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ORIGINAL RESEARCH

A Single Center Study Investigating Clinical Outcomes of Testing for Multiple Myeloma and Immune Deficiency at Low Globulin Levels

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Pages 345-358 | Received 06 Mar 2023, Accepted 23 May 2023, Published online: 30 May 2023

References

  • Zhang J, Sun W, Huang Z, et al. Light chain multiple myeloma, clinic features, responses to therapy and survival in a long-term study. World J Surg Oncol. 2014;12:234. doi:10.1186/1477-7819-12-234
  • Dupuis MM, Tuchman SA. Non-secretory multiple myeloma: from biology to clinical management. Once Targets There. 2016;9:7583–7590. doi:10.2147/OTT.S122241
  • Dilley M, Wangberg H, Noone J, Geng B. Primary immunodeficiency diseases treated with immunoglobulin and associated comorbidities. Allergy Asthma Proc. 2021;42(1):78–86. doi:10.2500/aap.2021.42.200113
  • Cunningham-Rundles C. Common variable immune deficiency: dissection of the variable. Immunol Rev. 2019;287(1):145–161. doi:10.1111/imr.12728
  • Patel SY, Carbone J, Jolles S. The expanding field of secondary antibody deficiency: causes, diagnosis, and management. Front Immunol. 2019;10:33. doi:10.3389/fimmu.2019.00033
  • Greenberger PA, Walker CL, Fitzsimons TE, Roberts M. Hypogammaglobulinemia associated with cytomegalovirus pneumonia. J Infect Dis. 1991;163(3):631–633. doi:10.1093/infdis/163.3.631
  • Holding S, Jolles S. Current screening approaches for antibody deficiency. Curr Opin Allergy Clin Immunol. 2015;15(6):547–555. doi:10.1097/ACI.0000000000000222
  • Jolles S, Borrell R, Zouwail S, et al. Calculated globulin (CG) as a screening test for antibody deficiency. Clin Exp Immunol. 2014;177(3):671–678. doi:10.1111/cei.12369
  • Hoo T, Lim EM, John M, D’Orsogna L, McLean-Tooke A. Calculated globulin as a screening tool for hypogammaglobulinaemia or paraproteins in hospitalized patients. Ann Clin Biochem. 2021;58(3):236–243. doi:10.1177/0004563221989737
  • Shields AM, Burns SO, Savic S, Richter AG; UK PIN COVID-19 Consortium. COVID-19 in patients with primary and secondary immunodeficiency: the United Kingdom experience. J Allergy Clin Immunol. 2021;147(3):870–875. doi:10.1016/j.jaci.2020.12.620
  • Adams RA, Smith L, Pickering PE. The incidence of monoclonal proteins during 7 years of screening in a district general hospital. Immunology. 1984;51(3):451–454.
  • Twycross A, Shorten A. Service evaluation, audit and research: what is the difference? Evid Based Nurs. 2014;17(3):65–66. doi:10.1136/eb-2014-101871
  • NHS England and NHS Improvement. Data Protection Policy. Available from: https://www.england.nhs.uk/wp-content/uploads/2019/10/data-protection-policy-v5.1.pdf. Accessed May 24, 2023.
  • Terpos E, Kleber M, Engelhardt M, et al.; European Myeloma Network. European Myeloma Network guidelines for the management of multiple myeloma-related complications. Haematologica. 2015;100(10):1254–1266. doi:10.3324/haematol.2014.117176
  • Cunningham-Rundles C. How I treat common variable immune deficiency. Blood. 2010;116(1):7–15. doi:10.1182/blood-2010-01-254417
  • Ameratunga R, Ahn Y, Steele R, Woon ST. The natural history of untreated primary hypogammaglobulinemia in adults: implications for the diagnosis and treatment of Common Variable Immunodeficiency Disorders (CVID). Front Immunol. 2019;10:1541. doi:10.3389/fimmu.2019.01541
  • Holding S, Khan S, Sewell WA, Jolles S, Dore PC. Using calculated globulin fraction to reduce diagnostic delay in primary and secondary hypogammaglobulinaemias: results of a demonstration project. Ann Clin Biochem. 2015;52(Pt 3):319–326. doi:10.1177/0004563214545791
  • Maffucci P, Filion CA, Boisson B, et al. Genetic diagnosis using whole exome sequencing in common variable immunodeficiency. Front Immunol. 2016;7:220. doi:10.3389/fimmu.2016.00220
  • Cunningham-Rundles C. Common variable immune deficiency: case studies. Blood. 2019;134(21):1787–1795. doi:10.1182/blood.2019002062
  • Ponsford MJ, Steven R, Bramhall K, et al. Clinical and laboratory characteristics of clozapine-treated patients with schizophrenia referred to a national immunodeficiency clinic reveals a B-cell signature resembling common variable immunodeficiency (CVID). J Clin Pathol. 2020;73(9):587–592. doi:10.1136/jclinpath-2019-206235
  • Jolles S, Chapel H, Litzman J. When to initiate immunoglobulin replacement therapy (IGRT) in antibody deficiency: a practical approach. Clin Exp Immunol. 2017;188(3):333–341. doi:10.1111/cei.12915
  • Arkwright PD, Gennery AR. Ten warning signs of primary immunodeficiency: a new paradigm is needed for the 21st century. Ann N Y Acad Sci. 2011;1238:7–14. doi:10.1111/j.1749-6632.2011.06206.x
  • Subbarayan A, Colarusso G, Hughes SM, et al. Clinical features that identify children with primary immunodeficiency diseases. Pediatrics. 2011;127(5):810–816. doi:10.1542/peds.2010-3680
  • Graziano V, Pecoraro A, Mormile I. Delay in diagnosis affects the clinical outcome in a cohort of CVID patients with marked reduction of IGA serum levels. Clin Immunol. 2017;180:1–4. doi:10.1016/j.clim.2017.03.011
  • Sánchez-Ramón S, Bermúdez A, González-Granado LI, Rodríguez-Gallego C, Sastre A, Soler-Palacín P; ID-Signal Onco-Haematology Group. Primary and secondary immunodeficiency diseases in oncohaematology: warning signs diagnosis, and management. Front Immunol. 2019;10:586. doi:10.3389/fimmu.2019.00586
  • Rajkumar SV. Evolving diagnostic criteria for multiple myeloma. Hematol Am Soc Hematol Educ Program. 2015;2015:272–278. doi:10.1182/asheducation-2015.1.272
  • Roberts G, Holmes J, Williams G, et al. Current costs of dialysis modalities: a comprehensive analysis within the United Kingdom. Perit Dial Int. 2022;42(6):578–584. doi:10.1177/08968608211061126
  • Hayes BH, Haberling DL, Kennedy JL, Varma JK, Fry AM, Vora NM. Burden of pneumonia-associated hospitalizations: United States, 2001–2014. Chest. 2018;153(2):427–437. doi:10.1016/j.chest.2017.09.041
  • Kelleher P, Misbah SA. What is Good’s syndrome? Immunological abnormalities in patients with thymoma. J Clin Pathol. 2003;56(1):12–16. doi:10.1136/jcp.56.1.12