• Saetta M, Shiner RJ, Angus GE, et al. Destructive index: a measurement of lung parenchymal destruction in smokers. Am Rev Respir Dis. 1985;131(5):764–769. doi:10.1164/arrd.1985.131.5.764
   PubMed Web of Science ®Google Scholar
• Wang Y, Xu J, Meng Y, Adcock IM, Yao X. Role of inflammatory cells in airway remodeling in COPD. Int J Chron Obstruct Pulmon Dis. 2018;13:3341–3348. doi:10.2147/copd.S176122
   PubMed Web of Science ®Google Scholar
• Barnes PJ. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2016;138(1):16–27. doi:10.1016/j.jaci.2016.05.011
   PubMed Web of Science ®Google Scholar
• Hou J, Sun Y. Role of regulatory T cells in disturbed immune homeostasis in patients with chronic obstructive pulmonary disease. Front Immunol. 2020;11:723. doi:10.3389/fimmu.2020.00723
   PubMed Web of Science ®Google Scholar
• Brusselle GG, Joos GF, Bracke KR. New insights into the immunology of chronic obstructive pulmonary disease. Lancet. 2011;378(9795):1015–1026. doi:10.1016/s0140-6736(11)60988-4
   PubMed Web of Science ®Google Scholar
• Yang L, Ma QL, Yao W, et al. Relationship between the anti-inflammatory properties of salmeterol/fluticasone and the expression of CD4⁺CD25⁺Foxp3⁺ regulatory T cells in COPD. Respir Res. 2011;12(1):142. doi:10.1186/1465-9921-12-142
   PubMedGoogle Scholar
• Tang Y, Zhang H, Xu H, et al. Dendritic cells promote treg expansion but Not Th17 generation in response to talaromyces marneffei yeast cells. Infect Drug Resist. 2020;13:805–813. doi:10.2147/idr.S239906
   PubMed Web of Science ®Google Scholar
• Yin Y, Xu N, Shi Y, et al. Astaxanthin protects dendritic cells from lipopolysaccharide-induced immune dysfunction. Mar Drugs. 2021;19(6):346. doi:10.3390/md19060346
   PubMed Web of Science ®Google Scholar
• Zhang H, Qiu SL, Tang QY, et al. Erythromycin suppresses neutrophil extracellular traps in smoking-related chronic pulmonary inflammation. Cell Death Dis. 2019;10(9):678. doi:10.1038/s41419-019-1909-2
   PubMedGoogle Scholar
• Karimi MH, Ebadi P, Pourfathollah AA, Moazzeni SM. Tolerance induction by CD40 blocking through specific antibody in dendritic cells. Iran J Allergy Asthma Immunol. 2010;9(3):141–147.
   PubMed Web of Science ®Google Scholar
• Kuang LJ, Deng TT, Wang Q, et al. Dendritic cells induce Tc1 cell differentiation via the CD40/CD40L pathway in mice after exposure to cigarette smoke. Am J Physiol Lung Cell Mol Physiol. 2016;311(3):L581–L589. doi:10.1152/ajplung.00002.2016
   PubMed Web of Science ®Google Scholar
• Ma R, Su H, Jiao K, Liu J. Role of Th17 cells, Treg cells, and Th17/Treg imbalance in immune homeostasis disorders in patients with chronic obstructive pulmonary disease. Immun Inflamm Dis. 2023;11(2):e784. doi:10.1002/iid3.784
   PubMed Web of Science ®Google Scholar
• Bozinovski S, Seow HJ, Chan SP, et al. Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette- smoke-induced lung inflammation in mice. Clin Sci. 2015;129(9):785–796. doi:10.1042/cs20140703
   PubMed Web of Science ®Google Scholar
• Xiong J, Zhou L, Tian J, et al. Cigarette smoke-induced lymphoid neogenesis in COPD involves IL-17/RANKL pathway. Front Immunol. 2020;11:588522. doi:10.3389/fimmu.2020.588522
   PubMed Web of Science ®Google Scholar
• Eich A, Urban V, Jutel M, et al. A randomized, placebo-controlled Phase 2 Trial of CNTO 6785 in chronic obstructive pulmonary disease. Copd. 2017;14(5):476–483. doi:10.1080/15412555.2017.1335697
   PubMedGoogle Scholar
• Cheng KJ, Zhou ML, Liu YC, Wang C, Xu YY. The role of CD40 in allergic rhinitis and airway remodelling. Mediators Inflamm. 2021;2021:6694109. doi:10.1155/2021/6694109
   PubMed Web of Science ®Google Scholar
• Raffin C, Vo LT, Bluestone JA. T(reg) cell-based therapies: challenges and perspectives. Nat Rev Immunol. 2020;20(3):158–172. doi:10.1038/s41577-019-0232-6
   PubMed Web of Science ®Google Scholar