1,790
Views
93
CrossRef citations to date
0
Altmetric
Review

Biomarkers in traumatic brain injury (TBI): a review

, , &
Pages 2989-3000 | Published online: 08 Nov 2018

References

  • RobbMAMcInnesPMCaliffRMBiomarkers and surrogate endpoints: developing common terminology and definitionsJAMA20163151107110826978201
  • MaasAIRMenonDKAdelsonPDInTBIR Participants and InvestigatorsTraumatic brain injury: integrated approaches to improve prevention, clinical care, and researchLancet Neurol20171612987104829122524
  • BuonoraJEYarnellAMLazarusRCMultivariate analysis of traumatic brain injury: development of an assessment scoreFront Neurol20156Suppl 16825870583
  • PardiniJBailesJEMaroonJCMild traumatic brain injury in adults and concussion in sportsWinnHRYoumans Neurological SurgeryPhiladelphia, PAElsevier201133803389
  • ZhangJPuvennaVJanigroDBiomarkers of Traumatic Brain Injury and Their Relationship to PathologyLaskowitzDGrantGCRC PressBoca Raton, FL USA2016
  • HawrylukGWManleyGTClassification of traumatic brain injury: past, present, and futureHandb Clin Neurol2015127152125702207
  • WilsonLStewartWDams-O’ConnorKThe chronic and evolving neurological consequences of traumatic brain injuryLancet Neurol2017161081382528920887
  • BazarianJJZhongJBlythBZhuTKavcicVPetersonDDiffusion tensor imaging detects clinically important axonal damage after mild traumatic brain injury: a pilot studyJ Neurotrauma20072491447145917892407
  • BazarianJJDonnellyKPetersonDRWarnerGCZhuTZhongJThe relation between posttraumatic stress disorder and mild traumatic brain injury acquired during Operations Enduring Freedom and Iraqi Freedom: a diffusion tensor imaging studyJ Head Trauma Rehabil20132811222647965
  • Chiara RicciardiMBokkersRPHButmanJATrauma-specific brain abnormalities in suspected mild traumatic brain injury patients identified in the first 48 hours after injury: a blinded magnetic resonance imaging comparative study including suspected acute minor stroke patientsJ Neurotrauma2017341233027215444
  • DonnemillerEBrenneisCWisselJImpaired dopaminergic neurotransmission in patients with traumatic brain injury: a SPET study using 123I-β-CIT and 123I-IBZMEur J Nucl Med20002791410141411007526
  • KulbeJRGeddesJWCurrent status of fluid biomarkers in mild traumatic brain injuryExp Neurol2016275Pt 333435225981889
  • PostiJPTakalaRSRunttiHThe levels of glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1 during the first week after a traumatic brain injury: correlations with clinical and imaging findingsNeurosurgery20167934566426963330
  • WelchRDAyazSILewisLMAbility of serum glial fibrillary acidic protein, ubiquitin C-terminal hydrolase-L1, and S100B to differentiate normal and abnormal head computed tomography findings in patients with suspected mild or moderate traumatic brain injuryJ Neurotrauma201633220321426467555
  • MenonDKErcoleACritical care management of traumatic brain injuryHandb Clin Neurol201714023927428187802
  • StiellIGWellsGAVandemheenKThe Canadian CT Head Rule for patients with minor head injuryLancet200135792661391139611356436
  • ManleyGTDiaz-ArrastiaRBrophyMCommon data elements for traumatic brain injury: recommendations from the Biospecimens and Biomarkers Working GroupArch Phys Med Rehabil201091111667167221044710
  • DuhaimeA-CGeanADHaackeEMCommon data elements in radiologic imaging of traumatic brain injuryArch Phys Med Rehabil201091111661166621044709
  • AdamsHKoliasAGHutchinsonPJThe role of surgical intervention in traumatic brain injuryNeurosurg Clin N Am201627451952827637401
  • VegaRAValadkaABNatural history of acute subdural hematomaNeurosurg Clin N Am201728224725528325459
  • SmithCNeurotraumaHandb Clin Neurol201714511513228987162
  • IfflandPGrantGGJanigroDMechanisms of cerebral edema leading to early seizures after traumatic brain injuryLoEHVascular Mechanisms in CNS TraumaSpringerNew York, Springer20142936
  • IvensSGabrielSGreenbergGFriedmanAShelefIBlood–brain barrier breakdown as a novel mechanism underlying cerebral hyper-perfusion syndromeJ Neurol2010257461562020361293
  • SchillingLWahlMBrain edema: pathogenesis and therapyKidney Int1997596975
  • MarchiNBazarianJJPuvennaVConsequences of repeated blood-brain barrier disruption in football playersPLoS One201383e5680523483891
  • PhamNFazioVCuculloLExtracranial sources of S100B do not affect serum levelsPLoS One201059e1269120844757
  • LindsayACostelloJTRealising the potential of urine and saliva as diagnostic tools in sport and exercise medicineSports Med2017471113127294353
  • LiYSunYLiJChanges of ubiquitin C-terminal hydrolase-L1 levels in serum and urine of patients with white matter lesionsJ Neurol Sci20153571–221522126232084
  • BeharierOKahnJShustermanESheinerES100B – a potential biomarker for early detection of neonatal brain damage following asphyxiaJ Matern Fetal Neonatal Med20122591523152822348227
  • SchiaviPLaccarinoCServadeiFThe value of the calcium binding protein S100 in the management of patients with traumatic brain injuryActa Biomed20128352022978053
  • MisuTTakanoRFujiharaKTakahashiTSatoSItoyamaYMarked increase in cerebrospinal fluid glial fibrillar acidic protein in neuromyelitis optica: an astrocytic damage markerJ Neurol Neurosurg Psychiatry200980557557719372295
  • HayakataTShiozakiTTasakiOChanges in CSF S100B and cytokine concentrations IN early-phase severe traumatic brain injuryShock200422210210715257081
  • ZhouZWLiFZhengZTErythropoietin regulates immune/inflammatory reaction and improves neurological function outcomes in traumatic brain injuryBrain Behav2017711e0082729201540
  • ReidAYBraginAGizaCCStabaRJEngelJThe progression of electrophysiologic abnormalities during epileptogenesis after experimental traumatic brain injuryEpilepsia201657101558156727495360
  • KleinPDingledineRAronicaECommonalities in epileptogenic processes from different acute brain insults: Do they translate?Epilepsia2018591376629247482
  • McAllisterTWGenetic factors in traumatic brain injuryHandb Clin Neurol201512872373925701917
  • LipskyRHLinMGenetic predictors of outcome following traumatic brain injuryHandb Clin Neurol2015127234125702208
  • BennetERReuter-RiceKLaskowitzDTGenetic influences in traumatic brain injuryLaskowitzDGrantGTranslational Research in Traumatic Brain InjuryBoca Raton, FLCRC Press/Taylor and Francis Group2016 Available from: https://www.ncbi.nlm.nih.gov/books/NBK326717/Accessed October 16, 2018
  • CotterDKelsoANeliganAGenetic biomarkers of posttraumatic epilepsy: a systematic reviewSeizure201746535828242442
  • WongVSLangleyBEpigenetic changes following traumatic brain injury and their implications for outcome, recovery and therapyNeurosci Lett2016625263327155457
  • MengQZhuangYYingZAgrawalRYangXGomez-PinillaFTraumatic brain injury induces genome-wide transcriptomic, methylomic, and network perturbations in brain and blood predicting neurological disordersEBioMedicine20171618419428174132
  • KurowskiBGTreble-BarnaAPitzerAJApplying systems biology methodology to identify genetic factors possibly associated with recovery after traumatic brain injuryJ Neurotrauma201734142280229028301983
  • WagnerAKRenDConleyYPSex and genetic associations with cerebrospinal fluid dopamine and metabolite production after severe traumatic brain injuryJ Neurosurg2007106453854717432702
  • OsierNDDixonCECatecholaminergic based therapies for functional recovery after TBIBrain Res20161640153526711850
  • YanHQKlineAEMaXHooghe-PetersELMarionDWDixonCETyrosine hydroxylase, but not dopamine beta-hydroxylase, is increased in rat frontal cortex after traumatic brain injuryNeuroreport200112112323232711496104
  • WagnerAKSokoloskiJERenDControlled cortical impact injury affects dopaminergic transmission in the rat striatumJ Neurochem200595245746516190869
  • WalkerLEJanigroDHeinemannURiikonenRBernardCPatelMWONOEP appraisal: molecular and cellular biomarkers for epilepsyEpilepsia20165791354136227374986
  • ChristensenJPedersenMGPedersenCBSideniusPOlsenJVestergaardMLong-term risk of epilepsy after traumatic brain injury in children and young adults: a population-based cohort studyLancet200937396691105111019233461
  • DiamondMLRitterACFaillaMDIL-1beta associations with posttraumatic epilepsy development: a genetics and biomarker cohort studyEpilepsia20145571109111924754437
  • PerssonLHardemarkHGGustafssonJS-100 protein and neuron-specific enolase in cerebrospinal fluid and serum: markers of cell damage in human central nervous systemStroke19871859119183629651
  • RaabeAGrolmsCKellerMDöhnertJSorgeOSeifertVCorrelation of computed tomography findings and serum brain damage markers following severe head injuryActa Neurochir199814087877929810445
  • RaabeAGrolmsCSorgeOZimmermannMSeifertVSerum S-100B protein in severe head injuryNeurosurgery199945347748310493369
  • BhattacharyaKWestabySPillaiRStandingSJJohnssonPTaggartDPSerum S100B and hypothermic circulatory arrest in adultsAnn Thorac Surg19996841225122910543483
  • UsuiAKatoKMuraseMNeural tissue-related proteins (NSE, G0α, 28-kDa calbindin-D, S100b and CK-BB) in serum and cerebrospinal fluid after cardiac arrestJ Neurol Sci19941231–21341398064306
  • MarchiNCavagliaMFazioVBhudiaSHalleneKJanigroDPeripheral markers of blood–brain barrier damageClin Chim Acta20043421–211215026262
  • MarchiNRasmussenPKapuralMPeripheral markers of brain damage and blood-brain barrier dysfunctionRestor Neurol Neurosci2003213–410912114530574
  • VogelbaumMAMasarykTMazzonePS100beta as a predictor of brain metastases: brain versus cerebrovascular damageCancer200510481782415971200
  • UndénJIngebrigtsenTRomnerBScandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults: an evidence and consensus-based updateBMC Med20131115023432764
  • JárányiZSzékelyMBobekIGálfyIGellérLSelmeciLImpairment of blood-brain barrier integrity during carotid surgery as assessed by serum S-100B protein concentrationsClin Chem Lab Med200341101320132214580159
  • KapuralMKrizanac-BengezLBarnettGSerum S-100β as a possible marker of blood–brain barrier disruptionBrain Res20029401–210210412020881
  • MussackTHauserCKlaussVSerum S-100B protein levels during and after successful carotid artery stenting or carotid endarterectomyJ Endovasc Ther2006131394616445322
  • RaabeAMenonDKGuptaSCzosnykaMPickardJDJugular venous and arterial concentrations of serum S-100B protein in patients with severe head injury: a pilot studyJ Neurol Neurosurg Psychiatry19986569309329854976
  • TeepkerMMunkKMyliusVSerum concentrations of s100b and NSE in migraineHeadache200949224525218783450
  • BellanderB-MOlafssonIHGhatanPHSecondary insults following traumatic brain injury enhance complement activation in the human brain and release of the tissue damage marker S100BActa Neurochir201115319010020686797
  • KleindienstASchmidtCParschHEmtmannIXuYBuchfelderMThe passage of S100B from brain to blood is not specifically related to the blood-brain barrier integrityCardiovasc Psychiatry Neurol20102010280129580129820671945
  • PlogBADashnawMLHitomiEBiomarkers of traumatic injury are transported from brain to blood via the glymphatic systemJ Neurosci201535251852625589747
  • BlythBJFarhavarAGeeCValidation of serum markers for blood-brain barrier disruption in traumatic brain injuryJ Neurotrauma20092691497150719257803
  • BlythBJFarahvarAGeeCAHawthornBABazarianJJ223: serum S-100b concentrations are an accurate indicator of blood brain barrier integrityAnn Emerg Med2008514538539
  • PlogBANedergaardMThe glymphatic system in central nervous system health and disease: past, present, and futureAnnu Rev Pathol20181337939429195051
  • SmithAJYaoXDixJAJinB-JVerkmanASTest of the ‘glymphatic’ hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchymaeLife20176pii: e27679
  • AsgariMde ZélicourtDKurtcuogluVGlymphatic solute transport does not require bulk flowSci Rep2016613863527929105
  • JinB-JSmithAJVerkmanASSpatial model of convective solute transport in brain extracellular space does not support a “glymphatic” mechanismJ Gen Physiol2016148648950127836940
  • MarchiNAngelovLMasarykTSeizure-promoting effect of blood–brain barrier disruptionEpilepsia200748473274217319915
  • KannerAAMarchiNFazioVSerum S100beta: a noninvasive marker of blood-brain barrier function and brain lesionsCancer2003972806281312767094
  • ThelinEPJeppssonEFrostellAUtility of neuron-specific enolase in traumatic brain injury; relations to S100B levels, outcome, and extracranial injury severityCrit Care201620128527604350
  • SavolaOPyhtinenJLeinoTKSiitonenSNiemelaOHillbomMEffects of head and extracranial injuries on serum protein S100B levels in trauma patientsJ Trauma20045661229123415211130
  • HasselblattMMoorenFCvon AhsenNSerum S100β increases in marathon runners reflect extracranial release rather than glial damageNeurology20046291634163615136701
  • DadasAWashingtonJMarchiNJanigroDImproving the clinical management of traumatic brain injury through the pharmacokinetic modeling of peripheral blood biomarkersFluids Barriers CNS20161312127903281
  • FazioVBhudiaSKMarchiNAumayrBJanigroDPeripheral detection of S100β during cardiothoracic surgery: what are we really measuring?Ann Thorac Surg2004781465215223400
  • DadasAJanigroDThe role and diagnostic significance of cellular barriers after concussive head traumaConcussion2018494CNC53
  • WeissLHaydockKPickrenJWLaneWWOrgan vascularity and metastatic frequencyAm J Pathol19801011011147446696
  • HubbardWBGreenbergSNorrisCEckJLavikEVandevordPDistinguishing the unique neuropathological profile of blast polytraumaOxid Med Cell Longev20172017517524928424745
  • HueCDChoFSCaoSTime course and size of blood–brain barrier opening in a mouse model of blast-induced traumatic brain injuryJ Neurotrauma201633131202121126414212
  • PapaLBrophyGMWelchRDTime course and diagnostic accuracy of glial and neuronal blood biomarkers GFAP and UCH-L1 in a large cohort of trauma patients with and without mild traumatic brain injuryJAMA Neurol201673555156027018834
  • GyorgyALingGWingoDTime-dependent changes in serum biomarker levels after blast traumatic brain injuryJ Neurotrauma20112861121112621428721
  • UndénLCalcagnileOUndénJReinstrupPBazarianJValidation of the Scandinavian guidelines for initial management of minimal, mild and moderate traumatic brain injury in adultsBMC Med201513129226645914
  • ThelinEPNelsonDWBellanderB-MSecondary peaks of S100B in serum relate to subsequent radiological pathology in traumatic brain injuryNeurocrit Care201420221722924146416
  • LinsenmaierUWirthSKanzK-GGeyerLLImaging minor head injury (MHI) in emergency radiology: MRI highlights additional intracranial findings after measurement of trauma biomarker S-100B in patients with normal CCTBr J Radiol20168910612015082726607648
  • ChoiHPuvennaVBrennanCS100B and S100B autoantibody as biomarkers for early detection of brain metastases in lung cancerTransl Lung Cancer Res20165441341927652205
  • MazzonePJMarchiNFazioVSmall vessel ischemic disease of the brain and brain metastases in lung cancer patientsPLoS One200949e724219789633
  • LochheadJJRonaldsonPTDavisTPHypoxic stress and inflammatory pain disrupt blood-brain barrier tight junctions: implications for drug delivery to the central nervous systemAAPS J201719491092028353217
  • KuperbergSJWadgaonkarRSepsis-associated encephalopathy: the blood–brain barrier and the sphingolipid rheostatFront Immunol2017859728670310
  • MeybohmPCavusEDörgesVRelease of protein S100B in haemorrhagic shock: Effects of small volume resuscitation combined with arginine vasopressinResuscitation200876344945617976887
  • KrizbaiIALenzserGSzatmariEBlood-brain barrier changes during COMPENSATED and decompensated hemorrhagic shockShock200524542843316247328
  • SteinerJMyintAMSchiltzKS100B serum levels in schizophrenia are presumably related to visceral obesity and insulin resistanceCardiovasc Psychiatry Neurol20102010648070748071120631894
  • SteinerJSchiltzKWalterMS100B serum levels are closely correlated with body mass index: an important caveat in neuropsy-chiatric researchPsychoneuroendocrinology201035232132419674846
  • PostiJPHossainITakalaRSGlial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1 are not specific biomarkers for mild CT-negative traumatic brain injuryJ Neurotrauma201734714271438
  • LuotoTMRajRPostiJPGardnerAJPanenkaWJIversonGLA systematic review of the usefulness of glial fibrillary acidic protein for predicting acute intracranial lesions following head traumaFront Neurol2017865229255443
  • Kaczor-UrbanowiczKEMartin Carreras-PresasCAroKTuMGarcia-GodoyFWongDTWSaliva diagnostics – current views and directionsExp Biol Med20172425459472
  • MichettiFCorvinoVGelosoMCThe S100B protein in biological fluids: more than a lifelong biomarker of brain distressJ Neurochem2012120564465922145907
  • PetersSAEvaluation of a generic physiologically based pharmacokinetic model for lineshape analysisClin Pharmacokinet200847426127518336055
  • LooJAYanWRamachandranPWongDTComparative human salivary and plasma proteomesJ Dent Res201089101016102320739693