Relative Hypoglycemia is Associated with Delirium in Critically Ill Patients with Diabetes: A Cohort Study

References

• Battle DE. Diagnostic and Statistical Manual of Mental Disorders (DSM). CoDAS. 2013;25(2):191–192. doi:10.1590/s2317-17822013000200017
   PubMedGoogle Scholar
• Carrington SJ, Barrett SL, Sivagamasundari U, et al. Describing the profile of diagnostic features in autistic adults using an abbreviated version of the diagnostic interview for social and communication disorders (DISCO-Abbreviated). J Autism Dev Disord. 2019;49(12):5036–5046. doi:10.1007/s10803-019-04214-7
   Web of Science ®Google Scholar
• Schubert M, Schürch R, Boettger S, et al. A hospital-wide evaluation of delirium prevalence and outcomes in acute care patients - a cohort study. BMC Health Serv Res. 2018;18(1):550. doi:10.1186/s12913-018-3345-x
   PubMed Web of Science ®Google Scholar
• Aldemir M, Ozen S, Kara IH, Sir A, Baç B. Predisposing factors for delirium in the surgical intensive care unit. Crit Care. 2001;5(5):265–270. doi:10.1186/cc1044
   PubMed Web of Science ®Google Scholar
• Van Rompaey B, Schuurmans MJ, Shortridge-Baggett LM, Truijen S, Bossaert L. Risk factors for intensive care delirium: a systematic review. Intensive Crit Care Nurs. 2008;24(2):98–107. doi:10.1016/j.iccn.2007.08.005
   PubMedGoogle Scholar
• Inouye SK. Predisposing and precipitating factors for delirium in hospitalized older patients. Dement Geriatr Cogn Disord. 1999;10(5):393–400. doi:10.1159/000017177
   PubMed Web of Science ®Google Scholar
• van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001;345(19):1359–1367. doi:10.1056/NEJMoa011300
   PubMed Web of Science ®Google Scholar
• Finfer S, Chittock DR, Su SY, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360(13):1283–1297. doi:10.1056/NEJMoa0810625
   PubMed Web of Science ®Google Scholar
• Krinsley JS, Schultz MJ, Spronk PE, et al. Mild hypoglycemia is independently associated with increased mortality in the critically ill. Crit Care. 2011;15(4):R173. doi:10.1186/cc10322
   Web of Science ®Google Scholar
• van Keulen K, Knol W, Belitser SV, et al. Glucose variability during delirium in diabetic and non-diabetic intensive care unit patients: a prospective cohort study. PLoS One. 2018;13(11):e0205637. doi:10.1371/journal.pone.0205637
   PubMed Web of Science ®Google Scholar
• van Keulen K, Knol W, Belitser SV, et al. Diabetes and glucose dysregulation and transition to delirium in ICU Patients. Crit Care Med. 2018;46(9):1444–1449. doi:10.1097/ccm.0000000000003285
   PubMed Web of Science ®Google Scholar
• Di Muzio F, Presello B, Glassford NJ, et al. Liberal versus conventional glucose targets in critically ill diabetic patients: an exploratory safety cohort assessment. Crit Care Med. 2016;44(9):1683–1691. doi:10.1097/ccm.0000000000001742
   Web of Science ®Google Scholar
• Kwan TN, Zwakman-Hessels L, Marhoon N, et al. Relative hypoglycemia in diabetic patients with critical illness. Crit Care Med. 2020;48(3):e233–e240. doi:10.1097/ccm.0000000000004213
   Web of Science ®Google Scholar
• Arbeláez AM, Rutlin JR, Hershey T, Powers WJ, Videen TO, Cryer PE. Thalamic activation during slightly subphysiological glycemia in humans. Diabetes Care. 2012;35(12):2570–2574. doi:10.2337/dc12-0297
   Web of Science ®Google Scholar
• Nathan DM, Kuenen J, Borg R, Zheng H, Schoenfeld D, Heine RJ. Translating the A1C assay into estimated average glucose values. Diabetes Care. 2008;31(8):1473–1478. doi:10.2337/dc08-0545
   PubMed Web of Science ®Google Scholar
• Rodríguez-Segade S, Rodríguez J, Paz JM, Camiña F. Translating the A1C assay into estimated average glucose values: response to Nathan et al. Diabetes Care. 2009;32(1):e10. doi:10.2337/dc08-1214
   Google Scholar
• Jacobi J, Bircher N, Krinsley J, et al. Guidelines for the use of an insulin infusion for the management of hyperglycemia in critically ill patients. Crit Care Med. 2012;40(12):3251–3276. doi:10.1097/CCM.0b013e3182653269
   PubMed Web of Science ®Google Scholar
• Jones AE, Trzeciak S, Kline JA. The sequential organ failure assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation. Crit Care Med. 2009;37(5):1649–1654. doi:10.1097/CCM.0b013e31819def97
   PubMed Web of Science ®Google Scholar
• Ely EW, Inouye SK, Bernard GR, et al. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA. 2001;286(21):2703–2710. doi:10.1001/jama.286.21.2703
   PubMed Web of Science ®Google Scholar
• Ely EW, Margolin R, Francis J, et al. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med. 2001;29(7):1370–1379. doi:10.1097/00003246-200107000-00012
   PubMed Web of Science ®Google Scholar
• Saager L, Duncan AE, Yared JP, et al. Intraoperative tight glucose control using hyperinsulinemic normoglycemia increases delirium after cardiac surgery. Anesthesiology. 2015;122(6):1214–1223. doi:10.1097/aln.0000000000000669
   Web of Science ®Google Scholar
• Berger M, Browndyke J, Mathew JP. Intraoperative glycemic control to prevent delirium after cardiac surgery: steering a course between Scylla and Charybdis. Anesthesiology. 2015;122(6):1186–1188. doi:10.1097/aln.0000000000000670
   Web of Science ®Google Scholar
• Shinohara M, Sato N. Bidirectional interactions between diabetes and Alzheimer’s disease. Neurochem Int. 2017;108:296–302. doi:10.1016/j.neuint.2017.04.020
   PubMed Web of Science ®Google Scholar
• Kar P, Plummer MP, Bellomo R, et al. Liberal glycemic control in critically Ill patients with type 2 diabetes: an exploratory study. Crit Care Med. 2016;44(9):1695–1703. doi:10.1097/ccm.0000000000001815
   Web of Science ®Google Scholar
• Finfer S, Liu B, Chittock DR, et al. Hypoglycemia and risk of death in critically ill patients. N Engl J Med. 2012;367(12):1108–1118. doi:10.1056/NEJMoa1204942
   PubMed Web of Science ®Google Scholar
• Arabi YM, Tamim HM, Rishu AH. Hypoglycemia with intensive insulin therapy in critically ill patients: predisposing factors and association with mortality. Crit Care Med. 2009;37(9):2536–2544. doi:10.1097/CCM.0b013e3181a381ad
   PubMed Web of Science ®Google Scholar
• Adler GK, Bonyhay I, Failing H, Waring E, Dotson S, Freeman R. Antecedent hypoglycemia impairs autonomic cardiovascular function: implications for rigorous glycemic control. Diabetes. 2009;58(2):360–366. doi:10.2337/db08-1153
   Web of Science ®Google Scholar
• Wright RJ, Frier BM. Vascular disease and diabetes: is hypoglycaemia an aggravating factor? Diabetes Metab Res Rev. 2008;24(5):353–363. doi:10.1002/dmrr.865
   PubMed Web of Science ®Google Scholar
• Gill GV, Woodward A, Casson IF, Weston PJ. Cardiac arrhythmia and nocturnal hypoglycaemia in type 1 diabetes--the ‘dead in bed’ syndrome revisited. Diabetologia. 2009;52(1):42–45. doi:10.1007/s00125-008-1177-7
   PubMed Web of Science ®Google Scholar
• Hutton RA, Mikhailidis D, Dormandy KM, Ginsburg J. Platelet aggregation studies during transient hypoglycaemia: a potential method for evaluating platelet function. J Clin Pathol. 1979;32(5):434–438. doi:10.1136/jcp.32.5.434
   Web of Science ®Google Scholar
• Wieczorek I, Pell AC, McIver B, MacGregor IR, Ludlam CA, Frier BM. Coagulation and fibrinolytic systems in type I diabetes: effects of venous occlusion and insulin-induced hypoglycaemia. Clin Sci. 1993;84(1):79–86. doi:10.1042/cs0840079
   Web of Science ®Google Scholar
• Krinsley JS, Egi M, Kiss A, et al. Diabetic status and the relation of the three domains of glycemic control to mortality in critically ill patients: an international multicenter cohort study. Crit Care. 2013;17(2):R37. doi:10.1186/cc12547
   PubMed Web of Science ®Google Scholar
• Mahmoodpoor A, Hamishehkar H, Beigmohammadi M, et al. Predisposing factors for hypoglycemia and its relation with mortality in critically Ill patients undergoing insulin therapy in an intensive care unit. Anesth Pain Med. 2016;6(1):e33849. doi:10.5812/aapm.33849
   Google Scholar