Changes in the Expression of Insulin Pathway, Neutrophil Elastase and Alpha 1 Antitrypsin Genes from Leukocytes of Young Individuals with Insulin Resistance

References

• Petersen MC, Shulman GI. Mechanisms of insulin action and insulin resistance. Physiol Rev. 2018;98(4):2133–2223. doi:10.1152/physrev.00063.2017
   PubMed Web of Science ®Google Scholar
• Wu W-C, Wei J-N, Chen S-C, et al. Progression of insulin resistance: a link between risk factors and the incidence of diabetes. Diabetes Res Clin Pract. 2020;161:108050. doi:10.1016/j.diabres.2020.108050
   Web of Science ®Google Scholar
• Lee CH, Lam KS. Obesity-induced insulin resistance and macrophage infiltration of the adipose tissue: a vicious cycle. J Diabetes Investig. 2019;10(1):29–31. doi:10.1111/jdi.12918
   Web of Science ®Google Scholar
• Mukherjee B, Hossain CM, Mondal L, Paul P, Ghosh MK. Obesity and insulin resistance: an abridged molecular correlation. Lipid Insights. 2013;6:1–11. doi:10.4137/lpi.s10805
   Google Scholar
• Marchesini G, Brizi M, Morselli-Labate AM, et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med. 1999;107(5):450–455. doi:10.1016/S0002-9343(99
   PubMed Web of Science ®Google Scholar
• Kim SH, Reaven GM. Insulin resistance and hyperinsulinemia: you can’t have one without the other. Diabetes Care. 2008;31(7):1433–1438. doi:10.2337/dc08-0045
   PubMed Web of Science ®Google Scholar
• Dali-Youcef N, Mecili M, Ricci R, Andrés E. Metabolic inflammation: connecting obesity and insulin resistance. Ann Med. 2013;45(3):242–253. doi:10.3109/07853890.2012.705015
   PubMed Web of Science ®Google Scholar
• Ohta Y, Kinugawa S, Matsushima S, et al. Oxidative stress impairs insulin signal in skeletal muscle and causes insulin resistance in postinfarct heart failure. Am J Physiol Heart Circ Physiol. 2011;300(5):H1637–44. doi:10.1152/ajpheart.01185.2009
   Web of Science ®Google Scholar
• Roden M, Price TB, Perseghin G, et al. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest. 1996;97(12):2859–2865. doi:10.1172/jci118742
   PubMed Web of Science ®Google Scholar
• Sears B, Perry M. The role of fatty acids in insulin resistance. Lipids Health Dis. 2015;14:121. doi:10.1186/s12944-015-0123-1
   PubMed Web of Science ®Google Scholar
• Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640–1645. doi:10.1161/circulationaha.109.192644
   PubMed Web of Science ®Google Scholar
• Ford ES, Li C, Zhao G. Prevalence and correlates of metabolic syndrome based on a harmonious definition among adults in the US. J Diabetes. 2010;2(3):180–193. doi:10.1111/j.1753-0407.2010.00078.x
   PubMed Web of Science ®Google Scholar
• CDC. Prediabetes - your chance to prevent type 2 diabetes. Available from: https://www.cdc.gov/diabetes/basics/prediabetes.html. Accessed June 16, 2021.
   Google Scholar
• Gutiérrez-Solis AL, Datta Banik S, Méndez-González RM. Prevalence of metabolic syndrome in Mexico: a systematic review and meta-analysis. Metab Syndr Relat Disord. 2017;16(8):395–405. doi:10.1089/met.2017.0157
   Web of Science ®Google Scholar
• Saklayen MG. The global epidemic of the metabolic syndrome. Curr Hypertens Rep. 2018;20(2):12. doi:10.1007/s11906-018-0812-z
   PubMed Web of Science ®Google Scholar
• Sigit FS, Tahapary DL, Trompet S, et al. The prevalence of metabolic syndrome and its association with body fat distribution in middle-aged individuals from Indonesia and the Netherlands: a cross-sectional analysis of two population-based studies. Diabetol Metab Syndr. 2020;12:2. doi:10.1186/s13098-019-0503-1
   PubMed Web of Science ®Google Scholar
• Lim SM, Choi DP, Rhee Y, Kim HC. Association between obesity indices and insulin resistance among healthy Korean adolescents: the JS high school study. PLoS One. 2015;10(5):e0125238. doi:10.1371/journal.pone.0125238
   Web of Science ®Google Scholar
• Sejooti SS, Naher S, Hoque M, Zaman MS, Aminur Rashid HM. Frequency of insulin resistance in nondiabetic adult Bangladeshi individuals of different obesity phenotypes. Diab Metabol Synd. 2019;13(1):62–67. doi:10.1016/j.dsx.2018.08.022
   Web of Science ®Google Scholar
• Samocha-Bonet D, Dixit VD, Kahn CR, et al. Metabolically healthy and unhealthy obese–the 2013 Stock Conference report. Obes Rev. 2014;15(9):697–708. doi:10.1111/obr.12199
   PubMed Web of Science ®Google Scholar
• Madeira FB, Silva AA, Veloso HF, et al. Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country. PLoS One. 2013;8(3):e60673. doi:10.1371/journal.pone.0060673
   PubMed Web of Science ®Google Scholar
• McLaughlin T, Allison G, Abbasi F, Lamendola C, Reaven G. Prevalence of insulin resistance and associated cardiovascular disease risk factors among normal weight, overweight, and obese individuals. Metabolism. 2004;53(4):495–499. doi:10.1016/j.metabol.2003.10.032
   PubMed Web of Science ®Google Scholar
• Honka M-J, Latva-Rasku A, Bucci M, et al. Insulin-stimulated glucose uptake in skeletal muscle, adipose tissue and liver: a positron emission tomography study. Eur J Endocrinol. 2018;178(5):523–531. doi:10.1530/eje-17-0882
   PubMed Web of Science ®Google Scholar
• Maratou E, Dimitriadis G, Kollias A, et al. Glucose transporter expression on the plasma membrane of resting and activated white blood cells. Eur J Clin Invest. 2007;37(4):282–290. doi:10.1111/j.1365-2362.2007.01786.x
   PubMed Web of Science ®Google Scholar
• Dimitriadis G, Maratou E, Boutati E, Psarra K, Papasteriades C, Raptis SA. Evaluation of glucose transport and its regulation by insulin in human monocytes using flow cytometry. Cytom A. 2005;64A(1):27–33. doi:10.1002/cyto.a.20108
   Web of Science ®Google Scholar
• White MF. The insulin signalling system and the IRS proteins. Diabetologia. 1997;40(2):S2–S17. doi:10.1007/s001250051387
   Web of Science ®Google Scholar
• White MF. IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab. 2002;283(3):E413–22. doi:10.1152/ajpendo.00514.2001
   Web of Science ®Google Scholar
• Döring G. The role of neutrophil elastase in chronic inflammation. Am J Respir Crit Care Med. 1994;150(6):S114–S117. doi:10.1164/ajrccm/150.6_Pt_2.S114
   Web of Science ®Google Scholar
• Janciauskiene S, Wrenger S, Immenschuh S, et al. The multifaceted effects of alpha1-antitrypsin on neutrophil functions. Front Pharmacol. 2018;9:341. doi:10.3389/fphar.2018.00341
   PubMed Web of Science ®Google Scholar
• Matamala N, Aggarwal N, Iadarola P, et al. Identification of novel short C-terminal transcripts of human SERPINA1 gene. PLoS One. 2017;12(1):e0170533. doi:10.1371/journal.pone.0170533
   Web of Science ®Google Scholar
• Cruz-Pineda WD, Parra-Rojas I, Rodríguez-Ruiz HA, Illades-Aguiar B, Matia-García I, Garibay-Cerdenares OL. The regulatory role of insulin in energy metabolism and leukocyte functions. J Leukoc Biol. 2021;1–12. doi:10.1002/JLB.2RU1220-847R
   Web of Science ®Google Scholar
• Casagrande FB, Ferreira S, de Sousa ESA, et al. Insulin modulates inflammatory cytokine release in acute stages and augments expression of adhesion molecules and leukocytes in lungs on chronic stages of paracoccidioidomycosis. Front Immunol. 2020;11:583385. doi:10.3389/fimmu.2020.583385
   Web of Science ®Google Scholar
• Ieronymaki E, Theodorakis EM, Lyroni K, et al. Insulin resistance in macrophages alters their metabolism and promotes an M2-like phenotype. J Immunol. 2019;202(6):1786–1797. doi:10.4049/jimmunol.1800065
   Web of Science ®Google Scholar
• Ebeling P, Koistinen HA, Koivisto VA. Insulin-independent glucose transport regulates insulin sensitivity. FEBS Lett. 1998;436(3):301–303. doi:10.1016/S0014-5793(98
   Web of Science ®Google Scholar
• Olson AL. Regulation of GLUT4 and insulin-dependent glucose flux. ISRN Mol Biol. 2012;2012:856987. doi:10.5402/2012/856987
   Google Scholar
• Uemura E, Greenlee HW. Insulin regulates neuronal glucose uptake by promoting translocation of glucose transporter GLUT3. Exp Neurol. 2006;198(1):48–53. doi:10.1016/j.expneurol.2005.10.035
   Web of Science ®Google Scholar
• James HA, O’Neill BT, Nair KS. Insulin regulation of proteostasis and clinical implications. Cell Metab. 2017;26(2):310–323. doi:10.1016/j.cmet.2017.06.010
   Web of Science ®Google Scholar
• Batista TM, Garcia-Martin R, Cai W, et al. Multi-dimensional transcriptional remodeling by physiological insulin in vivo. Cell Rep. 2019;26(12):3429–3443.e3. doi:10.1016/j.celrep.2019.02.081
   Web of Science ®Google Scholar
• O’Brien RM, Granner DK. Regulation of gene expression by insulin. Physiol Rev. 1996;76(4):1109–1161. doi:10.1152/physrev.1996.76.4.1109
   PubMed Web of Science ®Google Scholar
• Mansuy-Aubert V, Zhou QL, Xie X, et al. Imbalance between neutrophil elastase and its inhibitor α1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab. 2013;17(4):534–548. doi:10.1016/j.cmet.2013.03.005
   PubMed Web of Science ®Google Scholar
• Talukdar S, Oh DY, Bandyopadhyay G, et al. Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med. 2012;18(9):1407–1412. doi:10.1038/nm.2885
   PubMed Web of Science ®Google Scholar
• Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412–419. doi:10.1007/bf00280883
   PubMed Web of Science ®Google Scholar
• Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162(1):156–159. doi:10.1016/0003-2697(87
   PubMed Web of Science ®Google Scholar
• Crofts CA, Zinn C, Wheldon M, Schofield G. Hyperinsulinemia: a unifying theory of chronic disease? Diabesity. 2015;1(4):34. doi:10.15562/diabesity.2015.19
   Google Scholar
• Singh S, Bodas M, Bhatraju NK, et al. Hyperinsulinemia adversely affects lung structure and function. Am J Physiol Lung Cell Mol Physiol. 2016;310(9):L837–45. doi:10.1152/ajplung.00091.2015
   PubMed Web of Science ®Google Scholar
• Kolb H, Kempf K, Röhling M, Martin S. Insulin: too much of a good thing is bad. BMC Med. 2020;18(1):224. doi:10.1186/s12916-020-01688-6
   PubMed Web of Science ®Google Scholar
• Goldstein BJ, Muller-Wieland D, Kahn CR. Variation in insulin receptor messenger ribonucleic acid expression in human and rodent tissues. Mol Endocrinol. 1987;1(11):759–766. doi:10.1210/mend-1-11-759
   Google Scholar
• Leal MA, Aller P, Mas A, Carranza C, Calle C. Tissue-specific changes in insulin receptor mRNA concentrations in dexamethasone-treated and adrenalectomized rats. Endocr J. 1994;41(6):737–741. doi:10.1507/endocrj.41.737
   Web of Science ®Google Scholar
• Moyerbrailean GA, Richards AL, Kurtz D, et al. High-throughput allele-specific expression across 250 environmental conditions. Genome Res. 2016;26(12):1627–1638. doi:10.1101/gr.209759.116
   Web of Science ®Google Scholar
• Pezzino V, Papa V, Trischitta V, et al. Human insulin receptor radioimmunoassay: applicability to insulin-resistant states. Am J Physiol. 1989;257(3):E451–E457. doi:10.1152/ajpendo.1989.257.3.E451
   Web of Science ®Google Scholar
• Puig O, Tjian R. Transcriptional feedback control of insulin receptor by dFOXO/FOXO1. Genes Dev. 2005;19(20):2435–2446. doi:10.1101/gad.1340505
   PubMed Web of Science ®Google Scholar
• Cardellini M, Menghini R, Luzi A, et al. Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness. Diabetes. 2011;60(12):3265–3270. doi:10.2337/db11-0162
   Web of Science ®Google Scholar
• Kubota T, Inoue M, Kubota N, et al. Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity. Nat Commun. 2018;9(1):4863. doi:10.1038/s41467-018-07358-9
   PubMed Web of Science ®Google Scholar
• López-Vicario C, Titos E, Walker ME, et al. Leukocytes from obese individuals exhibit an impaired SPM signature. FASEB J. 2019;33(6):7072–7083. doi:10.1096/fj.201802587R
   PubMed Web of Science ®Google Scholar
• Solt CM, Hill JL, Vanderpool K, Foster MT. Obesity-induced immune dysfunction and immunosuppression: TEM observation of visceral and subcutaneous lymph node microarchitecture and immune cell interactions. Horm Mol Biol Clin Investig. 2019;39(2):1–14. doi:10.1515/hmbci-2018-0083
   Web of Science ®Google Scholar
• Ali M, Jasmin S, Fariduddin M, Alam SMK, Arslan MI, Biswas SK. Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects. Mol Biol Rep. 2018;45(5):1245–1252. doi:10.1007/s11033-018-4279-4
   Web of Science ®Google Scholar
• Ehlers MR. Immune-modulating effects of alpha-1 antitrypsin. Biol Chem. 2014;395(10):1187–1193. doi:10.1515/hsz-2014-0161
   PubMed Web of Science ®Google Scholar
• Ferdous M, Ali M, Mudi SR, et al. Expression of neutrophil elastase and myeloperoxidase mRNA in patients with newly diagnosed type 2 diabetes mellitus. Diab Metabol Synd. 2020;14(2):83–85. doi:10.1016/j.dsx.2020.01.001
   Web of Science ®Google Scholar
• Stuart CA, Wen G, Williamson ME, et al. Altered GLUT1 and GLUT3 gene expression and subcellular redistribution of GLUT4: protein in muscle from patients with acanthosis nigricans and severe insulin resistance. Metabolism. 2001;50(7):771–777. doi:10.1053/meta.2001.24202
   Web of Science ®Google Scholar
• Taha C, Mitsumoto Y, Liu Z, Skolnik EY, Klip A. The insulin-dependent biosynthesis of GLUT1 and GLUT3 glucose transporters in L6 muscle cells is mediated by distinct pathways: roles of p21 ras and pp70 S6 kinase. J Biol Chem. 1995;270(42):24678–24681. doi:10.1074/jbc.270.42.24678
   Web of Science ®Google Scholar
• Korgun ET, Demir R, Sedlmayr P, et al. Sustained hypoglycemia affects glucose transporter expression of human blood leukocytes. Blood Cells Mol Dis. 2002;28(2):152–159. doi:10.1006/bcmd.2002.0504
   Web of Science ®Google Scholar
• Maclver NJ, Jacobs SR, Wieman HL, Wofford JA, Coloff JL, Rathmell JC. Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. J Leukoc Biol. 2008;84(4):949–957. doi:10.1189/jlb.0108024
   Web of Science ®Google Scholar
• Palmer CS, Ostrowski M, Balderson B, Christian N, Crowe SM. Glucose metabolism regulates T cell activation, differentiation, and functions. Front Immunol. 2015;6:1. doi:10.3389/fimmu.2015.00001
   PubMed Web of Science ®Google Scholar
• Tsai S, Clemente-Casares X, Zhou AC, et al. Insulin receptor-mediated stimulation boosts T cell immunity during inflammation and Infection. Cell Metab. 2018;28(6):922–934.e4. doi:10.1016/j.cmet.2018.08.003
   Web of Science ®Google Scholar
• Fischer HJ, Sie C, Schumann E, et al. The insulin receptor plays a critical role in T cell function and adaptive immunity. J Immunol. 2017;198(5):1910. doi:10.4049/jimmunol.1601011
   PubMed Web of Science ®Google Scholar
• Yano H, Kinoshita M, Fujino K, et al. Insulin treatment directly restores neutrophil phagocytosis and bactericidal activity in diabetic mice and thereby improves surgical site Staphylococcus aureus infection. Infect Immun. 2012;80(12):4409–4416. doi:10.1128/iai.00787-12
   Web of Science ®Google Scholar