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ORIGINAL RESEARCH

Association of Thyroid Hormone Levels with Microvascular Complications in Euthyroid Type 2 Diabetes Mellitus Patients

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Pages 2467-2477 | Published online: 12 Aug 2022

References

  • Sun H, Saeedi P, Karuranga S, et al. IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119. doi:10.1016/j.diabres.2021.109119
  • Morrish NJ, Wang SL, Stevens LK, Fuller JH, Keen H. Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia. 2001;44(Suppl 2):S14–21.
  • Harding JL, Pavkov ME, Magliano DJ, Shaw JE, Gregg EW. Global trends in diabetes complications: a review of current evidence. Diabetologia. 2019;62(1):3–16.
  • Cheema S, Maisonneuve P, Zirie M, et al. Risk factors for microvascular complications of diabetes in a high-risk middle east population. J Diabetes Res. 2018;2018:8964027.
  • Raman R, Gupta A, Krishna S, Kulothungan V, Sharma T. Prevalence and risk factors for diabetic microvascular complications in newly diagnosed type II diabetes mellitus. Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study (SN-DREAMS, report 27). J Diabetes Complications. 2012;26(2):123–128.
  • Zoungas S, Woodward M, Li Q, et al. Impact of age, age at diagnosis and duration of diabetes on the risk of macrovascular and microvascular complications and death in type 2 diabetes. Diabetologia. 2014;57(12):2465–2474.
  • Yamazaki D, Hitomi H, Nishiyama A. Hypertension with diabetes mellitus complications. Hypertens Res. 2018;41(3):147–156.
  • Zhao W, Zeng H, Zhang X, et al. A high thyroid stimulating hormone level is associated with diabetic peripheral neuropathy in type 2 diabetes patients. Diabetes Res Clin Pract. 2016;115:122–129.
  • Jabbar A, Pingitore A, Pearce SH, Zaman A, Iervasi G, Razvi S. Thyroid hormones and cardiovascular disease. Nat Rev Cardiol. 2017;14(1):39–55.
  • Johnson L, Rayner B. A cross-sectional cohort study with microvascular complications in patients with type 2 diabetes with and without hypothyroidism. Cardiovasc J Afr. 2020;31(1):5–8. doi:10.5830/CVJA-2019-036
  • Mansournia N, Riyahi S, Tofangchiha S, et al. Subclinical hypothyroidism and diabetic nephropathy in Iranian patients with type 2 diabetes. J Endocrinol Invest. 2017;40(3):289–295.
  • Mehalingam V, Sahoo J, Bobby Z, Vinod KV. Thyroid dysfunction in patients with type 2 diabetes mellitus and its association with diabetic complications. J Family Med Primary Care. 2020;9(8):4277–4281.
  • Wu J, Li X, Tao Y, Wang Y, Peng Y. Free triiodothyronine levels are associated with diabetic nephropathy in euthyroid patients with type 2 diabetes. Int J Endocrinol. 2015;2015:204893.
  • Wang J, Li H, Tan M, et al. Association between thyroid function and diabetic nephropathy in euthyroid subjects with type 2 diabetes mellitus: a cross-sectional study in China. Oncotarget. 2019;10(2):88–97.
  • Zou J, Li Z, Tian F, et al. Association between normal thyroid hormones and diabetic retinopathy in patients with type 2 diabetes. Biomed Res Int. 2020;2020:8161797.
  • Kong X, Wang J, Gao G, et al. Association between free thyroxine levels and diabetic retinopathy in euthyroid patients with type 2 diabetes mellitus. Endocr Res. 2020;45(2):111–118.
  • Hu Y, Yan Z, Pan C. Associations of thyroid hormone levels and macrovascular complications in euthyroid type 2 diabetic patients. Diabetes Metab Syndr Obes. 2021;14:2683–2691.
  • American Diabetes Association. Standards of medical care in diabetes–2014. Diabetes Care. 2014;37(Suppl 1):S14–80.
  • Martin CL, Albers JW, Pop-Busui R. Neuropathy and related findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study. Diabetes Care. 2014;37(1):31–38.
  • Fong DS, Aiello L, Gardner TW, et al. Retinopathy in diabetes. Diabetes Care. 2004;27(Suppl 1):S84–87.
  • Penza P, Lombardi R, Camozzi F, Ciano C, Lauria G. Painful neuropathy in subclinical hypothyroidism: clinical and neuropathological recovery after hormone replacement therapy. Neurol Sci. 2009;30(2):149–151.
  • Yerdelen D, Ertorer E, Koç F. The effects of hypothyroidism on strength-duration properties of peripheral nerve. J Neurol Sci. 2010;294(1–2):89–91.
  • Han C, He X, Xia X, et al. Subclinical Hypothyroidism and Type 2 Diabetes: a Systematic Review and Meta-Analysis. PLoS One. 2015;10(8):e0135233.
  • Zhu FF, Yang LZ. The association between the levels of thyroid hormones and peripheral nerve conduction in patients with type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes. 2018;126(8):493–504.
  • Han Q, Zhang J, Wang Y, et al. Thyroid hormones and diabetic nephropathy: an essential relationship to recognize. Nephrology. 2019;24(2):160–169.
  • Liu P, Liu R, Chen X, et al. Can levothyroxine treatment reduce urinary albumin excretion rate in patients with early type 2 diabetic nephropathy and subclinical hypothyroidism? A randomized double-blind and placebo-controlled study. Curr Med Res Opin. 2015;31(12):2233–2240.
  • Zou J, Tian F, Zhang Y, et al. Association between Thyroid Hormone Levels and Diabetic Kidney Disease in Euthyroid Patients with Type 2 Diabetes. Sci Rep. 2018;8(1):4728.
  • Zhao W, Li X, Liu X, Lu L, Gao Z. Thyroid Function in patients with type 2 diabetes mellitus and diabetic nephropathy: a single center study. J Thyroid Res. 2018;2018:9507028.
  • Lin Y, Sun Z. Thyroid hormone ameliorates diabetic nephropathy in a mouse model of type II diabetes. J Endocrinol. 2011;209(2):185–191.
  • Yang JK, Liu W, Shi J, Li YB. An association between subclinical hypothyroidism and sight-threatening diabetic retinopathy in type 2 diabetic patients. Diabetes Care. 2010;33(5):1018–1020.
  • Wu J, Yue S, Geng J, et al. Relationship between diabetic retinopathy and subclinical hypothyroidism: a meta-analysis. Sci Rep. 2015;5:12212.
  • López-Noriega L, Cobo-Vuilleumier N, Narbona-Pérez ÁJ, et al. Levothyroxine enhances glucose clearance and blunts the onset of experimental type 1 diabetes mellitus in mice. Br J Pharmacol. 2017;174(21):3795–3810.
  • Lin Y, Sun Z. Thyroid hormone potentiates insulin signaling and attenuates hyperglycemia and insulin resistance in a mouse model of type 2 diabetes. Br J Pharmacol. 2011;162(3):597–610.
  • Kim BY, Kim CH, Jung CH, Mok JO, Suh KI, Kang SK. Association between subclinical hypothyroidism and severe diabetic retinopathy in Korean patients with type 2 diabetes. Endocr J. 2011;58(12):1065–1070.
  • Stefanowicz-Rutkowska MM, Baranowska-Jurkun A, Matuszewski W, Bandurska-Stankiewicz EM. Thyroid dysfunction in patients with diabetic retinopathy. Endokrynol Pol. 2020;71(2):176–183.
  • Lu M, Yang CB, Gao L, Zhao JJ. Mechanism of subclinical hypothyroidism accelerating endothelial dysfunction (Review). Exp Ther Med. 2015;9(1):3–10.
  • Nukada H. Ischemia and diabetic neuropathy. Handb Clin Neurol. 2014;126:469–487.
  • Vicinanza R, Coppotelli G, Malacrino C, et al. Oxidized low-density lipoproteins impair endothelial function by inhibiting non-genomic action of thyroid hormone-mediated nitric oxide production in human endothelial cells. Thyroid. 2013;23(2):231–238.
  • Taddei S, Caraccio N, Virdis A, et al. Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy. J Clin Endocrinol Metab. 2003;88(8):3731–3737.
  • Mantzouratou P, Lavecchia AM, Novelli R, Xinaris C. Thyroid Hormone Signalling Alteration in Diabetic Nephropathy and Cardiomyopathy: a “Switch” to the Foetal Gene Programme. Curr Diab Rep. 2020;20(11):58.
  • Cappola AR, Ladenson PW. Hypothyroidism and atherosclerosis. J Clin Endocrinol Metab. 2003;88(6):2438–2444.
  • Oflaz H, Kurt R, Cimen A, et al. Coronary flow reserve is also impaired in patients with subclinical hypothyroidism. Int J Cardiol. 2007;120(3):414–416.
  • Glaschke A, Weiland J, Del Turco D, Steiner M, Peichl L, Glösmann M. Thyroid hormone controls cone opsin expression in the retina of adult rodents. J Neurosci. 2011;31(13):4844–4851.
  • Biondi B, Kahaly GJ, Robertson RP. Thyroid Dysfunction and Diabetes Mellitus: two Closely Associated Disorders. Endocr Rev. 2019;40(3):789–824.