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Review

A review of the management of phantom limb pain: challenges and solutions

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Pages 1861-1870 | Published online: 07 Aug 2017

References

  • RichardsonCGlennSNurmikkoTHorganMIncidence of phantom phenomena including phantom limb pain 6 months after major lower limb amputation in patients with peripheral vascular diseaseClin J Pain200622435335816691088
  • KooijmanCMDijkstraPUGeertzenJHElzingaAvan der SchansCPPhantom pain and phantom sensations in upper limb amputees: an epidemiological studyPain2000871334110863043
  • EhdeDMCzernieckiJMSmithDGChronic phantom sensations, phantom pain, residual limb pain, and other regional pain after lower limb amputationArch Phys Med Rehabi200081810391044
  • DijkstraPUGeertzenJHStewartRvan der SchansCPPhantom pain and risk factors: a multivariate analysisJ Pain Symptom Manage200224657858512551807
  • RichardsonCCrawfordKMilnesKBouchEKulkarniJA clinical evaluation of postamputation phenomena including phantom limb pain after lower limb amputation in dysvascular patientsPain Manag Nurs201516456156926092194
  • FlorHRemapping somatosensory cortex after injuryAdv Neurol20039319520412894409
  • FinnerupNBSindrupSHJensenTSThe evidence for pharmacological treatment of neuropathic painPain2010150357358120705215
  • MooreRADerrySAldingtonDColePWiffenPJAmitriptyline for neuropathic pain in adultsCochrane Database Syst Rev20157CD00824226146793
  • WiffenPJDerrySMooreRAKalsoEACarbamazepine for chronic neuropathic pain and fibromyalgia in adultsCochrane Database Syst Rev20144CD00545124719027
  • MooreRAWiffenPJDerrySToelleTRiceASGabapentin for chronic neuropathic pain and fibromyalgia in adultsCochrane Database Syst Rev20144CD00793824771480
  • WiffenPJDerrySMooreRAAntiepileptic drugs for neuropathic pain and fibromyalgia – an overview of Cochrane reviewsCochrane Database Syst Rev201311CD01056724217986
  • WiffenPJDerrySMooreRALamotrigine for chronic neuropathic pain and fibromyalgia in adultsCochrane Database Syst Rev201312CD00604424297457
  • ShermanRAPublished treatments of phantom limb painAm J Phys Med19805952322447425113
  • AlviarMJHaleTDungcaMPharmacologic interventions for treating phantom limb painCochrane Database Syst Rev201610CD00638027737513
  • JahangiriMJayatungaAPBradleyJWDarkCHPrevention of phantom pain after major lower limb amputation by epidural infusion of diamorphine, clonidine and bupivacaineAnn R Coll Surg Engl19947653243267979074
  • NikolajsenLIlkjaerSChristensenJHKronerKJensenTSRandomised trial of epidural bupivacaine and morphine in prevention of stump and phantom pain in lower-limb amputationLancet19973509088135313579365449
  • NikolajsenLFinnerupNBKrampSVimtrupASKellerJJensenTSA randomized study of the effects of gabapentin on postamputation painAnesthesiology200610551008101517065896
  • RichardsonCNursing aspects of phantom limb pain following amputationBr J Nurs2008177422426
  • FlorHMaladaptive plasticity, memory for pain and phantom limb pain: review and suggestions for new therapiesExpert RevNeurother200885809818
  • BarbinJSeethaVCasillasJMPaysantJPerennouDThe effects of mirror therapy on pain and motor control of phantom limb in amputees: a systematic reviewAnn Phys Rehabil Med201659427027527256539
  • GuyattGHOxmanADVistGEGRADE Working GroupGRADE: an emerging consensus on rating quality of evidence and strength of recommendationsBMJ2008336765092492618436948
  • ThiemeHMorkischNRietzCDohleCBorgettoBThe efficacy of movement representation techniques for treatment of limb pain–a systematic review and meta-analysisJ Pain201617216718026552501
  • MalaveraASilvaFAFregniFCarrilloSGarciaRGRepetitive transcranial magnetic stimulation for phantom limb pain in land mine victims: a double-blinded, randomized, sham-controlled trialJ Pain201617891191827260638
  • RobinsonLRCzernieckiJMEhdeDMTrial of amitriptyline for relief of pain in amputees: results of a randomized controlled studyArch Phys Med Rehabil20048511614970960
  • BoneMCritchleyPBuggyDJGabapentin in postamputation phantom limb pain: a randomized, double-blind, placebo-controlled, cross-over studyReg Anesth Pain Med200227548148612373695
  • SmithDGEhdeDMHanleyMAEfficacy of gabapentin in treating chronic phantom limb and residual limb painJ Rehabil Res Dev200542564565416586190
  • AbbassKEfficacy of gabapentin for treatment of adults with phantom limb painAnn Pharmacother201246121707171123232019
  • NikolajsenLHansenCLNielsenJKellerJArendt-NielsenLJensenTSThe effect of ketamine on phantom pain: a central neuropathic disorder maintained by peripheral inputPain199667169778895233
  • NikolajsenLGottrupHKristensenAGJensenTSMemantine (a N-methyl-D-aspartate receptor antagonist) in the treatment of neuropathic pain after amputation or surgery: a randomized, double-blinded, cross-over studyAnesth Analg200091496096611004057
  • WiechKKieferRTTopfnerSA placebo-controlled randomized crossover trial of the N-methyl-D-aspartic acid receptor antagonist, memantine, in patients with chronic phantom limb painAnesth Analg200498240841314742379
  • MaierCDertwinkelRMansourianNEfficacy of the NMDA-receptor antagonist memantine in patients with chronic phantom limb pain–results of a randomized double-blinded, placebo-controlled trialPain2003103327728312791434
  • WuCLTellaPStaatsPSAnalgesic effects of intravenous lidocaine and morphine on postamputation pain: a randomized double-blind, active placebo-controlled, crossover trialAnesthesiology200296484184811964590
  • WuCLAgarwalSTellaPKMorphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trialAnesthesiology2008109228929618648238
  • RogersAGUse of amitriptyline (Elavil) for phantom limb pain in younger childrenJ Pain Symptom Manage198942962732528
  • UrbanBJFranceRDSteinbergerEKScottDLMaltbieAALong-term use of narcotic/antidepressant medication in the management of phantom limb painPain19862421911962870454
  • HarwoodDDHanumanthuSStoudemireAPathophysiology and management of phantom limb painGen Hosp Psychiatry19921421071181375574
  • IaconoRPSandykRBamfordCRAwerbuchGMaloneJMPost-amputation phantom pain and autonomous stump movements responsive to doxepinFunct Neurol1987233433483692275
  • RusyLMTroshynskiTJWeismanSJGabapentin in phantom limb pain management in children and young adults: report of seven casesJ Pain Symptom Manage2001211788211223317
  • SpiegelDRLappinenEGottliebMA presumed case of phantom limb pain treated successfully with duloxetine and pregabalinGen Hosp Psychiatry2010322228.e5e7
  • HardenRNHouleTTRembleTALinWWangKSaltzSTopiramate for phantom limb pain: a time-series analysisPain Med20056537537816266358
  • PattersonJFCarbamazepine in the treatment of phantom limb painSouth Med J1988819110011023047877
  • ElliottFLittleAMilbrandtWCarbamazepine for phantom-limb phenomenaN Engl J Med197629512678
  • BartuschSLSandersBJD’AlessioJGJerniganJRClonazepam for the treatment of lancinating phantom limb painClin J Pain199612159628722737
  • WallGCHeynemanCACalcitonin in phantom limb painAnn Pharmacother199933449950110332543
  • KesselCWorzRImmediate response of phantom limb pain to calcitoninPain198730179873614981
  • EichenbergerUNeffFSveticicGChronic phantom limb pain: the effects of calcitonin, ketamine, and their combination on pain and sensory thresholdsAnesth Analg200810641265127318349204
  • KnoxDJMcLeodBJGouckeCRAcute phantom limb pain controlled by ketamineAnaesth Intensive Care19952356206228787268
  • StannardCFPorterGEKetamine hydrochloride in the treatment of phantom limb painPain19935422272308233537
  • SakaiTSumikawaKPhantom limb pain exacerbated by intravenous ketamineJ Anesth201428464324292220
  • HackworthRJTokarzKAFowlerIMWallaceSCStedje-LarsenETProfound pain reduction after induction of memantine treatment in two patients with severe phantom limb painAnesth Analg200810741377137918806054
  • Ben AbrahamRMarouaniNKollenderYMellerIWeinbroumAADextromethorphan for phantom pain attenuation in cancer amputees: a double-blind crossover trial involving three patientsClin J Pain200218528228512218498
  • BergmansLSnijdelaarDGKatzJCrulBJMethadone for phantom limb painClin J Pain200218320320512048424
  • WuHSultanaRTaylorKBSzaboAA prospective randomized double-blinded pilot study to examine the effect of botulinum toxin type A injection versus Lidocaine/Depomedrol injection on residual and phantom limb pain: initial reportClin J Pain201228210811221750460
  • DavisRWSuccessful treatment for phantom painOrthopedics19931666916958321759
  • IlfeldBMMoeller-BertramTHanlingSRTreating intractable phantom limb pain with ambulatory continuous peripheral nerve blocks: a pilot studyPain Med201314693594223489466
  • CasaleRCeccherelliFLabeebAABiellaGEPhantom limb pain relief by contralateral myofascial injection with local anaesthetic in a placebo-controlled study: preliminary resultsJ Rehabil Med200941641842219479153
  • LierzPSchroegendorferKChoiSFelleiterPKressHGContinuous blockade of both brachial plexus with ropivacaine in phantom pain: a case reportPain19987821351379839824
  • HuseELarbigWFlorHBirbaumerNThe effect of opioids on phantom limb pain and cortical reorganizationPain2001901–2475511166969
  • MishraSBhatnagarSSinghalAKHigh-dose morphine for intractable phantom limb painClin J Pain20072319910117277651
  • JacobsonLChabalCBrodyMCRelief of persistent postamputation stump and phantom limb pain with intrathecal fentanylPain19893733173222755713
  • OilleWABeta adrenergic blockade and the phantom limbAnn Intern Med197073610441045
  • MarslandARWeekesJWAtkinsonRLLeongMGPhantom limb pain: a case for beta blockers?Pain19821232952976123103
  • AhmadSPhantom limb pain and propranololBr Med J197916160415
  • Power-SmithPTurkingtonDFluoxetine in phantom limb painBr J Psychiatry19931631051068353675
  • SatoKHiguchiHHishikawaYManagement of phantom limb pain and sensation with milnacipranJ Neuropsychiatry ClinNeurosci2008203368
  • StannardCFPhantom limb painBr J Hosp Med19935010583584
  • WesolowskiJALemaMJPhantom limb painReg Anesth19931821211278489979
  • WilliamsAMDeatonSBPhantom limb pain: elusive, yet realRehabil Nurs199722273779110847
  • WeinsteinSMPhantom limb pain and related disordersNeuro Clin1998164919936
  • RathSASeitzKSolimanNKahambaJFAntoniadisGRichterHPDREZ coagulations for deafferentation pain related to spinal and peripheral nerve lesions: indication and results of 79 consecutive proceduresStereotact Funct Neurosurg1997681–4 Pt 11611679711710
  • RamazanovRDrevalONAkatovOVZaretskyAAUltrasound microneurosurgeryNeurol Res1999211737610048059
  • SarisSCIaconoRPNasholdBSJrSuccessful treatment of phantom pain with dorsal root entry zone coagulationAppl Neurophysiol1988512–51881973389795
  • ZhengZHuYTaoWZhangXLiYDorsal root entry zone lesions for phantom limb pain with brachial plexus avulsion: a study of pain and phantom limb sensationStereotact Funct Neurosurg200987424925519556834
  • TomyczNDMoossyJJFollow-up 26 years after dorsal root entry zone thermocoagulation for brachial plexus avulsion and phantom limb painJ Neurosurg2011114119619920509732
  • XingGAcupuncture treatment of phantom limb pain–a report of 9 casesJ Tradit Chin Med199818319920110453614
  • MongaTNJaksicTAcupuncture in phantom limb painArch Phys Med Rehabil19816252292316972207
  • LuTVAcupuncture treatment for phantom limb painAltern Ther Health Med199845124
  • BradbrookDAcupuncture treatment of phantom limb pain and phantom limb sensation in amputeesAcupunct Med2004222939715253586
  • XueCCAcupuncture induced phantom limb and meridian phenomenon in acquired and congenital amputees. A suggestion of the use of acupuncture as a method for investigation of phantom limbChin Med J19869932472523095054
  • ShermanRAGallNGormlyJTreatment of phantom limb pain with muscular relaxation training to disrupt the pain–anxiety–tension cyclePain1979614755370738
  • HardenRNHouleTTGreenSBiofeedback in the treatment of phantom limb pain: a time-series analysisAppl Psychophysiol Biofeedback2005301839315889588
  • BelleggiaGBirbaumerNTreatment of phantom limb pain with combined EMG and thermal biofeedback: a case reportAppl Psychophysiol Biofeedback200126214114611480164
  • DoughertyJRelief of phantom limb pain after EMG biofeedback-assisted relaxation: a case reportBehav Res Ther19801843553577436982
  • FlorHDenkeCSchaeferMGrusserSEffect of sensory discrimination training on cortical reorganisation and phantom limb painLancet200135792701763176411403816
  • ConineTAHershlerCAlexanderSACrispRThe efficacy of Farabloc in the treatment of phantom limb pain. Canadian J RehabilSpring199363155161
  • RickardJAEffects of hypnosis in the treatment of residual stump pain and phantom limb pain [dissertation]Abstracts International: Section B: The Sciences and Engineering2005
  • BamfordCA multifaceted approach to the treatment of phantom limb pain using hypnosisContemporary Hypnosis2006233115126
  • SiegelEFControl of phantom limb pain by hypnosisAm J Clin Hypn1979214285286474456
  • RosenGWillochFBartensteinPBernerNRosjoSNeurophysiological processes underlying the phantom limb pain experience and the use of hypnosis in its clinical management: an intensive examination of two patientsInt J Clin Exp Hypn2001491385511190791
  • OakleyDAWhitmanLGHalliganPWHypnotic imagery as a treatment for phantom limb pain: two case reports and a reviewClin Rehabil200216436837712061470
  • ChanRHypnosis and phantom limb painAustralian Journal of Clinical & Experimental HypnosisAustralian Society of Hypnosis2006
  • BrownCLidoCReflexology treatment for patients with lower limb amputations and phantom limb pain–an exploratory pilot studyComplement Ther Clin Pract200814212413118396256
  • JohnsonMIMulveyMRBagnallAMTranscutaneous electrical nerve stimulation (TENS) for phantom pain and stump pain following amputation in adultsCochrane Database Syst Rev20158CD00726426284511
  • LundebergTRelief of pain from a phantom limb by peripheral stimulationJ Neurol1985232279822410571
  • FinsenVPersenLLovlienMTranscutaneous electrical nerve stimulation after major amputationJ Bone Joint Surg Br19887011091123257494
  • CarabelliRAKellermanWCPhantom limb pain: relief by application of TENS to contralateral extremityArch Phys Med Rehabil19856674664673874615
  • SalimMTranscutaneous electrical nerve stimulation in phantom limb painAltern Ther Clin Pract199744135137
  • GiuffridaOSimpsonLHalliganPWContralateral stimulation, using tens, of phantom limb pain: two confirmatory casesPain Med201011113314119788713
  • KatzJMelzackRAuricular transcutaneous electrical nerve stimulation (TENS) reduces phantom limb painJ Pain Symptom Manage19916273832007795
  • WinnemMFAmundsenTTreatment of phantom limb pain with TENSPain19821232993007043376
  • MulveyMRRadfordHEFawknerHJHirstLNeumannVJohnsonMITranscutaneous electrical nerve stimulation for phantom pain and stump pain in adult amputeesPain Pract201313428929622935086
  • AiyerRBarkinRLBhatiaAGungorSA systematic review on the treatment of phantom limb pain with spinal cord stimulationPain Manage2017715969
  • KrainickJUThodenURiechertTPain reduction in amputees by long-term spinal cord stimulation. Long-term follow-up study over 5 yearsJ Neurosurg19805233463506153710
  • CassinaIPinelliNMBentivegnaES.C.S. effectiveness in patients affected by peripheral chronic arterial disease: our 5 years experienceInt Angiol19931243783827515936
  • van DongenVCPLiemALPhantom limb and stump pain and its treatment with spinal cord stimulationJ Rehabil Sci199584110114
  • KumarKTothCNathRKLaingPEpidural spinal cord stimulation for treatment of chronic pain–some predictors of success. A 15-year experienceSurg Neurol1998502110120 discussion 120–1119701116
  • KatayamaYYamamotoTKobayashiKKasaiMOshimaHFukayaCMotor cortex stimulation for phantom limb pain: comprehensive therapy with spinal cord and thalamic stimulationStereotact Funct Neurosurg2001771–415916212378068
  • CarrollDJointCMaartensNShlugmanDSteinJAzizTZMotor cortex stimulation for chronic neuropathic pain: a preliminary study of 10 casesPain2000842–343143710666551
  • SaitohYHiranoSKatoAMotor cortex stimulation for deafferentation painNeurosurg Focus200111315
  • RouxFEIbarrolaDLazorthesYBerryIChronic motor cortex stimulation for phantom limb pain: a functional magnetic resonance imaging study: technical case reportNeurosurgery2001483681687 discussion 687–68811270562
  • SolJCCasauxJRouxFEChronic motor cortex stimulation for phantom limb pain: correlations between pain relief and functional imaging studiesStereotact Funct Neurosurg2001771–417217612378072
  • PereiraEACMooreTMoirLAzizTZLong-term motor cortex stimulation for phantom limb painBr J Neurosurg201529227227425340991
  • KumarKWyantGMNathRDeep brain stimulation for control of intractable pain in humans, present and future: a ten-year follow-upNeurosurgery1990265774781 discussion 781–7722352595
  • BittarRGOteroSCarterHAzizTZDeep brain stimulation for phantom limb painJ Clin Neurosc2005124399404
  • RasmussenKGRummansTAElectroconvulsive therapy for phantom limb painPain2000851–229729910692632
  • FukuiSShigemoriSKomodaYYamadaNNosakaSPhantom pain with beneficial response to electroconvulsive therapy (ECT) and regional cerebral blood flow (rCBF) studied with xenon-CTPain clinic2002134355359
  • AhmedMAMohamedSASayedDLong-term antalgic effects of repetitive transcranial magnetic stimulation of motor cortex and serum beta-endorphin in patients with phantom painNeurol Res201133995395822080997
  • BologniniNSpandriVFerraroFImmediate and sustained effects of 5-day transcranial direct current stimulation of the motor cortex in phantom limb painJ Pain201516765766525863170
  • GrammerGGWilliams-JosephSCesarAAdkinsonDKSpevakCSignificant reduction in phantom limb pain after low-frequency repetitive transcranial magnetic stimulation to the primary sensory cortexMil Med20151801e126e12825562869
  • BileyFCRogerian science, phantoms, and therapeutic touch: exploring potentials. Nurs Sci QWinter199694165169
  • LeskowitzEDPhantom limb pain treated with therapeutic touch: a case reportArch Phys Med Rehabil200081452252410768547
  • FerraroFJacopettiMSpalloneVItalian Consensus Conference on Pain in Neurorehabilitation (ICCPN)Diagnosis and treatment of pain in plexopathy, radiculopathy, peripheral neuropathy and phantom limb pain. Evidence and recommendations from the Italian Consensus Conference on Pain on NeurorehabilitationEur J Phys Rehabil Med201652685586627834472
  • CepedaMSAfricanoJMPoloRAlcalaRCarrDBAgreement between percentage pain reductions calculated from numeric rating scores of pain intensity and those reported by patients with acute or cancer painPain2003106343944214659527
  • ForouzanfarTWeberWEJKemlerMvan KleefMWhat is a meaningful pain reduction in patients with complex regional pain syndrome type 1?Clin J Pain200319528128512966253
  • CasaleRDamianiCRosatiVMirror therapy in the rehabilitation of lower-limb amputation: are there any contraindications?Am J Phys Med Rehabil2009881083784221119317
  • HanlingSRWallaceSCHollenbeckKJBelnapBDTulisMRPreamputation mirror therapy may prevent development of phantom limb pain: a case seriesAnesth Analg2010110261161419917622
  • WeeksSRAnderson-BarnesVCTsaoJWPhantom limb pain: theories and therapiesNeurologist201016527728620827116
  • RothgangelASBraunSMBeurskensAJSeitzRJWadeDTThe clinical aspects of mirror therapy in rehabilitation: a systematic review of the literatureInt J Rehabil Res201134111321326041
  • BrodieEEWhyteANivenCAAnalgesia through the looking-glass? A randomized controlled trial investigating the effect of viewing a ‘virtual’ limb upon phantom limb pain, sensation and movementEur J Pain200711442843616857400
  • BrunelliSMoroneGIosaMEfficacy of progressive muscle relaxation, mental imagery, and phantom exercise training on phantom limb: a randomized controlled trialArch Phys Med Rehabil201596218118725450123
  • YildirimMKananNThe effect of mirror therapy on the management of phantom limb painAgri201628312713427813030