Free Triiodothyronine Levels are Related to Executive Function and Scene Memory in Type 2 Diabetes Mellitus Patients Without Diagnosed Thyroid Diseases

References

• Contreras-Jurado C, Pascual A. Thyroid hormone regulation of APP (beta-amyloid precursor protein) gene expression in brain and brain cultured cells. Neurochem Int. 2012;60(5):484–487. doi:10.1016/j.neuint.2012.01.027
   PubMed Web of Science ®Google Scholar
• Belakavadi M, Dell J, Grover GJ, Fondell JD. Thyroid hormone suppression of beta-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events. Mol Cell Endocrinol. 2011;339(1–2):72–80. doi:10.1016/j.mce.2011.03.016
   Web of Science ®Google Scholar
• Oyanagi K, Negishi T, Tashiro T. Action of thyroxine on the survival and neurite maintenance of cerebellar granule neurons in culture. J Neurosci Res. 2015;93(4):592–603. doi:10.1002/jnr.23519
   Web of Science ®Google Scholar
• Petersen RC, Roberts RO, Knopman DS, et al. Mild cognitive impairment: ten years later. Arch Neurol. 2009;66(12):1447–1455. doi:10.1001/archneurol.2009.266
   PubMedGoogle Scholar
• Luo L, Yano N, Mao Q, Jackson IM, Stopa EG. Thyrotropin releasing hormone (TRH) in the hippocampus of Alzheimer patients. J Alzheimers Dis. 2002;4(2):97–103. doi:10.3233/JAD-2002-4204
   Web of Science ®Google Scholar
• Mariani E, Monastero R, Mecocci P, Mecocci P. Mild cognitive impairment: a systematic review. J Alzheimers Dis. 2007;12(1):23–35. doi:10.3233/JAD-2007-12104
   PubMed Web of Science ®Google Scholar
• Chaker L, Wolters FJ, Bos D, et al. Thyroid function and the risk of dementia: the Rotterdam Study. Neurology. 2016;87(16):1688–1695. doi:10.1212/WNL.0000000000003227
   PubMed Web of Science ®Google Scholar
• Rieben C, Segna D, da Costa BR, et al. Subclinical thyroid dysfunction and the risk of cognitive decline: a meta-analysis of prospective cohort studies. J Clin Endocrinol Metab. 2016;101(12):4945–4954. doi:10.1210/jc.2016-2129
   PubMed Web of Science ®Google Scholar
• Cappola AR, Arnold AM, Wulczyn K, Carlson M, Robbins J, Psaty BM. Thyroid function in the euthyroid range and adverse outcomes in older adults. J Clin Endocrinol Metab. 2015;100(3):1088–1096. doi:10.1210/jc.2014-3586
   PubMed Web of Science ®Google Scholar
• Johansson P, Almqvist EG, Johansson JO, et al. Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer’s disease. Psychoneuroendocrinology. 2013;38(7):1058–1066. doi:10.1016/j.psyneuen.2012.10.012
   PubMed Web of Science ®Google Scholar
• Davis JD, Podolanczuk A, Donahue JE, et al. Thyroid hormone levels in the prefrontal cortex of post-mortem brains of Alzheimer’s disease patients. Curr Aging Sci. 2008;1(3):175–181. doi:10.2174/1874609810801030175
   Google Scholar
• Baldini M, Colasanti A, Orsatti A, Airaghi L, Mauri MC, Cappellini MD. Neuropsychological functions and metabolic aspects in subclinical hypothyroidism: the effects of L-thyroxine. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(5):854–859. doi:10.1016/j.pnpbp.2009.04.009
   PubMed Web of Science ®Google Scholar
• Gussekloo J, van Exel E, de Craen AJ, Meinders AE, Frolich M, Westendorp RG. Thyroid status, disability and cognitive function, and survival in old age. JAMA. 2004;292(21):2591–2599. doi:10.1001/jama.292.21.2591
   PubMed Web of Science ®Google Scholar
• Reed HL, Reedy KR, Palinkas LA, et al. Impairment in cognitive and exercise performance during prolonged antarctic residence: effect of thyroxine supplementation in the polar triiodothyronine syndrome. J Clin Endocrinol Metab. 2001;86(1):110–116. doi:10.1210/jcem.86.1.7092
   Web of Science ®Google Scholar
• Chen Z, Liang X, Zhang C, et al. Correlation of thyroid dysfunction and cognitive impairments induced by subcortical ischemic vascular disease. Brain Behav. 2016;6(4):e00452. doi:10.1002/brb3.452
   Web of Science ®Google Scholar
• Zhang N, Ma Q, Chen XW, et al. [Effects of retinol acid and triiodothyronine on alleviating the impairment of cognitive function by sleep deprivation]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013;29(4):294–297, 300. Chinese.
   Google Scholar
• Ichioka S, Terao T, Hoaki N, Matsushita T, Hoaki T. Triiodothyronine may be possibly associated with better cognitive function and less extrapyramidal symptoms in chronic schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2012;39(1):170–174. doi:10.1016/j.pnpbp.2012.06.008
   Web of Science ®Google Scholar
• Nomoto S, Kinno R, Ochiai H, et al. The relationship between thyroid function and cerebral blood flow in mild cognitive impairment and Alzheimer’s disease. PLoS One. 2019;14(4):e0214676. doi:10.1371/journal.pone.0214676
   Web of Science ®Google Scholar
• Quinlan P, Horvath A, Wallin A, Svensson J. Low serum concentration of free triiodothyronine (FT3) is associated with increased risk of Alzheimer’s disease. PsychoneuroEndocrinology. 2019;99:112–119. doi:10.1016/j.psyneuen.2018.09.002
   PubMed Web of Science ®Google Scholar
• Cho NH, Shaw JE, Karuranga S, et al. IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271–281. doi:10.1016/j.diabres.2018.02.023
   PubMed Web of Science ®Google Scholar
• Wang L, Gao P, Zhang M, et al. Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013. JAMA. 2017;317(24):2515–2523. doi:10.1001/jama.2017.7596
   PubMed Web of Science ®Google Scholar
• Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539–553. doi:10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   PubMed Web of Science ®Google Scholar
• Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999;56(3):303–308. doi:10.1001/archneur.56.3.303
   PubMed Web of Science ®Google Scholar
• Tian S, Huang R, Han J, et al. Increased plasma Interleukin-1beta level is associated with memory deficits in type 2 diabetic patients with mild cognitive impairment. Psychoneuroendocrinology. 2018;96:148–154. doi:10.1016/j.psyneuen.2018.06.014
   Web of Science ®Google Scholar
• Nasreddine ZS, Phillips NA, Bedirian V, et al. The montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–699. doi:10.1111/j.1532-5415.2005.53221.x
   PubMed Web of Science ®Google Scholar
• Viscogliosi G, Chiriac IM, Andreozzi P, Ettorre E. Executive dysfunction assessed by Clock-Drawing Test in older non-demented subjects with metabolic syndrome is not mediated by white matter lesions. Psychiatry Clin Neurosci. 2015;69(10):620–629. doi:10.1111/pcn.12296
   Web of Science ®Google Scholar
• Leung JL, Lee GT, Lam YH, Chan RC, Wu JY. The use of the Digit Span Test in screening for cognitive impairment in acute medical inpatients. Int Psychogeriatr. 2011;23(10):1569–1574. doi:10.1017/S1041610211000792
   PubMed Web of Science ®Google Scholar
• Chen YL, Chen YH, Lieh-Mak F, Felice M. Semantic verbal fluency deficit as a familial trait marker in schizophrenia. Psychiatry Res. 2000;95(2):133–148. doi:10.1016/S0165-1781(00)00166-9
   Web of Science ®Google Scholar
• Crowe SF. The differential contribution of mental tracking, cognitive flexibility, visual search, and motor speed to performance on parts A and B of the Trail Making Test. J Clin Psychol. 1998;54(5):585–591. doi:10.1002/(SICI)1097-4679(199808)54:5<585::AID-JCLP4>3.0.CO;2-K
   PubMed Web of Science ®Google Scholar
• Vakil E, Blachstein H, Rochberg J, Vardi M. Characterization of memory impairment following closed-head injury in children using the Rey Auditory Verbal Learning Test (AVLT). Child Neuropsychol. 2004;10(2):57–66. doi:10.1080/09297040490911078
   PubMed Web of Science ®Google Scholar
• Won J, Callow DD, Pena GS, et al. Hippocampal functional connectivity and memory performance after exercise intervention in older adults with mild cognitive impairment. J Alzheimers Dis. 2021;82(3):1015–1031. doi:10.3233/JAD-210051
   Web of Science ®Google Scholar
• Stepien BK, Huttner WB. Transport, metabolism, and function of thyroid hormones in the developing mammalian brain. Front Endocrinol. 2019;10:209. doi:10.3389/fendo.2019.00209
   Web of Science ®Google Scholar
• Wallis K, Dudazy S, van Hogerlinden M, Nordstrom K, Mittag J, Vennstrom B. The thyroid hormone receptor alpha1 protein is expressed in embryonic postmitotic neurons and persists in most adult neurons. Mol Endocrinol. 2010;24(10):1904–1916. doi:10.1210/me.2010-0175
   Google Scholar
• Kotkowski E, Price LR, Franklin C, et al. A neural signature of metabolic syndrome. Hum Brain Mapp. 2019;40(12):3575–3588. doi:10.1002/hbm.24617
   PubMed Web of Science ®Google Scholar
• Rad SK, Arya A, Karimian H, et al. Mechanism involved in insulin resistance via accumulation of beta-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer’s disease. Drug Des Devel Ther. 2018;12:3999–4021. doi:10.2147/DDDT.S173970
   PubMed Web of Science ®Google Scholar
• Wang SH, Huang Y, Yuan Y, Xia WQ, Wang P, Huang R. LDL receptor knock-out mice show impaired spatial cognition with hippocampal vulnerability to apoptosis and deficits in synapses. Lipids Health Dis. 2014;13:175. doi:10.1186/1476-511X-13-175
   PubMed Web of Science ®Google Scholar
• Park HS, Park SS, Kim CJ, Shin MS, Kim TW. Exercise alleviates cognitive functions by enhancing hippocampal insulin signaling and neuroplasticity in high-fat diet-induced obesity. Nutrients. 2019;11(7):1603. doi:10.3390/nu11071603
   Web of Science ®Google Scholar
• Cope EC, LaMarca EA, Monari PK, et al. Microglia play an active role in obesity-associated cognitive decline. J Neurosci. 2018;38(41):8889–8904. doi:10.1523/JNEUROSCI.0789-18.2018
   Web of Science ®Google Scholar
• O’Grady JP, Dean DC 3rd, Yang KL, et al. Elevated insulin and insulin resistance are associated with altered myelin in cognitively unimpaired middle-aged adults. Obesity. 2019;27(9):1464–1471. doi:10.1002/oby.22558
   Web of Science ®Google Scholar
• Akcan N, Bundak R. Accuracy of tri-ponderal mass index and body mass index in estimating insulin resistance, hyperlipidemia, impaired liver enzymes or thyroid hormone function and vitamin D levels in children and adolescents. J Clin Res Pediatr Endocrinol. 2019;11(4):366–373. doi:10.4274/jcrpe.galenos.2019.2018.0279
   Web of Science ®Google Scholar
• Ferrannini E, Iervasi G, Cobb J, Ndreu R, Nannipieri M. Insulin resistance and normal thyroid hormone levels: prospective study and metabolomic analysis. Am J Physiol Endocrinol Metab. 2017;312(5):E429–E436. doi:10.1152/ajpendo.00464.2016
   PubMed Web of Science ®Google Scholar
• Jayanthi R, Srinivasan AR, Hanifah M, Maran AL. Associations among insulin resistance, Triacylglycerol/High Density Lipoprotein (TAG/HDL ratio) and thyroid hormone levels-A study on Type 2 diabetes mellitus in obese and overweight subjects. Diabetes Metab Syndr. 2017;11(Suppl 1):S121–S126. doi:10.1016/j.dsx.2016.12.020
   Web of Science ®Google Scholar
• Kwon H, Cho JH, Lee DY, et al. Association between thyroid hormone levels, body composition and insulin resistance in euthyroid subjects with normal thyroid ultrasound: the Kangbuk Samsung Health Study. Clin Endocrinol. 2018;89(5):649–655. doi:10.1111/cen.13823
   Web of Science ®Google Scholar
• Martinez B, Ortiz RM. Thyroid hormone regulation and insulin resistance: insights from animals naturally adapted to fasting. Physiology. 2017;32(2):141–151. doi:10.1152/physiol.00018.2016
   Web of Science ®Google Scholar
• Jornayvaz FR, Lee HY, Jurczak MJ, et al. Thyroid hormone receptor-alpha gene knockout mice are protected from diet-induced hepatic insulin resistance. Endocrinology. 2012;153(2):583–591. doi:10.1210/en.2011-1793
   Web of Science ®Google Scholar
• Lin Y, Sun Z. Thyroid hormone potentiates insulin signaling and attenuates hyperglycemia and insulin resistance in a mouse model of type 2 diabetes. Br J Pharmacol. 2011;162(3):597–610. doi:10.1111/j.1476-5381.2010.01056.x
   PubMed Web of Science ®Google Scholar
• Brenta G, Celi FS, Pisarev M, Schnitman M, Sinay I, Arias P. Acute thyroid hormone withdrawal in athyreotic patients results in a state of insulin resistance. Thyroid. 2009;19(6):665–669. doi:10.1089/thy.2009.0108
   Web of Science ®Google Scholar
• Wang J, Yuan Y, Cai R, et al. Association between plasma levels of PAI-1, tPA/PAI-1 molar ratio, and mild cognitive impairment in Chinese patients with type 2 diabetes mellitus. J Alzheimers Dis. 2018;63(2):835–845. doi:10.3233/JAD-171038
   PubMed Web of Science ®Google Scholar
• Salazar P, Cisternas P, Martinez M, Inestrosa NC. Hypothyroidism and cognitive disorders during development and adulthood: implications in the central nervous system. Mol Neurobiol. 2019;56(4):2952–2963. doi:10.1007/s12035-018-1270-y
   Web of Science ®Google Scholar
• Li M, Huang L, Yang D, et al. Atrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment. Endocrine. 2020;68(3):536–548. doi:10.1007/s12020-020-02249-w
   Web of Science ®Google Scholar
• Huang R, Han J, Tian S, et al. Association of plasma ghrelin levels and ghrelin rs4684677 polymorphism with mild cognitive impairment in type 2 diabetic patients. Oncotarget. 2017;8(9):15126–15135. doi:10.18632/oncotarget.14852
   Google Scholar
• Zhang H, Huang R, Tian S, et al. The CC genotype of insulin-induced gene 2 rs7566605 is a protective factor of hypercholesteremia susceptible to mild cognitive impairment, especially to the executive function of patients with type 2 diabetes mellitus. Biomed Res Int. 2020;2020:4935831. doi:10.1155/2020/4935831
   Web of Science ®Google Scholar