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REVIEW

Research Progress on Relationship Between Iron Overload and Lower Limb Arterial Disease in Type 2 Diabetes Mellitus

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Pages 2259-2264 | Published online: 30 Jul 2022

References

  • Chinese Diabetes Society. Guideline for the prevention and treatment of type 2 diabetes mellitus in China (2020 edition). Chin J Diabetes Mellit. 2021;37(04):311–398.
  • Saeedi P, Petersohn I, Salpea P, et al. IDF diabetes atlas committee. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019;157:107843. doi:10.1016/j.diabres.2019.107843
  • Lu X, Sun J, Bai JJ, Ming Y, Chen LR. Investigation and analysis of lower extremity arterial disease in hospitalized elderly type 2 diabetic patients. Int J Nurs Sci. 2018;5(1):45–49. doi:10.1016/j.ijnss.2017.10.020
  • Hoyt RE. Peripheral arterial disease in people with diabetes: response to consensus statement. Diabetes Care. 2004;27(8):2095;author reply 2095. doi:10.2337/diacare.27.8.2095
  • Jørgensen LB, Halekoh U, Jemec GBE, Sørensen JA, Yderstræde KB. Monitoring wound healing of diabetic foot ulcers using two-dimensional and three-dimensional wound measurement techniques: a prospective cohort study. Adv Wound Care. 2020;9(10):553–563. doi:10.1089/wound.2019.1000
  • Cheng Y, Wang J, Tang Y. Research progress of diabetic lower limb vascular disease. World Latest Med Inform. 2018;18(A2):81–82,85.
  • Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y. Regulators of iron homeostasis: new players in metabolism, cell death, and disease. Trends Biochem Sci. 2016;41(3):274–286. doi:10.1016/j.tibs.2015.11.012
  • Mainous AG 3rd, Gill JM, Carek PJ. Elevated serum transferrin saturation and mortality. Ann Fam Med. 2004;2(2):133–138. doi:10.1370/afm.25
  • Li X, Liu Y, Zheng Q, et al. Ferritin light chain interacts with PEN-2 and affects γ-secretase activity. Neurosci Lett. 2013;548:90–94. doi:10.1016/j.neulet.2013.05.018
  • Oh HL, Lee JA, Kim DH, Lim JS. Reference values for serum ferritin and percentage of transferrin saturation in Korean children and adolescents. Blood Res. 2018;53(1):18–24. doi:10.5045/br.2018.53.1.18
  • Elsayed ME, Sharif MU, Stack AG. Transferrin saturation: a body iron biomarker. Adv Clin Chem. 2016;75:71–97.
  • Simcox JA, McClain DA. Iron and diabetes risk. Cell Metab. 2013;17(3):329–341. doi:10.1016/j.cmet.2013.02.007
  • Muñoz M, García-Erce JA, Remacha ÁF. Disorders of iron metabolism. Part II: iron deficiency and iron overload. J Clin Pathol. 2011;64(4):287–296. PMID: 21177268. doi:10.1136/jcp.2010.086991
  • Hansen JB, Moen IW, Mandrup-Poulsen T. Iron: the hard player in diabetes pathophysiology. Acta Physiol. 2014;210(4):717–732. doi:10.1111/apha.12256
  • Huang J, Jones D, Luo B, et al. Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. Diabetes. 2011;60(1):80–87. doi:10.2337/db10-0593
  • Gao H, Yang J, Pan W, Yang M. Iron overload and the risk of diabetes in the general population: results of the Chinese health and nutrition survey cohort study. Diabetes Metab J. 2022;46(2):307–318. doi:10.4093/dmj.2020.0287
  • Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, Hu FB. Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA. 2004;291(6):711–717. doi:10.1001/jama.291.6.711
  • Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diabetes Care. 2004;27(10):2422–2428. doi:10.2337/diacare.27.10.2422
  • Haap M, Fritsche A, Mensing HJ, Häring HU, Stumvoll M. Association of high serum ferritin concentration with glucose intolerance and insulin resistance in healthy people. Ann Intern Med. 2003;139(10):869–871. doi:10.7326/0003-4819-139-10-200311180-00029
  • Guo L, Jiang F, Tang YT, Si MY, Jiao XY. The association of serum vascular endothelial growth factor and ferritin in diabetic microvascular disease. Diabetes Technol Ther. 2014;16(4):224–234. doi:10.1089/dia.2013.0181
  • Cempaka AR, Tseng SH, Yuan KC, et al. Dysregulated iron metabolism-associated dietary pattern predicts an altered body composition and metabolic syndrome. Nutrients. 2019;11(11):2733. doi:10.3390/nu11112733
  • Chang JS, Lin SM, Huang TC, et al. Serum ferritin and risk of the metabolic syndrome: a population-based study. Asia Pac J Clin Nutr. 2013;22(3):400–407. doi:10.6133/apjcn.2013.22.3.07
  • Jiang L, Wang K, Lo K, et al. Sex-specific association of circulating ferritin level and risk of type 2 diabetes: a dose-response meta-analysis of prospective studies. J Clin Endocrinol Metab. 2019;104(10):4539–4551. doi:10.1210/jc.2019-00495
  • Dominguez JH, Liu Y, Kelly KJ. Renal iron overload in rats with diabetic nephropathy. Physiol Rep. 2015;3(12):e12654. doi:10.14814/phy2.12654
  • Varghese J, James J, Vaulont S, Mckie A, Jacob M. Increased intracellular iron in mouse primary hepatocytes in vitro causes activation of the Akt pathway but decreases its response to insulin. Biochim Biophys Acta Gen Subj. 2018;1862(9):1870–1882. doi:10.1016/j.bbagen.2018.05.022
  • Aregbesola A, de Mello VDF, Lindström J, et al. Serum adiponectin/Ferritin ratio in relation to the risk of type 2 diabetes and insulin sensitivity. Diabetes Res Clin Pract. 2018;141:264–274. doi:10.1016/j.diabres.2018.05.012
  • Dahyaleh K, Sung HK, Prioriello M, et al. Iron overload reduces adiponectin receptor expression via a ROS/FOXO1-dependent mechanism leading to adiponectin resistance in skeletal muscle cells. J Cell Physiol. 2021;236(7):5339–5351. doi:10.1002/jcp.30240
  • Mokhtari H, Bagheri B, Rasouli M. Iron hypothesis and coronary artery disease in geriatric patients. Arch Physiol Biochem. 2020;126(1):17–22. doi:10.1080/13813455.2018.1486429
  • Wang Q, Ji J, Hao S, Zhang M, Li K, Qiao T. Iron together with lipid downregulates protein levels of ceruloplasmin in macrophages associated with rapid foam cell formation. J Atheroscler Thromb. 2016;23(10):1201–1211. doi:10.5551/jat.32292
  • Xu S. Iron and atherosclerosis: the link revisited. Trends Mol Med. 2019;25(8):659–661. doi:10.1016/j.molmed.2019.05.012
  • Chaudhary K, Promsote W, Ananth S, et al. Iron overload accelerates the progression of diabetic retinopathy in association with increased retinal renin expression. Sci Rep. 2018;8(1):3025. doi:10.1038/s41598-018-21276-2
  • Zou C, Liu X, Liu R, et al. Effect of the oral iron chelator deferiprone in diabetic nephropathy rats. J Diabetes. 2017;9(4):332–340. doi:10.1111/1753-0407.12420
  • Ding H, Zhang Q, Yu X, Chen L, Wang Z, Feng J. Lipidomics reveals perturbations in the liver lipid profile of iron-overloaded mice. Metallomics. 2021;13(10):mfab057. doi:10.1093/mtomcs/mfab057
  • Zhang XL, Dong Z, Wu SF, Zhang FF, Zhang JY. Relationship between serum ferritin levels and diabetic foot. J North China Univ Sci Technol. 2016;18(6):466–469.
  • Zhang Z, Liu D, Yi B, et al. Taurine supplementation reduces oxidative stress and protects the liver in an iron-overload murine model. Mol Med Rep. 2014;10(5):2255–2262. doi:10.3892/mmr.2014.2544
  • Silva M, da Costa Guerra JF, Sampaio AF, De lima WG, Silva ME, Pedrosa ML. Iron dextran increases hepatic oxidative stress and alters expression of genes related to lipid metabolism contributing to hyperlipidaemia in murine model. Biomed Res Int. 2015;2015:272617. doi:10.1155/2015/272617
  • Hu X, Cai X, Ma R, Fu W, Zhang C, Du X. Iron-load exacerbates the severity of atherosclerosis via inducing inflammation and enhancing the glycolysis in macrophages. J Cell Physiol. 2019;234(10):18792–18800. doi:10.1002/jcp.28518
  • Vinchi F, Porto G, Simmelbauer A, et al. Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction. Eur Heart J. 2020;41(28):2681–2695. doi:10.1093/eurheartj/ehz112
  • Ouyang S, You J, Zhi C, et al. Ferroptosis: the potential value target in atherosclerosis. Cell Death Dis. 2021;12(8):782. doi:10.1038/s41419-021-04054-3
  • Moroni F, Ammirati E, Norata GD, Magnoni M, Camici PG. The role of monocytes and macrophages in human atherosclerosis, plaque neoangiogenesis, and atherothrombosis. Mediators Inflamm. 2019;2019:7434376. doi:10.1155/2019/7434376
  • Mao HH, Cui HB. Research progress in serum ferritin and the stability of coronary atherosclerotic plaque. J China Prescription Drug. 2020;18(6):12–14.
  • Zhang M, Zhao HT, Cai J, Qiao T. Hepcidin-Fpn1 axis of macrophage iron metabolism and its role in atherosclerosis. Chin J Arteriosclerosis. 2018;26(09):946–952.
  • Kraml P. The role of iron in the pathogenesis of atherosclerosis. Physiol Res. 2017;66(Suppl 1):S55–S67. doi:10.33549/physiolres.933589
  • Feng Q, Liang YZ, Xia N. Analysis of the associated factors between atherosclerosis and serum ferritin in patients with type 2 diabetes. J Guangxi Med Univ. 2015;32(4):585–587.
  • Naito Y, Masuyama T, Ishihara M. Iron and cardiovascular diseases. J Cardiol. 2021;77(2):160–165. doi:10.1016/j.jjcc.2020.07.009
  • Colaiori I, Izzo R, Barbato E, et al. Severity of coronary atherosclerosis and risk of diabetes mellitus. J Clin Med. 2019;8(7):1069. doi:10.3390/jcm8071069
  • Durante W. Hydrogen sulfide therapy in diabetes-accelerated atherosclerosis: a whiff of success. Diabetes. 2016;65(10):2832–2834. doi:10.2337/dbi16-0042
  • Vinchi F, Muckenthaler MU, Da Silva MC, Balla G, Balla J, Jeney V. Atherogenesis and iron: from epidemiology to cellular level. Front Pharmacol. 2014;5:94. doi:10.3389/fphar.2014.00094
  • Ahluwalia N, Genoux A, Ferrieres J, et al. Iron status is associated with carotid atherosclerotic plaques in middle-aged adults. J Nutr. 2010;140(4):812–816. doi:10.3945/jn.109.110353
  • Zhan Y, Tang Z, Yu J. Serum ferritin, diabetes, diabetes control, and insulin resistance. Acta Diabetol. 2014;51(6):991–998. doi:10.1007/s00592-014-0656-1
  • Silvestre OM, Gonçalves A, Nadruz W Jr., et al. Ferritin levels and risk of heart failure-The atherosclerosis risk in communities study. Eur J Heart Fail. 2017;19(3):340–347. doi:10.1002/ejhf.701
  • de Godoy MF, Takakura IT, Machado RD, Grassi LV, Nogueira PR. Serum ferritin and obstructive coronary artery disease: angiographic correlation. Arq Bras Cardiol. 2007;88(4):430–433. English, Portuguese. doi:10.1590/s0066-782x2007000400011
  • Nemeth E, Ganz T. Hepcidin-ferroportin interaction controls systemic iron homeostasis. Int J Mol Sci. 2021;22(12):6493. doi:10.3390/ijms22126493