181
Views
0
CrossRef citations to date
0
Altmetric
RAPID COMMUNICATION

GW4869 Can Inhibit Epithelial-Mesenchymal Transition and Extracellular HSP90α in Gefitinib-Sensitive NSCLC Cells

, , , &
Pages 913-922 | Received 10 Aug 2023, Accepted 13 Oct 2023, Published online: 07 Nov 2023

References

  • Hyuna S, Jacques F, Me RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.21660
  • Ke E, Zhou Q, Wu Y. Emerging Paradigms in Targeted Treatments for Asian Patients with NSCLC. Expert Opin Pharmacother. 2015;16(8):1167–1176. doi:10.1517/14656566.2015.1040391
  • Rawluk J, Waller CF. Gefitinib. Recent Results Cancer Res. 2018;211:235–246.
  • Johnson M, Garassino MC, Mok T, et al. Treatment strategies and outcomes for patients with EGFR-mutant non-small cell lung cancer resistant to EGFR tyrosine kinase inhibitors: focus on novel therapies. Lung Cancer. 2022;170:41–51. doi:10.1016/j.lungcan.2022.05.011
  • Wu SG, Shih JY. Management of Acquired Resistance to EGFR TKI-targeted Therapy in Advanced Non-Small Cell Lung Cancer. Mol Cancer. 2018;17:38. doi:10.1186/s12943-018-0777-1
  • Esposito AR, Pasquale R, Sacco A, et al. Liquid Biopsy Testing Can Improve Selection of Advanced Non-Small-Cell Lung Cancer Patients to Rechallenge with Gefitinib. Cancers. 2019;11(10):1431. doi:10.3390/cancers11101431
  • Li W, Tsen F, Sahu D, et al. Extracellular Hsp90 (eHsp90) as the Actual Target in Clinical Trials: intentionally Or Unintentionally. Int Rev Cell Mol Biol. 2013;303:203–235.
  • Eguchi T, Taha EA, Calderwood SK, et al. Novel Model of Cancer Drug Resistance: oncosomal Release of Cytotoxic and Antibody-Based Drugs. Biology. 2020;9(3):47. doi:10.3390/biology9030047
  • Catalano M, O’Driscoll L. Inhibiting Extracellular Vesicles Formation and Release: a Review of EV Inhibitors. J Extracell Vesicles. 2020;9:1703244.
  • Eguchi T, Sogawa C, Ono K, et al. Cell Stress Induced Stressome Release Including Damaged Membrane Vesicles and Extracellular HSP90 by Prostate Cancer Cells. Cells. 2020;10(1):9. doi:10.3390/cells10010009
  • Jakobsen KR, Demuth C, Sorensen BS, et al. The Role of Epithelial to Mesenchymal Transition in Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer. Transl Lung Cancer Res. 2016;5(2):172–182. doi:10.21037/tlcr.2016.04.07
  • Nowak E, Bednarek I. Aspects of the Epigenetic Regulation of EMT Related to Cancer Metastasis. Cells. 2021;10.3435.
  • Jolly MK, Celia-Terrassa T. Dynamics of Phenotypic Heterogeneity Associated with EMT and Stemness during Cancer Progression. J Clin Med. 2019;9(1):8. doi:10.3390/jcm9010008
  • Shibue T, Weinberg RA. EMT, CSCs, and Drug Resistance: the Mechanistic Link and Clinical Implications. Nat Rev Clin Oncol. 2017;14(10):611–629. doi:10.1038/nrclinonc.2017.44
  • Li Y, Zhang T, Qin S, et al. Effects of UPF1 expression on EMT process by targeting E‑cadherin, N‑cadherin, Vimentin and Twist in a hepatocellular carcinoma cell line. Mol Med Rep. 2019;19(3):2137–2143. doi:10.3892/mmr.2019.9838
  • Xu K, Zhang C, Du T, et al. Progress of exosomes in the diagnosis and treatment of lung cancer. Biomed Pharmacother. 2021;134:111111. doi:10.1016/j.biopha.2020.111111
  • Trepel J, Mollapour M, Giaccone G, et al. Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer. 2010;10(8):537–549. doi:10.1038/nrc2887
  • Huang B, Pan J, Liu H, et al. High Expression of Plasma Extracellular HSP90α is Associated With the Poor Efficacy of Chemotherapy and Prognosis in Small Cell Lung Cancer. Front Mol Biosci. 2022;9:913043. doi:10.3389/fmolb.2022.913043
  • Lang BJ, Guerrero-Giménez ME, Prince TL, et al. Heat Shock Proteins are Essential Components in Transformation and Tumor Progression: cancer Cell Intrinsic Pathways and Beyond. Int J Mol Sci. 2019;20(18):4507. doi:10.3390/ijms20184507
  • Dong HM, Le YQ, Wang YH, et al. Extracellular Heat Shock Protein 90Alpha Mediates HDM-induced Bronchial Epithelial Barrier Dysfunction by Activating RhoA/MLC Signaling. Respir Res. 2017;18(1):111. doi:10.1186/s12931-017-0593-y
  • Hoter A, El-Sabban ME, Naim HY. The HSP90 Family: structure, Regulation, Function, and Implications in Health and Disease. Int J Mol Sci. 2018;19(9):2560. doi:10.3390/ijms19092560
  • Taha EA, Ono K, Eguchi T. Roles of Extracellular HSPs as Biomarkers in Immune Surveillance and Immune Evasion. Int J Mol Sci. 2019;20(18):4588. doi:10.3390/ijms20184588
  • Den RB, Lu B. Heat Shock Protein 90 Inhibition: rationale and Clinical Potential. Ther Adv Med Oncol. 2012;4(4):211–218. doi:10.1177/1758834012445574
  • Chen J, Rong N, Liu M, et al. The Exosome-Like Vesicles Derived From Androgen Exposed-Prostate Stromal Cells Promote Epithelial Cells Proliferation and Epithelial-Mesenchymal Transition. Toxicol Appl Pharmacol. 2021;411:115384. doi:10.1016/j.taap.2020.115384
  • Ruizhu S, Zhansheng H. Drug resistance mechanisms and progress in the treatment of EGFR-mutated lung adenocarcinoma. Oncol Lett. 2022;24(5):408. doi:10.3892/ol.2022.13528
  • Liao BC, Griesing S, Yang JC. Second-line treatment of EGFR T790M-negative non-small cell lung cancer patients. Ther Adv Med Oncol. 2019;11:1758835919890286. doi:10.1177/1758835919890286
  • Ji W, Choi YJ, Kang M-H. Efficacy of the CDK7 Inhibitor On EMT-Associated Resistance to 3Rd Generation EGFR-TKIs in Non-Small Cell Lung Cancer Cell Lines. Cells. 2020;9(12):2596. doi:10.3390/cells9122596
  • Dai B, Fan M, Yu R, et al. Novel Diphenyl Urea Derivative Serves as an Inhibitor On Human Lung Cancer Cell Migration by Disrupting EMT Via Wnt/beta-catenin and PI3K/Akt Signaling. Toxicol In Vitro. 2020;69:105000. doi:10.1016/j.tiv.2020.105000
  • Lauwers E, Wang YC, Gallardo R, et al. Hsp90 Mediates Membrane Deformation and Exosome Release. Mol Cell. 2018;71(5):689–702. doi:10.1016/j.molcel.2018.07.016
  • Chen R, Qian Z, Xu X, et al. Exosomes-Transmitted miR-7 Reverses Gefitinib Resistance by Targeting YAP in Non-Small-Cell Lung Cancer. Pharmacol Res. 2021;165:105442. doi:10.1016/j.phrs.2021.105442
  • You J, Li M, Cao L, et al. Snail1-Dependent Cancer-Associated Fibroblasts Induce Epithelial-Mesenchymal Transition in Lung Cancer Cells Via Exosomes. QJM. 2019;112(8):581–590. doi:10.1093/qjmed/hcz093
  • Yang Y, Li CW, Chan LC, et al. Exosomal PD-L1 Harbors Active Defense Function to Suppress T Cell Killing of Breast Cancer Cells and Promote Tumor Growth. Cell Res. 2018;28(8):862–864. doi:10.1038/s41422-018-0060-4
  • Tallon C, Hollinger KR. Nipping disease in the bud: nSMase2 inhibitors as therapeutics in extracellular vesicle-mediated diseases. Drug Discov Today. 2021;26(7):1656–1668. doi:10.1016/j.drudis.2021.03.025
  • Ghandour B, Dbaibo G, Darwiche N. The unfolding role of ceramide in coordinating retinoid-based cancer therapy. Biochem J. 2021;478(19):3621–3642. doi:10.1042/BCJ20210368
  • Chen G, Huang AC, Zhang W, et al. Exosomal PD-L1 contributes to immunosuppression and is associated with antiPD-1 response. Nature. 2018;560(7718):382. doi:10.1038/s41586-018-0392-8
  • Poggio M, Hu T, Pai CC, et al. Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory. Cell. 2019;177(2):414–27 e413. doi:10.1016/j.cell.2019.02.016
  • Wang G, Xie L, Li B, et al. A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis. Nat Commun. 2021;12(1):5733. doi:10.1038/s41467-021-25990-w
  • Rojas C, Barnaeva E, Thomas AG, et al. DPTIP, a newly identifed potent brain penetrant neutral sphingomyelin- nase 2 inhibitor, regulates astrocyte-peripheral immune communica- tion following brain inflammation. Sci Rep. 2018;8(1):17715. doi:10.1038/s41598-018-36144-2
  • Rojas C, Sala M, Thomas AG, et al. A novel and potent brain penetrant inhibitor of extracellular vesicle release. Br J Pharmacol. 2019;176(19):3857–3870. doi:10.1111/bph.14789
  • Wang F, Oudaert I, Tu C, et al. System Xc inhibition blocks bone marrow-multiple myeloma exosomal crosstalk, thereby countering bortezomib resistance. Cancer Lett. 2022;535:215649. doi:10.1016/j.canlet.2022.215649
  • Wong DS, Jay DG. Emerging Roles of Extracellular Hsp90 in Cancer. Adv Cancer Res. 2016;129:141–163.