Effects of Anti-Seizure Medication on Neuregulin-1 Gene and Protein in Patients with First-Episode Focal Epilepsy

References

• Hesdorffer DC, Logroscino G, Benn EKT, Katri N, Cascino G, Hauser WA. Estimating risk for developing epilepsy. Neurology. 2011;76:23–27. doi:10.1212/WNL.0b013e318204a36a
   PubMed Web of Science ®Google Scholar
• Fiest KM, Sauro KM, Wiebe S, et al. Prevalence and incidence of epilepsy: a systematic review and meta-analysis of international studies. Neurology. 2017;88:296–303. doi:10.1212/WNL.0000000000003509
   PubMed Web of Science ®Google Scholar
• Devinsky O, Vezzani A, O’Brien TJ, et al. Epilepsy. Nat Rev Dis Primers. 2018:4. doi:10.1038/nrdp.2018.24.
   PubMed Web of Science ®Google Scholar
• Chen Z, Rollo B, Antonic-Baker A, et al. New era of personalised epilepsy management. BMJ. 2020;371:1–5. doi:10.1136/bmj.m3658
   Google Scholar
• Niestroj LM, Perez-Palma E, Howrigan DP, et al. Epilepsy subtype-specific copy number burden observed in a genome-wide study of 17458 subjects. Brain. 2020;143:2106–2118. doi:10.1093/brain/awaa171
   PubMed Web of Science ®Google Scholar
• Jennum P, Debes NMM, Ibsen R, Kjellberg J. Long-term employment, education, and healthcare costs of childhood and adolescent onset of epilepsy. Epilepsy Behav. 2021;114:107256. doi:10.1038/s41598-018-26492-4
   PubMed Web of Science ®Google Scholar
• Marchiò M, Roli L, Giordano C, et al. High plasma levels of ghrelin and des-acyl ghrelin in responders to antiepileptic drugs. Neurology. 2018;91:e62–e66. doi:10.1212/WNL.0000000000005741
   PubMed Web of Science ®Google Scholar
• Mata I, Perez-Iglesias R, Roiz-Santiañez R, et al. Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophrenia. Neuroimage. 2010;53:1016–1022. doi:10.1007/s12035-014-8876-5
   PubMed Web of Science ®Google Scholar
• Giglio S, Broman KW, Matsumoto N, et al. Olfactory receptor-Gene clusters, genomic-inversion polymorphisms, and common chromosome rearrangements. Am J Hum Genet. 2001;68:874–883. doi:10.1093/brain/awaa171
   PubMed Web of Science ®Google Scholar
• Hu X, Fan Q, Hou H, Yan R. Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling. J Neurochem. 2016;136:234–249. doi:10.1111/jnc.13395
   PubMed Web of Science ®Google Scholar
• Tan W, Wang Y, Gold B, et al. Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. J Biol Chem. 2007;282:24343–24351. doi:10.1074/jbc.M702953200
   PubMed Web of Science ®Google Scholar
• Spahic H, Parmar P, Miller S, et al. Dysregulation of erbb4 signaling pathway in the dorsal hippocampus after neonatal hypoxia-ischemia and late deficits in pv+ interneurons, synaptic plasticity and working memory. Int J Mol Sci. 2023;24. doi:10.3390/ijms24010508
   Web of Science ®Google Scholar
• Lysko DE, Talbot WS. Unmyelinated sensory neurons use Neuregulin signals to promote myelination of interneurons in the CNS. Cell Rep. 2022;41. doi:10.1016/j.celrep.2022.111669
   Web of Science ®Google Scholar
• Fornasari BE, El Soury M, De Marchis S, Perroteau I, Geuna S, Gambarotta G. Neuregulin1 alpha activates migration of neuronal progenitors expressing ErbB4. Mol Cell Neurosci. 2016;77:87–94. doi:10.1016/j.mcn.2016.10.008
   PubMed Web of Science ®Google Scholar
• Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2001;2:127–137. doi:10.1038/35052073
   PubMed Web of Science ®Google Scholar
• Bublil EM, Yarden Y. The EGF receptor family: spearheading a merger of signaling and therapeutics. Curr Opin Cell Biol. 2007;19:124–134. doi:10.1016/j.ceb.2007.02.008
   PubMed Web of Science ®Google Scholar
• Le-Niculescu H, Roseberry K, Gill SS, et al. Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs. Mol Psychiatry. 2021;26:2776–2804. doi:10.1038/s41380-021-01061-w
   PubMed Web of Science ®Google Scholar
• Harrison PJ, Law AJ. Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biol Psychiatry. 2006;60:132–140. doi:10.1016/j.biopsych.2005.11.002
   PubMed Web of Science ®Google Scholar
• Zhu WY, Jiang P, He X, et al. Contribution of NRG1 gene polymorphisms in temporal lobe epilepsy. J Child Neurol. 2016;31:271–276. doi:10.1177/0883073815589757
   PubMed Web of Science ®Google Scholar
• Tan GH, Liu YY, Hu XL, Yin DM, Mei L, Xiong ZQ. Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons. Nat Neurosci. 2012;15:258–266. doi:10.1038/nn.3005
   Web of Science ®Google Scholar
• Miziak B, Borowicz-Reutt K, Rola R, Blaszczyk B, Czuczwar M, Czuczwar SJ. The prophylactic use of antiepileptic drugs in patients scheduled for neurosurgery. Curr Pharm Des. 2018;23:6411–6427. doi:10.2174/1381612823666171027125408
   Web of Science ®Google Scholar
• Nakazawa K, Sapkota K. The origin of NMDA receptor hypofunction in schizophrenia. Pharmacol Ther. 2020;205:107426. doi:10.1016/j.pharmthera.2019.107426
   PubMed Web of Science ®Google Scholar
• Rahman-Enyart A, Lai C, Prieto AL. Neuregulins 1, 2, and 3 promote early neurite outgrowth in ErbB4-expressing cortical GABAergic interneurons. Mol Neurobiol. 2020;57:3568–3588. doi:10.1007/s12035-020-01966-7
   PubMed Web of Science ®Google Scholar
• Wen L, Lu YS, Zhu XH, et al. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc Natl Acad Sci U S A. 2010;107:1211–1216. doi:10.1073/pnas.0910302107
   PubMed Web of Science ®Google Scholar
• Mostaid MS, Lee TT, Chana G, et al. Elevated peripheral expression of neuregulin-1 (NRG1) mRNA isoforms in clozapine-treated schizophrenia patients. Transl Psychiatry. 2017;7. doi:10.1038/s41398-017-0041-2
   Web of Science ®Google Scholar
• Liu X, Bates R, Yin DM, et al. Specific regulation of NRG1 isoform expression by neuronal activity. J Neurosci. 2011;31:8491–8501. doi:10.1523/JNEUROSCI.5317-10.2011
   PubMed Web of Science ®Google Scholar
• Fazzari P, Paternain AV, Valiente M, et al. Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature. 2010;464:1376–1380. doi:10.1038/nature08928
   PubMed Web of Science ®Google Scholar
• Bean JC, Lin TW, Sathyamurthy A, et al. Genetic labeling reveals novel cellular targets of schizophrenia susceptibility gene: distribution of gaba and non-gaba erbb4-positive cells in adult mouse brain. J Neurosci. 2014;34:13549–13566. doi:10.1523/JNEUROSCI.2021-14.2014
   PubMed Web of Science ®Google Scholar
• Wang J, Huang J, Yao S, et al. The ketogenic diet increases Neuregulin 1 expression via elevating histone acetylation and its anti-seizure effect requires ErbB4 kinase activity. Cell Biosci. 2021;11:1–14. doi:10.1186/s13578-021-00611-7
   PubMed Web of Science ®Google Scholar
• Zhang HX, Zhao JP, Lv LX, et al. Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia. Neurosci Lett. 2008;438:1–5. doi:10.1016/j.neulet.2007.09.051
   PubMed Web of Science ®Google Scholar
• Dominguez SL, Hegde GV, Hanson JE, et al. Antibody-mediated stabilization of NRG1 induces behavioral and electrophysiological alterations in adult mice. Sci Rep. 2018;8:1–13. doi:10.1038/s41598-018-26492-4
   PubMed Web of Science ®Google Scholar
• Zhu JM, Li KX, Cao SX, et al. Increased NRG1-ErbB4 signaling in human symptomatic epilepsy. Sci Rep. 2017;7:1–7. doi:10.1038/s41598-016-0028-x
   PubMed Web of Science ®Google Scholar
• Esnafoglu E. Levels of peripheral Neuregulin 1 are increased in non-medicated autism spectrum disorder patients. J Clin Neurosci. 2018;57:43–45. doi:10.1016/j.jocn.2018.08.043
   PubMed Web of Science ®Google Scholar
• Paterson C, Cumming B, Law AJ. Temporal dynamics of the neuregulin-ErbB network in the murine prefrontal cortex across the lifespan. Cereb Cortex. 2020;30:3325–3339. doi:10.1093/cercor/bhz312
   PubMed Web of Science ®Google Scholar
• Amini E, Rezaei M, Mohamed Ibrahim N, et al. A molecular approach to epilepsy management: from current therapeutic methods to preconditioning efforts. Mol Neurobiol. 2015;52:492–513. doi:10.1007/s12035-014-8876-5
   PubMed Web of Science ®Google Scholar
• Li KX, Lu YM, Xu ZH, et al. Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy. Nat Neurosci. 2012;15:267–273. doi:10.1111/jnc.13395
   Web of Science ®Google Scholar