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REVIEW

Interventions to Improve Quality of Life in Multiple Sclerosis: New Opportunities and Key Talking Points

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Pages 55-68 | Received 20 May 2023, Accepted 05 Sep 2023, Published online: 19 Sep 2023

References

  • Cuerda-Ballester M, Martínez-Rubio D, García-Pardo MP, et al. Relationship of motor impairment with cognitive and emotional alterations in patients with multiple sclerosis. Int J Environ Res Public Health. 2023;20(2):1387. doi:10.3390/ijerph20021387
  • Immune-Mediated Disease. National multiple sclerosis society. Available from: http://www.nationalmssociety.org/What-is-MS/Definition-of-MS/Immune-mediated-disease. Accessed December 30, 2020.
  • Nelson LM, Wallin MT, Marrie RA, et al. A new way to estimate neurologic disease prevalence in the United States: illustrated with MS. Neurology. 2019;92(10):469–480. doi:10.1212/WNL.0000000000007044
  • Giovannoni G, Fole JF, Brandes DW. Hidden disabilities in multiple sclerosis? The impact of multiple sclerosis on patients and their caregivers. Eur Neurol Rev. 2013;8(1):2. doi:10.17925/ENR.2013.08.S1.2
  • Browne P, Chandraratna D, Angood C, et al. Atlas of multiple sclerosis 2013: a growing global problem with widespread inequity. Neurology. 2014;83(11):1022–1024. doi:10.1212/WNL.0000000000000768
  • Wallin MT, Culpepper WJ, Campbell JD, et al. The prevalence of MS in the United States: a population-based estimate using health claims data. Neurology. 2019;92(10):e1029–e1040. doi:10.1212/WNL.0000000000007035
  • Newsome SD, Aliotta PJ, Bainbridge J, et al. A Framework of Care in Multiple Sclerosis, Part 1: updated Disease Classification and Disease-Modifying Therapy Use in Specific Circumstances. Int J MS Care. 2016;18(6):314–323. doi:10.7224/1537-2073.2016-051
  • Somerset M, Campbell R, Sharp DJ, Peters TJ. What do people with MS want and expect from health‐care services?. Health Expect Int J Public Particip Health Care Health Policy. 2001;4(1):29–37. doi:10.1046/j.1369-6513.2001.00111.x
  • Rezapour A, Almasian Kia A, Goodarzi S, Hasoumi M, Nouraei Motlagh S, Vahedi S. The impact of disease characteristics on multiple sclerosis patients’ quality of life. Epidemiol Health. 2017;39. doi:10.4178/epih.e2017008
  • Barin L, Salmen A, Disanto G, et al. The disease burden of Multiple Sclerosis from the individual and population perspective: which symptoms matter most?. Mult Scler Relat Disord. 2018;25:112–121. doi:10.1016/j.msard.2018.07.013
  • Faraclas E, Lynn J, Lau JD, Merlo A. Health-Related Quality of Life in people with Multiple Sclerosis: how does this Population Compare to Population-based Norms in Different Health Domains?. J Patient-Rep Outcomes. 2022;6(1):12. doi:10.1186/s41687-022-00415-4
  • Faraclas E, Merlo A, Lynn J, Lau JD. Perceived facilitators, needs, and barriers to health related quality of life in people with multiple sclerosis: a qualitative investigation. J Patient-Rep Outcomes. 2022;6(1):89. doi:10.1186/s41687-022-00496-1
  • Disanto G, Berlanga AJ, Handel AE, et al. Heterogeneity in Multiple Sclerosis: scratching the Surface of a Complex Disease. Autoimmune Dis. 2011;2011. doi:10.4061/2011/932351
  • Contrò V, Schiera G, Macchiarella A, Sacco A, Lombardo G, Proia P. Multiple sclerosis: physical activity and well-being. Mult Scler. 2017;2:6.
  • Weeks J. Foundation Health Measure Report, Health-Related Quality of Life and Well-Being. Washington: Office of Disease Prevention and Health Promotion; 2020.
  • Healthy People 2030 Framework - Healthy People 2030 | health.gov. Available from: https://health.gov/healthypeople/about/healthy-people-2030-framework. Accessed March 28, 2023.
  • Motl RW, Mowry EM, Ehde DM, et al. Wellness and multiple sclerosis: the National MS Society establishes a Wellness Research Working Group and research priorities. Mult Scler Houndmills Basingstoke Engl. 2018;24(3):262–267. doi:10.1177/1352458516687404
  • Dalgas U, Langeskov-Christensen M, Stenager E, Riemenschneider M, Hvid LG. Exercise as Medicine in Multiple Sclerosis—Time for a Paradigm Shift: preventive, Symptomatic, and Disease-Modifying Aspects and Perspectives. Curr Neurol Neurosci Rep. 2019;19(11):88. doi:10.1007/s11910-019-1002-3
  • Mendozzi L, Tovo A, Grosso C, et al. Changing Lifestyle of Persons With Multiple Sclerosis: development, Feasibility and Preliminary Results of a Novel High-Impact Collaborative Intervention in Leisure Environments. Int J Phys Med Rehabil. 2018;06(02). doi:10.4172/2329-9096.1000461
  • Department N, Rehabilitation Hospital C, Iasi R, Schreiner TG. “Gr.T. Popa” University of Medicine and Pharmacy, Iasi, Romania, et al. New insights on depression in multiple sclerosis – a literature review. Romanian J Neurol. 2020;19(4):237–243. doi:10.37897/RJN.2020.4.4
  • Silva MD, Cavalcanti DB. Evaluation of quality of life in multiple sclerosis patients: impact of fatigue, anxiety and depression. Int J Med. 2019;26:339. doi:10.6084/m9.figshare.11312930.v1
  • Al-Sharman A, Khalil H, El-Salem K, Aldughmi M, Aburub A. The effects of aerobic exercise on sleep quality measures and sleep-related biomarkers in individuals with Multiple Sclerosis: a pilot randomised controlled trial. NeuroRehabilitation. 2019;45(1):107–115. doi:10.3233/nre-192748
  • Tollár J, Nagy F, Tóth BE, et al. Exercise Effects on Multiple Sclerosis Quality of Life and Clinical–Motor Symptoms. Med Sci Sports Exerc. 2020;52(5):1007. doi:10.1249/MSS.0000000000002228
  • Harrison AM, Safari R, Mercer T, et al. Which exercise and behavioural interventions show most promise for treating fatigue in multiple sclerosis? A network meta-analysis. Mult Scler Houndmills Basingstoke Engl. 2021;27(11):1657–1678. doi:10.1177/1352458521996002
  • Farrell JW, Merkas J, Pilutti LA. The effect of exercise training on gait, balance, and physical fitness asymmetries in persons with chronic neurological conditions: a systematic review of randomized controlled trials. Front Physiol. 2020;11:585765. doi:10.3389/fphys.2020.585765
  • Nauta IM, Bertens D, Fasotti L, et al. Cognitive rehabilitation and mindfulness reduce cognitive complaints in multiple sclerosis (REMIND-MS): a randomized controlled trial. Mult Scler Relat Disord. 2023;71:104529. doi:10.1016/j.msard.2023.104529
  • Harand C, Defer G. Psychological interventions in multiple sclerosis: improving cognition and quality of life. Ann Phys Rehabil Med. 2020;63(2):148–153. doi:10.1016/j.rehab.2018.10.002
  • PEDro scale – pEDro; 2016. Available from: https://pedro.org.au/english/resources/pedro-scale/. Accessed July 27, 2023.
  • Amin NS, Tayebi HME. More gain, less pain: how resistance training affects immune system functioning in multiple sclerosis patients: a review. Mult Scler Relat Disord. 2023;69. doi:10.1016/j.msard.2022.104401
  • Zrzavy T. Effects of normobaric hypoxic endurance training on fatigue in patients with multiple sclerosis: a randomized prospective pilot study. J Neurol. 2021;268(12):4809. doi:10.1007/s00415-021-10596-5
  • Salarvand S, Heidari ME, Farahi K, Teymuri E, Almasian M, Bitaraf S. Effectiveness of massage therapy on fatigue and pain in patients with multiple sclerosis: a systematic review and meta-analysis. Mult Scler J Exp Transl Clin. 2021;7(2):20552173211022780. doi:10.1177/20552173211022779
  • Moss-Morris R, Harrison AM, Safari R, et al. Which behavioural and exercise interventions targeting fatigue show the most promise in multiple sclerosis? A systematic review with narrative synthesis and meta-analysis. Behav Res Ther. 2021;137:103464. doi:10.1016/j.brat.2019.103464
  • d’Arma A, Saresella M, Rossi V, et al. Increased levels of beta-endorphin and noradrenaline after a brief high-impact multidimensional rehabilitation program in multiple sclerosis. Life. 2022;12(5):755. doi:10.3390/life12050755
  • Cancelli A, Cottone C, Giordani A, et al. Personalized, bilateral whole-body somatosensory cortex stimulation to relieve fatigue in multiple sclerosis. Mult Scler Houndmills Basingstoke Engl. 2018;24(10):1366–1374. doi:10.1177/1352458517720528
  • Nourbakhsh B, Waubant E, Evers AWM, Solomon AJ. Ethical considerations in the treatment of multiple sclerosis fatigue. Mult Scler Relat Disord. 2021;54:103129. doi:10.1016/j.msard.2021.103129
  • Feys P, Moumdjian L, Van Halewyck F, et al. Effects of an individual 12-week community-located “start-to-run” program on physical capacity, walking, fatigue, cognitive function, brain volumes, and structures in persons with multiple sclerosis. Mult Scler Houndmills Basingstoke Engl. 2019;25(1):92–103. doi:10.1177/1352458517740211
  • Cortés-Pérez I, Sánchez-Alcalá M, Nieto-Escámez FA, Castellote-Caballero Y, Obrero-Gaitán E, Osuna-Pérez MC. Virtual reality-based therapy improves fatigue, impact, and quality of life in patients with multiple sclerosis. a systematic review with a meta-analysis. Sensors. 2021;21(21):7389. doi:10.3390/s21217389
  • Di Cara M, Grezzo D, Palmeri R, et al. Psychological well-being in people with multiple sclerosis: a descriptive review of the effects obtained with mindfulness interventions. Neurol Sci off J Ital Neurol Soc Ital Soc Clin Neurophysiol. 2022;43(1):211–217. doi:10.1007/s10072-021-05686-1
  • Rezaian Langroudi R, Ghiasian M, Roozbehani M, Shamsaei F. Comparison of the Effectiveness of Group Therapy Based on Acceptance and Commitment and Amantadine on Pain, Fatigue and Quality of Life in Patients with Multiple Sclerosis. Avicenna J Nursing Midwifery Care. 2020;28(3):251–262. doi:10.30699/ajnmc.28.3.251
  • Homayuni A, Abedini S, Hosseini Z, Etemadifar M, Ghanbarnejad A. Explaining the facilitators of quality of life in patients with multiple sclerosis: a qualitative study. BMC Neurol. ;21(1):193. doi: 10.1186/s12883-021-02213-9
  • Ozkul C, Guclu-Gunduz A, Eldemir K, Apaydin Y, Yazici G, Irkec C. Combined exercise training improves cognitive functions in multiple sclerosis patients with cognitive impairment: a single-blinded randomized controlled trial. Mult Scler Relat Disord. 2020;45:102419. doi:10.1016/j.msard.2020.102419
  • Montañés‐Masias B, Bort‐Roig J, Pascual JC, Soler J, Briones‐Buixassa L. Online psychological interventions to improve symptoms in multiple sclerosis: a systematic review. Acta Neurol Scand. 2022;146(5):448–464. doi:10.1111/ane.13709
  • Grazioli E, Nigro E, Cerulli C, et al. Case Report: concurrent Resistance and Aerobic Training Regulate Adiponectin Expression and Disease Severity in Multiple Sclerosis: a Case Study. Front Neurosci. 2020;14. doi:10.3389/fnins.2020.567302
  • Naro A, Leo A, Russo M, et al. Breakthroughs in the spasticity management: are non-pharmacological treatments the future?. J Clin Neurosci off J Neurosurg Soc Australas. 2017;39:16–27. doi:10.1016/j.jocn.2017.02.044
  • Zucchella C, Mantovani E, De Icco R, Tassorelli C, Sandrini G, Tamburin S. Non-invasive Brain and Spinal Stimulation for Pain and Related Symptoms in Multiple Sclerosis: a Systematic Review. Front Neurosci. 2020;14:547069. doi:10.3389/fnins.2020.547069
  • Amatya B, Young J, Khan F. Non-pharmacological interventions for chronic pain in multiple sclerosis: a Cochrane systematic review. Ann Phys Rehabil Med. 2018;61:e106. doi:10.1016/j.rehab.2018.05.227
  • Krupp L. Fatigue is intrinsic to multiple sclerosis (MS) and is the most commonly reported symptom of the disease. Mult Scler Houndmills Basingstoke Engl. 2006;12(4):367–368. doi:10.1191/135248506ms1373ed
  • Weiland TJ, Jelinek GA, Marck CH, et al. Clinically Significant Fatigue: prevalence and Associated Factors in an International Sample of Adults with Multiple Sclerosis Recruited via the Internet. PLoS ONE. 2015;10(2):e0115541. doi:10.1371/journal.pone.0115541
  • Kobelt G, Langdon D, Jönsson L. The effect of self-assessed fatigue and subjective cognitive impairment on work capacity: the case of multiple sclerosis. Mult Scler Houndmills Basingstoke Engl. 2019;25(5):740–749. doi:10.1177/1352458518769837
  • Mikuľáková W, Klímová E, Kendrová L, Gajdoš M, Chmelík M. Effect of rehabilitation on fatigue level in patients with multiple sclerosis. Med Sci Monit Int Med J Exp Clin Res. 2018;24:5761–5770. doi:10.12659/MSM.909183
  • Razazian N, Yavari Z, Farnia V, et al. Exercising impacts on fatigue, depression, and paresthesia in female patients with multiple sclerosis. Med Sci Sports Exerc. 2016;48(5):796–803. doi:10.1249/MSS.0000000000000834
  • Halabchi F, Alizadeh Z, Sahraian MA, Abolhasani M. Exercise prescription for patients with multiple sclerosis; potential benefits and practical recommendations. BMC Neurol. 2017;17(1):185. doi:10.1186/s12883-017-0960-9
  • Pilutti LA, Edwards T, Motl RW, Sebastião E. Functional electrical stimulation cycling exercise in people with multiple sclerosis: secondary effects on cognition, symptoms, and quality of life. Int J MS Care. 2019;21(6):258–264. doi:10.7224/1537-2073.2018-048
  • Proschinger S, Kuhwand P, Rademacher A, et al. Fitness, physical activity, and exercise in multiple sclerosis: a systematic review on current evidence for interactions with disease activity and progression. J Neurol. 2022;269(6):2922–2940. doi:10.1007/s00415-021-10935-6
  • Motl RW. Physical Activity and Healthy Aging with Multiple Sclerosis?Literature Review and Research Directions. US Neurol. 2016;12(01):29. doi:10.17925/USN.2016.12.01.29
  • Zielińska-Nowak E, Włodarczyk L, Kostka J, Miller E. New Strategies for Rehabilitation and Pharmacological Treatment of Fatigue Syndrome in Multiple Sclerosis. J Clin Med. 2020;9(11):3592. doi:10.3390/jcm9113592
  • Sahu M, Tripathi R, Jha NK, Jha SK, Ambasta RK, Kumar P. Cross talk mechanism of disturbed sleep patterns in neurological and psychological disorders. Neurosci Biobehav Rev. 2022;140:104767. doi:10.1016/j.neubiorev.2022.104767
  • Gravesteijn AS, de Groot V, Hulst HE. The future for non-pharmacological treatments in MS: looking back and moving forward. Mult Scler J. 2021;27(11):1640–1642. doi:10.1177/13524585211005344
  • Ysrraelit MC, Fiol MP, Gaitán MI, Correale J. Quality of life assessment in multiple sclerosis: different perception between patients and neurologists. Front Neurol. 2017;8:729. doi:10.3389/fneur.2017.00729
  • Patten SB, Marrie RA, Carta MG. Depression in multiple sclerosis. Int Rev Psychiatry Abingdon Engl. 2017;29(5):463–472. doi:10.1080/09540261.2017.1322555
  • Feinstein A, Magalhaes S, Richard JF, Audet B, Moore C. The link between multiple sclerosis and depression. Nat Rev Neurol. 2014;10(9):507–517. doi:10.1038/nrneurol.2014.139
  • Newsome SD, Aliotta PJ, Bainbridge J, et al. A framework of care in multiple sclerosis, part 2. Int J MS Care. 2017;19(1):42–56. doi:10.7224/1537-2073.2016-062
  • Chwastiak LA, Ehde DM. Psychiatric Issues in Multiple Sclerosis. Psychiatr Clin North Am. 2007;30(4):803–817. doi:10.1016/j.psc.2007.07.003
  • Pompili M, Forte A, Palermo M, et al. Suicide risk in multiple sclerosis: a systematic review of current literature. J Psychosom Res. 2012;73(6):411–417. doi:10.1016/j.jpsychores.2012.09.011
  • Kidd T, Carey N, Mold F, et al. A systematic review of the effectiveness of self-management interventions in people with multiple sclerosis at improving depression, anxiety and quality of life. PLoS ONE. 2017;12(10):e0185931. doi:10.1371/journal.pone.0185931
  • Islas MÁ M, Ciampi E. Assessment and Impact of Cognitive Impairment in Multiple Sclerosis: an Overview. Biomedicines. 2019;7(1). doi:10.3390/biomedicines7010022
  • Foley FW, Benedict RHB, Gromisch ES, DeLuca J. The need for screening, assessment, and treatment for cognitive dysfunction in multiple sclerosis. Int J MS Care. 2012;14(2):58–64. doi:10.7224/1537-2073-14.2.58
  • McNicholas N, O’Connell K, Yap SM, Killeen RP, Hutchinson M, McGuigan C. Cognitive dysfunction in early multiple sclerosis: a review. QJM Mon J Assoc Physicians. 2018;111(6):359–364. doi:10.1093/qjmed/hcx070
  • Cadden M, Arnett P. Factors Associated with employment status in individuals with multiple sclerosis. Int J MS Care. 2015;17(6):284–291. doi:10.7224/1537-2073.2014-057
  • Migliore S, Ghazaryan A, Simonelli I, et al. Cognitive impairment in relapsing-remitting multiple sclerosis patients with very mild clinical disability. Behav Neurol. 2017;2017:7404289. doi:10.1155/2017/7404289
  • Negaresh R, Motl RW, Zimmer P, Mokhtarzade M, Baker JS. Effects of exercise training on multiple sclerosis biomarkers of central nervous system and disease status: a systematic review of intervention studies. Eur J Neurol. 2019;26(5):711–721. doi:10.1111/ene.13929
  • Pilutti LA, Platta ME, Motl RW, Latimer-Cheung AE. The safety of exercise training in multiple sclerosis: a systematic review. J Neurol Sci. 2014;343(1–2):3–7. doi:10.1016/j.jns.2014.05.016
  • Rooney S, Riemenschneider M, Dalgas U, et al. Physical activity is associated with neuromuscular and physical function in patients with multiple sclerosis independent of disease severity. Disabil Rehabil. 2021;43(5):632–639. doi:10.1080/09638288.2019.1634768
  • PRIME PubMed | effects of Pilates-based telerehabilitation on physical performance and quality of life in patients with multiple sclerosis. Available from: https://www.unboundmedicine.com/medline/citation/37147864/Effects_of_Pilates-based_telerehabilitation_on_physical_performance_and_quality_of_life_in_patients_with_multiple_sclerosis. Accessed July 31, 2023.
  • Canavarro M, Serra A, Simões M, et al. The World Health Organization Quality of Life Assessment (WHOQOL). Development and psychometric properties. Int J Behav Med. 2009;16(2):116–124. doi:10.1007/s12529-008-9024-2
  • Kefaliakos A, Pliakos I, Diomidous M. Managing the quality of life in patients with multiple sclerosis: a literature review. In: Unifying the Applications and Foundations of Biomedical and Health Informatics. IOS Press; 2016:220–221. doi:10.3233/978-1-61499-664-4-220
  • Opara J, Jaracz K, Brola W. Quality of life in multiple sclerosis. J Med Life. 2010;3(4):352–358.
  • Nortvedt MW, Riise T. The use of quality of life measures in multiple sclerosis research. Mult Scler J. 2003;9(1):63–72. doi:10.1191/1352458503ms871oa
  • Crank H, Carter A, Humphreys L, et al. Qualitative investigation of exercise perceptions and experiences in people with multiple sclerosis before, during, and after participation in a personally tailored exercise program. Arch Phys Med Rehabil. 2017;98(12):2520–2525. doi:10.1016/j.apmr.2017.05.022
  • Learmonth YC, Motl RW. Physical activity and exercise training in multiple sclerosis: a review and content analysis of qualitative research identifying perceived determinants and consequences. Disabil Rehabil. 2016;38(13):1227–1242. doi:10.3109/09638288.2015.1077397
  • Learmonth YC, Adamson BC, Balto JM, et al. Multiple sclerosis patients need and want information on exercise promotion from healthcare providers: a qualitative study. Health Expect Int J Public Particip Health Care Health Policy. 2017;20(4):574–583. doi:10.1111/hex.12482
  • Solaro C, Gamberini G, Masuccio FG. Depression in Multiple Sclerosis: epidemiology, Aetiology, Diagnosis and Treatment. CNS Drugs. 2018;32(2):117–133. doi:10.1007/s40263-018-0489-5
  • Hind D, Cotter J, Thake A, et al. Cognitive behavioural therapy for the treatment of depression in people with multiple sclerosis: a systematic review and meta-analysis. BMC Psychiatry. 2014;14(1):5. doi:10.1186/1471-244X-14-5
  • Gomes KE, Ruiz JA, Raskin SA, et al. The Role of Cognitive Impairment on Physical Therapy Attendance and Outcomes in Multiple Sclerosis. J Neurol Phys Ther. 2022;46(1):34–40. doi:10.1097/NPT.0000000000000375
  • Malcomson KS, Lowe-Strong AS, Dunwoody L. What can we learn from the personal insights of individuals living and coping with Multiple Sclerosis?. Disabil Rehabil. 2008;30(9):662–674. doi:10.1080/09638280701400730