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Review

Challenges in implementing and maintaining osteoporosis therapy

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Pages 759-769 | Published online: 13 Aug 2014

References

  • Dawson-HughesBLookerACTostesonANJohanssonHKanisJAMeltonLJThe potential impact of the National Osteoporosis Foundation guidance on treatment eligibility in the USA: an update in NHANES 2005–2008Osteoporos Int201223381182021717247
  • BurgeRDawson-HughesBSolomonDHWongJBKingATostesonAIncidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025J Bone Miner Res200722346547517144789
  • CooperCColeZAHolroydCRIOF CSA Working Group on Fracture EpidemiologySecular trends in the incidence of hip and other osteoporotic fracturesOsteoporos Int20112251277128821461721
  • JohnellOKanisJAAn estimate of the worldwide prevalence and disability associated with osteoporotic fracturesOsteoporos Int200617121726173316983459
  • KanisJAJohnellORequirements for DXA for the management of osteoporosis in EuropeOsteoporos Int200516322923815618996
  • AdachiJDAdamiSGehlbachSGLOW InvestigatorsImpact of prevalent fractures on quality of life: baseline results from the global longitudinal study of osteoporosis in womenMayo Clin Proc201085980681320634496
  • SaleJEBeatonDPosenJElliot-GibsonVBogochESystematic review on interventions to improve osteoporosis investigation and treatment in fragility fracture patientsOsteoporos Int20112272067208221607808
  • ShepherdAJCassARRayLATanAWilkinsonGSTreatment for older men with fracturesOsteoporos Int20122331041105121811867
  • DelmasPDvan de LangerijtLWattsNBIMPACT Study GroupUnderdiagnosis of vertebral fractures is a worldwide problem: the IMPACT studyJ Bone Miner Res200520455756315765173
  • Shibli-RahhalAVaughan-SarrazinMSRichardsonKCramPTesting and treatment for osteoporosis following hip fracture in an integrated US. healthcare delivery systemOsteoporos Int201122122973298021271339
  • LeslieWDGiangregorioLMYogendranMA population-based analysis of the post-fracture care gap 1996–2008: the situation is not improvingOsteoporos Int20122351623162921476038
  • FeldsteinACNicholsGAElmerPJSmithDHAickinMHersonMOlder women with fractures: patients falling through the cracks of guideline-recommended osteoporosis screening and treatmentJ Bone Joint Surg Am200385-A122294230214668497
  • JohnellKFastbomJUndertreatment of osteoporosis in the oldest old? A nationwide study of over 700,000 older peopleArch Osteoporos200941–2172320234854
  • KiebzakGMBeinartGAPerserKAmbroseCGSiffSJHeggenessMHUndertreatment of osteoporosis in men with hip fractureArch Intern Med2002162192217222212390065
  • MajumdarSRLixLMYogendranMMorinSNMetgeCJLeslieWDPopulation-based trends in osteoporosis management after new initiations of long-term systemic glucocorticoids (1998–2008)J Clin Endocrinol Metab20129741236124222298803
  • McKeownEBykerkVPDe LeonFCATCH InvestigatorsQuality assurance study of the use of preventative therapies in glucocorticoid-induced osteoporosis in early inflammatory arthritis: results from the CATCH cohortRheumatology (Oxford)20125191662166922539481
  • KanisJAMcCloskeyEVJohanssonHCooperCRizzoliRReginsterJYScientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the Committee of Scientific Advisors of the International Osteoporosis Foundation (IOF)European guidance for the diagnosis and management of osteoporosis in postmenopausal womenOsteoporos Int2013241235723079689
  • National Osteoporosis Foundation2013 Clinician’s Guide to the Prevention and Treatment of OsteoporosisWashington, DCNational Osteoporosis Foundation2013 Available from: http://nof.org/hcp/resources/913Accessed May 24, 2013
  • nice.org.uk [homepage on the Internet]Alendronate, etidronate, risedronate, raloxifene, strontium ranelate and teriparatide for the secondary prevention of osteoporotic fragility fractures in postmenopausal women [NICE technology appraisal guidance TA161]NHS National Institute for Health and Clinical Excellence (NICE)2011 [updated August 27, 2013; cited May 24, 2013]. Available from: http://guidance.nice.org.uk/TA161Accessed October 24, 2013
  • NHS National Institute for Health and Clinical Excellence (NICE)Alendronate, Etidronate, Risedronate, Raloxifene and Strontium Ranelate for the Primary Prevention of Osteoporotic Fragility Fractures in Postmenopausal Women (Amended). NICE Technology Appraisal Guidance 160 (Amended)LondonNational Institute for Health and Clinical Excellence2011 Available from: http://www.nice.org.uk/nicemedia/live/11746/47176/47176.pdfAccessed May 24, 2013
  • PapaioannouAMorinSCheungAMScientific Advisory Council of Osteoporosis Canada2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summaryCMAJ2010182171864187320940232
  • iofbonehealth.org [homepage on the Internet]National and regional osteoporosis guidelinesInternational Osteoporosis Foundation2013 [cited May 24, 2013]. Available from: http://www.iofbonehealth.org/national-regional-osteoporosis-guidelinesAccessed October 24, 2013
  • health.ny.gov [homepage on the Internet]FDA-approved medications for osteoporosis treatmentNew York State Osteoporosis Prevention and Education Program2012 [updated Jun 2012, cited May 24, 2013]. Available from: http://www.health.ny.gov/diseases/conditions/osteoporosis/fda_meds_and_prevention.htmAccessed October 24, 2013
  • nof.gov [homepage on the Internet]Types of osteoporosis medicationsNational Osteoporosis Foundation2013 [cited May 24, 2013]. Available from: http://www.nof.org/articles/22Accessed October 24, 2013
  • shef.ac.uk [homepage on the Internet]FRAX® WHO Fracture Risk Assessment ToolWorld Health Organization Collaborating Centre for Metabolic Bone Diseases, University of Sheffield2013 [cited May 24, 2013]. Available from: http://www.shef.ac.uk/FRAX/Accessed October 24, 2013
  • KanisJAWorld Health Organization Scientific GroupAssessment of Osteoporosis at the Primary Health Care Level. Technical ReportSheffieldWorld Health Organization Collaborating Centre for Metabolic Bone Diseases, University of Sheffield2007
  • KanisJAOdénAMcCloskeyEVJohanssonHWahlDACooperCIOF Working Group on Epidemiology and Quality of LifeA systematic review of hip fracture incidence and probability of fracture worldwideOsteoporos Int20122392239225622419370
  • LewieckiEMCompstonJEMillerPDFRAX® Position Development Conference MembersOfficial positions for FRAX® bone mineral density and FRAX® simplification from Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX®J Clin Densitom201114322623621810530
  • CanalisEMazziottiGGiustinaABilezikianJPGlucocorticoid-induced osteoporosis: pathophysiology and therapyOsteoporos Int200718101319132817566815
  • WeinsteinRSClinical practice. Glucocorticoid-induced bone diseaseN Engl J Med20113651627021732837
  • GrossmanJMGordonRRanganathVKAmerican College of Rheumatology 2010 recommendations for the prevention and treatment of glucocorticoid-induced osteoporosisArthritis Care Res (Hoboken)201062111515152620662044
  • Bone and Tooth Society, National Osteoporosis Society, Royal College of PhysiciansGlucocorticoid-induced osteoporosis: guidelines for prevention and treatmentLondon: LondonRoyal College of Physicians2002
  • DevogelaerJPGoemaereSBoonenSEvidence-based guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis: a consensus document of the Belgian Bone ClubOsteoporos Int200617181916217586
  • AdachiJDSaagKGDelmasPDTwo-year effects of alendronate on bone mineral density and vertebral fracture in patients receiving glucocorticoids: a randomized, double-blind, placebo-controlled extension trialArthritis Rheum200144120221111212161
  • VestergaardPSchwartzKPinholtEMRejnmarkLMosekildeLGastric and esophagus events before and during treatment of osteoporosisCalcif Tissue Int201086211011519957165
  • EnsrudKELuiLYTaylorBCOsteoporotic Fractures Research GroupRenal function and risk of hip and vertebral fractures in older womenArch Intern Med2007167213313917242313
  • NickolasTLMcMahonDJShaneERelationship between moderate to severe kidney disease and hip fracture in the United StatesJ Am Soc Nephrol200617113223323217005938
  • JamalSAWestSLMillerPDFracture risk assessment in patients with chronic kidney diseaseOsteoporos Int20122341191119821901475
  • CocoMRushHIncreased incidence of hip fractures in dialysis patients with low serum parathyroid hormoneAm J Kidney Dis20003661115112111096034
  • Kidney disease: Improving Global Outcomes (KDIGO) CKD-MBD Work GroupKDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)Kidney Int Suppl2009113S1S130
  • MoeSDrüekeTCunninghamJKidney Disease: Improving Global Outcomes (KDIGO)Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)Kidney Int200669111945195316641930
  • MillerPDThe kidney and bisphosphonatesBone2011491778121232648
  • fda.gov [homepage on the Internet]FDA drug safety communication: New contraindication and updated warning on kidney impairment for Reclast (zoledronic acid)US Food and Drug Administration (FDA)2011 [updated September 20, 2011, cited October 10, 2013]. Available from: http://www.fda.gov/Drugs/DrugSafety/ucm270199.htmAccessed October 10, 2013
  • Fosamax®(alendronate sodium) [package insert]Whitehouse Station, NJMerck and Co, Inc2012
  • Actonel® (risedronate sodium) [package insert]Norwich Pharmaceuticals, IncNorth Norwich, NY2012
  • Boniva® (ibandronate sodium) [package insert]San Francisco, CAGenentech, Inc2011
  • UhligKBernsJSKestenbaumBKDOQI US commentary on the 2009 KDIGO Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of CKD-Mineral and Bone Disorder (CKD-MBD)Am J Kidney Dis201055577379920363541
  • MillerPDFragility fractures in chronic kidney disease: an opinion-based approachCleve Clin J Med2009761271572319952296
  • DonaldsonMGCawthonPMLuiLYOsteoporotic Fractures in Men (MrOS) Study GroupEstimates of the proportion of older white men who would be recommended for pharmacologic treatment by the new US National Osteoporosis Foundation guidelinesJ Bone Miner Res20102571506151120200971
  • KanisJABianchiGBilezikianJPTowards a diagnostic and therapeutic consensus in male osteoporosisOsteoporos Int201122112789279821509585
  • GatesBJDasSManagement of osteoporosis in elderly menMaturitas201169211311921481552
  • MacLeanCNewberrySMaglioneMSystematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosisAnn Intern Med2008148319721318087050
  • LiuHPaigeNMGoldzweigCLScreening for osteoporosis in men: a systematic review for an American College of Physicians guidelineAnn Intern Med2008148968570118458282
  • EbelingPRClinical practice. Osteoporosis in menN Engl J Med2008358141474148218385499
  • CenterJRBliucDNguyenTVEismanJARisk of subsequent fracture after low-trauma fracture in men and womenJAMA2007297438739417244835
  • BliucDNguyenNDMilchVENguyenTVEismanJACenterJRMortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and womenJAMA2009301551352119190316
  • KannegaardPNvan der MarkSEikenPAbrahamsenBExcess mortality in men compared with women following a hip fracture. National analysis of comedications, comorbidity and survivalAge Ageing201039220320920075035
  • WehrenLEHawkesWGOrwigDLHebelJRZimmermanSIMagazinerJGender differences in mortality after hip fracture: the role of infectionJ Bone Miner Res200318122231223714672359
  • CawthonPMEwingSKMcCullochCEOsteoporotic Fractures in Men (MrOS) Research GroupLoss of hip BMD in older men: the osteoporotic fractures in men (MrOS) studyJ Bone Miner Res200924101728173519419308
  • EnsrudKETaylorBCPaudelMLOsteoporotic Fractures in Men Study GroupSerum 25-hydroxyvitamin D levels and rate of hip bone loss in older menJ Clin Endocrinol Metab20099482773278019454586
  • NielsonCMMarshallLMAdamsALOsteoporotic Fractures in Men Study Research GroupBMI and fracture risk in older men: the osteoporotic fractures in men study (MrOS)J Bone Miner Res201126349650220814955
  • SolimeoSLWeberTJGoldDTOlder men’s explanatory model for osteoporosisGerontologist201151453053921310768
  • SambrookPNFlahiveJHoovenFHPredicting fractures in an international cohort using risk factor algorithms without BMDJ Bone Miner Res201126112770277721887705
  • BoonenSDejaegerEVanderschuerenDOsteoporosis and osteoporotic fracture occurrence and prevention in the elderly: a geriatric perspectiveBest Pract Res Clin Endocrinol Metab200822576578519028356
  • RizzoliRBruyereOCannata-AndiaJBManagement of osteoporosis in the elderlyCurr Med Res Opin200925102373238719650751
  • Prieto-AlhambraDNoguesXJavaidMKAn increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW)Ann Rheum Dis201372691191722730372
  • SwitzerJAJaglalSBogochEROvercoming barriers to osteoporosis care in vulnerable elderly patients with hip fracturesJ Orthop Trauma200923645445919550234
  • KamatariMKotoSOzawaNFactors affecting long-term compliance of osteoporotic patients with bisphosphonate treatment and QOL assessment in actual practice: alendronate and risedronateJ Bone Miner Metab200725530230917704995
  • SaleJEGignacMAHawkerGDecision to take osteoporosis medication in patients who have had a fracture and are ‘high’ risk for future fracture: a qualitative studyBMC Musculoskelet Disord2011129221554729
  • HaasumYFastbomJFratiglioniLJohnellKUndertreatment of osteoporosis in persons with dementia? A population-based studyOsteoporos Int20122331061106821499775
  • SchneiderJLFinkHAEwingSKEnsrudKECummingsSRStudy of Osteoporotic Fractures (SOF) Research GroupThe association of Parkinson’s disease with bone mineral density and fracture in older womenOsteoporos Int20081971093109718301855
  • PazianasMCooperCEbetinoFHRussellRGLong-term treatment with bisphosphonates and their safety in postmenopausal osteoporosisTher Clin Risk Manag2010632534320668715
  • StevensonMJonesMLDe NigrisEBrewerNDavisSOakleyJA systematic review and economic evaluation of alendronate, etidronate, risedronate, raloxifene and teriparatide for the prevention and treatment of postmenopausal osteoporosisHealth Technol Assess2005922116015929857
  • Díez-PérezAOlmosJMNoguésXRisk factors for prediction of inadequate response to antiresorptivesJ Bone Miner Res201227481782422161773
  • CooperCJakobFChinnCFracture incidence and changes in quality of life in women with an inadequate clinical outcome from osteoporosis therapy: the Observational Study of Severe Osteoporosis (OSSO)Osteoporos Int200819449350117968611
  • BarbagalloMDominguezLJMaugeriDICARO Study GroupQuality of life in osteoporotic women with inadequate clinical response to antiresorptive drugs: results from the ICARO studyAging Clin Exp Res200719Suppl 3242718180604
  • iofbonehealth.org [homepage on the Internet]Inadequate Responders Working GroupInternational Osteoporosis Foundation [cited May 24, 2013]. Available from: http://www.iofbonehealth.org/bonehealth/inadequate-responders-working-groupAccessed October 24, 2013
  • Diez-PerezAAdachiJDAgnusdeiDIOF CSA Inadequate Responders Working GroupTreatment failure in osteoporosisOsteoporos Int201223122769277422836278
  • CutlerDMEverettWThinking outside the pillbox – medication adherence as a priority for health care reformN Engl J Med2010362171553155520375400
  • World Health OrganizationAdherence to Long-Term Therapies: Evidence for ActionGenevaWorld Health Organization2003 Available from: http://www.who.int/chp/knowledge/publications/adherence_report/en/Accessed May 24, 2013
  • CramerJAGoldDTSilvermanSLLewieckiEMA systematic review of persistence and compliance with bisphosphonates for osteoporosisOsteoporos Int20071881023103117308956
  • SampalisJSAdachiJDRampakakisEVaillancourtJKarellisAKindunduCLong-term impact of adherence to oral bisphosphonates on osteoporotic fracture incidenceJ Bone Miner Res201227120221021976304
  • HadjiPClausVZillerVIntorciaMKostevKSteinleTGRAND: the German retrospective cohort analysis on compliance and persistence and the associated risk of fractures in osteoporotic women treated with oral bisphosphonatesOsteoporos Int201223122323121308365
  • LandfeldtEStrömORobbinsSBorgströmFAdherence to treatment of primary osteoporosis and its association to fractures – the Swedish Adherence Register Analysis (SARA)Osteoporos Int201223243344321286686
  • LekkerkerkerFKanisJAAlsayedNGroup for the Respect of Ethics and Excellence in Science (GREES)Adherence to treatment of osteoporosis: a need for studyOsteoporos Int200718101311131717585359
  • LiLRoddamAGitlinMPersistence with osteoporosis medications among postmenopausal women in the UK General Practice Research DatabaseMenopause2012191334021926926
  • NetelenbosJCGeusensPPYpmaGBuijsSJAdherence and profile of non-persistence in patients treated for osteoporosis – a large-scale, long-term retrospective study in The NetherlandsOsteoporos Int20112251537154620838773
  • HalpernRBeckerLIqbalSUKazisLEMacariosDBadamgaravEThe association of adherence to osteoporosis therapies with fracture, all-cause medical costs, and all-cause hospitalizations: a retrospective claims analysis of female health plan enrollees with osteoporosisJ Manag Care Pharm2011171253921204588
  • LandfeldtELundkvistJStrömOThe societal burden of poor persistence to treatment of osteoporosis in SwedenBone201148238038820850576
  • RossSSamuelsEGairyKIqbalSBadamgaravESirisEA meta-analysis of osteoporotic fracture risk with medication nonadherenceValue Health201114457158121669382
  • CottéFEMercierFDe PouvourvilleGRelationship between compliance and persistence with osteoporosis medications and fracture risk in primary health care in France: a retrospective case-control analysisClin Ther200830122410242219167600
  • PatrickARBrookhartMALosinaEThe complex relation between bisphosphonate adherence and fracture reductionJ Clin Endocrinol Metab20109573251325920444916
  • SirisESHarrisSTRosenCJAdherence to bisphosphonate therapy and fracture rates in osteoporotic women: relationship to vertebral and nonvertebral fractures from 2 US claims databasesMayo Clin Proc20068181013102216901023
  • CenterJRBliucDNguyenNDNguyenTVEismanJAOsteoporosis medication and reduced mortality risk in elderly women and menJ Clin Endocrinol Metab20119641006101421289270
  • HorneRWeinmanJPatients’ beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illnessJ Psychosom Res199947655556710661603
  • HorneRWeinmanJHankinsMThe beliefs about medicines questionnaire: the development and evaluation of a new method for assessing the cognitive representation of medicationPsychol Health1999141124
  • SirisESGehlbachSAdachiJDFailure to perceive increased risk of fracture in women 55 years and older: the Global Longitudinal Study of Osteoporosis in Women (GLOW)Osteoporos Int2011221273520358360
  • SolomonDHBrookhartMATsaoPPredictors of very low adherence with medications for osteoporosis: towards development of a clinical prediction ruleOsteoporos Int20112261737174320878392
  • Barrett-ConnorEWadeSWDoTPTreatment satisfaction and persistence among postmenopausal women on osteoporosis medications: 12-month results from POSSIBLE US™Osteoporos Int201223273374121625886
  • Penning-van BeestFJGoettschWGErkensJAHeringsRMDeterminants of persistence with bisphosphonates: a study in women with postmenopausal osteoporosisClin Ther200628223624216678644
  • CarrAJThompsonPWCooperCFactors associated with adherence and persistence to bisphosphonate therapy in osteoporosis: a cross-sectional surveyOsteoporos Int200617111638164416896510
  • SkedrosJGHolyoakJDPittsTCKnowledge and opinions of orthopaedic surgeons concerning medical evaluation and treatment of patients with osteoporotic fractureJ Bone Joint Surg Am2006881182416391245
  • LewieckiEMBabbittAMPiziakVKOzturkZEBoneHGAdherence to and gastrointestinal tolerability of monthly oral or quarterly intravenous ibandronate therapy in women with previous intolerance to oral bisphosphonates: a 12-month, open-label, prospective evaluationClin Ther200830460562118498910
  • CramerJALynchNOGaudinAFWalkerMCowellWThe effect of dosing frequency on compliance and persistence with bisphosphonate therapy in postmenopausal women: a comparison of studies in the United States, the United Kingdom, and FranceClin Ther200628101686169417157124
  • BartlRGötteSHadjiPHammerschmidtTAdherence with daily and weekly administration of oral bisphosphonates for osteoporosis treatmentDtsch Med Wochenschr20061312212571262 German16755420
  • ReckerRRGallagherRMacCosbePEEffect of dosing frequency on bisphosphonate medication adherence in a large longitudinal cohort of womenMayo Clin Proc200580785686116007889
  • BrankinEWalkerMLynchNAsprayTLisYCowellWThe impact of dosing frequency on compliance and persistence with bisphosphonates among postmenopausal women in the UK: evidence from three databasesCurr Med Res Opin20062271249125616834823
  • Penning-van BeestFJErkensJAOlsonMHeringsRMDeterminants of non-compliance with bisphosphonates in women with postmenopausal osteoporosisCurr Med Res Opin20082451337134418380910
  • LeeYKNhoJHHaYCKooKHPersistence with intravenous zoledronate in elderly patients with osteoporosisOsteoporos Int20122392329233322179417
  • ZillerVKostevKKyvernitakisIBoeckhoffJHadjiPPersistence and compliance of medications used in the treatment of osteoporosis – analysis using a large scale, representative, longitudinal German databaseInt J Clin Pharmacol Ther201250531532222541835
  • BauerDCBlackDEnsrudKUpper gastrointestinal tract safety profile of alendronate: the fracture intervention trialArch Intern Med2000160451752510695692
  • LibermanUALong-term safety of bisphosphonate therapy for osteoporosis: a review of the evidenceDrugs Aging200623428929816732688
  • WooCGaoGWadeSHochbergMCGastrointestinal side effects in postmenopausal women using osteoporosis therapy: 1-year findings in the POSSIBLE US studyCurr Med Res Opin20102641003100920201623
  • ReckerRRLewieckiEMMillerPDReiffelJSafety of bisphosphonates in the treatment of osteoporosisAm J Med2009122Suppl 2S22S3219187809
  • GrimaDTPapaioannouAAiriaPIoannidisGAdachiJDAdverse events, bone mineral density and discontinuation associated with generic alendronate among postmenopausal women previously tolerant of brand alendronate: a retrospective cohort studyBMC Musculoskelet Disord2010116820388226
  • KanisJAReginsterJYKaufmanJMA reappraisal of generic bisphosphonates in osteoporosisOsteoporos Int201223121322121953472
  • NadrashTAPlushnerSLDelateTClinical pharmacists’ role in improving osteoporosis treatment rates among elderly patients with untreated atraumatic fracturesAnn Pharmacother200842333434018303134
  • GiangregorioLDolovichLCranneyAOsteoporosis risk perceptions among patients who have sustained a fragility fracturePatient Educ Couns200974221322018977628
  • BoudouLGerbayBChopinFOllagnierEColletPThomasTManagement of osteoporosis in fracture liaison service associated with long-term adherence to treatmentOsteoporos Int20112272099210621528360
  • Ojeda-BrunoSNaranjoAFrancisco-HernándezFSecondary prevention program for osteoporotic fractures and long-term adherence to bisphosphonatesOsteoporos Int20112261821182820924747
  • NewmanEDMatzkoCKOlenginskiTPGlucocorticoid-Induced Osteoporosis Program (GIOP): a novel, comprehensive, and highly successful care program with improved outcomes at 1 yearOsteoporos Int20061791428143416865312
  • CottéFEDe PouvourvilleGCost of non-persistence with oral bisphosphonates in post-menopausal osteoporosis treatment in FranceBMC Health Serv Res20111115121702989
  • PatrickARSchousboeJTLosinaESolomonDHThe economics of improving medication adherence in osteoporosis: validation and application of a simulation modelJ Clin Endocrinol Metab20119692762277021733991