165
Views
1
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Astragaloside IV Ameliorates Streptozotocin Induced Pancreatic β-Cell Apoptosis and Dysfunction Through SIRT1/P53 and Akt/GSK3β/Nrf2 Signaling Pathways

, , , , &
Pages 131-140 | Published online: 13 Jan 2022

References

  • Li L, Hou X, Xu R, Liu C, Tu M. Research review on the pharmacological effects of astragaloside IV. Fundam Clin Pharmacol. 2017;31(1):17–36. doi:10.1111/fcp.12232
  • Zhang J, Wu C, Gao L, Du G, Qin X. Astragaloside IV derived from astragalus membranaceus: a research review on the pharmacological effects. Adv Pharmacol. 2020;87:89–112. doi:10.1016/bs.apha.2019.08.002
  • Zhang R, Xing B, Zhao J, et al. Astragaloside IV relieves gestational diabetes mellitus in genetic mice through reducing hepatic gluconeogenesis. Can J Physiol Pharmacol. 2020;98(7):466–472. doi:10.1139/cjpp-2019-0548
  • Zhu Y, Qian X, Li J, et al. Astragaloside-IV protects H9C2 (2-1) cardiomyocytes from high glucose-induced injury via miR-34a-mediated autophagy pathway. Artif Cells Nanomed Biotechnol. 2019;47(1):4172–4181. doi:10.1080/21691401.2019.1687492
  • Remedi MS, Emfinger C. Pancreatic β-cell identity in diabetes. Diabetes Obes Metab. 2016;18(Suppl 1):110–116. doi:10.1111/dom.12727
  • Wang F, Xi Y, Liu W, et al. Sanbai melon seed oil exerts its protective effects in a diabetes mellitus model via the Akt/GSK-3β/Nrf2 pathway. J Diabetes Res. 2019;2019:5734723. doi:10.1155/2019/5734723
  • Yu H, Zhen J, Yang Y, Du J, Leng J, Tong Q. Rg1 protects H9C2 cells from high glucose-/palmitate-induced injury via activation of Akt/GSK-3β/Nrf2 pathway. J Cell Mol Med. 2020;24(14):8194–8205. doi:10.1111/jcmm.15486
  • Zhu F, Shao J, Tian Y, Xu Z. Sulfiredoxin-1 protects retinal ganglion cells from high glucose-induced oxidative stress and inflammatory injury by potentiating Nrf2 signaling via the Akt/GSK-3β pathway. Int Immunopharmacol. 2021;101:108221. doi:10.1016/j.intimp.2021.108221
  • Feng J, Xie L, Yu X, et al. Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation. Biochem Biophys Res Commun. 2021;544:22–30. doi:10.1016/j.bbrc.2021.01.069
  • Qin CD, Ma DN, Ren ZG, et al. Astragaloside IV inhibits metastasis in hepatoma cells through the suppression of epithelial-mesenchymal transition via the Akt/GSK-3β/β-catenin pathway. Oncol Rep. 2017;37(3):1725–1735. doi:10.3892/or.2017.5389
  • Kerforne T, Giraud S, Danion J, et al. Rapid or slow time to brain death? Impact on kidney graft injuries in an allotransplantation porcine model. Int J Mol Sci. 2020;19:3671.
  • Feige JN, Lagouge M, Canto C, et al. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab. 2008;8(5):347–358. doi:10.1016/j.cmet.2008.08.017
  • He W, Wang Y, Zhang MZ, et al. Sirt1 activation protects the mouse renal medulla from oxidative injury. J Clin Invest. 2010;120(4):1056–1068. doi:10.1172/JCI41563
  • Kume S, Uzu T, Horiike K, et al. Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. J Clin Invest. 2010;120(4):1043–1055. doi:10.1172/JCI41376
  • Kitada M, Kume S, Takeda-Watanabe A, Kanasaki K, Koya D. Sirtuins and renal diseases: relationship with aging and diabetic nephropathy. Clin Sci. 2013;124(3):153–164. doi:10.1042/CS20120190
  • Polak-Jonkisz D, Laszki-Szcząchor K, Rehan L, Pilecki W, Filipowski H, Sobieszczańska M. Nephroprotective action of sirtuin 1 (SIRT1). J Physiol Biochem. 2013;69(4):957–961. doi:10.1007/s13105-013-0268-1
  • Ma F, Wu J, Jiang Z, et al. P53/NRF2 mediates SIRT1’s protective effect on diabetic nephropathy. Biochim Biophys Acta Mol Cell Res. 1866;2019:1272–1281.
  • Ben Y, Hao J, Zhang Z, et al. Astragaloside IV inhibits mitochondrial-dependent apoptosis of the dorsal root ganglion in diabetic peripheral neuropathy rats through modulation of the SIRT1/p53 signaling pathway. Diabetes Metab Syndr Obes. 2021;14:1647–1661. doi:10.2147/DMSO.S301068
  • Luo G, Xiao L, Wang D, et al. Resveratrol protects against ethanol-induced impairment of insulin secretion in INS-1 cells through SIRT1-UCP2 axis. Toxicol In Vitro. 2020;65:104808. doi:10.1016/j.tiv.2020.104808
  • Liu Y, Han J, Zhou Z, Li D. Tangeretin inhibits streptozotocin-induced cell apoptosis via regulating NF-κB pathway in INS-1 cells. J Cell Biochem. 2019;120(3):3286–3293. doi:10.1002/jcb.27596
  • Bai X, Li X, Tian J, Zhou Z. Antiangiogenic treatment diminishes renal injury and dysfunction via regulation of local Akt in early experimental diabetes. PLoS One. 2014;9(4):e96117. doi:10.1371/journal.pone.0096117
  • Huang X, Sun J, Chen G, et al. Resveratrol promotes diabetic wound healing via SIRT1-FOXO1-c-Myc signaling pathway-mediated angiogenesis. Front Pharmacol. 2019;10:421.
  • Hussein AG, Mohamed RH, Shalaby SM, Abd El Motteleb DM. Vitamin K(2) alleviates type 2 diabetes in rats by induction of osteocalcin gene expression. Nutrition. 2018;47:33–38. doi:10.1016/j.nut.2017.09.016
  • Chen L, Su X, Hu Y. Berberine down-regulated myostatin expression and facilitated metabolism via smad pathway in insulin resistant mice. Diabetes Metab Syndr Obes. 2020;47:4561–4569. doi:10.2147/DMSO.S275301
  • Cong PF, Qu YC, Chen JP, et al. Growth inhibition and apoptosis induction by alternol in pancreatic carcinoma cells. World J Gastroenterol. 2015;21(15):4526–4535. doi:10.3748/wjg.v21.i15.4526
  • Qiao Y, Fan CL, Tang MK. Astragaloside IV protects rat retinal capillary endothelial cells against high glucose-induced oxidative injury. Drug Des Devel Ther. 2017;11:3567–3577. doi:10.2147/DDDT.S152489
  • Wang YN, Zhao SL, Su YY, et al. Astragaloside IV attenuates high glucose-induced EMT by inhibiting the TGF-β/Smad pathway in renal proximal tubular epithelial cells. Biosci Rep. 2020;40(6). doi:10.1042/BSR20190987.
  • Deng LL. Astragaloside IV as potential antioxidant against diabetic ketoacidosis in juvenile mice through activating JNK/Nrf2 signaling pathway. Arch Med Res. 2020;51(7):654–663. doi:10.1016/j.arcmed.2020.06.013
  • Karbasforooshan H, Karimi G. The role of SIRT1 in diabetic cardiomyopathy. Biomed Pharmacother. 2017;90:386–392. doi:10.1016/j.biopha.2017.03.056
  • Wang X, Gao Y, Tian N, et al. Astragaloside IV inhibits glucose-induced epithelial-mesenchymal transition of podocytes through autophagy enhancement via the SIRT-NF-κB p65 axis. Sci Rep. 2019;9(1):323. doi:10.1038/s41598-018-36911-1