Triptolide induces lysosomal-mediated programmed cell death in MCF-7 breast cancer cells

References

• National Cancer Institute’s Website Available from: http://seer.cancer.gov/statfacts/html/breast.html#incidence-mortality
   Google Scholar
• ParkinDMBrayFFerlayJPisaniPGlobal cancer statistics, 2002CA Cancer J Clin2005557410815761078
   PubMed Web of Science ®Google Scholar
• SiegelRNaishadhamDJemalACancer statistics, 2012CA Cancer J Clin2012621102922237781
   PubMed Web of Science ®Google Scholar
• LiFQLuXZLiangXBTriptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activationJ Neuroimmunol2004148243114975583
   PubMed Web of Science ®Google Scholar
• QiuDKaoPNImmunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. fDrugs R D2003411812568630
   PubMedGoogle Scholar
• BrinkerAMMaJLipskyPERaskinIMedicinal chemistry and pharmacology of genus TripterygiumPhytochemistry20076873276617250858
   PubMed Web of Science ®Google Scholar
• ChanMAKohlmeierJEBrandenMJungMBenedictSHTriptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506Phytother Res19991346446710479754
   PubMed Web of Science ®Google Scholar
• TitovDVGilmanBHeQLXPB, a subunit of TFIIH, is a target of the natural product triptolideNat Chem Biol2011718218821278739
   PubMed Web of Science ®Google Scholar
• ChoiYJKimTGKimYHImmunosuppressant PG490 (triptolide) induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cellsBiochem Pharmacol20036627328012826269
   PubMed Web of Science ®Google Scholar
• LeeKYChangWTQiuDKaoPNRosenGDPG490 (triptolide) cooperates with tumor necrosis factor-α to induce apoptosis in tumor cellsJ Biol Chem1999274134511345510224110
   PubMed Web of Science ®Google Scholar
• CarterBZMakDHSchoberWDTriptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5Blood20081113742375018187663
   PubMed Web of Science ®Google Scholar
• KroschTCSangwanVBanerjeeSTriptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor-kappa B activityAm J Surg201320538739623428154
   PubMed Web of Science ®Google Scholar
• JainMVPaczullaAMKlonischTInterconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy developmentJ Cell Mol Med201317122923301705
   PubMed Web of Science ®Google Scholar
• MaghsoudiNZakeriZLockshinRAProgrammed cell death and apoptosis – where it came from and where it is going: from Elie Metchnikoff to the control of caspasesExp Oncol20123414615223069998
   PubMedGoogle Scholar
• SchweichelJUMerkerHJThe morphology of various types of cell death in prenatal tissuesTeratology197372532664807128
   PubMedGoogle Scholar
• ZakeriZFQuaglinoDLathamTLockshinRADelayed internucleosomal DNA fragmentation in programmed cell deathFASEB J199374704788462789
   PubMed Web of Science ®Google Scholar
• KitanakaCKatoKIjiriRIncreased Ras expression and caspase-independent neuroblastoma cell death: possible mechanism of spontaneous neuroblastoma regressionJ Natl Cancer Inst20029435836811880474
   PubMedGoogle Scholar
• de LizRHorstHPizzolattiMGFrödeTSGirardDActivation of human neutrophils by the anti-inflammatory mediator Esenbeckia leiocarpa leads to atypical apoptosisMediators Inflamm2012201219838222649276
   PubMed Web of Science ®Google Scholar
• HalabyRZakeriZLockshinRAMetabolic events during programmed cell death in insect labial glandsBiochem Cell Biol1994725976017654333
   PubMed Web of Science ®Google Scholar
• de DuveCThe lysosome turns fiftyNat Cell Biol2005784784916136179
   PubMed Web of Science ®Google Scholar
• LuzioLPPryorPRBrightNALysosomes: fusion and functionNat Rev Mol Cell Biol2007862263217637737
   PubMed Web of Science ®Google Scholar
• LinderSShoshanMCLysosomes and endoplasmic reticulum: Targets for improved, selective anticancer therapyDrug Resist Updat2005819920416055370
   PubMed Web of Science ®Google Scholar
• JohanssonAAppelqvistHNilssonCKagedalKRobergKOllingerKRegulation of apoptosis-associated lysosomal membrane permeabilizationApoptosis20101552754020077016
   PubMed Web of Science ®Google Scholar
• ČesenMHPeganKSpesATurkBLysosomal pathway to cell death and their therapeutic applicationsExp Cell Res20123181245125122465226
   PubMed Web of Science ®Google Scholar
• CheriyathVKuhnsMAKalaycioMEBordenECPotentiation of apoptosis by histone deacetylase inhibitors and doxorubicin combination: cytoplasmic cathepsin B as a mediator of apoptosis in multiple myelomaBr J Cancer201110495796721364585
   PubMed Web of Science ®Google Scholar
• KirkegaardTRothAGPetersenNHHsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathologyNature201046354955320111001
   PubMed Web of Science ®Google Scholar
• ShreeTOlsonOCElieBTMacrophages and cathepsin proteases blunt chemotherapeutic response in breast cancerGenes Dev2011252465247922156207
   PubMed Web of Science ®Google Scholar
• PaquetCSanéATBeaucheminMBertrandRCaspase- and mitochondrial dysfunction-dependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosisLeukemia20051978479115759029
   PubMed Web of Science ®Google Scholar
• MosmannTRapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assaysJ Immunol Methods19836555636606682
   PubMed Web of Science ®Google Scholar
• TanBJTanBHChiuGNEffect of triptolide on focal adhesion kinase and survival in MCF-7 breast cancer cellsOncol Rep2011261315132121805042
   PubMed Web of Science ®Google Scholar
• JänickeRUSprengartMLWatiMRPorterAGCaspase-3 is required for DNA fragmentation and morphological changes associated with apoptosisJ Biol Chem1998273935793609545256
   PubMed Web of Science ®Google Scholar
• TaimenPKallajokiMNuMA and nuclear lamins behave differently in Fas-mediated apoptosisJ Cell Sci200311657158312508117
   PubMed Web of Science ®Google Scholar
• LiuJJiangZXiaoJEffects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell linesPhytomedicine2009161006101319524422
   PubMed Web of Science ®Google Scholar
• SoundararajanRSayatRRobertsonGSMarignariPATriptolide: an inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cellsCancer Biol Ther200982054206219783906
   PubMed Web of Science ®Google Scholar
• LeuenrothSJOkuharaDShotwellJDTriptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney diseaseProc Natl Acad Sci U S A20071044389439417360534
   PubMed Web of Science ®Google Scholar
• CorsonTWCavgaHAberleNCrewsCMTriptolide directly inhibits dCTP pyrophosphataseChembiochem2011121767177321671327
   PubMed Web of Science ®Google Scholar
• SemenovDVAronovPAKuliginaEVPotapenkoMORichterVAOligonucleosome DNA fragmentation of caspase 3 deficient MCF-7 cells in palmitate-induced apoptosisNucleosides Nucleotides Nucleic Acids20042383183615560068
   PubMed Web of Science ®Google Scholar
• MizushimaNTransgenic models of autophagyDereticVAutophagy in Immunity and Infection: A Novel Immune EffectorWeinheimWiley-VCH20065565
   Google Scholar
• MessinaMEJrHalabyRDoes triptolide induce lysosomal-mediated apoptosis in human breast cancer cells?Med Hypotheses201177919321486687
   PubMed Web of Science ®Google Scholar
• BrattonSBSalvesenGSRegulation of the Apaf-1-caspase-9 apoptosomeJ Cell Sci20101233209321420844150
   PubMed Web of Science ®Google Scholar
• GermainMAffarEBD’AmoursDDixitVMSalvesenGSPoirierGGCleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7J Biol Chem1999274283792838410497198
   PubMed Web of Science ®Google Scholar
• BoucherDBlaisVDenaultJBCaspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysisProc Natl Acad Sci U S A20121095669567422451931
   PubMed Web of Science ®Google Scholar
• LockshinRAProgrammed cell death. Activation of lysis by a mechanism involving the synthesis of proteinJ Insect Physiol196915150515165348113
   PubMed Web of Science ®Google Scholar
• SchweichelJUMerkerHJThe morphology of various types of cell death in prenatal tissuesTeratology197372532664807128
   PubMedGoogle Scholar
• JuhászGCsikósGSinkaRErdélyiMSassMThe Drosophila homolog of Aut1 is essential for autophagy and developmentFEBS Lett200354315415812753924
   PubMed Web of Science ®Google Scholar
• LockshinRAZakeriZApoptosis, autophagy, and moreInt J Biochem Cell Biol2004362405241915325581
   PubMed Web of Science ®Google Scholar
• JochováJZakeriZLockshinRARearrangement of the tubulin and actin cytoskeleton during programmed cell death in Drosophila salivary glandsCell Death Differ1997414014916465220
   PubMed Web of Science ®Google Scholar
• HalabyRMartinezMLLockshinRZakeriZ20-Hydroxyecdysone induces apoptosis in the labial glands of Manduca sextaJ Res Lepid200337310
   Google Scholar
• PooleARTumour lysosomal enzymes and invasive growthDingleJTLysosomes in Biology and Pathology3AmsterdamNorth-Holland Publishing Company1973303337
   Google Scholar
• YuHLouJRDingWQClioquinol independently targets NF-kappaB and lysosome pathways in human cancer cellsAnticancer Res2010302087209220651355
   PubMed Web of Science ®Google Scholar
• IvanovaSRepnikUBojicLPetelinATurkVTurkBLysosomes in apoptosisMethods Enzymol200844218319918662570
   PubMed Web of Science ®Google Scholar
• BoyaPAndreauKPoncetDLysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashionJ Exp Med20031971323133412756268
   PubMed Web of Science ®Google Scholar
• CirmanTOresićKMazovecGDSelective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsinsJ Biol Chem20042793578358714581476
   PubMed Web of Science ®Google Scholar
• KimJKlionskyDJAutophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cellsAnnu Rev Biochem20006930334210966461
   PubMed Web of Science ®Google Scholar
• ZhaoMAntunesFEatonJWBrunkUTLysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosisEur J Biochem20032703778378612950261
   PubMedGoogle Scholar
• BrunkUTNeuzilJEatonJWLysosomal involvement in apoptosisRedox Rep20016919711450988
   PubMed Web of Science ®Google Scholar
• LeistMJäätteläMTriggering of apoptosis by cathepsinsCell Death Differ2001832432611550083
   PubMed Web of Science ®Google Scholar
• Lamparska-PrzybyszMGajkowskaBMotylTCathepsins and BID are involved in the molecular switch between apoptosis and autophagy in breast cancer MCF-7 cells exposed to camptothecinJ Physiol Pharmacol20055615917916077201
   PubMedGoogle Scholar
• ReddingSWHavemanCWTreating the discomfort of oral ulceration resulting from cancer chemotherapyCompend Contin Educ Dent19992038939239439611692345
   PubMedGoogle Scholar
• LorigKRSobelDSRitterPLLaurentDHobbsMEffect of a self management program on patients with chronic diseaseEff Clin Pract2001425626211769298
   PubMedGoogle Scholar
• XueLYChiuSMOleinickNLStaurosporine-induced death of MCF-7 human breast cancer cells: a distinction between caspase-3-dependent steps of apoptosis and the critical lethal lesionsExp Cell Res200328313514512581734
   PubMed Web of Science ®Google Scholar
• BrownJMWoutersBGApoptosis, p53, and tumor cell sensitivity to anticancer agentsCancer Res1999591391139910197600
   PubMed Web of Science ®Google Scholar