Triglyceride Glucose Index is Related with the Risk of Mild Cognitive Impairment in Type 2 Diabetes

References

• Lovic D, Piperidou A, Zografou I, Grassos H, Pittaras A, Manolis A. The growing epidemic of diabetes mellitus. Curr Vasc Pharmacol. 2020;18(2):104–109. doi:10.2174/1570161117666190405165911
   PubMed Web of Science ®Google Scholar
• Koekkoek P, Kappelle L, van den Berg E, Rutten G, Biessels G. Cognitive function in patients with diabetes mellitus: guidance for daily care. Lancet Neurol. 2015;14(3):329–340. doi:10.1016/s1474-4422(14)70249-2
   Web of Science ®Google Scholar
• You Y, Liu Z, Chen Y, et al. The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis. Acta Diabetol. 2021;58(6):671–685. doi:10.1007/s00592-020-01648-9
   PubMed Web of Science ®Google Scholar
• Palta P, Schneider AL, Biessels GJ, Touradji P, Hill-Briggs F. Magnitude of cognitive dysfunction in adults with type 2 diabetes: a meta-analysis of six cognitive domains and the most frequently reported neuropsychological tests within domains. J Int Neuropsychol Soc. 2014;20(3):278–291. doi:10.1017/S1355617713001483
   PubMed Web of Science ®Google Scholar
• van den Berg E, Kloppenborg RP, Kessels RP, Kappelle LJ, Biessels GJ. Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: a systematic comparison of their impact on cognition. Biochim Biophys Acta. 2009;1792(5):470–481. doi:10.1016/j.bbadis.2008.09.004
   PubMed Web of Science ®Google Scholar
• Gudala K, Bansal D, Schifano F, Bhansali A. Diabetes mellitus and risk of dementia: a meta-analysis of prospective observational studies. J Diabetes Investig. 2013;4(6):640–650. doi:10.1111/jdi.12087
   PubMed Web of Science ®Google Scholar
• Crichton G, Elias M, Buckley J, Murphy K, Bryan J, Frisardi V. Metabolic syndrome, cognitive performance, and dementia. J Alzheimers Dis. 2012;30(s2):S77–S87. doi:10.3233/jad-2011-111022
   Web of Science ®Google Scholar
• Lamport D, Lawton C, Mansfield M, Dye L. Impairments in glucose tolerance can have a negative impact on cognitive function: a systematic research review. Neurosci Biobehav Rev. 2009;33(3):394–413. doi:10.1016/j.neubiorev.2008.10.008
   PubMed Web of Science ®Google Scholar
• Ruis C, Biessels G, Gorter K, van den Donk M, Kappelle L, Rutten G. Cognition in the early stage of type 2 diabetes. Diabetes Care. 2009;32(7):1261–1265. doi:10.2337/dc08-2143
   PubMed Web of Science ®Google Scholar
• Arnold SE, Arvanitakis Z, Macauley-Rambach SL, et al. Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums. Nat Rev Neurol. 2018;14(3):168–181. doi:10.1038/nrneurol.2017.185
   PubMed Web of Science ®Google Scholar
• Luo A, Xie Z, Wang Y, et al. Type 2 diabetes mellitus-associated cognitive dysfunction: advances in potential mechanisms and therapies. Neurosci Biobehav Rev. 2022;137:104642. doi:10.1016/j.neubiorev.2022.104642
   PubMed Web of Science ®Google Scholar
• DeFronzo R, Tobin J, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237(3):E214–E223. doi:10.1152/ajpendo.1979.237.3.E214
   PubMed Web of Science ®Google Scholar
• Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, Turner R. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412–419. doi:10.1007/bf00280883
   PubMed Web of Science ®Google Scholar
• Guerrero-Romero F, Simental-Mendia LE, Gonzalez-Ortiz M, et al. The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp. J Clin Endocrinol Metab. 2010;95(7):3347–3351. doi:10.1210/jc.2010-0288
   PubMed Web of Science ®Google Scholar
• Vasques A, Novaes F, de Oliveira MS, et al. TyG index performs better than HOMA in a Brazilian population: a hyperglycemic clamp validated study. Diabetes Res Clin Pract. 2011;93(3):e98–e100. doi:10.1016/j.diabres.2011.05.030
   PubMed Web of Science ®Google Scholar
• Lin HY, Zhang XJ, Liu YM, Geng LY, Guan LY, Li XH. Comparison of the triglyceride glucose index and blood leukocyte indices as predictors of metabolic syndrome in healthy Chinese population. Sci Rep. 2021;11(1):10036. doi:10.1038/s41598-021-89494-9
   PubMed Web of Science ®Google Scholar
• Guo W, Zhu W, Wu J, et al. Triglyceride glucose index is associated with arterial stiffness and 10-year cardiovascular disease risk in a Chinese population. Front Cardiovasc Med. 2021;8:585776. doi:10.3389/fcvm.2021.585776
   PubMed Web of Science ®Google Scholar
• Hong S, Han K, Park CY. The insulin resistance by triglyceride glucose index and risk for dementia: population-based study. Alzheimers Res Ther. 2021;13(1):9. doi:10.1186/s13195-020-00758-4
   PubMed Web of Science ®Google Scholar
• Ng TP, Feng L, Nyunt MS, et al. Metabolic syndrome and the risk of mild cognitive impairment and progression to dementia: follow-up of the Singapore longitudinal ageing study cohort. JAMA Neurol. 2016;73(4):456–463. doi:10.1001/jamaneurol.2015.4899
   PubMed Web of Science ®Google Scholar
• González HM, Tarraf W, Schneiderman N, et al. Prevalence and correlates of mild cognitive impairment among diverse Hispanics/latinos: study of latinos-investigation of neurocognitive aging results. Alzheimers Dement. 2019;15(12):1507–1515. doi:10.1016/j.jalz.2019.08.202
   Web of Science ®Google Scholar
• Winblad B, Palmer K, Kivipelto M, et al. Mild cognitive impairment--beyond controversies, towards a consensus: report of the international working group on mild cognitive impairment. J Intern Med. 2004;256(3):240–246. doi:10.1111/j.1365-2796.2004.01380.x
   PubMed Web of Science ®Google Scholar
• Weyman-Vela Y, Simental-Mendía LE, Camacho-Luis A, Gamboa-Gómez CI, Guerrero-Romero F. The triglycerides and glucose index is associated with mild cognitive impairment in older adults. Endocr Res. 2022;47(2):89–93. doi:10.1080/07435800.2022.2061508
   PubMed Web of Science ®Google Scholar
• Teng Z, Feng J, Dong Y, et al. Triglyceride glucose index is associated with cerebral small vessel disease burden and cognitive impairment in elderly patients with type 2 diabetes mellitus. Front Endocrinol. 2022;13:970122. doi:10.3389/fendo.2022.970122
   PubMed Web of Science ®Google Scholar
• Er L, Wu S, Chou H, et al. Triglyceride glucose-body mass index is a simple and clinically useful surrogate marker for insulin resistance in nondiabetic individuals. PLoS One. 2016;11(3):e0149731. doi:10.1371/journal.pone.0149731
   PubMed Web of Science ®Google Scholar
• Wang X, Liu J, Cheng Z, Zhong Y, Chen X, Song W. Triglyceride glucose-body mass index and the risk of diabetes: a general population-based cohort study. Lipids Health Dis. 2021;20(1):99. doi:10.1186/s12944-021-01532-7
   PubMed Web of Science ®Google Scholar
• American Diabetes Association. Standards of medical care in diabetes--2010. Diabetes Care. 2010;33 Suppl 1(Suppl 1):S11–S61. doi:10.2337/dc10-S011
   Web of Science ®Google Scholar
• Saadeh S, Younossi ZM, Remer EM, et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology. 2002;123(3):745–750. doi:10.1053/gast.2002.35354
   PubMed Web of Science ®Google Scholar
• Albert M, DeKosky S, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease, Alzheimer’s & dementia. J Alzheimers Assoc. 2011;7(3):270–279. doi:10.1016/j.jalz.2011.03.008
   PubMed Web of Science ®Google Scholar
• Nasreddine Z, Phillips N, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–699. doi:10.1111/j.1532-5415.2005.53221.x
   PubMed Web of Science ®Google Scholar
• Qu Y, Hu HY, Ou YN, et al. Association of body mass index with risk of cognitive impairment and dementia: a systematic review and meta-analysis of prospective studies. Neurosci Biobehav Rev. 2020;115:189–198. doi:10.1016/j.neubiorev.2020.05.012
   PubMed Web of Science ®Google Scholar
• West RK, Livny A, Ravona-Springer R, et al. Higher BMI is associated with smaller regional brain volume in older adults with type 2 diabetes. Diabetologia. 2020;63(11):2446–2451. doi:10.1007/s00125-020-05264-8
   PubMed Web of Science ®Google Scholar
• Carmichael OT, Neiberg RH, Dutton GR, et al. Long-term change in physiological markers and cognitive performance in type 2 diabetes: the look AHEAD study. J Clin Endocrinol Metab. 2020;105(12):e4778–e4791. doi:10.1210/clinem/dgaa591
   Web of Science ®Google Scholar
• Anjum I, Fayyaz M, Wajid A, Sohail W, Ali A. Does obesity increase the risk of dementia: a literature review. Cureus. 2018;10(5):e2660. doi:10.7759/cureus.2660
   PubMed Web of Science ®Google Scholar
• Yamamoto H, Kato Y. Relationship between plasma insulin-like growth factor I (IGF-I) levels and body mass index (BMI) in adults. Endocr J. 1993;40(1):41–45. doi:10.1507/endocrj.40.41
   PubMed Web of Science ®Google Scholar
• Harvey J, Solovyova N, Irving A. Leptin and its role in hippocampal synaptic plasticity. Prog Lipid Res. 2006;45(5):369–378. doi:10.1016/j.plipres.2006.03.001
   PubMed Web of Science ®Google Scholar
• Singh M, Dykens JA, Simpkins JW. Novel mechanisms for estrogen-induced neuroprotection. Exp Biol Med. 2006;231(5):514–521. doi:10.1177/153537020623100505
   Web of Science ®Google Scholar
• Yang Y, Ma D, Wang Y, et al. Intranasal insulin ameliorates tau hyperphosphorylation in a rat model of type 2 diabetes. J Alzheimers Dis. 2013;33(2):329–338. doi:10.3233/jad-2012-121294
   Web of Science ®Google Scholar
• Brankatschk M, Dunst S, Nemetschke L, Eaton S. Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic insulin signaling. Elife. 2014;3. doi:10.7554/eLife.02862
   Web of Science ®Google Scholar
• Tucsek Z, Toth P, Sosnowska D, et al. Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer’s disease. J Gerontol a Biol Sci Med Sci. 2014;69(10):1212–1226. doi:10.1093/gerona/glt177
   PubMed Web of Science ®Google Scholar
• Blázquez E, Velázquez E, Hurtado-Carneiro V, Ruiz-Albusac JM. Insulin in the brain: its pathophysiological implications for states related with central insulin resistance, type 2 diabetes and Alzheimer’s disease. Front Endocrinol. 2014;5:161. doi:10.3389/fendo.2014.00161
   PubMed Web of Science ®Google Scholar
• Dineley KT, Jahrling JB, Denner L. Insulin resistance in Alzheimer’s disease. Neurobiol Dis. 2014;72(Pt A):92–103. doi:10.1016/j.nbd.2014.09.001
   Web of Science ®Google Scholar
• Morris JK, Vidoni ED, Honea RA, Burns JM. Impaired glycemia increases disease progression in mild cognitive impairment. Neurobiol Aging. 2014;35(3):585–589. doi:10.1016/j.neurobiolaging.2013.09.033
   Web of Science ®Google Scholar
• Schrijvers EM, Witteman JC, Sijbrands EJ, Hofman A, Koudstaal PJ, Breteler MM. Insulin metabolism and the risk of Alzheimer disease: the Rotterdam study. Neurology. 2010;75(22):1982–1987. doi:10.1212/WNL.0b013e3181ffe4f6
   PubMed Web of Science ®Google Scholar
• Huang CC, Lee CC, Hsu KS. An investigation into signal transduction mechanisms involved in insulin-induced long-term depression in the CA1 region of the hippocampus. J Neurochem. 2004;89(1):217–231. doi:10.1111/j.1471-4159.2003.02307.x
   Web of Science ®Google Scholar
• Izumi Y, Yamada KA, Matsukawa M, Zorumski CF. Effects of insulin on long-term potentiation in hippocampal slices from diabetic rats. Diabetologia. 2003;46:1007–1012. doi:10.1007/s00125-003-1144-2
   Web of Science ®Google Scholar
• Ghasemi R, Zarifkar A, Rastegar K, Maghsoudi N, Moosavi M. Insulin protects against Aβ-induced spatial memory impairment, hippocampal apoptosis and MAPKs signaling disruption. Neuropharmacology. 2014;85:113–120. doi:10.1016/j.neuropharm.2014.01.036
   PubMed Web of Science ®Google Scholar
• Sharma S, Taliyan R. Neuroprotective role of indirubin-3’-monoxime, a GSKβ inhibitor in high fat diet induced cognitive impairment in mice. Biochem Biophys Res Commun. 2014;452(4):1009–1015. doi:10.1016/j.bbrc.2014.09.034
   Web of Science ®Google Scholar
• Lee S, Tong M, Hang S, Deochand C, de la Monte S. CSF and brain indices of insulin resistance, oxidative stress and neuro-inflammation in early versus late Alzheimer’s disease. J Alzheimers Dis Parkinsonism. 2013;3:128. doi:10.4172/2161-0460.1000128
   Google Scholar
• Xia S, Xia W, Huang J, Zou H, Tao J, Yang Y. The factors contributing to cognitive dysfunction in type 2 diabetic patients. Ann Transl Med. 2020;8(4):104. doi:10.21037/atm.2019.12.113
   Web of Science ®Google Scholar
• Geijselaers S, Sep S, Claessens D, et al. The role of hyperglycemia, insulin resistance, and blood pressure in diabetes-associated differences in cognitive performance-the Maastricht study. Diabetes Care. 2017;40(11):1537–1547. doi:10.2337/dc17-0330
   Web of Science ®Google Scholar
• Banks W, Owen J, Erickson M. Insulin in the brain: there and back again. Pharmacol Ther. 2012;136(1):82–93. doi:10.1016/j.pharmthera.2012.07.006
   PubMed Web of Science ®Google Scholar
• Langa K, Levine D. The diagnosis and management of mild cognitive impairment: a clinical review. JAMA. 2014;312(23):2551–2561. doi:10.1001/jama.2014.13806
   PubMed Web of Science ®Google Scholar
• Luck T, Pabst A, Rodriguez FS, et al. Age-, sex-, and education-specific norms for an extended CERAD neuropsychological assessment battery-results from the population-based LIFE-adult-study. Neuropsychology. 2018;32(4):461–475. doi:10.1037/neu0000440
   PubMed Web of Science ®Google Scholar
• Ihle A, Gouveia ÉR, Gouveia BR, et al. The relation of education, occupation, and cognitive activity to cognitive status in old age: the role of physical frailty. Int Psychogeriatr. 2017;29(9):1469–1474. doi:10.1017/s1041610217000795
   Web of Science ®Google Scholar
• Stern Y, Albert S, Tang MX, Tsai WY. Rate of memory decline in AD is related to education and occupation: cognitive reserve? Neurology. 1999;53(9):1942–1947. doi:10.1212/wnl.53.9.1942
   PubMed Web of Science ®Google Scholar
• Roe CM, Xiong C, Miller JP, Morris JC. Education and Alzheimer disease without dementia: support for the cognitive reserve hypothesis. Neurology. 2007;68(3):223–228. doi:10.1212/01.wnl.0000251303.50459.8a
   PubMed Web of Science ®Google Scholar
• Bennett DA, Wilson RS, Schneider JA, et al. Education modifies the relation of AD pathology to level of cognitive function in older persons. Neurology. 2003;60(12):1909–1915. doi:10.1212/01.wnl.0000069923.64550.9f
   PubMed Web of Science ®Google Scholar
• Garibotto V, Borroni B, Kalbe E, et al. Education and occupation as proxies for reserve in aMCI converters and AD: FDG-PET evidence. Neurology. 2008;71(17):1342–1349. doi:10.1212/01.wnl.0000327670.62378.c0
   PubMed Web of Science ®Google Scholar
• Baker LD, Cross DJ, Minoshima S, Belongia D, Watson GS, Craft S. Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. Arch Neurol. 2011;68(1):51–57. doi:10.1001/archneurol.2010.225
   PubMedGoogle Scholar