A Prospective Cohort Study of Elevated Serum NLRP1 Levels to Prognosticate Neurological Outcome After Acute Intracerebral Hemorrhage at a Single Academic Institution

References

• Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H, Hanley DF. Spontaneous intracerebral hemorrhage. N Engl J Med. 2001;344(19):1450–1460. doi:10.1056/NEJM200105103441907
   PubMed Web of Science ®Google Scholar
• Tu WJ, Zhao Z, Yin P, et al. Estimated burden of stroke in China in 2020. JAMA Network Open. 2023;6(3):e231455. doi:10.1001/jamanetworkopen.2023.1455
   PubMed Web of Science ®Google Scholar
• Tu WJ, Wang LD; Special Writing Group of China Stroke Surveillance Report. China stroke surveillance report 2021. Mil Med Res. 2023;10(1):33. doi:10.1186/s40779-023-00463-x
   PubMed Web of Science ®Google Scholar
• Morotti A, Goldstein JN. Diagnosis and management of acute intracerebral hemorrhage. Emerg Med Clin North Am. 2016;34(4):883–899. doi:10.1016/j.emc.2016.06.010
   PubMed Web of Science ®Google Scholar
• Mendiola JMF, Arboix A, García-Eroles L, Sánchez-López MJ. Acute spontaneous lobar cerebral hemorrhages present a different clinical profile and a more severe early prognosis than deep subcortical intracerebral hemorrhages-A Hospital-Based Stroke Registry Study. Biomedicines. 2023;11(1):223. doi:10.3390/biomedicines11010223
   PubMed Web of Science ®Google Scholar
• Tschoe C, Bushnell CD, Duncan PW, Alexander-Miller MA, Wolfe SQ. Neuroinflammation after intracerebral hemorrhage and potential therapeutic targets. J Stroke. 2020;22(1):29–46. doi:10.5853/jos.2019.02236
   PubMed Web of Science ®Google Scholar
• Sheth KN. Spontaneous intracerebral hemorrhage. N Engl J Med. 2022;387(17):1589–1596. doi:10.1056/NEJMra2201449
   PubMed Web of Science ®Google Scholar
• Zhu H, Wang Z, Yu J, et al. Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage. Prog Neurobiol. 2019;178:101610. doi:10.1016/j.pneurobio.2019.03.003
   PubMed Web of Science ®Google Scholar
• Weimar C, Kleine-Borgmann J. Epidemiology, prognosis and prevention of non-traumatic intracerebral hemorrhage. Curr Pharm Des. 2017;23(15):2193–2196. doi:10.2174/1381612822666161027152234
   PubMed Web of Science ®Google Scholar
• Kwah LK, Diong J. National Institutes of Health Stroke Scale (NIHSS). J Physiother. 2014;60(1):61. doi:10.1016/j.jphys.2013.12.012
   PubMed Web of Science ®Google Scholar
• LoPresti MA, Bruce SS, Camacho E, et al. Hematoma volume as the major determinant of outcomes after intracerebral hemorrhage. J Neurol Sci. 2014;345(1–2):3–7. doi:10.1016/j.jns.2014.06.057
   PubMed Web of Science ®Google Scholar
• Wu X, Liu M, Yan T, et al. Plasma PRPC levels correlate with severity and prognosis of intracerebral hemorrhage. Front Neurol. 2022;13:913926. doi:10.3389/fneur.2022.913926
   PubMedGoogle Scholar
• Wu X, Yan T, Wang Z, et al. Role of plasma Apo-J as a biomarker of severity and outcome after intracerebral hemorrhage: a prospective and cohort study. Clin Chim Acta. 2022;533:148–155. doi:10.1016/j.cca.2022.06.018
   PubMed Web of Science ®Google Scholar
• Yan T, Wang ZF, Wu XY, et al. Plasma SIRT3 as a biomarker of severity and prognosis after acute intracerebral hemorrhage: a prospective cohort study. Neuropsychiatr Dis Treat. 2022;18:2199–2210. doi:10.2147/NDT.S376717
   PubMed Web of Science ®Google Scholar
• Wang Z, Wu X, Yan T, et al. Elevated plasma complement C1q levels contribute to a poor prognosis after acute primary intracerebral hemorrhage: a prospective cohort study. Front Immunol. 2022;13:920754. doi:10.3389/fimmu.2022.920754
   PubMed Web of Science ®Google Scholar
• Cai Y, Zhuang YK, Wu XY, et al. Serum hypoxia-inducible factor 1alpha levels correlate with outcomes after intracerebral hemorrhage. Ther Clin Risk Manag. 2021;17:717–726. doi:10.2147/TCRM.S313433
   PubMed Web of Science ®Google Scholar
• Rathinam VA, Fitzgerald KA. Inflammasome complexes: emerging mechanisms and effector functions. Cell. 2016;165(4):792–800. doi:10.1016/j.cell.2016.03.046
   PubMed Web of Science ®Google Scholar
• de Carvalho Ribeiro M, Szabo G. Role of the inflammasome in liver disease. Annu Rev Pathol. 2024;17:345–365. doi:10.1146/annurev-pathmechdis-032521-102529
   Web of Science ®Google Scholar
• Chung C, Seo W, Silwal P, Jo EK. Crosstalks between inflammasome and autophagy in cancer. J Hematol Oncol. 2020;13(1):100. doi:10.1186/s13045-020-00936-9
   PubMed Web of Science ®Google Scholar
• Chavarría-Smith J, Vance RE. The NLRP1 inflammasomes. Immunol Rev. 2015;265(1):22–34. doi:10.1111/imr.12283
   PubMed Web of Science ®Google Scholar
• Mi L, Min X, Chai Y, Zhang J, Chen X. NLRP1 inflammasomes: a potential target for the treatment of several types of brain injury. Front Immunol. 2022;13:863774. doi:10.3389/fimmu.2022.863774
   PubMed Web of Science ®Google Scholar
• Bauernfried S, Hornung V. Human NLRP1: from the shadows to center stage. J Exp Med. 2022;219(1):e20211405. doi:10.1084/jem.20211405
   PubMed Web of Science ®Google Scholar
• Puleo MG, Miceli S, Di Chiara T, et al. Molecular mechanisms of inflammasome in ischemic stroke pathogenesis. Pharmaceuticals. 2022;15(10):1168. doi:10.3390/ph15101168
   Web of Science ®Google Scholar
• Chen J, Zhang C, Yan T, et al. Atorvastatin ameliorates early brain injury after subarachnoid hemorrhage via inhibition of pyroptosis and neuroinflammation. J Cell Physiol. 2021;236(10):6920–6931. doi:10.1002/jcp.30351
   PubMed Web of Science ®Google Scholar
• de Rivero Vaccari JP, Lotocki G, Alonso OF, Bramlett HM, Dietrich WD, Keane RW. Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury. J Cereb Blood Flow Metab. 2009;29(7):1251–1261. doi:10.1038/jcbfm.2009.46
   PubMed Web of Science ®Google Scholar
• Fann DY, Lee SY, Manzanero S, et al. Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke. Cell Death Dis. 2013;4(9):e790. doi:10.1038/cddis.2013.326
   PubMed Web of Science ®Google Scholar
• Wu Y, Huang X, Yang L, Liu Y. Purinergic neurotransmission receptor P2X4 silencing alleviates intracerebral hemorrhage-induced neuroinflammation by blocking the NLRP1/Caspase-1 pathway. Sci Rep. 2023;13(1):14288. doi:10.1038/s41598-023-40748-8
   PubMed Web of Science ®Google Scholar
• Adamczak S, Dale G, de Rivero Vaccari JP, Bullock MR, Dietrich WD, Keane RW. Inflammasome proteins in cerebrospinal fluid of brain-injured patients as biomarkers of functional outcome: clinical article. J Neurosurg. 2012;117(6):1119–1125. doi:10.3171/2012.9.JNS12815
   PubMed Web of Science ®Google Scholar
• Wu Q, Wang XL, Yu Q, et al. Inflammasome proteins in cerebrospinal fluid of patients with subarachnoid hemorrhage are biomarkers of early brain injury and functional outcome. World Neurosurg. 2016;94:472–479. doi:10.1016/j.wneu.2016.07.039
   PubMed Web of Science ®Google Scholar
• Tao C, Wang Y, Xiao S. Clinical significance of CT angiographic assessment of collateral circulation combined with serum NLRP1 levels in ischemic stroke patients. Medicine (Baltimore). 2023;102(13):e33433. doi:10.1097/MD.0000000000033433
   PubMed Web of Science ®Google Scholar
• Kothari RU, Brott T, Broderick JP, et al. The ABCs of measuring intracerebral hemorrhage volumes. Stroke. 1996;27(8):1304–1305. doi:10.1161/01.str.27.8.1304
   PubMed Web of Science ®Google Scholar
• You S, Zheng D, Delcourt C, et al. Determinants of early versus delayed neurological deterioration in intracerebral hemorrhage. Stroke. 2019;50(6):1409–1414. doi:10.1161/STROKEAHA.118.024403
   PubMed Web of Science ®Google Scholar
• Zhao Y, Yang J, Zhao H, Ding Y, Zhou J, Zhang Y. The association between hyperglycemia and the prognosis of acute spontaneous intracerebral hemorrhage. Neurol Res. 2017;39(2):152–157. doi:10.1080/01616412.2016.1270575
   PubMed Web of Science ®Google Scholar
• Fonseca S, Costa F, Seabra M, Dias R, Soares A, Dias C. Systemic inflammation status at admission affects the outcome of intracerebral hemorrhage by increasing perihematomal edema but not the hematoma growth. Acta Neurol Belg. 2021;121(3):649–659. doi:10.1007/s13760-019-01269-2
   PubMed Web of Science ®Google Scholar
• Zhu Y, Xie Z, Shen J, et al. Association between systemic inflammatory response syndrome and hematoma expansion in intracerebral hemorrhage. Adv Clin Exp Med. 2022;31(5):489–498. doi:10.17219/acem/145852
   PubMed Web of Science ®Google Scholar
• Xue M, Yong VW. Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation. Lancet Neurol. 2020;19(12):1023–1032. doi:10.1016/S1474-4422(20)30364-1
   PubMed Web of Science ®Google Scholar
• Shi K, Tian DC, Li ZG, Ducruet AF, Lawton MT, Shi FD. Global brain inflammation in stroke. Lancet Neurol. 2019;18(11):1058–1066. doi:10.1016/S1474-4422(19)30078-X
   PubMed Web of Science ®Google Scholar
• Xiao L, Zheng H, Li J, Wang Q, Sun H. Neuroinflammation mediated by NLRP3 inflammasome after intracerebral hemorrhage and potential therapeutic targets. Mol Neurobiol. 2020;57(12):5130–5149. doi:10.1007/s12035-020-02082-2
   PubMed Web of Science ®Google Scholar
• Gan H, Zhang L, Chen H, et al. The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats. Exp Mol Med. 2021;53(11):1807–1818. doi:10.1038/s12276-021-00702-y
   PubMed Web of Science ®Google Scholar
• Fahy RJ, Exline MC, Gavrilin MA, et al. Inflammasome mRNA expression in human monocytes during early septic shock. Am J Respir Crit Care Med. 2008;177(9):983–988. doi:10.1164/rccm.200703-418OC
   PubMed Web of Science ®Google Scholar
• de Rivero Vaccari JP, Dietrich WD, Keane RW. Therapeutics targeting the inflammasome after central nervous system injury. Transl Res. 2016;167(1):35–45. doi:10.1016/j.trsl.2015.05.003
   PubMed Web of Science ®Google Scholar
• de Rivero Vaccari JP, Brand F, Adamczak S, et al. Exosome-mediated inflammasome signaling after central nervous system injury. J Neurochem. 2016;136 Suppl 1(1):39–48. doi:10.1111/jnc.13036
   PubMedGoogle Scholar
• Taabazuing CY, Griswold AR, Bachovchin DA. The NLRP1 and CARD8 inflammasomes. Immunol Rev. 2020;297(1):13–25. doi:10.1111/imr.12884
   PubMed Web of Science ®Google Scholar
• Bauernfried S, Scherr MJ, Pichlmair A, Duderstadt KE, Hornung V. Human NLRP1 is a sensor for double-stranded RNA. Science. 2021;371(6528):eabd0811. doi:10.1126/science.abd0811
   PubMed Web of Science ®Google Scholar
• Boehme AK, Hays AN, Kicielinski KP, et al. Systemic inflammatory response syndrome and outcomes in intracerebral hemorrhage. Neurocrit Care. 2016;25(1):133–140. doi:10.1007/s12028-016-0255-9
   PubMed Web of Science ®Google Scholar
• Hagen M, Sembill JA, Sprügel MI, et al. Systemic inflammatory response syndrome and long-term outcome after intracerebral hemorrhage. Neurol Neuroimmunol Neuroinflamm. 2019;6(5):e588. doi:10.1212/NXI.0000000000000588
   PubMed Web of Science ®Google Scholar
• Hu YY, Dong XQ, Yu WH, Zhang ZY. Change in plasma S100B level after acute spontaneous basal ganglia hemorrhage. Shock. 2010;33(2):134–140. doi:10.1097/SHK.0b013e3181ad5c88
   PubMed Web of Science ®Google Scholar