Evaluation of the cardiotoxicity and resuscitation of rats of a newly developed mixture of a QX-314 analog and levobupivacaine

References

• LimTMacleodBRiesCSchwarzSThe quaternary lidocaine derivative, QX-314, produces long-lasting local anesthesia in animal models in vivoAnesthesiology2007107230531117667576
   PubMed Web of Science ®Google Scholar
• ZhaoYZhouCLiuJThe quaternary lidocaine derivative QX-314 produces long-lasting intravenous regional anesthesia in ratsPLoS One201496e9970424932639
   PubMed Web of Science ®Google Scholar
• NakagawaHHiuraAComparison of the transport of QX-314 through TRPA1, TRPM8, and TRPV1 channelsJ Pain Res2013622323023525210
   PubMed Web of Science ®Google Scholar
• RiesCPillaiRChungCWangJMacLeodBSchwarzSQX-314 produces long-lasting local anesthesia modulated by transient receptor potential vanilloid receptors in miceAnesthesiology2009111112212619512885
   PubMed Web of Science ®Google Scholar
• WelkEPetscheUFleischerEHandwerkerHAltered excitability of afferent C-fibres of the rat distal to a nerve site exposed to capsaicinNeurosci Lett19833832452506195557
   PubMed Web of Science ®Google Scholar
• BrenneisCKistnerKPuopoloMBupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve blockBr J Pharmacol2014171243845124117225
   PubMed Web of Science ®Google Scholar
• VijayBSMitraSJamilSNRefractory cardiac arrest due to inadvertent intravenous injection of 0.25% bupivacaine used for local infiltration anesthesiaAnesth Essays Res20137113013225885735
   PubMedGoogle Scholar
• BruceRAn up-and-down procedure for acute toxicity testingFundam Appl Toxicol1985511511573987991
   PubMedGoogle Scholar
• CheungHMLeeSMMacLeodBARiesCRSchwarzSKA comparison of the systemic toxicity of lidocaine versus its quaternary derivative QX-314 in miceCan J Anesth201158544345021369774
   PubMed Web of Science ®Google Scholar
• AumeierCKasdorfBGruberMLipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart modelBr J Anaesth2013112473574124169820
   PubMed Web of Science ®Google Scholar
• OhmuraSKawadaMOhtaTYamamotoKKobayashiTSystemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused ratsAnesth Analg200193374374811524350
   PubMed Web of Science ®Google Scholar
• LichtmanAHThe up-and-down method substantially reduces the number of animals required to determine antinociceptive ED 50 valuesJ Pharmacol Toxicol Methods1998402818510100496
   PubMed Web of Science ®Google Scholar
• GessnerPKIsobolographic analysis of interactions: an update on applications and utilityToxicology199510521611798571354
   PubMed Web of Science ®Google Scholar
• TallaridaRJThe interaction index: a measure of drug synergismPain200298116316812098628
   PubMed Web of Science ®Google Scholar
• CovinoBGUltralong-acting local anesthetic agentsJ Am Soc Anesthesiol1981544263264
   Web of Science ®Google Scholar
• TsuchiyaHUenoTMizogamiMTakakuraKLocal anesthetics structure-dependently interact with anionic phospholipid membranes to modify the fluidityChem Biol Interact20101831192419853592
   PubMed Web of Science ®Google Scholar
• MetsBJanickiPKJamesMFErskineRSasmanBLidocaine and bupivacaine cardiorespiratory toxicity is additive: a study in ratsAnesth Analg19927546116141530175
   PubMed Web of Science ®Google Scholar
• KrikavaIJarkovskýJStouracPNovákováMSevcikPThe effects of lidocaine on bupivacaine-induced cardiotoxicity in the isolated rat heartPhysiol Res201059suppl 1S65S6920626222
   PubMed Web of Science ®Google Scholar
• FukudaKNakajimaTViswanathanPCBalserJRCompound-specific Na+ channel pore conformational changes induced by local anaestheticsJ Physiol20055641213115677685
   PubMed Web of Science ®Google Scholar
• ClarksonCWHondeghemLMMechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during the action potential with slow recovery from block during diastoleAnesthesiology19856243964052580463
   PubMed Web of Science ®Google Scholar
• Rivera-AcevedoREPlessSAAhernCASchwarzSKThe quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitroJ Am Soc Anesthesiol2011114614251434
   Web of Science ®Google Scholar
• ButterworthJTStrichartzGRMolecular mechanisms of local anesthesia: a reviewAnesthesiology19907247117342157353
   PubMed Web of Science ®Google Scholar
• HilleBLocal anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reactionJ Gen Physiol1977694497515300786
   PubMed Web of Science ®Google Scholar
• de Queiroz SiqueiraMChassardDMusardHResuscitation with lipid, epinephrine, or both in levobupivacaine-induced cardiac toxicity in newborn pigletsBr J Anaesth2014112472973424091473
   PubMed Web of Science ®Google Scholar
• GrobanLDealDDVernonJCJamesRLButterworthJCardiac resuscitation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine in anesthetized dogsAnesth Analg2001921374311133597
   PubMed Web of Science ®Google Scholar
• KariyaNCossonCMazoitJ-XComparative effect of lidocaine, bupivacaine and RAC 109 on myocardial conduction and contractility in the rabbitEur J Pharmacol2012691111011722683876
   PubMed Web of Science ®Google Scholar
• ValenzuelaCDelponETamkunMMTamargoJSnydersDJStereoselective block of a human cardiac potassium channel (Kv1. 5) by bupivacaine enantiomersBiophys J19956924188527655
   PubMed Web of Science ®Google Scholar
• ValenzuelaCSnydersDJBennettPBTamargoJHondeghemLMStereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytesCirculation19959210301430247586272
   PubMed Web of Science ®Google Scholar
• HillerDBDi GregorioGRipperREpinephrine impairs lipid resuscitation from bupivacaine overdose: a threshold effectAnesthesiology2009111349850519704251
   PubMed Web of Science ®Google Scholar
• WeinbergGLinBZhengSPartitioning effect in lipid resuscitation: further evidence for the lipid sinkCrit Care Med201038112268226920959762
   PubMed Web of Science ®Google Scholar
• ZausigYAZinkWKeilMLipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine-or mepivacaine-induced cardiac arrestAnesth Analg200910941323132619762764
   PubMed Web of Science ®Google Scholar