165
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Genetic Variants of CYP4F2 Associated with Ischemic Stroke Susceptibility in the Han Population from Southern China

, , , , , , , , & show all
Pages 599-607 | Received 23 Mar 2023, Accepted 26 May 2023, Published online: 15 Jun 2023

References

  • Saini V, Guada L, Yavagal DR. Global epidemiology of stroke and access to acute ischemic stroke interventions. Neurology. 2021;97(20 Suppl 2):S6–S16. doi:10.1212/WNL.0000000000012781
  • Su EJ, Lawrence DA. Diabetes and the treatment of ischemic stroke. J Diabetes Complications. 2022;36(11):108318. doi:10.1016/j.jdiacomp.2022.108318
  • Sarwar N, Gao P, Seshasai SR, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet. 2010;375(9733):2215–2222. doi:10.1016/S0140-6736(10)60484-9
  • Ferrari F, Villa RF. Brain bioenergetics in chronic hypertension: risk factor for acute ischemic stroke. Biochem Pharmacol. 2022;205:115260. doi:10.1016/j.bcp.2022.115260
  • Arboix A, Jiménez C, Massons J, Parra O, Besses C. Hematological disorders: a commonly unrecognized cause of acute stroke. Expert Rev Hematol. 2016;9(9):891–901. doi:10.1080/17474086.2016.1208555
  • Wang YJ, Li ZX, Gu HQ, et al. China stroke statistics 2019: a report from the National Center for hEalthcare Quality Management in Neurological Diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations. Stroke Vasc Neurol. 2020;5(3):211–239. doi:10.1136/svn-2020-000457
  • Collaborators GN. Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the global burden of disease study 2016. Lancet Neurol. 2019;18(5):459–480. doi:10.1016/S1474-4422(18)30499-X
  • Xu J, Zhang X, Jin A, et al. Trends and risk factors associated with stroke recurrence in China, 2007–2018. JAMA Netw Open. 2022;5(6):e2216341. doi:10.1001/jamanetworkopen.2022.16341
  • Ekkert A, Šliachtenko A, Grigaitė J, Burnytė B, Utkus A, Jatužis D. Ischemic stroke genetics: what is new and how to apply it in clinical practice? Genes. 2021;13(1):48. doi:10.3390/genes13010048
  • Lasker JM, Chen WB, Wolf I, Bloswick BP, Wilson PD, Powell PK. Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11. J Biol Chem. 2000;275(6):4118–4126. doi:10.1074/jbc.275.6.4118
  • Kikuta Y, Kusunose E, Kusunose M. Characterization of human liver leukotriene B(4) omega-hydroxylase P450 (CYP4F2). J Biochem. 2000;127(6):1047–1052. doi:10.1093/oxfordjournals.jbchem.a022696
  • Sontag TJ, Parker RS. Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. J Biol Chem. 2002;277(28):25290–25296. doi:10.1074/jbc.M201466200
  • Kehl F, Cambj-Sapunar L, Maier KG, et al. 20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat. Am J Physiol Heart Circ Physiol. 2002;282(4):H1556–H1565. doi:10.1152/ajpheart.00924.2001
  • Williams JM, Fan F, Murphy S, et al. Role of 20-HETE in the antihypertensive effect of transfer of chromosome 5 from brown Norway to dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol. 2012;302(10):H1509–H1518. doi:10.1152/ajpregu.00604.2011
  • Stec DE, Roman RJ, Flasch A, Rieder MJ. Functional polymorphism in human CYP4F2 decreases 20-HETE production. Physiol Genomics. 2007;30(1):74–81. doi:10.1152/physiolgenomics.00003.2007
  • Di Fusco D, Ciccacci C, Rufini S, Forte V, Novelli G, Borgiani P. Resequencing of VKORC1, CYP2C9 and CYP4F2 genes in Italian patients requiring extreme low and high warfarin doses. Thromb Res. 2013;132(1):123–126. doi:10.1016/j.thromres.2013.05.002
  • Zhuang W, Wen W, Xuan B, et al. Effect of CYP2C9, CYP4F2 and VKORC1 genetic polymorphisms on pharmacokinetics and pharmacodynamics of mean daily maintenance dose of warfarin in Chinese patients. Blood Coagul Fibrinolysis. 2015;26(2):167–174. doi:10.1097/MBC.0000000000000213
  • Hirata TDC, Dagli-Hernandez C, Genvigir FDV, et al. Cardiovascular pharmacogenomics: an update on clinical studies of antithrombotic drugs in Brazilian patients. Mol Diagn Ther. 2021;25(6):735–755. doi:10.1007/s40291-021-00549-z
  • Peng D, Wei C, Zhang X, et al. Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers. Cancer Cell Int. 2021;21(1):566. doi:10.1186/s12935-021-02266-3
  • Wacholder S, Chanock S, Garcia-Closas M, El Ghormli L, Rothman N. Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst. 2004;96(6):434–442. doi:10.1093/jnci/djh075
  • Zhang T, Yu K, Li X. Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) rs1558139, rs2108622 polymorphisms and susceptibility to several cardiovascular and cerebrovascular diseases. BMC Cardiovasc Disord. 2018;18(1):29. doi:10.1186/s12872-018-0763-y
  • Colàs-Campàs L, Royo JL, Montserrat MV, et al. The rs2108622 polymorphism is related to the early risk of ischemic stroke in non-valvular atrial fibrillation subjects under oral anticoagulation. Pharmacogenomics J. 2018;18(5):652–656. doi:10.1038/s41397-017-0007-z
  • Munshi A, Sharma V, Kaul S, et al. Association of 1347 G/A cytochrome P450 4F2 (CYP4F2) gene variant with hypertension and stroke. Mol Biol Rep. 2012;39(2):1677–1682. doi:10.1007/s11033-011-0907-y
  • Liao D, Yi X, Zhang B, Zhou Q, Lin J. Interaction between CYP4F2 rs2108622 and CPY4A11 rs9333025 variants is significantly correlated with susceptibility to ischemic stroke and 20-hydroxyeicosatetraenoic acid level. Genet Test Mol Biomarkers. 2016;20(5):223–228. doi:10.1089/gtmb.2015.0205
  • Deng S, Zhu G, Liu F, et al. CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(4):664–668. doi:10.1016/j.pnpbp.2010.03.009
  • Liang T, Liang A, Zhang X, et al. The association study between CYP20A1, CYP4F2, CYP2D6 gene polymorphisms and coronary heart disease risk in the Han population in southern China. Genes Genomics. 2022;44(9):1125–1135. doi:10.1007/s13258-021-01125-9
  • He R, Li M, Li A, et al. CYP4F2 and CYP3A5 gene polymorphisms and lung cancer in Chinese Han population. Clin Exp Med. 2020;20(3):461–468. doi:10.1007/s10238-020-00631-6
  • Ward NC, Croft KD, Blacker D, et al. Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls. Clin Sci. 2011;121(11):501–507. doi:10.1042/CS20110215
  • Fan F, Ge Y, Lv W, et al. Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology. Front Biosci. 2016;21(7):1427–1463. doi:10.2741/4465
  • Roman RJ, Fan F. 20-HETE: hypertension and Beyond. Hypertension. 2018;72(1):12–18. doi:10.1161/HYPERTENSIONAHA.118.10269
  • Dunn KM, Renic M, Flasch AK, Harder DR, Falck J, Roman RJ. Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2008;295(6):H2455–H2465. doi:10.1152/ajpheart.00512.2008
  • Omura T, Tanaka Y, Miyata N, et al. Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury. Stroke. 2006;37(5):1307–1313. doi:10.1161/01.STR.0000217398.37075.07
  • Kawasaki T, Marumo T, Shirakami K, et al. Increase of 20-HETE synthase after brain ischemia in rats revealed by PET study with 11C-labeled 20-HETE synthase-specific inhibitor. J Cereb Blood Flow Metab. 2012;32(9):1737–1746. doi:10.1038/jcbfm.2012.68
  • Shekhar S, Varghese K, Li M, et al. Conflicting roles of 20-HETE in hypertension and stroke. Int J Mol Sci. 2019;20(18):4500. doi:10.3390/ijms20184500
  • Rudilosso S, Rodríguez-Vázquez A, Urra X, Arboix A. The potential impact of neuroimaging and translational research on the clinical management of lacunar stroke. Int J Mol Sci. 2022;23(3):1497. doi:10.3390/ijms23031497