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Review

Vulvodynia: a consideration of clinical and methodological research challenges and recommended solutions

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Pages 2425-2436 | Published online: 09 Oct 2017

References

  • BornsteinJGoldsteinATStockdaleCK2015 ISSVD, ISSWSH, and IPPS consensus terminology and classification of persistent vulvar pain and vulvodyniaJ Sex Med20161360761227045260
  • ReedBDHarlowSDSenAPrevalence and demographic characteristics of vulvodynia in a population-based sampleAm J Obstet Gynecol2012206170.e1e921963307
  • HarlowBLStewartEGA population-based assessment of chronic unexplained vulvar pain: have we underestimated the prevalence of vulvodynia?J Am Med Womens Assoc (1972)200358828812744420
  • ReedBDHaefnerHKSenAGorenfloDVulvodynia incidence and remission rates among adult women: a 2-year follow-up studyObstet Gynecol200811223123718669716
  • HarlowBLKunitzCGNguyenRHRydellSATurnerRMMacLehoseRFPrevalence of symptoms consistent with a diagnosis of vulvodynia: population-based estimates from 2 geographic regionsAm J Obstet Gynecol201421040.e1e824080300
  • ArnoldLDBachmannGARosenRRhoadsGGAssessment of vulvodynia symptoms in a sample of US women: a prevalence survey with a nested case control studyAm J Obstet Gynecol2007196128.e1e617306651
  • PukallCFGoldsteinATBergeronSVulvodynia: definition, prevalence, impact, and pathophysiological factorsJ Sex Med20161329130426944461
  • BergeronSRosenNOMorinMGenital pain in women: beyond interference with intercoursePain20111521223122521324589
  • ReedBDLegockiLJPlegueMASenAHaefnerHKHarlowSDFactors associated with vulvodynia incidenceObstet Gynecol201412322523124402591
  • SadownikLAEtiology, diagnosis, and clinical management of vulvodyniaInt J Womens Health2014643744924833921
  • LeusinkPKaptheijnsALaanEvan BovenKLagro-JanssenAComorbidities among women with vulvovaginal complaints in family practiceJ Sex Med20161322022526782608
  • ReedBDHarlowSDSenAEdwardsRMChenDHaefnerHKRelationship between vulvodynia and chronic comorbid pain conditionsObstet Gynecol201212014515122914403
  • NguyenRHVeasleyCSmolenskiDLatent class analysis of comorbidity patterns among women with generalized and localized vulvodynia: preliminary findingsJ Pain Res2013630330923637555
  • ZolnounDARohlJMooreCGPerinetti-LiebertCLamvuGMMaixnerWOverlap between orofacial pain and vulvar vestibulitis syndromeClin J Pain20082418719118287822
  • BairESimmonsEHartungJDesiaKMaixnerWZolnounDNatural history of comorbid orofacial pain among women with vestibulodyniaClin J Pain201531737824566384
  • LesterRABrottoLASadownikLAProvoked vestibulodynia and the health care implications of comorbid pain conditionsJ Obstet Gynaecol Can201537995100526629720
  • ReedBDPlegueMAWilliamsDASenAPresence of spontaneous pain and comorbid pain conditions identifies vulvodynia subgroupsJ Low Genit Tract Dis201620576326704330
  • ReedBDHaefnerHKPunchMRRothRSGorenfloDWGillespieBWPsychosocial and sexual functioning in women with vulvodynia and chronic pelvic pain: a comparative evaluationJ Reprod Med20004562463210986680
  • Iglesias-RiosLHarlowSDReedBDDepression and posttraumatic stress disorder among women with vulvodynia: evidence from the population-based woman to woman health studyJ Womens Health (Larchmt)20152455756225950702
  • MashebRMWangELozanoCKernsRDPrevalence and correlates of depression in treatment-seeking women with vulvodyniaJ Obstet Gynaecol20052578679116368586
  • ArnoldLDBachmannGARosenRKellySRhoadsGGVulvodynia: characteristics and associations with comorbidities and quality of lifeObstet Gynecol200610761762416507933
  • NguyenRHEcklundAMMaclehoseRFVeasleyCHarlowBLCo-morbid pain conditions and feelings of invalidation and isolation among women with vulvodyniaPsychol Health Med20121758959822329615
  • BrauerMter KuileMMLaanETrimbosBCognitive-affective correlates and predictors of superficial dyspareuniaJ Sex Marital Ther20093512419105077
  • MashebRMLozano-BlancoCKohornEIMinkinMJKernsRDAssessing sexual function and dyspareunia with the Female Sexual Function Index (FSFI) in women with vulvodyniaJ Sex Marital Ther20043031532415672599
  • SuttonKSPukallCFChamberlainSPain ratings, sensory thresholds, and psychosocial functioning in women with provoked vestibulodyniaJ Sex Marital Ther20093526228119466666
  • SmithKBPukallCFA systematic review of relationship adjustment and sexual satisfaction among women with provoked vestibulodyniaJ Sex Res20114816619121409713
  • AylingKUssherJM“If sex hurts, am I still a woman?” The subjective experience of vulvodynia in hetero-sexual womenArch Sex Behav20083729430417876696
  • ElmerstigEWijmaBBerteroCWhy do young women continue to have sexual intercourse despite pain?J Adolesc Health20084335736318809133
  • PazmanyEBergeronSVerhaegheJVan OudenhoveLEnzlinPSexual communication, dyadic adjustment, and psychosexual well-being in premenopausal women with self-reported dyspareunia and their partners: a controlled studyJ Sex Med2014111786179724690206
  • SmithKBPukallCFSexual function, relationship adjustment, and the relational impact of pain in male partners of women with provoked vulvar painJ Sex Med2014111283129324612656
  • BergeronSCorsini-MuntSAertsLRancourtKRosenNOFemale sexual pain disorders: a review of the literature on etiology and treatmentCurr Sex Health Rep20157159169
  • BornsteinJGoldschmidNSaboEHyperinnervation and mast cell activation may be used as histopathologic diagnostic criteria for vulvar vestibulitisGynecol Obstet Invest20045817117815249746
  • LandryJMartinovTMengistuHRepeated hapten exposure induces persistent tactile sensitivity in mice modeling localized provoked vulvodyniaPLoS One201712e016967228158195
  • GoldsteinATBelkinZRKrapfJMPolymorphisms of the androgen receptor gene and hormonal contraceptive induced provoked vestibulodyniaJ Sex Med2014112764277125187224
  • HarlowBLVitonisAEStewartEGInfluence of oral contraceptive use on the risk of adult-onset vulvodyniaJ Reprod Med20085310211018357801
  • ReedBDHarlowSDLegockiLJOral contraceptive use and risk of vulvodynia: a population-based longitudinal studyBJOG20131201678168423937077
  • MorinMBinikYMBourbonnaisDKhaliféSOuelletSBergeronSHeightened pelvic floor muscle tone and altered contractility in women with provoked vestibulodyniaJ Sex Med20171459260028364981
  • ZolnounDHartmannKLamvuGAs-SanieSMaixnerWSteegeJA conceptual model for the pathophysiology of vulvar vestibulitis syndromeObstet Gynecol Surv20066139540116719941
  • HeddiniUBohm-StarkeNGrönbladhANybergFNilssonKWJohannessonUSerotonin receptor gene (5HT-2A) polymorphism is associated with provoked vestibulodynia and comorbid symptoms of painJ Sex Med2014113064307125174699
  • Bohm-StarkeNHilligesMBrodda-JansenGRylanderETorebjörkEPsychophysical evidence of nociceptor sensitization in vulvar vestibulitis syndromePain20019417718311690731
  • PukallCFBinikYMKhaliféSAmselRAbbotFVVestibular tactile and pain thresholds in women with vulvar vestibulitis syndromePain200096163175
  • KhandkerMBradySSVitonisAFMacLehoseRFStewartEGHarlowBLThe influence of depression and anxiety on risk of adult onset vulvodyniaJ Womens Health (Larchmt)2011201445145121823918
  • HarlowBLStewartEGAdult-onset vulvodynia in relation to childhood violence victimizationAm J Epidemiol200516187188015840620
  • KhandkerMBradySSStewartEGHarlowBLIs chronic stress during childhood associated with adult-onset vulvodynia?J Womens Health (Larchmt)20142364965625046165
  • LandryTBergeronSBiopsychosocial factors associated with dyspareunia in a community sample of adolescent girlsArch Sex Behav20114087788920567891
  • DesrochersGBergeronSLandryTJodoinMDo psychosexual factors play a role in the etiology of provoked vestibulodynia? A critical reviewJ Sex Marital Ther20083419822618398760
  • DesrochersGBergeronSKhaliféSDupuisMJJodoinMFear avoidance and self-efficacy in relation to pain and sexual impairment in women with provoked vestibulodyniaClin J Pain20092552052719542801
  • BoernerKERosenNOAcceptance of vulvovaginal pain in women with provoked vestibulodynia and their partners: associations with pain, psychological, and sexual adjustmentJ Sex Med2015121450146225869256
  • LeonardMTCanoAJohansenABChronic pain in a couples context: a review and integration of theoretical models and empirical evidenceJ Pain2006737739016750794
  • Stark TaylorSDavisMCZautraAJRelationship status and quality moderate daily pain-related changes in physical disability, affect, and cognitions in women with chronic painPain201315414715323200258
  • RosenNORancourtKCorsini-MuntSBergeronSBeyond a “woman’s problem”: the role of relationship processes in genital painCurr Sex Health Rep20146110
  • RancourtKMFlynnMBergeronSRosenNOIt takes two: sexual communication patterns and the sexual and relational adjustment of couples coping with provoked vestibulodyniaJ Sex Med20171443444328189562
  • RosenNOBergeronSSadikajGGlowackaMDelisleIBaxterMImpact of partner responses on sexual function in women with vulvodynia and their partners: a dyadic daily experience studyHealth Psychol20143382383124245835
  • RosenNOMuiseABergeronSImpettEABoudreauGApproach and avoidance sexual goals in couples with provoked vestibulodynia: associations with sexual, relational, and psychological well-beingJ Sex Med2015121781179026176989
  • BoisKBergeronSRosenNMayrandMHBrassardASadikajGIntimacy, sexual satisfaction, and sexual distress in vulvodynia couples: an observational studyHealth Psychol20163553154026690636
  • RosenNOBoisKMayrandMHVannierSBergeronSObserved and perceived disclosure and empathy are associated with better relationship adjustment and quality of life in couples coping with vulvodyniaArch Sex Behav2016451945195627164894
  • LuaLLHolletteYParmPAllenbackGDandoluVCurrent practice patterns for management of vulvodynia in the United StatesArch Gynecol Obstet201729566967428000024
  • GoldsteinATPukallCFBrownCBergeronSSteinAKellogg-SpadtSVulvodynia: assessment and treatmentJ Sex Med20161357259027045258
  • PukallCFMitchellLSGoldsteinATNon-medical, medical, and surgical approaches for the treatment of provoked vestibulodyniaCurr Sex Health Rep20168240248
  • RosenbaumTYPhysical therapy management and treatment of sexual pain disordersLeiblumSRPrinciples and Practice of Sex Therapy4th edNew YorkGuilford Press2007157177
  • BergeronSMorinMLordMJIntegrating pelvic floor rehabilitation and cognitive-behavioural therapy for sexual pain: what have we learned and were do we go from here?Sex Relation Ther201025289298
  • MorinMCarrollMSBergeronSSystematic review of the effectiveness of physical therapy modalities in women with provoked vestibulodyniaSex Med Rev2017529532228363763
  • TommolaPUnkila-KallioLPaavonenJSurgical treatment of vulvar vestibulitis: a reviewActa Obstet Gynecol Scand2010891385139520955094
  • MashebRMKernsRDLozanoCMinkinMJRichmanSA randomized clinical trial for women with vulvodynia: cognitive-behavioral therapy vs. supportive psychotherapyPain2009141314019022580
  • BergeronSKhaliféSDupuisMJMcDuffPA randomized clinical trial comparing group cognitive-behavioral therapy and a topical steroid for women with dyspareuniaJ Consult Clin Psychol20168425926826727408
  • BergeronSBinikYMKhaliféSA randomized comparison of group cognitive-behavioral therapy, surface electromyographic biofeedback, and vestibulectomy in the treatment of dyspareunia resulting from vulvar vestibulitisPain20019129730611275387
  • LandryTBergeronSDupuisMJDesrochersGThe treatment of provoked vestibulodynia: a critical reviewClin J Pain20082415517118209522
  • BrottoLABassonRSmithKBDriscollMSadownikLMindfulness- based group therapy for women with provoked vestibulodyniaMindfulness (N Y)20156417432
  • Corsini-MuntSBergeronSRosenNOMayrandMHDelisleIFeasibility and preliminary effectiveness of a novel cognitive-behavioral couple therapy for provoked vestibulodynia: a pilot studyJ Sex Med2014112515252725059263
  • BrottoLAYongPSmithKBSadownikLAImpact of a multidisciplinary vulvodynia program on sexual functioning and dyspareuniaJ Sex Med20151223824725354520
  • SadownikLASealBNBrottoLAProvoked vestibulodynia: women’s experience of participating in a multidisciplinary vulvodynia programJ Sex Med201291086109322353181
  • MundayPBuchanARavenhillGWiggsABrooksFA qualitative study of women with vulvodynia – II: response to a multidisciplinary approach to managementJ Reprod Med200752192217286062
  • SpoelstraSKDijkstraJRvan DrielMFSchultzWCLong-term results of an individualized, multifaceted, and multidisciplinary therapeutic approach to provoked vestibulodyniaJ Sex Med2011848949620646179
  • GoubertLCraigKDVervoortTFacing others in pain: the effects of empathyPain200511828528816289804
  • HadjistavropoulosTCraigKDDuckSA biopsychosocial formulation of pain communicationPsychol Bull201113791093921639605
  • SullivanMJThornBHaythornthwaiteJATheoretical perspectives on the relation between catastrophizing and painClin J Pain200117526411289089
  • DewitteMVan LankveldJCrombezGUnderstanding sexual pain: a cognitive-motivational accountPain201115225125321122993
  • FarrellJCacchioniTThe medicalization of women’s sexual painJ Sex Res20124932833622720824
  • DewitteMOn the interpersonal dynamics of sexualityJ Sex Marital Ther20144020923224102171
  • KeefeFJRumbleMEScipioCDGiordanoLAPerriLMPsychological aspects of persistent pain: current state of the scienceJ Pain2004519521115162342
  • BrottoLABassonRCarlsonMZhuCImpact of an integrated mindfulness and cognitive behavioral treatment for provoked vestibulodynia (IMPROVED): a qualitative studySex Relation Ther201328319
  • BorsookDKalsoETransforming pain medicine: adapting to science and societyEur J Pain2013171109112523468059
  • BergeronSRosenNOCorsini-MuntSPainful sexLevineSBRisenCBAlthofSEHandbook of Clinical Sexuality for Mental Health Professionals3rd edNew YorkBrunner-Routledge2016
  • PukallCFBergeronSBrownCBachmannGWesselmannURecommendations for self-report outcome measures in vulvodynia clinical trialsClin J Pain20173375676527841834
  • DavisSNBergeronSBoisKSadikajGBinikYMStebenMA prospective 2-year examination of cognitive and behavioral correlates of provoked vestibulodynia outcomesClin J Pain20153133334124977392
  • FosterDCFalsettaMLWoellerCFSite-specific mesenchymal control of inflammatory pain to yeast challenge in vulvodynia-afflicted and pain-free womenPain201515638639625679469
  • BroderickJEKeefeFJSchneiderSCognitive behavioral therapy for chronic pain is effective, but for whom?Pain20161572115212327227692
  • GrosenKOlesenAEGramMPredictors of opioid efficacy in patients with chronic pain: a prospective multicenter observational cohort studyPLoS One201712e017172328158269
  • WertliMMRasmussen-BarrEHeldUWeiserSBachmannLMBrunnerFFear-avoidance beliefs-a moderator of treatment efficacy in patients with low back pain: a systematic reviewSpine J2014142658267824614254
  • DesrochersGBergeronSKhaliféSDupuisMJJodoinMProvoked vestibulodynia: psychological predictors of topical and cognitive-behavioral treatment outcomeBehav Res Ther20104810611519879555
  • BrownCBachmannGFosterDRawlinsonLWanJLingFMilnacipran in provoked vestibulodynia: efficacy and predictors of treatment successJ Low Genit Tract Dis20151914014425089551
  • NguyenRHTurnerRMRydellSAMaclehoseRFHarlowBLPerceived stereotyping and seeking care for chronic vulvar painPain Med2013141461146723742116
  • AnderssonGInternet-delivered psychological treatmentsAnnu Rev Clin Psychol20161215717926652054
  • DearBFGandyMKarinEThe pain course: a randomised controlled trial examining an Internet-delivered pain management program when provided with different levels of clinician supportPain20151561920193526039902
  • JonesLMMcCabeMPThe effectiveness of an Internet-based psychological treatment program for female sexual dysfunctionJ Sex Med201182781279221771279
  • MorinMDumoulinCBergeronSRandomized clinical trial of multimodal physiotherapy treatment compared to overnight lidocaine ointment in women with provoked vestibulodynia: design and methodsContemp Clin Trials201646525926600287
  • StrassbergDSLoweKVolunteer bias in sexuality researchArch Sex Behav1995243693827661653
  • PonteMKlempererESahayAChrenMMEffects of vulvodynia on quality of lifeJ Am Acad Dermatol200960707619022532
  • BlairKLPukallCFSmithKBCappellJDifferential associations of communication and love in heterosexual, lesbian, and bisexual women’s perceptions and experiences of chronic vulvar and pelvic painJ Sex Marital Ther20154149852424918840
  • LickDJDursoLEJohnsonKLMinority stress and physical health among sexual minoritiesPerspect Psychol Sci2013852154826173210
  • AndersenJPZouCExclusion of sexual minority couples from researchHealth Sci J2015910
  • EglestonBLDunbrackRLJrHallMJClinical trials that explicitly exclude gay and lesbian patientsN Engl J Med20103621054105520237357
  • Corsini-MuntSBergeronSRosenNOA comparison of cognitive-behavioral couple therapy and lidocaine in the treatment of provoked vestibulodynia: study protocol for a randomized clinical trialTrials20141550625540035
  • LindströmSKvistLJTreatment of provoked vulvodynia in a Swedish cohort using desensitization exercises and cognitive behavioral therapyBMC Womens Health20151510826603697
  • FosterDCKotokMBHuangLSOral desipramine and topical lidocaine for vulvodynia: a randomized controlled trialObstet Gynecol201011658359320733439
  • KazdinAEUnderstanding how and why psychotherapy leads to changePsychother Res20091941842819034715
  • KraemerHCWilsonGTFairburnCGAgrasWSMediators and moderators of treatment effects in randomized clinical trialsArch Gen Psychiatry20025987788312365874
  • KazdinAEMediators and mechanisms of change in psychotherapy researchAnnu Rev Clin Psychol2007312717716046
  • LaurenceauJPHayesAMFeldmanGCSome methodological and statistical issues in the study of change processes in psychotherapyClin Psychol Rev20072768269517328996
  • MacKinnonDPFairchildAJFritzMSMediation analysisAnnu Rev Psychol20075859361416968208
  • BrottoLASadownikLThomsonSImpact of educational seminars on women with provoked vestibulodyniaJ Obstet Gynaecol Can20103213213820181314