Investigating the Diagnostic and Therapeutic Potential of SREBF2-Related Lipid Metabolism Genes in Colon Cancer

References

• Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.21492
   PubMed Web of Science ®Google Scholar
• Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66(4):683–691. doi:10.1136/gutjnl-2015-310912
   PubMed Web of Science ®Google Scholar
• Dekker E, Tanis PJ, Vleugels JLA, Kasi PM, Wallace MB. Colorectal cancer. Lancet. 2019;394(10207):1467–1480. doi:10.1016/S0140-6736(19)32319-0
   PubMed Web of Science ®Google Scholar
• Medema JP. Cancer stem cells: the challenges ahead. Nat Cell Biol. 2013;15(4):338–344. doi:10.1038/ncb2717
   PubMed Web of Science ®Google Scholar
• Nassar D, Blanpain C. Cancer Stem Cells: basic Concepts and Therapeutic Implications. Annu Rev Pathol. 2016;11(1):47–76. doi:10.1146/annurev-pathol-012615-044438
   PubMedGoogle Scholar
• Röhrig F, Schulze A. The multifaceted roles of fatty acid synthesis in cancer. Nat Rev Canc. 2016;16(11): 732–749 doi:10.1038/nrc.2016.89.
   PubMed Web of Science ®Google Scholar
• Bian X, Liu R, Meng Y, Xing D, Xu D, Lu Z. Lipid metabolism and cancer. J Exp Med. 2021;218(1): 2610–23 doi:10.1084/jem.20201606.
   Web of Science ®Google Scholar
• Pascual G, Avgustinova A, Mejetta S, et al. Targeting metastasis-initiating cells through the fatty acid receptor CD36. Nature. 2017;541(7635):41–45. doi:10.1038/nature20791
   PubMed Web of Science ®Google Scholar
• Yang P, Su C, Luo X, et al. Dietary oleic acid-induced CD36 promotes cervical cancer cell growth and metastasis via up-regulation Src/ERK pathway. Cancer Lett. 2018;438:76–85 doi:10.1016/j.canlet.2018.09.006.
   PubMed Web of Science ®Google Scholar
• Jiang M, Wu N, Xu B, et al. Fatty acid-induced CD36 expression via O-GlcNAcylation drives gastric cancer metastasis. Theranostics. 2019;9(18):5359–5373. doi:10.7150/thno.34024
   PubMed Web of Science ®Google Scholar
• Chin K, DeVries S, Fridlyand J, et al. Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Canc Cell. 2006;10(6):529–541. doi:10.1016/j.ccr.2006.10.009
   PubMed Web of Science ®Google Scholar
• Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 1997;89(3):331–340. doi:10.1016/S0092-8674(00)80213-5
   PubMed Web of Science ®Google Scholar
• Griffiths B, Lewis CA, Bensaad K, et al. Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth. Canc Metab. 2013;1(1):3. doi:10.1186/2049-3002-1-3
   PubMedGoogle Scholar
• Xue L, Qi H, Zhang H, et al. Targeting SREBP-2-regulated mevalonate metabolism for cancer therapy. Front Oncol. 2020;10:1510. doi:10.3389/fonc.2020.01510
   PubMed Web of Science ®Google Scholar
• Li X, Wu JB, Li Q, Shigemura K, Chung LWK, Huang W-C. SREBP-2 promotes stem cell-like properties and metastasis by transcriptional activation of c-Myc in prostate cancer. Oncotarget. 2016;7(11):12869 doi:10.18632/oncotarget.7331.
   PubMedGoogle Scholar
• Jie Z, Xie Z, Xu W, et al. SREBP-2 aggravates breast cancer associated osteolysis by promoting osteoclastogenesis and breast cancer metastasis. Biochim Biophys Acta Mol Basis Dis. 2019;1865(1):115–125. doi:10.1016/j.bbadis.2018.10.026
   PubMed Web of Science ®Google Scholar
• Armengol S, Arretxe E, Enzunza L, et al. SREBP-2-driven transcriptional activation of human SND1 oncogene. Oncotarget. 2017;8(64):108181–108194. doi:10.18632/oncotarget.22569
   PubMedGoogle Scholar
• Prabhu AV, Luu W, Li D, Sharpe LJ, Brown AJ. DHCR7: a vital enzyme switch between cholesterol and vitamin D production. Prog Lipid Res. 2016;64:138–151. doi:10.1016/j.plipres.2016.09.003
   PubMed Web of Science ®Google Scholar
• Korade Z, Heffer M, Mirnics K. Medication effects on developmental sterol biosynthesis. Mol Psychiatry. 2022;27(1):490–501. doi:10.1038/s41380-021-01074-5
   PubMed Web of Science ®Google Scholar
• Silvente-Poirot S, Poirot M. Cholesterol epoxide hydrolase and cancer. Curr Opin Pharmacol. 2012;12(6):696–703. doi:10.1016/j.coph.2012.07.007
   PubMed Web of Science ®Google Scholar
• DeBarber AE, Eroglu Y, Merkens LS, Pappu AS, Steiner RD. Smith-Lemli-Opitz syndrome. Expert Rev Mol Med. 2011;13:e24. doi:10.1017/S146239941100189X
   PubMed Web of Science ®Google Scholar
• Ong J-S, Cuellar-Partida G, Lu Y, et al. Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study. Int J Epidemiol. 2016;45(5):1619–1630. doi:10.1093/ije/dyw207
   PubMed Web of Science ®Google Scholar
• Winsløw UC, Nordestgaard BG, Afzal S. High plasma 25-hydroxyvitamin D and high risk of nonmelanoma skin cancer: a Mendelian randomization study of 97 849 individuals. Br J Dermatol. 2018;178(6):1388–1395. doi:10.1111/bjd.16127
   PubMed Web of Science ®Google Scholar
• Chen Y, Yan W, Yang K, et al. Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer. J Exp Clin Cancer Res. 2023;42(1):36. doi:10.1186/s13046-023-02611-6
   PubMed Web of Science ®Google Scholar
• Li Y, Zhou Y, Huang M, et al. DHCR7 promotes tumorigenesis via activating PI3K/AKT/mTOR signalling pathway in bladder cancer. Cell Signal. 2023;102:110553. doi:10.1016/j.cellsig.2022.110553
   PubMed Web of Science ®Google Scholar
• Weitz J, Koch M, Debus J, Höhler T, Galle PR, Büchler MW. Colorectal cancer. Lancet. 2005;365(9454):153–165. doi:10.1016/S0140-6736(05)17706-X
   PubMed Web of Science ®Google Scholar
• Shehab M, Abualigah L, Shambour Q, et al. Machine learning in medical applications: a review of state-of-The-art methods. Comput Biol Med. 2022;145(145):105458. doi:10.1016/j.compbiomed.2022.105458
   PubMedGoogle Scholar
• Su Y, Tian X, Gao R, et al. Colon cancer diagnosis and staging classification based on machine learning and bioinformatics analysis. Comput Biol Med. 2022;145:105409. doi:10.1016/j.compbiomed.2022.105409
   PubMed Web of Science ®Google Scholar
• Jiang X, Tan J, Li J, et al. DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. Canc Cell. 2008;13(6):529–541. doi:10.1016/j.ccr.2008.04.019
   PubMed Web of Science ®Google Scholar
• Chen M-S, Y-H L, Chen X, et al. growth factor-independent 1 is a tumor suppressor gene in colorectal cancer. Mol Cancer Res. 2019;17(3):697–708. doi:10.1158/1541-7786.MCR-18-0666
   PubMed Web of Science ®Google Scholar
• Tsukamoto S, Ishikawa T, Iida S, et al. Clinical significance of osteoprotegerin expression in human colorectal cancer. Clin Cancer Res. 2011;17(8):2444–2450. doi:10.1158/1078-0432.CCR-10-2884
   PubMed Web of Science ®Google Scholar
• Lin G, He X, Ji H, Shi L, Davis RW, Zhong S. Reproducibility Probability Score--incorporating measurement variability across laboratories for gene selection. Nat Biotechnol. 2006;24(12):1476–1477. doi:10.1038/nbt1206-1476
   PubMed Web of Science ®Google Scholar
• Ryan BM, Zanetti KA, Robles AI, et al. Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer. Int, J, Cancer. 2014;134(6):1399–1407. doi:10.1002/ijc.28457
   PubMed Web of Science ®Google Scholar
• Vlachavas E-I, Pilalis E, Papadodima O, et al. radiogenomic analysis of f-18-fluorodeoxyglucose positron emission tomography and gene expression data elucidates the epidemiological complexity of colorectal cancer landscape. Comput Struct Biotechnol J. 2019;17:177–185. doi:10.1016/j.csbj.2019.01.007
   PubMed Web of Science ®Google Scholar
• Leek JT. svaseq: removing batch effects and other unwanted noise from sequencing data. Nucleic Acids Res. 2014;42(21):e161–e161. doi:10.1093/nar/gku864
   PubMed Web of Science ®Google Scholar
• Ritchie ME, Phipson B, Wu D, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47–e47. doi:10.1093/nar/gkv007
   PubMed Web of Science ®Google Scholar
• Guo S, Xu Z, Dong X, et al. GPSAdb: a comprehensive web resource for interactive exploration of genetic perturbation RNA-seq datasets. Nucleic Acids Res. 2023;51(D1):D964–D968. doi:10.1093/nar/gkac1066
   PubMed Web of Science ®Google Scholar
• Martin-Perez M, Urdiroz-Urricelqui U, Bigas C, Benitah SA. The role of lipids in cancer progression and metastasis. Cell Metab. 2022;34(11):1675–1699. doi:10.1016/j.cmet.2022.09.023
   PubMed Web of Science ®Google Scholar
• Currie E, Schulze A, Zechner R, Walther TC, Farese RV. Cellular fatty acid metabolism and cancer. Cell Metab. 2013;18(2):153–161. doi:10.1016/j.cmet.2013.05.017
   PubMed Web of Science ®Google Scholar
• Shimano H, Sato R. SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology. Nat Rev Endocrinol. 2017;13(12):710–730. doi:10.1038/nrendo.2017.91
   PubMed Web of Science ®Google Scholar
• Bengoechea-Alonso MT, Ericsson J. SREBP in signal transduction: cholesterol metabolism and beyond. Curr Opin Cell Biol. 2007;19(2):215–222. doi:10.1016/j.ceb.2007.02.004
   PubMed Web of Science ®Google Scholar
• Zhang K-L, Zhu -W-W, Wang S-H, et al. Organ-specific cholesterol metabolic aberration fuels liver metastasis of colorectal cancer. Theranostics. 2021;11(13):6560–6572. doi:10.7150/thno.55609
   PubMed Web of Science ®Google Scholar
• York AG, Williams KJ, Argus JP, et al. limiting cholesterol biosynthetic flux spontaneously engages type i ifn signaling. Cell. 2015;163(7):1716–1729. doi:10.1016/j.cell.2015.11.045
   PubMed Web of Science ®Google Scholar
• Li X, Roberti R, Blobel G. Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum. Nature. 2015;517(7532):104–107. doi:10.1038/nature13797
   PubMed Web of Science ®Google Scholar
• Kim JH, Lee JN, Paik YK. Cholesterol biosynthesis from lanosterol. A concerted role for Sp1 and NF-Y-binding sites for sterol-mediated regulation of rat 7-dehydrocholesterol reductase gene expression. J Biol Chem. 2001;276(21):18153–18160. doi:10.1074/jbc.M101661200
   PubMed Web of Science ®Google Scholar
• Prabhu AV, Sharpe LJ, Brown AJ. The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): evidence of a cooperative regulatory program in cholesterol synthesis. Biochim Biophys Acta. 2014;1842(10):1431–1439. doi:10.1016/j.bbalip.2014.07.006
   PubMedGoogle Scholar
• Gerrick KY, Gerrick ER, Gupta A, Wheelan SJ, Yegnasubramanian S, Jaffee EM. Transcriptional profiling identifies novel regulators of macrophage polarization. PLoS One. 2018;13(12):e0208602. doi:10.1371/journal.pone.0208602
   PubMed Web of Science ®Google Scholar
• Goossens P, Rodriguez-Vita J, Etzerodt A, et al. Membrane cholesterol efflux drives tumor-associated macrophage reprogramming and tumor progression. Cell Metab. 2019;29(6):1376–1389.e4. doi:10.1016/j.cmet.2019.02.016
   PubMed Web of Science ®Google Scholar
• Ma K, Zhang L. Overview: lipid metabolism in the tumor microenvironment. Adv Exp Med Biol. 2021;1316:41–47 doi:10.1084/jem.20201606.
   PubMed Web of Science ®Google Scholar
• Prieur X, Mok CYL, Velagapudi VR, et al. Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes. 2011;60(3):797–809. doi:10.2337/db10-0705
   PubMed Web of Science ®Google Scholar
• Fischer-Posovszky P, Wang QA, Asterholm IW, Rutkowski JM, Scherer PE. Targeted deletion of adipocytes by apoptosis leads to adipose tissue recruitment of alternatively activated M2 macrophages. Endocrinology. 2011;152(8):3074–3081. doi:10.1210/en.2011-1031
   PubMed Web of Science ®Google Scholar
• Mantovani A, Allavena P, Marchesi F, Garlanda C. Macrophages as tools and targets in cancer therapy. Nat Rev Drug Discov. 2022;21(11):799–820. doi:10.1038/s41573-022-00520-5
   PubMed Web of Science ®Google Scholar
• Peña-Romero AC, Orenes-Piñero E. dual effect of immune cells within tumour microenvironment: pro- and anti-tumour effects and their triggers. Cancers. 2022;14(7):1681. doi:10.3390/cancers14071681
   PubMed Web of Science ®Google Scholar
• Zou J, Liu S, Long J, Yan B. High DHCR7 expression predicts poor prognosis for cervical cancer. Comput Math Methods Med. 2022;2022:8383885. doi:10.1155/2022/8383885
   PubMed Web of Science ®Google Scholar
• Xiao J, Li W, Zheng X, et al. Targeting 7-dehydrocholesterol reductase integrates cholesterol metabolism and IRF3 activation to eliminate infection. Immunity. 2020;52(1):109–122.e6. doi:10.1016/j.immuni.2019.11.015
   PubMed Web of Science ®Google Scholar