Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study

References

• Wardle-Pinkston S, Slavish DC, Taylor DJ. Insomnia and cognitive performance: A systematic review and meta-analysis. Sleep Med Rev. 2019;48:101205. doi:10.1016/j.smrv.2019.07.008.
   PubMed Web of Science ®Google Scholar
• Winkelman JW. Insomnia Disorder. N Engl J Med. 2015;373(15):1437–1444. doi:10.1056/NEJMcp1412740.
   PubMed Web of Science ®Google Scholar
• Morin CM, Benca R. Chronic insomnia. Lancet. 2012;379:1129–1141. doi:10.1016/S0140-6736(11)60750-2.
   PubMed Web of Science ®Google Scholar
• Blanken TF, Benjamins JS, Borsboom D, et al. Insomnia disorder subtypes derived from life history and traits of affect and personality. Lancet Psychiatry. 2019;6(2):151–163. doi:10.1016/S2215-0366(18)30464-4.
   PubMed Web of Science ®Google Scholar
• Sivertsen B, Overland S, Neckelmann D, et al. The long-term effect of insomnia on work disability: the HUNT-2 historical cohort study. Am J Epidemiol. 2006;163:1018–1024. doi:10.1093/aje/kwj145
   PubMed Web of Science ®Google Scholar
• Sutton EL. Insomnia. Med Clin North Am. 2014;98:565–581. doi:10.1016/j.mcna.2014.01.008.
   PubMed Web of Science ®Google Scholar
• Fortier-Brochu E, Beaulieu-Bonneau S, Ivers H, Morin CM. Insomnia and daytime cognitive performance: a meta-analysis. Sleep Med Rev. 2012;16(1):83–94. doi:10.1016/j.smrv.2011.03.008.
   PubMed Web of Science ®Google Scholar
• Blackwell T, Yaffe K, Ancoli-Israel S, et al. Poor sleep is associated with impaired cognitive function in older women: the study of osteoporotic fractures. J Gerontol a Biol Sci Med Sci. 2006;61(4):405–410. doi:10.1093/gerona/61.4.405
   PubMed Web of Science ®Google Scholar
• Altena E, Vrenken H, Van Der Werf YD, van den Heuvel OA, Van Someren EJ. Reduced orbitofrontal and parietal gray matter in chronic insomnia: a voxel-based morphometric study. Biol Psychiatry. 2010;67(2):182–185. doi:10.1016/j.biopsych.2009.08.003.
   PubMed Web of Science ®Google Scholar
• Stoffers D, Moens S, Benjamins J, et al. Orbitofrontal gray matter relates to early morning awakening: a neural correlate of insomnia complaints? Front Neurol. 2012;3:105. doi:10.3389/fneur.2012.00105.
   PubMedGoogle Scholar
• Riemann D, Voderholzer U, Spiegelhalder K, et al. Chronic insomnia and MRI-measured hippocampal volumes: a pilot study. Sleep. 2007;30(8):955–958. doi:10.1093/sleep/30.8.955
   PubMed Web of Science ®Google Scholar
• Jespersen KV, Stevner A, Fernandes H, et al. Reduced structural connectivity in Insomnia Disorder. J Sleep Res. 2019;12:e12901. doi:10.1111/jsr.12901.
   Web of Science ®Google Scholar
• Zhao L, Wang E, Zhang X, et al. Cortical structural connectivity alterations in primary insomnia: insights from MRI-based morphometric correlation analysis. Biomed Res Int. 2015;2015:817595. doi:10.1155/2015/817595.
   PubMed Web of Science ®Google Scholar
• Spiegelhalder K, Riemann D. Losing sleep. Lancet Neurol. 2015;14(6):571. doi:10.1016/S1474-4422(15)00065-4.
   Google Scholar
• Tagliazucchi E, van Someren EJW. The large-scale functional connectivity correlates of consciousness and arousal during the healthy and pathological human sleep cycle. Neuroimage. 2017;160:55–72. doi:10.1016/j.neuroimage.2017.06.026.
   Web of Science ®Google Scholar
• Kay DB, Buysse DJ. Hyperarousal and beyond: new insights to the pathophysiology of insomnia disorder through functional neuroimaging studies. Brain Sci. 2017;7(3):pii: E23. doi:10.3390/brainsci7030023.
   Web of Science ®Google Scholar
• Kay DB, Karim HT, Soehner AM, et al. Subjective-objective sleep discrepancy is associated with alterations in regional glucose metabolism in patients with insomnia and good sleeper controls. Sleep. 2017;40:11. doi:10.1093/sleep/zsx155.
   Web of Science ®Google Scholar
• Hermans LWA, Leufkens TR, van Gilst MM, et al. Sleep EEG characteristics associated with sleep onset misperception. Sleep Med. 2019;57:70–79. doi:10.1016/j.sleep.2019.01.031
   PubMed Web of Science ®Google Scholar
• Haydon PG. Astrocytes and the modulation of sleep. Curr Opin Neurobiol. 2017;44:28–33. doi:10.1016/j.conb.2017.02.008.
   PubMed Web of Science ®Google Scholar
• Garofalo S, Picard K, Limatola C, et al. Role of glia in the regulation of sleep in health and disease. Compr Physiol. 2020;10:2. doi:10.1002/cphy.c190022
   Web of Science ®Google Scholar
• Zhang P, Tan CW, Chen GH, et al. Patients with chronic insomnia disorder have increased serum levels of neurofilaments, neuron-specific enolase and S100B: does organic brain damage exist? Sleep Med. 2018;48:163–171. doi:10.1016/j.sleep.2017.12.012
   PubMed Web of Science ®Google Scholar
• Di C, Zeng Y, Mao J, Gu W. Dynamic changes and clinical significance of serum S100B protein and glial fibrillary acidic protein in patients with delayed encephalopathy after acute carbon monoxide poisoning. Pak J Med Sci. 2018;34(4):945–949. doi:10.12669/pjms.344.15363
   Web of Science ®Google Scholar
• Breitling B, Brunkhorst R, Verhoff M, Foerch C. Post-mortem serum concentrations of GFAP correlate with agony time but do not indicate a primary cerebral cause of death. PLoS One. 2018;13(10):e0205323. doi:10.1371/journal.pone.0205323
   Web of Science ®Google Scholar
• Deuschle M, Schredl M, Wisch C, et al. Serum brain-derived neurotrophic factor (BDNF) in sleep disordered patients: relation to sleep stage N3 and rapid eye movement (REM) sleep across diagnostic entities. J Sleep Res. 2018;27(1):73–77. doi:10.1111/jsr.12577
   PubMed Web of Science ®Google Scholar
• Tang X, Zhou C, Gao J, et al. Serum BDNF and GDNF in Chinese male patients with deficit schizophrenia and their relationships with neurocognitive dysfunction. BMC Psychiatry. 2019;19(1):254. doi:10.1186/s12888-019-2231-3
   Web of Science ®Google Scholar
• Morin CM, Drake CL, Harvey AG, et al. Insomnia disorder. Nat Rev Dis Primers. 2015;1:15026. doi:10.1038/nrdp.2015.26
   PubMed Web of Science ®Google Scholar
• Mollayeva T, Thurairajah P, Burton K, Mollayeva S, Shapiro CM, Colantonio A. The Pittsburgh sleep quality index as a screening tool for sleep dysfunction in clinical and non-clinical samples: A systematic review and meta-analysis. Sleep Med Rev. 2016;25:52–73. doi:10.1016/j.smrv.2015.01.009
   PubMed Web of Science ®Google Scholar
• Carpenter JS, Andrykowski MA. Psychometric evaluation of the Pittsburgh Sleep Quality Index. J Psychosom Res. 1998;45(1):5–13. doi:10.1016/s0022-3999(97)00298-5
   PubMed Web of Science ®Google Scholar
• Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56–62. doi:10.1136/jnnp.23.1.56
   PubMed Web of Science ®Google Scholar
• Chen X, Zhang R, Xiao Y, Dong J, Niu X, Kong W. Reliability and validity of the Beijing version of the Montreal Cognitive Assessment in the evaluation of cognitive function of adult patients with OSAHS. PLoS One. 2015;10:e0132361. doi:10.1371/journal.pone.0132361
   PubMed Web of Science ®Google Scholar
• Zimmerman M, Martin J, Clark HJ, McGonigal P, Harris L, Holst CG. Measuring anxiety in depressed patients: A comparison of the Hamilton anxiety rating scale and the DSM-5 anxious distress specifier interview. Psychiatr Res. 2017;93:59–63. doi:10.1016/j.jpsychires.2017.05.014
   Web of Science ®Google Scholar
• Hori T, Sugita Y, Koga E, et al. Proposed supplements and amendments to ‘A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects’, the Rechtschaffen & Kales (1968) standard. Psychiatry Clin Neurosci. 2001;55:305–310. doi:10.1046/j.1440-1819.2001.00810.x
   PubMed Web of Science ®Google Scholar
• Abrahams S, Pickering A, Polkey CE, Morris RG. Spatial memory deficits in patients with unilateral damage to the right hippocampal formation. Neuropsychologia. 1997;35:11–24. doi:10.1016/s0028-3932(96)00051-6
   PubMed Web of Science ®Google Scholar
• Porter VR, Buxton WG, Avidan AY. Sleep, cognition and dementia. Curr Psychiatry Rep. 2015;17:97. doi:10.1007/s11920-015-0631-8
   Web of Science ®Google Scholar
• Chen GH, Xia L, Wang F, et al. Patients with chronic insomnia have selective impairments in memory that are modulated by cortisol. Psychophysiology. 2016;53:1567–1576. doi:10.1111/psyp.12700
   Web of Science ®Google Scholar
• Tsoporis JN, Marks A, Haddad A, Dawood F, Liu PP, Parker TG. S100B expression modulates left ventricular remodeling after myocardial infarction in mice. Circulation. 2005;111(5):598–606. doi:10.1161/01.CIR.0000154554.65287.F5
   Web of Science ®Google Scholar
• Carvalho DZ, Schönwald SV, Schumacher-Schuh AF, et al. Overnight S100B in Parkinson’s disease: a glimpse into sleep-related neuroinflammation. Neurosci Lett. 2015;608:57–63. doi:10.1016/j.neulet.2015.10.010
   Web of Science ®Google Scholar
• Bouvier D, Giguère Y, Pereira B, et al. Cord blood S100B: reference ranges and interest for early identification of newborns with brain injury. Clin Chem Lab Med. 2019. doi:10.1515/cclm-2019-0737
   Web of Science ®Google Scholar
• Faridaalee G, Keyghobadi Khajeh F. Serum and cerebrospinal fluid levels of S-100β is a biomarker for spinal cord injury; a systematic review and meta-analysis. Arch Acad Emerg Med. 2019;7(1):e19.
   Google Scholar
• Morera-Fumero AL, Díaz-Mesa E, Abreu-Gonzalez P, Fernandez-Lopez L, Cejas-Mendez MDR. Day/night changes in serum S100B protein concentrations in acute paranoid schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2017;75:207–212. doi:10.1016/j.pnpbp.2017.02.007
   PubMed Web of Science ®Google Scholar
• Potokar M, Morita M, Wiche G, Jorgačevski J. The diversity of intermediate filaments in astrocytes. Cells. 2020;9(7):E1604. doi:10.3390/cells9071604
   Web of Science ®Google Scholar
• McMahon PJ, Panczykowski DM, Yue JK, et al. Measurement of the glial fibrillary acidic protein and its breakdown products GFAP-BDP biomarker for the detection of traumatic brain injury compared to computed tomography and magnetic resonance imaging. J Neurotrauma. 2015;32(8):527–533. doi:10.1089/neu.2014.3635
   PubMed Web of Science ®Google Scholar
• Gan ZS, Stein SC, Swanson R, et al. Blood biomarkers for traumatic brain injury: a quantitative assessment of diagnostic and prognostic accuracy. Front Neurol. 2019;10:446. doi:10.3389/fneur.2019.00446
   PubMed Web of Science ®Google Scholar
• Papa L, Lewis LM, Falk JL, et al. Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention. Ann Emerg Med. 2012;59(6):471–483. doi:10.1016/j.annemergmed.2011.08.021
   PubMed Web of Science ®Google Scholar
• Zagrebelsky M, Tacke C, Korte M. BDNF signaling during the lifetime of dendritic spines [published online ahead of print, 2020 Jun 14]. Cell Tissue Res. 2020;10. doi:10.1007/s00441-020-03226-5.
   Web of Science ®Google Scholar
• Wei C, Sun Y, Chen N, Chen S, Xiu M, Zhang X. Interaction of oxidative stress and BDNF on executive dysfunction in patients with chronic schizophrenia. Psychoneuroendocrinology. 2019;111:104473. doi:10.1016/j.psyneuen.2019.104473
   Web of Science ®Google Scholar
• Costa CM, Oliveira GL, Fonseca ACS, Lana RC, Polese JC, Pernambuco AP. Levels of cortisol and neurotrophic factor brain-derived in Parkinson’s disease. Neurosci Lett. 2019;708:134359. doi:10.1016/j.neulet.2019.134359
   PubMed Web of Science ®Google Scholar
• Faraguna U, Vyazovskiy VV, Nelson AB, Tononi G, Cirelli C. A causal role for brain-derived neurotrophic factor in the homeostatic regulation of sleep. J Neurosci. 2008;28(15):4088–4095. doi:10.1523/JNEUROSCI.5510-07.2008
   PubMed Web of Science ®Google Scholar
• Autry AE, Monteggia LM. Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev. 2012;64(2):238–258. doi:10.1124/pr.111.005108
   PubMed Web of Science ®Google Scholar
• Walker M, Xu XM. History of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and its use for spinal cord injury repair. Brain Sci. 2018;8(6):pii: E109. doi:10.3390/brainsci8060109
   Web of Science ®Google Scholar
• Ibáñez CF, Andressoo JO. Biology of GDNF and its receptors - Relevance for disorders of the central nervous system. Neurobiol Dis. 2017;97(Pt B):80–89. doi:10.1016/j.nbd.2016.01.021
   PubMed Web of Science ®Google Scholar
• Duarte Azevedo M, Sander S, Tenenbaum L. GDNF, A neuron-derived factor upregulated in glial cells during disease. J Clin Med. 2020;9(2):456. doi:10.3390/jcm9020456
   Web of Science ®Google Scholar
• Ayanlaja AA, Zhang B, Ji G, et al. The reversible effects of glial cell line-derived neurotrophic factor (GDNF) in the human brain. Semin Cancer Biol. 2018;53:212–222. doi:10.1016/j.semcancer.2018.07.005
   PubMed Web of Science ®Google Scholar
• Frank MG. Astroglial regulation of sleep homeostasis. Curr Opin Neurobiol. 2013;23(5):812–818. doi:10.1016/j.conb.2013.02.009
   Web of Science ®Google Scholar
• Giese M, Unternährer E, Hüttig H, et al. BDNF: an indicator of insomnia? Mol Psychiatry. 2014;19(2):151–152. doi:10.1038/mp.2013.10
   PubMed Web of Science ®Google Scholar
• Mikoteit T, Brand S, Eckert A, Holsboer-Trachsler E, Beck J. Brain-derived neurotrophic factor is a biomarker for subjective insomnia but not objectively assessable poor sleep continuity. J Psychiatr Res. 2019;110:103–109. doi:10.1016/j.jpsychires.2018.12.020
   PubMed Web of Science ®Google Scholar
• He YY, Zhang XY, Yung WH, Zhu JN, Wang JJ. Role of BDNF in central motor structures and motor diseases. Mol Neurobiol. 2013;48(3):783–793. doi:10.1007/s12035-013-8466-y
   PubMed Web of Science ®Google Scholar
• Meis S, Endres T, Lessmann V. Postsynaptic BDNF signalling regulates long-term potentiation at thalamo-amygdala afferents. J Physiol. 2012;590(1):193–208. doi:10.1113/jphysiol.2011.220434
   Web of Science ®Google Scholar
• Mizuno M, Yamada K, Olariu A, Nawa H, Nabeshima T. Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats. J Neurosci. 2000;20(18):7116–7121. doi:10.1523/JNEUROSCI.20-18-07116.2000
   PubMed Web of Science ®Google Scholar
• Fan TT, Chen WH, Shi L, et al. Objective sleep duration is associated with cognitive deficits in primary insomnia: BDNF may play a role. Sleep. 2019;42:1. doi:10.1093/sleep/zsy192
   Web of Science ®Google Scholar
• Gerlai R, McNamara A, Choi-Lundberg DL, et al. Impaired water maze learning performance without altered dopaminergic function in mice heterozygous for the GDNF mutation. Eur J Neurosci. 2001;14(7):1153–1163. doi:10.1046/j.0953-816x.2001.01724.x
   Web of Science ®Google Scholar
• Naumenko VS, Kondaurova EM, Bazovkina DV, et al. Effect of GDNF on depressive-like behavior, spatial learning and key genes of the brain dopamine system in genetically predisposed to behavioral disorders mouse strains. Behav Brain Res. 2014;274:1–9. doi:10.1016/j.bbr.2014.07.045
   Web of Science ®Google Scholar
• Nanobashvili A, Airaksinen MS, Kokaia M, et al. Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor alpha 2. Proc Natl Acad Sci U S A. 2000;97:12312–12317. doi:10.1073/pnas.97.22.12312
   PubMed Web of Science ®Google Scholar
• Pertusa M, García-Matas S, Mammeri H, et al. Expression of GDNF transgene in astrocytes improves cognitive deficits in aged rats. Neurobiol Aging. 2008;29(9):1366–1379. doi:10.1016/j.neurobiolaging.2007.02.026
   PubMed Web of Science ®Google Scholar
• Deng Q, Terunuma M, Fellin T, Moss SJ, Haydon PG. Astrocytic activation of A1 receptors regulates the surface expression of NMDA receptors through a Src kinase dependent pathway. Glia. 2011;59(7):1084–1093. doi:10.1002/glia.21181
   Web of Science ®Google Scholar
• Zhang JM, Wang HK, Ye CQ, et al. ATP released by astrocytes mediates glutamatergic activity-dependent heterosynaptic suppression. Neuron. 2003;40(5):971–982. doi:10.1016/S0896-6273(03)00717-7
   PubMed Web of Science ®Google Scholar
• Serrano A, Haddjeri N, Lacaille JC, Robitaille R. GABAergic network activation of glial cells underlies hippocampal heterosynaptic depression. J Neurosci. 2006;26(20):5370–5382. doi:10.1523/JNEUROSCI.5255-05.2006
   Web of Science ®Google Scholar
• Porkka-Heiskanen T, Strecker RE, Thakkar M, Bjorkum AA, Greene RW, McCarley RW. Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science. 1997;276(5316):1265–1268. doi:10.1126/science.276.5316.1265
   PubMed Web of Science ®Google Scholar
• Halassa MM, Florian C, Fellin T, et al. Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss. Neuron. 2009;61(2):213–219. doi:10.1016/j.neuron.2008.11.024
   PubMed Web of Science ®Google Scholar
• Pál B. Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability. Cell Mol Life Sci. 2018;75(16):2917–2949. doi:10.1007/s00018-018-2837-5
   Web of Science ®Google Scholar
• Poskanzer KE, Yuste R. Astrocytes regulate cortical state switching in vivo. Proc Natl Acad Sci USA. 2016;113(19):E2675E2684. doi:10.1073/pnas.1520759113
   Web of Science ®Google Scholar
• Pelluru D, Konadhode RR, Bhat NR, Shiromani PJ. Optogenetic stimulation of astrocytes in the posterior hypothalamus increases sleep at night in C57BL/6J mice. Eur J Neurosci. 2016;43(10):1298–1306. doi:10.1111/ejn.13074
   Web of Science ®Google Scholar
• Zhou X, Oishi Y, Cherasse Y, et al. Extracellular adenosine and slow-wave sleep are increased after ablation of nucleus accumbens core astrocytes and neurons in mice. Neurochem Int. 2019;124:256–263. doi:10.1016/j.neuint.2019.01.020
   Web of Science ®Google Scholar
• Xie L, Kang H, Xu Q, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013;342(6156):373–377. doi:10.1126/science.1241224
   PubMed Web of Science ®Google Scholar
• Murphy-Royal C, Gordon GR, Bains JS. Stress-induced structural and functional modifications of astrocytes-Further implicating glia in the central response to stress. Glia. 2019;67(10):1806–1820. doi:10.1002/glia.23610
   Web of Science ®Google Scholar
• Duenas Z, Caicedo-Mera JC, Torner L. Global effects of early life stress on neurons and glial cells. Curr Pharm Des. 2018;23(39):6042–6049. doi:10.2174/1381612823666170224111641
   Web of Science ®Google Scholar
• Pillai V, Roth T, Mullins HM, Drake CL. Moderators and mediators of the relationship between stress and insomnia: stressor chronicity, cognitive intrusion, and coping. Sleep. 2014;37(7):1199–1208. doi:10.5665/sleep.3838
   PubMed Web of Science ®Google Scholar
• Dolsen MR, Crosswell AD, Prather AA. Links between stress, sleep, and inflammation: are there sex differences? Curr Psychiatry Rep. 2019;21(2):8. doi:10.1007/s11920-019-0993-4
   Web of Science ®Google Scholar