The Associations of Gender, Menopause, Age, and Asthma with REM-Predominant Obstructive Sleep Apnea: A Prospective Observational Study

References

• Senaratna CV, Perret JL, Lodge CJ, et al. Prevalence of obstructive sleep apnea in the general population: a systematic review. Sleep Med Rev. 2017;34:70–81.
   PubMed Web of Science ®Google Scholar
• Benjafield AV, Ayas NT, Eastwood PR, et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med. 2019;7(8):687–698. doi:10.1016/S2213-2600(19)30198-5
   PubMed Web of Science ®Google Scholar
• Fenik VB, Davies RO, Kubin L. REM sleep-like atonia of hypoglossal (XII) motoneurons is caused by loss of noradrenergic and serotonergic inputs. Am J Respir Crit Care Med. 2005;172(10):1322–1330. doi:10.1164/rccm.200412-1750OC
   Web of Science ®Google Scholar
• Haba-Rubio J, Janssens JP, Rochat T, Sforza E. Rapid eye movement-related disordered breathing: clinical and polysomnographic features. Chest. 2005;128(5):3350–3357. doi:10.1378/chest.128.5.3350
   PubMed Web of Science ®Google Scholar
• Almeneessier AS, Nashwan SZ, Olaish A, Al Anbi E, BaHammam AS. Long-term adherence to continuous positive airway pressure in patients with REM-only obstructive sleep apnea: a prospective cohort study. J Thorac Dis. 2017;9(10):3755–3765. doi:10.21037/jtd.2017.09.57
   Web of Science ®Google Scholar
• Almeneessier AS, Alshahrani M, Aleissi S, Hammad OS, Olaish AH, BaHammam AS. Comparison between blood pressure during obstructive respiratory events in REM and NREM sleep using pulse transit time. Sci Rep. 2020;10(1):3342. doi:10.1038/s41598-020-60281-2
   Web of Science ®Google Scholar
• Mokhlesi B, Finn LA, Hagen EW, et al. Obstructive sleep apnea during REM sleep and hypertension. Results of the wisconsin sleep cohort. Am J Respir Crit Care Med. 2014;190(10):1158–1167. doi:10.1164/rccm.201406-1136OC
   PubMed Web of Science ®Google Scholar
• Conwell W, Patel B, Doeing D, et al. Prevalence, clinical features, and CPAP adherence in REM-related sleep-disordered breathing: a cross-sectional analysis of a large clinical population. Sleep Breath. 2012;16(2):519–526. doi:10.1007/s11325-011-0537-6
   PubMed Web of Science ®Google Scholar
• Koo BB, Dostal J, Ioachimescu O, Budur K. The effects of gender and age on REM-related sleep-disordered breathing. Sleep Breath. 2008;12(3):259–264. doi:10.1007/s11325-007-0161-7
   PubMed Web of Science ®Google Scholar
• Czeisler CA, Zimmerman JC, Ronda JM, Moore-Ede MC, Weitzman ED. Timing of REM sleep is coupled to the circadian rhythm of body temperature in man. Sleep. 1980;2(3):329–346. doi:10.1093/sleep/2.3.329
   PubMed Web of Science ®Google Scholar
• Dalal PK, Agarwal M. Postmenopausal syndrome. Indian J Psychiatry. 2015;57(Suppl 2):S222–S232. doi:10.4103/0019-5545.161483
   PubMed Web of Science ®Google Scholar
• BaHammam AS, Pandi-Perumal SR, Piper A, et al. Gender differences in patients with obesity hypoventilation syndrome. J Sleep Res. 2016;25(4):445–453. doi:10.1111/jsr.12400
   PubMed Web of Science ®Google Scholar
• Johns MW. Reliability and factor analysis of the epworth sleepiness scale. Sleep. 1992;15(4):376–381. doi:10.1093/sleep/15.4.376
   PubMed Web of Science ®Google Scholar
• Berry RB, Brooks R, Gamaldo C, et al. AASM scoring manual updates for 2017 (version 2.4). J Clin Sleep Med. 2017;13(5):665–666. doi:10.5664/jcsm.6576
   PubMed Web of Science ®Google Scholar
• Aurora RN, Crainiceanu C, Gottlieb DJ, Kim JS, Punjabi NM. Obstructive sleep apnea during REM sleep and cardiovascular disease. Am J Respir Crit Care Med. 2018;197(5):653–660. doi:10.1164/rccm.201706-1112OC
   PubMed Web of Science ®Google Scholar
• Khan A, Harrison SL, Kezirian EJ, et al. Obstructive sleep apnea during rapid eye movement sleep, daytime sleepiness, and quality of life in older men in Osteoporotic Fractures in Men (MrOS) Sleep Study. J Clin Sleep Med. 2013;9(3):191–198.
   Web of Science ®Google Scholar
• Koo BB, Patel SR, Strohl K, Hoffstein V. Rapid eye movement-related sleep-disordered breathing: influence of age and gender. Chest. 2008;134(6):1156–1161. doi:10.1378/chest.08-1311
   PubMed Web of Science ®Google Scholar
• O’Connor C, Thornley KS, Hanly PJ. Gender differences in the polysomnographic features of obstructive sleep apnea. Am J Respir Crit Care Med. 2000;161(5):1465–1472.
   Web of Science ®Google Scholar
• Resta O, Carpanano GE, Lacedonia D, et al. Gender difference in sleep profile of severely obese patients with obstructive sleep apnea (OSA). Respir Med. 2005;99(1):91–96. doi:10.1016/j.rmed.2004.05.014
   PubMed Web of Science ®Google Scholar
• Al Oweidat K, AlRyalat SA, Al-Essa M, Obeidat N. Comparing REM- and NREM-related obstructive sleep apnea in Jordan: a Cross-Sectional Study. Can Respir J. 2018;2018:9270329. doi:10.1155/2018/9270329
   PubMed Web of Science ®Google Scholar
• Mano M, Hoshino T, Sasanabe R, et al. Impact of gender and age on rapid eye movement-related obstructive sleep apnea: a Clinical Study of 3234 Japanese OSA patients. Int J Environ Res Public Health. 2019;16(6):1068. doi:10.3390/ijerph16061068
   Web of Science ®Google Scholar
• Mokhlesi B, Punjabi NM. “REM-related” obstructive sleep apnea: an epiphenomenon or a clinically important entity? Sleep. 2012;35(1):5–7. doi:10.5665/sleep.1570
   PubMed Web of Science ®Google Scholar
• Duce B, Kulkas A, Langton C, Toyras J, Hukins C. The prevalence of REM-related obstructive sleep apnoea is reduced by the AASM 2012 hypopnoea criteria. Sleep Breath. 2018;22(1):57–64. doi:10.1007/s11325-017-1526-1
   Web of Science ®Google Scholar
• Lin CM, Davidson TM, Ancoli-Israel S. Gender differences in obstructive sleep apnea and treatment implications. Sleep Med Rev. 2008;12(6):481–496. doi:10.1016/j.smrv.2007.11.003
   PubMed Web of Science ®Google Scholar
• Alotair H, Bahammam A. Gender differences in Saudi patients with obstructive sleep apnea. Sleep Breath. 2008;12(4):323–329. doi:10.1007/s11325-008-0184-8
   PubMed Web of Science ®Google Scholar
• LoMauro A, Aliverti A. Sex differences in respiratory function. Breathe (Sheff). 2018;14(2):131–140. doi:10.1183/20734735.000318
   Google Scholar
• Varga AW, Mokhlesi B. REM obstructive sleep apnea: risk for adverse health outcomes and novel treatments. Sleep Breath. 2019;23(2):413–423. doi:10.1007/s11325-018-1727-2
   PubMed Web of Science ®Google Scholar
• Chami HA, Baldwin CM, Silverman A, et al. Sleepiness, quality of life, and sleep maintenance in REM versus non-REM sleep-disordered breathing. Am J Respir Crit Care Med. 2010;181(9):997–1002. doi:10.1164/rccm.200908-1304OC
   PubMed Web of Science ®Google Scholar
• Punjabi NM, Bandeen-Roche K, Marx JJ, Neubauer DN, Smith PL, Schwartz AR. The association between daytime sleepiness and sleep-disordered breathing in NREM and REM sleep. Sleep. 2002;25(3):307–314.
   Web of Science ®Google Scholar
• Hoshino T, Sasanabe R, Murotani K, et al. Insomnia as a symptom of rapid eye movement-related obstructive sleep apnea. J Clin Med. 2020;9(6):1821.
   Web of Science ®Google Scholar
• Levartovsky A, Dafna E, Zigel Y, Tarasiuk A. Breathing and snoring sound characteristics during sleep in adults. J Clin Sleep Med. 2016;12(3):375–384. doi:10.5664/jcsm.5588
   Web of Science ®Google Scholar
• Perez-Padilla JR, West P, Kryger M. Snoring in normal young adults: prevalence in sleep stages and associated changes in oxygen saturation, heart rate, and breathing pattern. Sleep. 1987;10(3):249–253. doi:10.1093/sleep/10.3.249
   Web of Science ®Google Scholar
• Pevernagie D, Aarts RM, De Meyer M. The acoustics of snoring. Sleep Med Rev. 2010;14(2):131–144. doi:10.1016/j.smrv.2009.06.002
   Web of Science ®Google Scholar
• Acosta-Castro P, Hirotsu C, Marti-Soler H, et al. REM-associated sleep apnoea: prevalence and clinical significance in the HypnoLaus cohort. Eur Respir J. 2018;52(2):1702484. doi:10.1183/13993003.02484-2017
   Web of Science ®Google Scholar
• Appleton SL, Vakulin A, Martin SA, et al. Hypertension is associated with undiagnosed OSA during rapid eye movement sleep. Chest. 2016;150(3):495–505. doi:10.1016/j.chest.2016.03.010
   PubMed Web of Science ®Google Scholar
• Kong DL, Qin Z, Shen H, Jin HY, Wang W, Wang ZF. Association of obstructive sleep apnea with asthma: a meta-analysis. Sci Rep. 2017;7(1):4088. doi:10.1038/s41598-017-04446-6
   PubMed Web of Science ®Google Scholar
• Catterall JR, Douglas NJ, Calverley PM, et al. Irregular breathing and hypoxaemia during sleep in chronic stable asthma. Lancet. 1982;1(8267):301–304. doi:10.1016/S0140-6736(82)91567-7
   PubMed Web of Science ®Google Scholar
• Haxhiu MA, Kc P, Moore CT, et al. Brain stem excitatory and inhibitory signaling pathways regulating bronchoconstrictive responses. J Appl Physiol. 2005;98(6):1961–1982. doi:10.1152/japplphysiol.01340.2004
   PubMed Web of Science ®Google Scholar
• Shapiro CM, Catterall JR, Montgomery I, Raab GM, Douglas NJ. Do asthmatics suffer bronchoconstriction during rapid eye movement sleep? Br Med J. 1986;292(6529):1161–1164. doi:10.1136/bmj.292.6529.1161
   Web of Science ®Google Scholar
• Gutierrez MJ, Zhu J, Rodriguez-Martinez CE, Nino CL, Nino G. Nocturnal phenotypical features of obstructive sleep apnea (OSA) in asthmatic children. Pediatr Pulmonol. 2013;48(6):592–600.
   PubMed Web of Science ®Google Scholar
• Perez GF, Gutierrez MJ, Huseni S, et al. Oximetry signal processing identifies REM sleep-related vulnerability trait in asthmatic children. Sleep Disord. 2013;2013:406157. doi:10.1155/2013/406157
   Google Scholar