Sex-Specific Associations Between Serum Phosphate Concentration and Cardiometabolic Disease: A Cohort Study on the Community-Based Older Chinese Population

References

• Ndisang JF, Rastogi S. Cardiometabolic diseases and related complications: current status and future perspective. Biomed Res Int. 2013;2013:467682. doi:10.1155/2013/467682
   PubMed Web of Science ®Google Scholar
• World Health Organisation. World Health Statistics 2020: Monitoring Health for the SDGs, Sustainable Development Goals. World Health Organisation; 2020.
   Google Scholar
• Liu M, Liu S-W, Wang L-J, et al. Burden of diabetes, hyperglycaemia in China from to 2016: findings from the 1990 to 2016, global burden of disease study. Diabetes Metab. 2019;45(3):286–293. doi:10.1016/j.diabet.2018.08.008
   PubMed Web of Science ®Google Scholar
• International Diabetes Federation. IDF Diabetes Atlas. 9th ed. International Diabetes Federation; 2019.
   Google Scholar
• Mao W, Yip C-MW, Chen W. Complications of diabetes in China: health system and economic implications. BMC Public Health. 2019;19:269. doi:10.1186/s12889-019-6569-8
   PubMed Web of Science ®Google Scholar
• Levy J, Stern Z, Gutman A, Naparstek Y, Avioli LV, Avioli LV. Plasma calcium and phosphate levels in an adult noninsulin-dependent diabetic population. Calcif Tissue Int. 1986;39:316–318. doi:10.1007/BF02555197
   PubMed Web of Science ®Google Scholar
• DeFronzo RA, Lang R. Hypophosphatemia and glucose intolerance: evidence for tissue insensitivity to insulin. N Eng J Med. 1980;303(22):1259–1263. doi:10.1056/NEJM198011273032203
   Web of Science ®Google Scholar
• Gudmundsdottir H, Strand AH, Kjeldsen SE, Høieggen A, Os I. Serum phosphate, blood pressure, and the metabolic syndrome—20‐year follow‐up of middle‐aged men. J Clin Hypertens. 2008;10(11):814–821. doi:10.1111/j.1751-7176.2008.00032.x
   Web of Science ®Google Scholar
• Billington EO, Gamble GD, Bristow S, Reid IR. Serum phosphate is related to adiposity in healthy adults. Eur J Clin Invest. 2017;47(7):486–493. doi:10.1111/eci.12769
   Web of Science ®Google Scholar
• Håglin LM, Törnkvist B, Bäckman LO. High serum phosphate and triglyceride levels in smoking women and men with CVD risk and type 2 diabetes. Diabetol Metab Syndr. 2014;6:39. doi:10.1186/1758-5996-6-39
   PubMed Web of Science ®Google Scholar
• Huang CX, Plantinga LC, Fink NE, Melamed ML, Coresh J, Powe NR. Phosphate levels and blood pressure in incident hemodialysis patients: a longitudinal study. Adv Chronic Kidney Dis. 2008;15(3):321–331. doi:10.1053/j.ackd.2008.04.012
   Web of Science ®Google Scholar
• Haap M, Heller E, Thamer C, Tschritter O, Stefan N, Fritsche A. Association of serum phosphate levels with glucose tolerance, insulin sensitivity and insulin secretion in non-diabetic subjects. Eur J Clin Nutr. 2006;60:734–739. doi:10.1038/sj.ejcn.1602375
   PubMed Web of Science ®Google Scholar
• Nowicki M, Fliser D, Fode P, Ritz E. Changes in plasma phosphate levels influence insulin sensitivity under euglycemic conditions. J Clin Endocrinol Metab. 1996;81:156–159. doi:10.1210/jcem.81.1.8550745
   Web of Science ®Google Scholar
• Park KS, Park J, Choi SH, et al. Serum phosphorus concentration and coronary artery calcification in subjects without renal dysfunction. PLoS One. 2016;11(3):e0151007. doi:10.1371/journal.pone.0151007
   Web of Science ®Google Scholar
• Onufrak SJ, Bellasi A, Cardarelli F, et al. Investigation of gender heterogeneity in the associations of serum phosphorus with incident coronary artery disease and all-cause mortality. Am J Epidemiol. 2009;169(1):67–77. doi:10.1093/aje/kwn285
   Web of Science ®Google Scholar
• Hu C, Jia W. Diabetes in China: epidemiology and genetic risk factors and their clinical utility in personalized medication. Diabetes. 2018;67(1):3–11. doi:10.2337/dbi17-0013
   PubMed Web of Science ®Google Scholar
• Gerdts E, Regitz-Zagrosek V. Sex differences in cardiometabolic disorders. Nat Med. 2019;25:1657–1666. doi:10.1038/s41591-019-0643-8
   PubMed Web of Science ®Google Scholar
• Ministry of Health PRC. Reference Intervals for Common Clinical Biochemistry Tests. Vol WS/T 404. National Health and Family Planning Commission PRC; 2015.
   Google Scholar
• US Department of Health and Human Services. 2008 Physical Activity Guidelines for Americans. First ed. US Department of Health and Human Services; 2008.
   Google Scholar
• Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines. Hypertension. 2017;71:e13–e115. doi:10.1161/HYP.0000000000000065
   PubMed Web of Science ®Google Scholar
• Chinese Diabetes Society. Guidelines for prevention and treatment of type 2 diabetes in China. Chin J Diabetes. 2018;10(1):4–67.
   Google Scholar
• Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation. 2005;112(17):2735–2752. doi:10.1161/CIRCULATIONAHA.105.169404
   PubMed Web of Science ®Google Scholar
• Fang L, Li X. [Level of serum phosphorus and adult type 2 diabetes mellitus]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016;41(5):502–506. Chinese. doi:10.11817/j.issn.1672-7347.2016.05.009
   PubMedGoogle Scholar
• Shimodaira M, Okaniwa S, Nakayama T. Reduced serum phosphorus levels were associated with metabolic syndrome in men but not in women: a cross-sectional study among the Japanese population. Ann Nutr Metab. 2017;71:150–156. doi:10.1159/000480354
   Web of Science ®Google Scholar
• Akter S, Eguchi M, Kochi T, Kabe I, Nanri A, Mizoue T. Association of serum calcium and phosphate concentrations with glucose metabolism markers: the Furukawa Nutrition and Health Study. Nutrients. 2020;12(8):2344. doi:10.3390/nu12082344
   Web of Science ®Google Scholar
• Lorenzo C, Hanley AJ, Rewers MJ, Haffner SM. Calcium and phosphate concentrations and future development of type 2 diabetes: the Insulin Resistance Atherosclerosis Study. Diabetologia. 2014;57(7):1366–1374. doi:10.1007/s00125-014-3241-9
   Web of Science ®Google Scholar
• Jhuang YH, Kao TW, Peng TC, Chen WL, Chang PK, Wu LW. Serum phosphorus as a risk factor of metabolic syndrome in the elderly in Taiwan: a Large-Population Cohort Study. Nutrients. 2019;11(10):2340. doi:10.3390/nu11102340
   Web of Science ®Google Scholar
• Johnson MA, Tekkanat K, Schmaltz SP, Fox IH. Adenosine triphosphate turnover in humans. Decreased degradation during relative hyperphosphatemia. J Clin Invest. 1989;84(3):990–995. doi:10.1172/JCI114263
   Web of Science ®Google Scholar
• Khattab M, Abi-Rashed C, Ghattas H, Hlais S, Obeid O. Phosphorus ingestion improves oral glucose tolerance of healthy male subjects: a crossover experiment. Nutr J. 2015;14:112. doi:10.1186/s12937-015-0101-5
   PubMed Web of Science ®Google Scholar
• Paula FJ, Plens AE, Foss MC. Effects of hypophosphatemia on glucose tolerance and insulin secretion. Horm Metab Res. 1998;30(5):281–284. doi:10.1055/s-2007-978884
   Web of Science ®Google Scholar
• Ditzel J, Lervang -H-H. Disturbance of inorganic phosphate metabolism in diabetes mellitus: its impact on the development of diabetic late complications. Curr Diabetes Rev. 2010;6(5):323–333. doi:10.2174/157339910793360833
   PubMedGoogle Scholar
• Raikou VD, Kyriaki D, Gavriil S. Importance of serum phosphate in elderly patients with diabetes mellitus. World J Diabetes. 2020;11(10):416–424. doi:10.4239/wjd.v11.i10.416
   Web of Science ®Google Scholar
• van der Vaart A, Yeung S, van Dijk P, Bakker S, de Borst M. Phosphate and fibroblast growth factor 23 in diabetes. Clin Sci (Lond). 2021;135(14):1669–1687. doi:10.1042/CS20201290
   Web of Science ®Google Scholar
• Rakugi H, Ogihara T. The metabolic syndrome in the Asian population. Curr Hypertens Rep. 2005;7:103–109. doi:10.1007/s11906-005-0082-4
   Web of Science ®Google Scholar
• Obeid OA. Low phosphorus status might contribute to the onset of obesity. Obes Rev. 2013;14(8):659–664. doi:10.1111/obr.12039
   PubMed Web of Science ®Google Scholar
• Tremblay A, Royer -M-M, Chaput J-P, Doucet É. Adaptive thermogenesis can make a difference in the ability of obese individuals to lose body weight. Int J Obes (Lond). 2012;37:759–764. doi:10.1038/ijo.2012.124
   Web of Science ®Google Scholar
• Jung RT, Shetty PS, James WPT, Barrand MA, Callingham BA. Reduced thermogenesis in obesity. Nature. 1979;279:322–323. doi:10.1038/279322a0
   PubMed Web of Science ®Google Scholar
• Ayoub JJ, Samra MJA, Hlais SA, Bassil MS, Obeid OA. Effect of phosphorus supplementation on weight gain and waist circumference of overweight/obese adults: a randomized clinical trial. Nutr Diabetes. 2015;5:e189. doi:10.1038/nutd.2015.38
   Web of Science ®Google Scholar
• Stoian M, Stoica V. The role of disturbances of phosphate metabolism in metabolic syndrome. Maedica (Bucur). 2014;9(3):255–260.
   PubMedGoogle Scholar
• Nabuco HCG, Tomeleri CM, Junior PS, et al. Lower protein and higher carbohydrate intake are related with altering metabolic syndrome components in elderly women: a cross-sectional study. Exp Gerontol. 2018;103:132–137. doi:10.1016/j.exger.2018.01.013
   Web of Science ®Google Scholar
• Ix JH, De Boer IH, Peralta CA. Serum phosphorus concentrations and arterial stiffness among individuals with normal kidney function to moderate kidney disease in Mesa. Clin J Am Soc Nephrol. 2009;4(3):609–615. doi:10.2215/CJN.04100808
   PubMed Web of Science ®Google Scholar
• Park W, Kim BS, Lee JE, et al. Serum phosphate levels and the risk of cardiovascular disease and metabolic syndrome: a double-edged sword. Diabetes Res Clin Pract. 2009;83(1):119–125. doi:10.1016/j.diabres.2008.08.018
   PubMed Web of Science ®Google Scholar
• Haglin L, Lindblad A, Bygren L. Original communication hypophosphataemia in the metabolic syndrome. Gender differences in body weight and blood glucose. Eur J Clin Nutr. 2001;55:493–498. doi:10.1038/sj.ejcn.1601209
   Web of Science ®Google Scholar
• Yoo KD, Kang S, Choi Y, et al. Sex, age, and the association of serum phosphorus with all-cause mortality in adults with normal kidney function. Am J Kidney Dis. 2015;67(1):79–88. doi:10.1053/j.ajkd.2015.06.027
   Web of Science ®Google Scholar
• Castelli WP. Epidemiology of coronary heart disease: the Framingham study. Am J Med. 1984;76(2):4–12. doi:10.1016/0002-9343(84)90952-5
   Web of Science ®Google Scholar
• Sigdel M, Kumar A, Gyawali P, Shrestha R, Tuladhar ET, Jha B. Association of high sensitivity C-reactive protein with the components of metabolic syndrome in diabetic and non-diabetic individuals. J Clin Diagn Res. 2014;8(6):11–13. doi:10.7860/JCDR/2014/8085.4522
   Google Scholar
• Campos-Obando N, Lahousse L, Brusselle G, et al. Serum phosphate levels are related to all-cause, cardiovascular and COPD mortality in men. Eur J Epidemiol. 2018;33(9):859–871. doi:10.1007/s10654-018-0407-7
   Web of Science ®Google Scholar
• Ko GT, Wai HP, Tang JS. Effects of age on plasma glucose levels in non-diabetic Hong Hong Chinese. Croat Med J. 2006;47(5):709–713.
   PubMed Web of Science ®Google Scholar