68
Views
21
CrossRef citations to date
0
Altmetric
Perspectives

EMA401: an old antagonist of the AT2R for a new indication in neuropathic pain

&
Pages 439-443 | Published online: 20 Feb 2017

References

  • McKinleyMJAlbistonALAllenAMThe brain renin-angiotensin system: location and physiological rolesInt J Biochem Cell Biol200335690191812676175
  • BohlenderJImbodenHAngiotensinergic neurotransmission in the peripheral autonomic nervous systemFront Biosci20121724192432
  • SmithMTWyseBDEdwardsSRSmall molecule angiotensin II type 2 receptor (AT2R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding and efficacy in ratsPain Med201314569270523489258
  • McCarthyTSpinifex Pharmaceuticals EMA401: A Novel Treatment of Neuropathic Pain. Australasian Life Science Investment Summit1122012Melbourne, VIC, Australia
  • NishimuraHRenin-angiotensin system in vertebrates: phylogenetic view of structure and functionAnat Sci Int Epub2016107
  • HunyadyLCattKJPleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin IIMol Endocrinol200620595397016141358
  • TsutsumiKSaavedraJMCharacterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brainAm J Physiol19912611 pt 2R209R2161858948
  • AllenAMMoellerIJenkinsTAAngiotensin receptors in the nervous systemBrain Res Bull199847117289766385
  • Pelegrini-da-SilvaAMartinsARPradoWAA new role for the renin-angiotensin system in the rat periaqueductal gray matter: angiotensin receptor-mediated modulation of nociceptionNeuroscience2005132245346315802196
  • PorrelloERDelbridgeLMDThomasWGThe angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptorFront Biosci200914958972
  • WanYWallinderCPlouffeBDesign, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonistJ Med Chem200447245995600815537354
  • McCarthyCAVinhACallawayJKWiddopREAngiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of strokeStroke20094041482148919246705
  • AltermanMDevelopment of selective non-peptide angiotensin II type 2 receptor agonistsJ Renin Angiotensin Aldosterone Syst2010111576619880657
  • AnandUFacerPYiangouYAngiotensin II type 2 receptor (AT2 R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neuronsEur J Pain20131771012102623255326
  • BlankleyCJHodgesJCKlutchkoSinventorsWarner-Lambert CompanyPatent: substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties US5246943 A1992519
  • SmithMTWyseBDinventorsThe University Of QueenslandPatent: method of treatment or prophylaxisWO 2006066361 A120041224
  • EnglandKGPCT Written Opinion of the International Searching Authority4262006
  • PappMLiXZhuangJWangRUhalBDAngiotensin receptor subtype AT(1) mediates alveolar epithelial cell apoptosis in response to ANG IIAm J Physiol Lung Cell Mol Physiol20022824L713L71811880296
  • MantloNBKimDOndeykaDPotent imidazo[4,5-b]- pyridine angiotensin II antagonists which exhibit balanced affinity to the AT1 and AT2 receptor subtypesBioorg Med Chem Lett199441722
  • SmithMTWyseBDEdwardsSRSmall molecule angiotensin II type 2 receptor (AT2R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in ratsPain Med201314569270523489258
  • RiceASDworkinRHMcCarthyTDEMA401-003 study group. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trialLancet201438399291637164724507377
  • McCarthyTDevelopment of EMA401 as an orally-administered, highly-selective angiotensin II type 2 receptor antagonist for the treatment of neuropathic painJ Peripher Nerv Syst201419Suppl 2S13S1425269730
  • SmithMTAnandPRiceASSelective small molecule angiotensin II type 2 receptor antagonists for neuropathic pain: preclinical and clinical studiesPain2016157Suppl 1S33S4126785154
  • NovartisReimagining Medicine Available from: https://www.novartis.com/sites/www.novartis.com/files/2016-01-novartis-jpm-presentation.pdfAccessed January 27, 2016
  • NovartisQ4 and Full Year 2015 Results Available from: https://www.novartis.com/sites/www.novartis.com/files/q4-2015-ir-presentation.pdfAccessed January 27, 2016