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ORIGINAL RESEARCH

The Anti-Obesity Potential of Cyperus rotundus Extract Containing Piceatannol, Scirpusin A and Scirpusin B from Rhizomes: Preclinical and Clinical Evaluations

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Pages 369-382 | Published online: 09 Feb 2022

References

  • Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA. 2003;289(1):76–79. doi:10.1001/jama.289.1.76
  • World Health Organization. Obesity and overweight; 2018. Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Accessed September 4, 2019.
  • Garg SK, Maurer H, Reed K, Selagamsetty R. Diabetes and cancer: two diseases with obesity as a common risk factor. Diabetes Obes Metab. 2014;16(2):97–110. doi:10.1111/dom.12124
  • Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell. 2001;104(4):531–543. doi:10.1016/S0092-8674(01)00240-9
  • Kusminski CM, Bickel PE, Scherer PE. Targeting adipose tissue in the treatment of obesity-associated diabetes. Nat Rev Drug Discov. 2016;15(9):639–660. doi:10.1038/nrd.2016.75
  • Gooda Sahib N, Saari N, Ismail A, Khatib A, Mahomoodally F, Abdul Hamid A. Plants’ metabolites as potential antiobesity agents. Sci World J. 2012;2012:436039. doi:10.1100/2012/436039
  • Tungmunnithum D, Thongboonyou A, Pholboon A, Yangsabai A. Flavonoids and other phenolic compounds from medicinal plants for pharmaceutical and medical aspects: an overview. Medicines. 2018;5(3):93.
  • Chou Y, Ho C, Pan M. Stilbenes: chemistry and molecular mechanisms of anti-obesity. Curr Pharmacol Rep. 2018;4:202–209. doi:10.1007/s40495-018-0134-5
  • Almagro L, Belchí-Navarro S, Sabater-Jara AB, et al. Bioproduction of trans-resveratrol from Grapevine cell cultures. In: Ramawat KG, Mérillon J-M, editors. Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes. Berlin, Heidelberg: Springer Berlin Heidelberg; 2013:1683–1713.
  • Kershaw J, Kim K-H. The therapeutic potential of piceatannol, a natural stilbene, in metabolic diseases: a review. J Med Food. 2017;20(5):427–438. doi:10.1089/jmf.2017.3916
  • Hong EH, Heo EY, Song JH, et al. Trans-scirpusin A showed antitumor effects via autophagy activation and apoptosis induction of colorectal cancer cells. Oncotarget. 2017;8(25):41401–41411. doi:10.18632/oncotarget.17388
  • Sano S, Sugiyama K, Ito T, Katano Y, Ishihata A. Identification of the strong vasorelaxing substance scirpusin B, a dimer of piceatannol, from passion fruit (Passiflora edulis) seeds. J Agric Food Chem. 2011;59(11):6209–6213. doi:10.1021/jf104959t
  • Nakajima K, Taguchi H, Endo T, Yosioka I. The constituents of Scirpus fluviatilis (TORR.) A. GRAY. I.: the structures of two new hydroxystilbene dimers, Scirpusin A and B. Chem Pharm Bull. 1978;26(10):3050–3057. doi:10.1248/cpb.26.3050
  • Majeed M, Kalyanam N, Sarang B, et al.; Inventors; Sami Labs Limited (Bangalore, IN), assignee. Composition comprising scirpusin A and scirpusin B and anti-adipogenesis/anti-obesity potential thereof; 2016.
  • Peerzada AM, Ali HH, Naeem M, Latif M, Bukhari AH, Tanveer A. Cyperus rotundus L.: traditional uses, phytochemistry, and pharmacological activities. J Ethnopharmacol. 2015;174:540–560. doi:10.1016/j.jep.2015.08.012
  • Jung SH, Kim SJ, Jun BG, et al. Alpha-cyperone, isolated from the rhizomes of Cyperus rotundus, inhibits LPS-induced COX-2 expression and PGE2 production through the negative regulation of NFkappaB signalling in RAW 264.7 cells. J Ethnopharmacol. 2013;147(1):208–214. doi:10.1016/j.jep.2013.02.034
  • Kamala A, Middha SK, Karigar CS. Plants in traditional medicine with special reference to Cyperus rotundus L: a review. 3 Biotech. 2018;8(7):309. doi:10.1007/s13205-018-1328-6
  • Trivedi VP, Mann AS. Vegetable drugs regulating fat metabolism in caraka (Lekhaniya Dravyas). Q J Crude Drug Res. 1972;12(4):1988–1999. doi:10.3109/13880207209083244
  • Lemaure B, Touche A, Zbinden I, et al. Administration of cyperus rotundus tubers extract prevents weight gain in obese Zucker rats. Phytother Res. 2007;21(8):724–730. doi:10.1002/ptr.2147
  • Mohamed GA. Iridoids and other constituents from Cyperus rotundus L. rhizomes. Bull Fac Pharm Cairo Univ. 2015;53(1):5–9. doi:10.1016/j.bfopcu.2015.01.001
  • Lin S-Q, Zhou Z-L, Zhang H-L, Yin W-Q. Phenolic glycosides from the rhizomes of Cyperus rotundus and their antidepressant activity. J Korean Soc Appl Biol Chem. 2015;58(5):685–691. doi:10.1007/s13765-015-0092-0
  • Hu Q-P, Cao X-M, Hao D-L, Zhang -L-L. Chemical composition, antioxidant, DNA damage protective, cytotoxic and antibacterial activities of cyperus rotundus rhizomes essential oil against foodborne pathogens. Sci Rep. 2017;7(1):45231. doi:10.1038/srep45231
  • Morrison S, McGee SL. 3T3-L1 adipocytes display phenotypic characteristics of multiple adipocyte lineages. Adipocyte. 2015;4(4):295–302. doi:10.1080/21623945.2015.1040612
  • Setoguchi Y, Oritani Y, Ito R, et al. Absorption and metabolism of piceatannol in rats. J Agric Food Chem. 2014;62(12):2541–2548. doi:10.1021/jf404694y
  • Kwon JY, Seo SG, Heo YS, et al. Piceatannol, natural polyphenolic stilbene, inhibits adipogenesis via modulation of mitotic clonal expansion and insulin receptor-dependent insulin signaling in early phase of differentiation. J Biol Chem. 2012;287(14):11566–11578. doi:10.1074/jbc.M111.259721
  • Tung YC, Lin YH, Chen HJ, et al. Piceatannol exerts anti-obesity effects in C57BL/6 mice through modulating adipogenic proteins and gut microbiota. Molecules. 2016;21(11):1419. doi:10.3390/molecules21111419
  • Brown JD, Buscemi J, Milsom V, Malcolm R, O’Neil PM. Effects on cardiovascular risk factors of weight losses limited to 5–10. Transl Behav Med. 2016;6(3):339–346. doi:10.1007/s13142-015-0353-9
  • Ranasinghe C, Gamage P, Katulanda P, Andraweera N, Thilakarathne S, Tharanga P. Relationship between body mass index (BMI) and body fat percentage, estimated by bioelectrical impedance, in a group of Sri Lankan adults: a cross sectional study. BMC Public Health. 2013;13(1):797. doi:10.1186/1471-2458-13-797
  • Alberti KG, Zimmet P, Shaw J. The metabolic syndrome--a new worldwide definition. Lancet. 2005;366(9491):1059–1062. doi:10.1016/S0140-6736(05)67402-8
  • Lam BC, Koh GC, Chen C, Wong MT, Fallows SJ. Comparison of Body Mass Index (BMI), Body Adiposity Index (BAI), Waist Circumference (WC), Waist-To-Hip Ratio (WHR) and Waist-To-Height Ratio (WHtR) as predictors of cardiovascular disease risk factors in an adult population in Singapore. PLoS One. 2015;10(4):e0122985. doi:10.1371/journal.pone.0122985
  • Fischer S, Schatz U, Julius U. Practical recommendations for the management of hyperlipidemia. Atheroscler Suppl. 2015;18:194–198. doi:10.1016/j.atherosclerosissup.2015.02.029
  • Lefterova MI, Haakonsson AK, Lazar MA, Mandrup S. PPARgamma and the global map of adipogenesis and beyond. Trends Endocrinol Metab. 2014;25(6):293–302. doi:10.1016/j.tem.2014.04.001
  • Spiegelman BM, Frank M, Green H. Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development. J Biol Chem. 1983;258(16):10083–10089. doi:10.1016/S0021-9258(17)44608-4
  • Elmasri H, Karaaslan C, Teper Y, et al. Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells. FASEB J. 2009;23(11):3865–3873. doi:10.1096/fj.09-134882
  • Yin W, Carballo-Jane E, McLaren DG, et al. Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia. J Lipid Res. 2012;53(1):51–65. doi:10.1194/jlr.M019927
  • Bergen WG, Mersmann HJ. Comparative aspects of lipid metabolism: impact on contemporary research and use of animal models. J Nutr. 2005;135(11):2499–2502. doi:10.1093/jn/135.11.2499
  • Ahima RS. Revisiting leptin’s role in obesity and weight loss. J Clin Invest. 2008;118(7):2380–2383. doi:10.1172/JCI36284
  • Clement K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998;392(6674):398–401. doi:10.1038/32911
  • Myers MG Jr, Leibel RL, Seeley RJ, Schwartz MW. Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab. 2010;21(11):643–651. doi:10.1016/j.tem.2010.08.002
  • Bjorntorp P. Do stress reactions cause abdominal obesity and comorbidities? Obesity Reviews. 2001;2(2):73–86. doi:10.1046/j.1467-789x.2001.00027.x
  • Fardet L, Feve B. Systemic glucocorticoid therapy: a review of its metabolic and cardiovascular adverse events. Drugs. 2014;74(15):1731–1745. doi:10.1007/s40265-014-0282-9
  • Masuzaki H, Ogawa Y, Hosoda K, et al. Glucocorticoid regulation of leptin synthesis and secretion in humans: elevated plasma leptin levels in Cushing’s syndrome. J Clin Endocrinol Metab. 1997;82(8):2542–2547. doi:10.1210/jcem.82.8.4128
  • Macedo IC, Medeiros LF, Oliveira C, et al. Cafeteria diet-induced obesity plus chronic stress alter serum leptin levels. Peptides. 2012;38(1):189–196. doi:10.1016/j.peptides.2012.08.007
  • Banks WA, Coon AB, Robinson SM, et al. Triglycerides induce leptin resistance at the blood-brain barrier. Diabetes. 2004;53(5):1253–1260. doi:10.2337/diabetes.53.5.1253