Gut Microbiota Dysbiosis and Inflammation Dysfunction in Late-Life Depression: An Observational Cross-Sectional Analysis

References

• Pomara N, Bruno D, Plaska CR, et al. Plasma amyloid-beta dynamics in late-life major depression: a longitudinal study. Transl Psychiatry. 2022;12(1):301. doi:10.1038/s41398-022-02077-8
   PubMed Web of Science ®Google Scholar
• Chang DD, Eyreeuro HA, Abbott R, et al. Pharmacogenetic guidelines and decision support tools for depression treatment: application to late-life. Pharmacogenomics. 2018;19(16):1269–1284. doi:10.2217/pgs-2018-0099
   PubMed Web of Science ®Google Scholar
• Kok RM, Reynolds CF. Management of depression in older adults: a review. JAMA. 2017;317(20):2114–2122. doi:10.1001/jama.2017.5706
   PubMed Web of Science ®Google Scholar
• Diniz BS, Butters MA, Albert SM, Dew MA, Reynolds CF 3rd. Late-life depression and risk of vascular dementia and Alzheimer’s disease: systematic review and meta-analysis of community-based cohort studies. Br J Psychiatry. 2013;202(5):329–335. doi:10.1192/bjp.bp.112.118307
   PubMed Web of Science ®Google Scholar
• Wang HX, Wang YP. Gut microbiota-brain axis. Chin Med J. 2016;129(19):2373–2380. doi:10.4103/0366-6999.190667
   PubMed Web of Science ®Google Scholar
• Zhuang ZQ, Shen LL, Li WW, et al. Gut microbiota is altered in patients with Alzheimer’s disease. J Alzheimers Dis. 2018;63(4):1337–1346. doi:10.3233/JAD-180176
   PubMed Web of Science ®Google Scholar
• Xu Y, Wang Y, Li H, et al. Altered fecal microbiota composition in older adults with frailty. Front Cell Infect Microbiol. 2021;11:696186. doi:10.3389/fcimb.2021.696186
   PubMed Web of Science ®Google Scholar
• Lee SH, Shin C, Ko YH, et al. Plasminogen activator inhibitor-1: potential inflammatory marker in late-life depression. Clin Psychopharmacol Neurosci. 2023;21(1):147–161. doi:10.9758/cpn.2023.21.1.147
   PubMed Web of Science ®Google Scholar
• Bruunsgaard H, Pedersen M, Pedersen BK. Aging and proinflammatory cytokines. Curr Opin Hematol. 2001;8(3):131–136. doi:10.1097/00062752-200105000-00001
   PubMed Web of Science ®Google Scholar
• Linnemann C, Lang UE. Pathways connecting late-life depression and dementia. Front Pharmacol. 2020;11:279. doi:10.3389/fphar.2020.00279
   PubMed Web of Science ®Google Scholar
• Goldsmith DR, Rapaport MH, Miller BJ. A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression. Mol Psychiatry. 2016;21(12):1696–1709. doi:10.1038/mp.2016.3
   PubMed Web of Science ®Google Scholar
• Morais LH, Schreiber H, Mazmanian SK. The gut microbiota-brain axis in behaviour and brain disorders. Nat Rev Microbiol. 2021;19(4):241–255. doi:10.1038/s41579-020-00460-0
   PubMed Web of Science ®Google Scholar
• Menard C, Hodes GE, Russo SJ. Pathogenesis of depression: insights from human and rodent studies. Neuroscience. 2016;321:138–162. doi:10.1016/j.neuroscience.2015.05.053
   PubMed Web of Science ®Google Scholar
• Leng F, Edison P. Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? Nat Rev Neurol. 2021;17(3):157–172. doi:10.1038/s41582-020-00435-y
   PubMed Web of Science ®Google Scholar
• Sorboni SG, Moghaddam HS, Jafarzadeh-Esfehani R, Soleimanpour S. A comprehensive review on the role of the gut microbiome in human neurological disorders. Clin Microbiol Rev. 2022;35(1):e0033820. doi:10.1128/CMR.00338-20
   PubMed Web of Science ®Google Scholar
• Dogaru IA, Puiu MG, Manea M, Dionisie V. Current perspectives on pharmacological and non-pharmacological interventions for the inflammatory mechanism of unipolar depression. Brain Sci. 2022;12(10):1403. doi:10.3390/brainsci12101403
   PubMed Web of Science ®Google Scholar
• Morris JC, Ernesto C, Schafer K, et al. Clinical dementia rating training and reliability in multicenter studies: the Alzheimer’s Disease Cooperative Study experience. Neurology. 1997;48(6):1508–1510. doi:10.1212/wnl.48.6.1508
   PubMed Web of Science ®Google Scholar
• Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–699. doi:10.1111/j.1532-5415.2005.53221.x
   PubMed Web of Science ®Google Scholar
• Yong N, Hu H, Fan X, et al. Prevalence and risk factors for depression and anxiety among outpatient migraineurs in mainland China. J Headache Pain. 2012;13(4):303–310. doi:10.1007/s10194-012-0442-9
   PubMed Web of Science ®Google Scholar
• Yesavage JA, Brink TL, Rose TL, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982;17(1):37–49. doi:10.1016/0022-3956(82)90033-4
   PubMed Web of Science ®Google Scholar
• Liu A, Peng Y, Zhu W, et al. Analysis of factors associated with depression in community-dwelling older adults in Wuhan, China. Front Aging Neurosci. 2021;13:743193. doi:10.3389/fnagi.2021.743193
   PubMed Web of Science ®Google Scholar
• Rognes T, Flouri T, Nichols B, Quince C, Mahe F. VSEARCH: a versatile open source tool for metagenomics. PeerJ. 2016;4:e2584. doi:10.7717/peerj.2584
   PubMed Web of Science ®Google Scholar
• Quast C, Pruesse E, Yilmaz P, et al. The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Nucleic Acids Res. 2013;41(Database issue):D590–D596. doi:10.1093/nar/gks1219
   PubMed Web of Science ®Google Scholar
• Lozupone C, Knight R. UniFrac: a new phylogenetic method for comparing microbial communities. Appl Environ Microbiol. 2005;71(12):8228–8235. doi:10.1128/AEM.71.12.8228-8235.2005
   PubMed Web of Science ®Google Scholar
• Ryan J, Pilkington L, Neuhaus K, Ritchie K, Ancelin ML, Saffery R. Investigating the epigenetic profile of the inflammatory gene IL-6 in late-life depression. BMC Psychiatry. 2017;17(1):354. doi:10.1186/s12888-017-1515-8
   PubMed Web of Science ®Google Scholar
• Charlton RA, Lamar M, Zhang A, et al. Associations between pro-inflammatory cytokines, learning, and memory in late-life depression and healthy aging. Int J Geriatr Psychiatry. 2018;33(1):104–112. doi:10.1002/gps.4686
   PubMed Web of Science ®Google Scholar
• Kim JM, Stewart R, Kim JW, et al. Changes in pro-inflammatory cytokine levels and late-life depression: a two year population based longitudinal study. Psychoneuroendocrinology. 2018;90:85–91. doi:10.1016/j.psyneuen.2018.02.006
   PubMed Web of Science ®Google Scholar
• Bremmer MA, Beekman AT, Deeg DJ, et al. Inflammatory markers in late-life depression: results from a population-based study. J Affect Disord. 2008;106(3):249–255. doi:10.1016/j.jad.2007.07.002
   PubMed Web of Science ®Google Scholar
• Kuo CY, Lin CH, Lane HY. Molecular basis of late-life depression. Int J Mol Sci. 2021;22(14):7421. doi:10.3390/ijms22147421
   PubMed Web of Science ®Google Scholar
• Zhang J, He H, Qiao Y, et al. Priming of microglia with IFN-gamma impairs adult hippocampal neurogenesis and leads to depression-like behaviors and cognitive defects. Glia. 2020;68(12):2674–2692. doi:10.1002/glia.23878
   PubMed Web of Science ®Google Scholar
• Buspavanich P, Adli M, Himmerich H, et al. Faster speed of onset of the depressive episode is associated with lower cytokine serum levels (IL-2, −4, −6, −10, TNF-alpha and IFN-gamma) in patients with major depression. J Psychiatr Res. 2021;141:287–292. doi:10.1016/j.jpsychires.2021.06.033
   PubMed Web of Science ®Google Scholar
• Papageorgiou IE, Lewen A, Galow LV, et al. TLR4-activated microglia require IFN-gamma to induce severe neuronal dysfunction and death in situ. Proc Natl Acad Sci U S A. 2016;113(1):212–217. doi:10.1073/pnas.1513853113
   PubMed Web of Science ®Google Scholar
• Jiang H, Ling Z, Zhang Y, et al. Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav Immun. 2015;48:186–194. doi:10.1016/j.bbi.2015.03.016
   PubMed Web of Science ®Google Scholar
• Ye X, Wang D, Zhu H, et al. Gut microbiota changes in patients with major depressive disorder treated with vortioxetine. Front Psychiatry. 2021;12:641491. doi:10.3389/fpsyt.2021.641491
   PubMedGoogle Scholar
• Lee SM, Dong TS, Krause-Sorio B, et al. The intestinal microbiota as a predictor for antidepressant treatment outcome in geriatric depression: a prospective pilot study. Int Psychogeriatr. 2022;34(1):33–45. doi:10.1017/S1041610221000120
   PubMed Web of Science ®Google Scholar
• Hasani A, Ebrahimzadeh S, Hemmati F, Khabbaz A, Hasani A, Gholizadeh P. The role of akkermansia muciniphila in obesity, diabetes and atherosclerosis. J Med Microbiol. 2021;70(10). doi:10.1099/jmm.0.001435
   PubMed Web of Science ®Google Scholar
• Peirce JM, Alvina K. The role of inflammation and the gut microbiome in depression and anxiety. J Neurosci Res. 2019;97(10):1223–1241. doi:10.1002/jnr.24476
   PubMed Web of Science ®Google Scholar
• Boehme M, van de Wouw M, Bastiaanssen TFS, et al. Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome. Mol Psychiatry. 2020;25(10):2567–2583. doi:10.1038/s41380-019-0425-1
   PubMed Web of Science ®Google Scholar
• Wang J, Xu W, Wang R, Cheng R, Tang Z, Zhang M. The outer membrane protein Amuc_1100 of Akkermansia muciniphila promotes intestinal 5-HT biosynthesis and extracellular availability through TLR2 signalling. Food Funct. 2021;12(8):3597–3610. doi:10.1039/d1fo00115a
   PubMed Web of Science ®Google Scholar
• Cheung SG, Goldenthal AR, Uhlemann AC, Mann JJ, Miller JM, Sublette ME. Systematic review of gut microbiota and major depression. Front Psychiatry. 2019;10:34. doi:10.3389/fpsyt.2019.00034
   PubMed Web of Science ®Google Scholar
• Zheng P, Zeng B, Zhou C, et al. Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism. Mol Psychiatry. 2016;21(6):786–796. doi:10.1038/mp.2016.44
   PubMed Web of Science ®Google Scholar
• Guillemin GJ, Brew BJ, Noonan CE, Takikawa O, Cullen KM. Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer’s disease hippocampus. Neuropathol Appl Neurobiol. 2005;31(4):395–404. doi:10.1111/j.1365-2990.2005.00655.x
   PubMed Web of Science ®Google Scholar
• Zhang X, Shi L, Sun T, Guo K, Geng S. Dysbiosis of gut microbiota and its correlation with dysregulation of cytokines in psoriasis patients. BMC Microbiol. 2021;21(1):78. doi:10.1186/s12866-021-02125-1
   PubMed Web of Science ®Google Scholar
• Wang H, Luo J, Chen X, et al. Clinical observation of the effects of oral opioid on inflammatory cytokines and gut microbiota in patients with moderate to severe cancer pain: a Retrospective Cohort Study. Pain Ther. 2022;11(2):667–681. doi:10.1007/s40122-022-00386-w
   PubMed Web of Science ®Google Scholar
• Lin H, An Y, Tang H, Wang Y. Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat model. J Agric Food Chem. 2019;67(13):3624–3632. doi:10.1021/acs.jafc.9b00249
   PubMed Web of Science ®Google Scholar
• Williams BL, Hornig M, Parekh T, Lipkin WI, Biron C. Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances. mBio. 2012;3(1). doi:10.1128/mBio.00261-11
   Web of Science ®Google Scholar
• Dong Z, Shen X, Hao Y, et al. Gut microbiome: a potential indicator for differential diagnosis of major depressive disorder and general anxiety disorder. Front Psychiatry. 2021;12:651536. doi:10.3389/fpsyt.2021.651536
   PubMed Web of Science ®Google Scholar
• Barandouzi ZA, Starkweather AR, Henderson WA, Gyamfi A, Cong XS. Altered composition of gut microbiota in depression: a systematic review. Front Psychiatry. 2020;11:541. doi:10.3389/fpsyt.2020.00541
   PubMed Web of Science ®Google Scholar
• Pinart M, Dotsch A, Schlicht K, et al. Gut microbiome composition in obese and non-obese persons: a systematic review and meta-analysis. Nutrients. 2021;14(1):12. doi:10.3390/nu14010012
   PubMed Web of Science ®Google Scholar
• Hou YP, He QQ, Ouyang HM, et al. Human gut microbiota associated with obesity in Chinese children and adolescents. Biomed Res Int. 2017;2017:7585989. doi:10.1155/2017/7585989
   PubMed Web of Science ®Google Scholar
• Zacarias MF, Collado MC, Gomez-Gallego C, et al. Pregestational overweight and obesity are associated with differences in gut microbiota composition and systemic inflammation in the third trimester. PLoS One. 2018;13(7):e0200305. doi:10.1371/journal.pone.0200305
   PubMed Web of Science ®Google Scholar
• Milaneschi Y, Simmons WK, van Rossum EFC, Penninx BW. Depression and obesity: evidence of shared biological mechanisms. Mol Psychiatry. 2019;24(1):18–33. doi:10.1038/s41380-018-0017-5
   PubMed Web of Science ®Google Scholar
• Hu S, Li A, Huang T, et al. Gut microbiota changes in patients with bipolar depression. Adv Sci. 2019;6(14):1900752. doi:10.1002/advs.201900752
   Web of Science ®Google Scholar
• Deng D, Su H, Song Y, et al. Altered fecal microbiota correlated with systemic inflammation in male subjects with methamphetamine use disorder. Front Cell Infect Microbiol. 2021;11:783917. doi:10.3389/fcimb.2021.783917
   PubMed Web of Science ®Google Scholar
• Ling Z, Jin G, Yan X, et al. Fecal dysbiosis and immune dysfunction in Chinese elderly patients with schizophrenia: an Observational Study. Front Cell Infect Microbiol. 2022;12:886872. doi:10.3389/fcimb.2022.886872
   PubMed Web of Science ®Google Scholar
• Carniel BP, da Rocha NS. Brain-derived neurotrophic factor (BDNF) and inflammatory markers: perspectives for the management of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2021;108:110151. doi:10.1016/j.pnpbp.2020.110151
   PubMed Web of Science ®Google Scholar
• Wei Y, Wang T, Li G, et al. Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder. Front Psychiatry. 2022;13:941728. doi:10.3389/fpsyt.2022.941728
   PubMed Web of Science ®Google Scholar