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REVIEW

Is Intermittent Fasting Better Than Continuous Energy Restriction for Adults with Overweight and Obesity?

ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 2813-2826 | Received 02 Jun 2022, Accepted 31 Aug 2022, Published online: 15 Sep 2022

References

  • Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol. 2021;9(6):373–392. doi:10.1016/S2213-8587(21)00045-0
  • China Medical Information Guide. Report on nutrition and chronic diseases in China (2020): more than half of adult residents in China are overweight or obese. Chin Med Inform Guide. 2020;35(24):15.
  • Abdelaal M, le Roux CW, Docherty NG. Morbidity and mortality associated with obesity. Ann Transl Med. 2017;5(7):161. doi:10.21037/atm.2017.03.107
  • Rodriguez AJ, Scott D, Ebeling P. Effect of weight loss induced by energy restriction on measures of arterial compliance: a systematic review and meta-analysis. Atherosclerosis. 2016;252:201–202. doi:10.1016/j.atherosclerosis.2016.06.043
  • Zhang MG, Chu TS, Zhu GF, et al. Clinical effects of light fasting in the treatment of abnormal glucose tolerance. Heart J. 2016;28(2):192–193. doi:10.13191/j.chj.2016.0052
  • MacLean PS, Wing RR, Davidson T, et al. NIH working group report: innovative research to improve maintenance of weight loss. Obesity. 2015;23(1):7–15. doi:10.1002/oby.20967
  • de Cabo R, Mattson MP. Effects of intermittent fasting on health, aging, and disease. N Engl J Med. 2019;381(26):2541–2551. doi:10.1056/NEJMra1905136
  • St-Onge M-P, Ard J, Baskin ML, et al. Meal timing and frequency: implications for cardiovascular disease prevention: a scientific statement from the American Heart Association. Circulation. 2017;135(9):e96–e121. doi:10.1161/CIR.0000000000000476
  • Alhamdan BA, Garcia-Alvarez A, Alzahrnai AH, et al. Alternate-day versus daily energy restriction diets: which is more effective for weight loss? A systematic review and meta-analysis. Obes Sci Pract. 2016;2(3):293–302. doi:10.1002/osp4.52
  • Trepanowski JF, Kroeger CM, Barnosky A, et al. Effect of alternate-day fasting on weight loss, weight maintenance, and cardioprotection among metabolically healthy obese adults: a randomized clinical trial. JAMA Intern Med. 2017;177(7):930–938. doi:10.1001/jamainternmed.2017.0936
  • Ganesan K, Habboush Y, Sultan S. Intermittent fasting: the choice for a healthier lifestyle. Cureus. 2018;10(7):e2947. doi:10.7759/cureus.2947
  • Mosley M, Spencer M. The FastDiet: Lose Weight, Stay Healthy, and Live Longer with the Simple Secret of Intermittent Fasting. New York: Atria; 2013.
  • Patterson RE, Sears DD. Metabolic effects of intermittent fasting. Annu Rev Nutr. 2017;37(1):371–393. doi:10.1146/annurev-nutr-071816-064634
  • Carter S, Clifton PM, Keogh JB. Effect of intermittent compared with continuous energy restricted diet on glycemic control in patients with type 2 diabetes: a randomized noninferiority trial. JAMA Netw Open. 2018;1(3):e180756. doi:10.1001/jamanetworkopen.2018.0756
  • Sundfor TM, Svendsen M, Tonstad S. Effect of intermittent versus continuous energy restriction on weight loss, maintenance and cardiometabolic risk: a randomized 1-year trial. Nutr Metab Cardiovasc Dis. 2018;28(7):698–706. doi:10.1016/j.numecd.2018.03.009
  • Hajek P, Przulj D, Pesola F, et al. A randomised controlled trial of the 5:2 diet. PLoS One. 2021;16(11):e258853. doi:10.1371/journal.pone.0258853
  • Sun GL, Deng CJ, Huang LC, et al. Effect of “5+2” intermittent fasting combined with medium-chain triacylglycerol on body fat and glycolipid metabolism in overweight/obese patients. Guangxi Med. 2020;42(21):2800–2805. doi:10.11675/j.issn.0253-4304.2020.21.11
  • Harris L, Hamilton S, Azevedo LB, et al. Intermittent fasting interventions for treatment of overweight and obesity in adults: a systematic review and meta-analysis. JBI Database Syst Rev Implement Rep. 2018;16(2):507–547. doi:10.11124/JBISRIR-2016-003248
  • Rynders CA, Thomas EA, Zaman A, Pan Z, Catenacci VA, Melanson EL. Effectiveness of intermittent fasting and time-restricted feeding compared to continuous energy restriction for weight loss. Nutrients. 2019;11(10):2442. doi:10.3390/nu11102442
  • Garaulet M, Gomez-Abellan P, Alburquerque-Bejar JJ, Lee YC, Ordovas JM, Scheer FA. Timing of food intake predicts weight loss effectiveness. Int J Obes. 2013;37(4):604–611. doi:10.1038/ijo.2012.229
  • Jakubowicz D, Barnea M, Wainstein J, Froy O. High caloric intake at breakfast vs. dinner differentially influences weight loss of overweight and obese women. Obesity. 2013;21(12):2504–2512. doi:10.1002/oby.20460
  • Xie Z, Sun Y, Ye Y, et al. Randomized controlled trial for time-restricted eating in healthy volunteers without obesity. Nat Commun. 2022;13(1):1003. doi:10.1038/s41467-022-28662-5
  • Lowe DA, Wu N, Rohdin-Bibby L, et al. Effects of time-restricted eating on weight loss and other metabolic parameters in women and men with overweight and obesity: the TREAT randomized clinical trial. JAMA Intern Med. 2020;180(11):1491–1499. doi:10.1001/jamainternmed.2020.4153
  • Liu D, Huang Y, Huang C, et al. Calorie restriction with or without time-restricted eating in weight loss. N Engl J Med. 2022;386(16):1495–1504. doi:10.1056/NEJMoa2114833
  • Catenacci VA, Pan Z, Ostendorf D, et al. A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obesity. 2016;24(9):1874–1883. doi:10.1002/oby.21581
  • Trepanowski JF, Kroeger CM, Barnosky A, et al. Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: secondary analysis of a randomized controlled trial. Clin Nutr. 2018;37(6Pt A):1871–1878. doi:10.1016/j.clnu.2017.11.018
  • Coutinho SR, Halset EH, Gåsbakk S, et al. Compensatory mechanisms activated with intermittent energy restriction: a randomized control trial. Clin Nutr. 2018;37(3):815–823. doi:10.1016/j.clnu.2017.04.002
  • Steger FL, Donnelly JE, Hull HR, Li X, Hu J, Sullivan DK. Intermittent and continuous energy restriction result in similar weight loss, weight loss maintenance, and body composition changes in a 6 month randomized pilot study. Clin Obes. 2021;11(2):e12430. doi:10.1111/cob.12430
  • Schübel R, Nattenmüller J, Sookthai D, et al. Effects of intermittent and continuous calorie restriction on body weight and metabolism over 50 wk: a randomized controlled trial. Am J Clin Nutr. 2018;108(5):933–945. doi:10.1093/ajcn/nqy196
  • Headland ML, Clifton PM, Keogh JB. Effect of intermittent compared to continuous energy restriction on weight loss and weight maintenance after 12 months in healthy overweight or obese adults. Int J Obes. 2019;43(10):2028–2036. doi:10.1038/s41366-018-0247-2
  • Pinto AM, Bordoli C, Buckner LP, et al. Intermittent energy restriction is comparable to continuous energy restriction for cardiometabolic health in adults with central obesity: a randomized controlled trial; the Met-IER study. Clin Nutr. 2020;39(6):1753–1763. doi:10.1016/j.clnu.2019.07.014
  • Opstad TB, Sundfør T, Tonstad S, Seljeflot I. Effect of intermittent and continuous caloric restriction on Sirtuin1 concentration depends on sex and body mass index. Nutr Metab Cardiovasc Dis. 2021;31(6):1871–1878. doi:10.1016/j.numecd.2021.03.005
  • Conley M, Le Fevre L, Haywood C, Proietto J. Is two days of intermittent energy restriction per week a feasible weight loss approach in obese males? A randomised pilot study. Nutr Diet. 2018;75(1):65–72. doi:10.1111/1747-0080.12372
  • Pannen ST, Maldonado SG, Nonnenmacher T, et al. Adherence and dietary composition during intermittent vs. continuous calorie restriction: follow-up data from a randomized controlled trial in adults with overweight or obesity. Nutrients. 2021;13(4):1195. doi:10.3390/nu13041195
  • Isenmann E, Dissemond J, Geisler S. The effects of a macronutrient-based diet and time-restricted feeding (16:8) on body composition in physically active individuals-A 14-week randomised controlled trial. Nutrients. 2021;13(9):3122. doi:10.3390/nu13093122
  • Chow LS, Manoogian E, Alvear A, et al. Time-restricted eating effects on body composition and metabolic measures in humans who are overweight: a feasibility study. Obesity. 2020;28(5):860–869. doi:10.1002/oby.22756
  • Thomas EA, Zaman A, Sloggett KJ, et al. Early time-restricted eating compared with daily caloric restriction: a randomized trial in adults with obesity. Obesity. 2022;30(5):1027–1038. doi:10.1002/oby.23420
  • Bhutani S, Klempel MC, Kroeger CM, Trepanowski JF, Varady KA. Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans. Obesity. 2013;21(7):1370–1379. doi:10.1002/oby.20353
  • Cho AR, Moon JY, Kim S, et al. Effects of alternate day fasting and exercise on cholesterol metabolism in overweight or obese adults: a pilot randomized controlled trial. Metabolism. 2019;93:52–60. doi:10.1016/j.metabol.2019.01.002
  • Conrozier T, Eymard F, Chouk M, Chevalier X. Impact of obesity, structural severity and their combination on the efficacy of viscosupplementation in patients with knee osteoarthritis. BMC Musculoskelet Disord. 2019;20(1):376. doi:10.1186/s12891-019-2748-0
  • Moro T, Tinsley G, Bianco A, et al. Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. J Transl Med. 2016;14(1):290. doi:10.1186/s12967-016-1044-0
  • Aqeel M, Forster A, Richards EA, et al. Correction: Marah Aqeel et al. “The effect of timing of exercise and eating on postprandial response in adults: a systematic review”. Nutrients. 2020;12(5):221. doi:10.3390/nu12051263
  • Mohr AE, Ramos C, Tavarez K, Arciero PJ. Lower postprandial thermogenic response to an unprocessed whole food meal compared to an iso-energetic/macronutrient meal replacement in young women: a single-blind randomized cross-over trial. Nutrients. 2020;12(8):2469. doi:10.3390/nu12082469
  • Bowen J, Brindal E, James-Martin G, Noakes M. Randomized trial of a high protein, partial meal replacement program with or without alternate day fasting: similar effects on weight loss, retention status, nutritional, metabolic, and behavioral outcomes. Nutrients. 2018;10(9):1145. doi:10.3390/nu10091145
  • Liu F, Li QF, Li HL, et al. A multicenter, open clinical study on the effect of meal replacement-assisted “5+2 light fasting” on weight loss in overweight/obese adults in China. China Med J. 2021;56(04):422–425. doi:10.3969/j.issn.1008-1070.2021.04.019
  • Tang F, Lin X. Effects of fasting-mimicking diet and specific meal replacement foods on blood glucose control in patients with type 2 diabetes: a randomized controlled trial. Oxid Med Cell Longev. 2020;2020:6615295. doi:10.1155/2020/6615295
  • Arciero PJ, Arciero KM, Poe M, et al. Intermittent fasting two days versus one day per week, matched for total energy intake and expenditure, increases weight loss in overweight/obese men and women. Nutr J. 2022;21(1):36. doi:10.1186/s12937-022-00790-0
  • Arciero PJ, Ormsbee MJ, Gentile CL, Nindl BC, Brestoff JR, Ruby M. Increased protein intake and meal frequency reduces abdominal fat during energy balance and energy deficit. Obesity. 2013;21(7):1357–1366. doi:10.1002/oby.20296
  • Arciero PJ, Edmonds R, He F, et al. Protein-pacing caloric-restriction enhances body composition similarly in obese men and women during weight loss and sustains efficacy during long-term weight maintenance. Nutrients. 2016;8(8):476. doi:10.3390/nu8080476
  • Russell-Mayhew S, McVey G, Bardick A, Ireland A. Mental health, wellness, and childhood overweight/obesity. J Obes. 2012;2012:281801. doi:10.1155/2012/281801
  • Pearl RL, Wadden TA, Hopkins CM, et al. Association between weight bias internalization and metabolic syndrome among treatment-seeking individuals with obesity. Obesity. 2017;25(2):317–322. doi:10.1002/oby.21716
  • Hjelmesaeth J, Rosenvinge JH, Gade H, Friborg O. Effects of cognitive behavioral therapy on eating behaviors, affective symptoms, and weight loss after bariatric surgery: a randomized clinical trial. Obes Surg. 2019;29(1):61–69. doi:10.1007/s11695-018-3471-x
  • Stice E, Davis K, Miller NP, Marti CN. Fasting increases risk for onset of binge eating and bulimic pathology: a 5-year prospective study. J Abnorm Psychol. 2008;117(4):941–946. doi:10.1037/a0013644
  • Van Dorsten B, Lindley EM. Cognitive and behavioral approaches in the treatment of obesity. Med Clin North Am. 2011;95(5):971–988. doi:10.1016/j.mcna.2011.06.008
  • Chu DT, Minh NN, Nga VT, et al. An update on obesity: mental consequences and psychological interventions. Diabetes Metab Syndr. 2019;13(1):155–160. doi:10.1016/j.dsx.2018.07.015
  • Rees M, Collins CE, De Vlieger N, McDonald VM. Non-surgical interventions for hospitalized adults with class II or class III obesity: a scoping review. Diabetes Metab Syndr Obes. 2021;14:417–429. doi:10.2147/DMSO.S280735
  • Juchacz K, Klos P, Dziedziejko V, Wojciak RW. The effectiveness of supportive psychotherapy in weight loss in a group of young overweight and obese women. Nutrients. 2021;13(2):532. doi:10.3390/nu13020532
  • Welton S, Minty R, O’Driscoll T, et al. Intermittent fasting and weight loss: systematic review. Can Fam Physician. 2020;66(2):117–125.
  • Harvie MN, Pegington M, Mattson MP, et al. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women. Int J Obes. 2011;35(5):714–727. doi:10.1038/ijo.2010.171
  • Cava E, Yeat NC, Mittendorfer B. Preserving healthy muscle during weight loss. Adv Nutr. 2017;8(3):511–519. doi:10.3945/an.116.014506
  • Willoughby D, Hewlings S, Kalman D. Body composition changes in weight loss: strategies and supplementation for maintaining lean body mass, a brief review. Nutrients. 2018;10(12):12. doi:10.3390/nu10121876
  • Sandoval C, Santibanez S, Villagran F. Effectiveness of intermittent fasting to potentiate weight loss or muscle gains in humans younger than 60 years old: a systematic review. Int J Food Sci Nutr. 2021;72(6):734–745. doi:10.1080/09637486.2020.1868412
  • Keenan S, Cooke MB, Belski R. The effects of intermittent fasting combined with resistance training on lean body mass: a systematic review of human studies. Nutrients. 2020;12(8):2349. doi:10.3390/nu12082349
  • Zuo L, He F, Tinsley GM, Pannell BK, Ward E, Arciero PJ. Comparison of high-protein, intermittent fasting low-calorie diet and heart healthy diet for vascular health of the obese. Front Physiol. 2016;7:350. doi:10.3389/fphys.2016.00350
  • Dong TA, Sandesara PB, Dhindsa DS, et al. Intermittent fasting: a heart healthy dietary pattern? Am J Med. 2020;133(8):901–907. doi:10.1016/j.amjmed.2020.03.030
  • Cioffi I, Evangelista A, Ponzo V, et al. Intermittent versus continuous energy restriction on weight loss and cardiometabolic outcomes: a systematic review and meta-analysis of randomized controlled trials. J Transl Med. 2018;16(1):371. doi:10.1186/s12967-018-1748-4
  • Wilkinson MJ, Manoogian E, Zadourian A, et al. Ten-hour time-restricted eating reduces weight, blood pressure, and atherogenic lipids in patients with metabolic syndrome. Cell Metab. 2020;31(1):92–104. doi:10.1016/j.cmet.2019.11.004
  • Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CM. Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. Cell Metab. 2018;27(6):1212–1221. doi:10.1016/j.cmet.2018.04.010
  • Templeman I, Smith HA, Chowdhury E, et al. A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults. Sci Transl Med. 2021;13(598):598. doi:10.1126/scitranslmed.abd8034
  • Patikorn C, Roubal K, Veettil SK, et al. Intermittent fasting and obesity-related health outcomes: an umbrella review of meta-analyses of randomized clinical trials. JAMA Netw Open. 2021;4(12):e2139558. doi:10.1001/jamanetworkopen.2021.39558
  • Johari MI, Yusoff K, Haron J, et al. A randomised controlled trial on the effectiveness and adherence of modified alternate-day calorie restriction in improving activity of non-alcoholic fatty liver disease. Sci Rep. 2019;9(1):11232. doi:10.1038/s41598-019-47763-8
  • Cai H, Qin YL, Shi ZY, et al. Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty liver disease: a randomised controlled trial. Bmc Gastroenterol. 2019;19(1):219. doi:10.1186/s12876-019-1132-8
  • Fitzgerald KC, Vizthum D, Henry-Barron B, et al. Effect of intermittent vs. daily calorie restriction on changes in weight and patient-reported outcomes in people with multiple sclerosis. Mult Scler Relat Disord. 2018;23:33–39. doi:10.1016/j.msard.2018.05.002
  • Morales-Suarez-Varela M, Collado SE, Peraita-Costa I, Llopis-Morales A, Soriano JM. Intermittent fasting and the possible benefits in obesity, diabetes, and multiple sclerosis: a systematic review of randomized clinical trials. Nutrients. 2021;13(9):3179. doi:10.3390/nu13093179
  • Hofer SJ, Carmona-Gutierrez D, Mueller MI, Madeo F. The ups and downs of caloric restriction and fasting: from molecular effects to clinical application. Embo Mol Med. 2022;14(1):e14418. doi:10.15252/emmm.202114418
  • Santos HO. Intermittent fasting and fat mass: What is the clinical magnitude? Obesities. 2022;2(1):1–7. doi:10.3390/obesities2010001
  • Varady KA, Cienfuegos S, Ezpeleta M, Gabel K. Clinical application of intermittent fasting for weight loss: progress and future directions. Nat Rev Endocrinol. 2022;18(5):309–321. doi:10.1038/s41574-022-00638-x
  • Kopp W. Development of obesity: the driver and the passenger. Diabetes Metab Syndr Obes. 2020;13:4631–4642. doi:10.2147/DMSO.S280146
  • Kumar NK, Merrill JD, Carlson S, German J, Yancy WJ. Adherence to low-carbohydrate diets in patients with diabetes: a narrative review. Diabetes Metab Syndr Obes. 2022;15:477–498. doi:10.2147/DMSO.S292742