145
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Effects of Aripiprazole on Olanzapine Population Pharmacokinetics and Initial Dosage Optimization in Schizophrenia Patients

, , , , , , , & ORCID Icon show all
Pages 479-490 | Received 15 Dec 2023, Accepted 22 Feb 2024, Published online: 08 Mar 2024

References

  • Jauhar S, Johnstone M, McKenna PJ. Schizophrenia. Lancet. 2022;399(10323):473–486. doi:10.1016/s0140-6736(21)01730-x
  • Srivastava A, Dada O, Qian J, et al. Epigenetics of schizophrenia. Psychiatry Res. 2021;305:114218. doi:10.1016/j.psychres.2021.114218
  • Messias EL, Chen CY, Eaton WW. Epidemiology of schizophrenia: review of findings and myths. Psychiatr Clin North Am. 2007;30(3):323–338. doi:10.1016/j.psc.2007.04.007
  • Kowalski K, Zebrowska-Rozanska P, Karpinski P, et al. Profiling gut microbiota signatures associated with the deficit subtype of schizophrenia: findings from a case-control study. Prog Neuropsychopharmacol Biol Psychiatry. 2023;127:110834. doi:10.1016/j.pnpbp.2023.110834
  • Xiong Z, Wang H, Qu Y, et al. The mitochondria in schizophrenia with 22q11.2 deletion syndrome: from pathogenesis to therapeutic promise of targeted natural drugs. Prog Neuropsychopharmacol Biol Psychiatry. 2023;127:110831. doi:10.1016/j.pnpbp.2023.110831
  • Zhilyaeva TV, Kasyanov ED, Rukavishnikov GV, et al. Pterin metabolism, inflammation and oxidative stress biochemical markers in schizophrenia: factor analysis and assessment of clinical symptoms associations. Prog Neuropsychopharmacol Biol Psychiatry. 2023;127:110823. doi:10.1016/j.pnpbp.2023.110823
  • Jentsch JD, Roth RH. The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology. 1999;20(3):201–225. doi:10.1016/S0893-133X(98)00060-8
  • de Bartolomeis A, Ciccarelli M, De Simone G, Mazza B, Barone A, Vellucci L. Canonical and non-canonical antipsychotics’ dopamine-related mechanisms of present and next generation molecules: a systematic review on translational highlights for treatment response and treatment-resistant schizophrenia. Int J Mol Sci. 2023;24(6). doi:10.3390/ijms24065945
  • Lu Z, Zhang Y, Sun Y, et al. Therapeutic outcomes wide association scan of different antipsychotics in patients with schizophrenia: randomized clinical trials and multi-ancestry validation. Psychiatry Clin Neurosci. 2023;77(9):486–496. doi:10.1111/pcn.13567
  • Bahta M, Ogbaghebriel A, Russom M, Tesfamariam EH, Berhe T. Impact of adverse reactions to first-generation antipsychotics on treatment adherence in outpatients with schizophrenia: a cross-sectional study. Ann Gen Psychiatry. 2021;20(1):27. doi:10.1186/s12991-021-00348-0
  • Mutwalli H, Keeler JL, Bektas S, Dhopatkar N, Treasure J, Himmerich H. Eating cognitions, emotions and behaviour under treatment with second generation antipsychotics: a systematic review and meta-analysis. J Psychiatr Res. 2023;160:137–162. doi:10.1016/j.jpsychires.2023.02.006
  • Lieberman JA. Dopamine partial agonists: a new class of antipsychotic. CNS Drugs. 2004;18(4):251–267. doi:10.2165/00023210-200418040-00005
  • Cepaityte D, Siafis S, Papazisis G. Safety of antipsychotic drugs: a systematic review of disproportionality analysis studies. Behav Brain Res. 2021;404:113168. doi:10.1016/j.bbr.2021.113168
  • Soria-Chacartegui P, Villapalos-Garcia G, Zubiaur P, Abad-Santos F, Koller D. Genetic polymorphisms associated with the pharmacokinetics, pharmacodynamics and adverse effects of olanzapine, aripiprazole and risperidone. Front Pharmacol. 2021;12:711940. doi:10.3389/fphar.2021.711940
  • Zhao L, Liu H, Wang W, Wang Y, Xiu M, Li S. Carnitine metabolites and cognitive improvement in patients with schizophrenia treated with olanzapine: a prospective longitudinal study. Front Pharmacol. 2023;14:1255501. doi:10.3389/fphar.2023.1255501
  • Ding J, Zhang Y, Zhang Y, et al. Effects of age, sex, and comedication on the plasma concentrations of olanzapine in Chinese patients with schizophrenia based on therapeutic drug monitoring data. J Clin Psychopharmacol. 2022;42(6):552–559. doi:10.1097/JCP.0000000000001618
  • Karwautz A, Zeiler M, Schwarzenberg J, et al. Therapeutic drug monitoring in adolescents with anorexia nervosa for safe treatment with adjunct olanzapine. Eur Eat Disord Rev. 2023. doi:10.1002/erv.3022
  • Miroshnichenko II, Pozhidaev IV, Ivanova SA, Baymeeva NV. Therapeutic drug monitoring of olanzapine and cytochrome P450 genotyping in nonsmoking subjects. Ther Drug Monit. 2020;42(2):325–329. doi:10.1097/FTD.0000000000000695
  • Xiao T, Wang Z, Li G, et al. What to do about missed doses? A retrospective study of olanzapine in the elderly. Drug Des Devel Ther. 2021;15:3411–3423. doi:10.2147/DDDT.S316110
  • Zhu X, Hu J, Xiao T, Huang S, Wen Y, Shang D. An interpretable stacking ensemble learning framework based on multi-dimensional data for real-time prediction of drug concentration: the example of olanzapine. Front Pharmacol. 2022;13:975855. doi:10.3389/fphar.2022.975855
  • Iwahashi K. Olanzapine metabolism by CYP1A2/CYP2D6 and hyperglycaemia. Acta Neuropsychiatr. 2004;16(4):229–230. doi:10.1111/j.0924-2708.2004.00089.x
  • Rojas-Macetas A, Medalla-Garro G, Saravia M, et al. Potential polymorphic CYP1A2 and CYP2D6-mediated pharmacokinetic interactions between risperidone or olanzapine and selected drugs intended to treat COVID-19. Drug Metab Bioanal Lett. 2022. doi:10.2174/1872312815666221125112724
  • Xin Y, Gao L, Tuo Y, et al. Understanding inter-individual variability in pharmacokinetics/pharmacodynamics of aripiprazole in children with tic disorders: individualized administration based on physiological development and CYP2D6 genotypes. Front Pharmacol. 2022;13:1048498. doi:10.3389/fphar.2022.1048498
  • Islam F, Marshe VS, Magarbeh L, et al. Effects of CYP2C19 and CYP2D6 gene variants on escitalopram and aripiprazole treatment outcome and serum levels: results from the CAN-BIND 1 study. Transl Psychiatry. 2022;12(1):366. doi:10.1038/s41398-022-02124-4
  • Kneller LA, Zubiaur P, Koller D, Abad-Santos F, Hempel G. Influence of CYP2D6 phenotypes on the pharmacokinetics of aripiprazole and dehydro-aripiprazole using a physiologically based pharmacokinetic approach. Clin Pharmacokinet. 2021;60(12):1569–1582. doi:10.1007/s40262-021-01041-x
  • Xiu M, Zhao L, Sun Q, Lang X. Efficacy of low-dose olanzapine in combination with sertraline on negative symptoms and psychosocial functioning in schizophrenia: a randomized controlled trial. Curr Neuropharmacol. 2023. doi:10.2174/1570159X21666230913152344
  • Brothwood PL, Husain M, Pinson J, Oloyede E, Davey P, Whiskey E. Clozapine in combination with olanzapine long-acting injection: the intersection of treatment-resistant schizophrenia and poor medication adherence-a case report. J Clin Psychopharmacol. 2023;43(5):472–474. doi:10.1097/JCP.0000000000001746
  • Liu JL, Tan ZM, Jiao SJ. Repetitive transcranial magnetic stimulation combined with olanzapine and amisulpride for treatment-refractory schizophrenia. World J Psychiatry. 2023;13(7):453–460. doi:10.5498/wjp.v13.i7.453
  • Sun L, Mills R, Sadler BM, Rege B. Population pharmacokinetics of olanzapine and samidorphan when administered in combination in healthy subjects and patients with schizophrenia. J Clin Pharmacol. 2021;61(11):1430–1441. doi:10.1002/jcph.1911
  • Anderson BJ, Holford NH. Mechanism-based concepts of size and maturity in pharmacokinetics. Annu Rev Pharmacol Toxicol. 2008;48:303–332. doi:10.1146/annurev.pharmtox.48.113006.094708
  • Horacek J, Bubenikova-Valesova V, Kopecek M, et al. Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia. CNS Drugs. 2006;20(5):389–409. doi:10.2165/00023210-200620050-00004
  • Komossa K, Rummel-Kluge C, Hunger H, et al. Olanzapine versus other atypical antipsychotics for schizophrenia. Cochrane Database Syst Rev. 2010;(3):CD006654. doi:10.1002/14651858.CD006654.pub2
  • Ennis C, Kemp JD, Cox B. Characterisation of inhibitory 5-hydroxytryptamine receptors that modulate dopamine release in the striatum. J Neurochem. 1981;36(4):1515–1520. doi:10.1111/j.1471-4159.1981.tb00594.x
  • Matsui-Sakata A, Ohtani H, Sawada Y. Pharmacokinetic-pharmacodynamic analysis of antipsychotics-induced extrapyramidal symptoms based on receptor occupancy theory incorporating endogenous dopamine release. Drug Metab Pharmacokinet. 2005;20(3):187–199. doi:10.2133/dmpk.20.187
  • Mao JH, Han L, Liu XQ, Jiao Z. Significant predictors for olanzapine pharmacokinetics: a systematic review of population pharmacokinetic studies. Expert Rev Clin Pharmacol. 2023;16(6):575–588. doi:10.1080/17512433.2023.2219055
  • Callaghan JT, Bergstrom RF, Ptak LR, Beasley CM. Olanzapine: pharmacokinetic and pharmacodynamic profile. Clin Pharmacokinet. 1999;37(3):177–193. doi:10.2165/00003088-199937030-00001
  • Bigos KL, Pollock BG, Coley KC, et al. Sex, race, and smoking impact olanzapine exposure. J Clin Pharmacol. 2008;48(2):157–165. doi:10.1177/0091270007310385
  • Beasley CM, Sanger T, Satterlee W, Tollefson G, Tran P, Hamilton S. Olanzapine versus placebo: results of a double-blind, fixed-dose olanzapine trial. Psychopharmacology. 1996;124(1–2):159–167. doi:10.1007/BF02245617
  • Solmi M, Fornaro M, Ostinelli EG, et al. Safety of 80 antidepressants, antipsychotics, anti-attention-deficit/hyperactivity medications and mood stabilizers in children and adolescents with psychiatric disorders: a large scale systematic meta-review of 78 adverse effects. World Psychiatry. 2020;19(2):214–232. doi:10.1002/wps.20765
  • Shen X, Chen X, Lu J, et al. Pharmacogenetics-based population pharmacokinetic analysis and dose optimization of valproic acid in Chinese southern children with epilepsy: effect of ABCB1 gene polymorphism. Front Pharmacol. 2022;13:1037239. doi:10.3389/fphar.2022.1037239
  • Thyssen A, Vermeulen A, Fuseau E, Fabre MA, Mannaert E. Population pharmacokinetics of oral risperidone in children, adolescents and adults with psychiatric disorders. Clin Pharmacokinet. 2010;49(7):465–478. doi:10.2165/11531730-000000000-00000
  • Chen CY, Zhou Y, Cui YM, Yang T, Zhao X, Wu Y. Population pharmacokinetics and dose simulation of oxcarbazepine in Chinese paediatric patients with epilepsy. J Clin Pharm Therapeutics. 2019;44(2):300–311. doi:10.1111/jcpt.12792
  • Wang ZZ, Zhang YF, Huang WC, et al. Effects of comedication and genetic factors on the population pharmacokinetics of lamotrigine: a prospective analysis in Chinese patients with epilepsy. Front Pharmacol. 2019;10:832. doi:10.3389/fphar.2019.00832
  • Hirose T, Mamiya N, Yamada S, Taguchi M, Kameya T, Kikuchi T. The antipsychotic drug aripiprazole (abilify). Nihon Yakurigaku Zasshi. 2006;128(5):331–345. doi:10.1254/fpj.128.331
  • Kane JM, Carson WH, Saha AR, et al. Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder. J Clin Psychiatry. 2002;63(9):763–771. doi:10.4088/jcp.v63n0903
  • Mamo D, Graff A, Mizrahi R, Shammi CM, Romeyer F, Kapur S. Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET study. Am J Psychiatry. 2007;164(9):1411–1417. doi:10.1176/appi.ajp.2007.06091479
  • Sarkisyan G, Roberts AJ, Hedlund PB. The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior. Behav Brain Res. 2010;209(1):99–108. doi:10.1016/j.bbr.2010.01.022
  • Fraguas D, Almenta Gallego D, Arques-Egea S, et al. Aripiprazole for the treatment of schizophrenia: recommendations of a panel of Spanish experts on its use in clinical practice. Int J Psychiatry Clin Pract. 2022:1–10. doi:10.1080/13651501.2022.2064308