FBLN5 as One Presumably Prognostic Gene Potentially Modulating Tumor Immune Microenvironment for Renal Clear Cell Carcinoma in Children and Young Adults

References

• Xia C, Dong X, Li H, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chinese Med J. 2022;135(5):584–590. doi:10.1097/CM9.0000000000002108
   PubMed Web of Science ®Google Scholar
• Xu X, Zhu D. Prognostic significance of subclassifying stage pT3a renal tumors with fat invasion: a retrospective study of 99 patients. J Int Med Res. 2021;49(8):3000605211033178. doi:10.1177/03000605211033178
   Web of Science ®Google Scholar
• Aldrink JH, Heaton TE, Dasgupta R, et al. Update on Wilms tumor. J Pediatr Surg. 2019;54(3):390–397. doi:10.1016/j.jpedsurg.2018.09.005
   PubMed Web of Science ®Google Scholar
• Muir TE, Cheville JC, Lager DJ. Metanephric adenoma, nephrogenic rests, and Wilms’ tumor: a histologic and immunophenotypic comparison. Am J Surg Pathol. 2001;25(10):1290–1296. doi:10.1097/00000478-200110000-00010
   PubMed Web of Science ®Google Scholar
• Capitanio U, Bensalah K, Bex A, et al. Epidemiology of Renal Cell Carcinoma. Europ urol. 2019;75(1):74–84. doi:10.1016/j.eururo.2018.08.036
   PubMed Web of Science ®Google Scholar
• Turajlic S, Swanton C, Boshoff C. Kidney cancer: the next decade. J Exp Med. 2018;215(10):2477–2479. doi:10.1084/jem.20181617
   PubMed Web of Science ®Google Scholar
• Motzer RJ. New perspectives on the treatment of metastatic renal cell carcinoma: an introduction and historical overview. oncologist. 2011;16(Suppl S2):1–3. doi:10.1634/theoncologist.2011-S2-01
   PubMedGoogle Scholar
• Hammers H. Immunotherapy in kidney cancer: the past, present, and future. Curr Opinion Urol. 2016;26(6):543–547. doi:10.1097/MOU.0000000000000338
   PubMed Web of Science ®Google Scholar
• Schwartz M, Zhang Y, Rosenblatt JD. B cell regulation of the anti-tumor response and role in carcinogenesis. J Immunother Cancer. 2016;4(1):40. doi:10.1186/s40425-016-0145-x
   PubMedGoogle Scholar
• Klümper N, Ralser DJ, Bawden EG, et al. LAG3 (LAG-3, CD223) DNA methylation correlates with LAG3 expression by tumor and immune cells, immune cell infiltration, and overall survival in clear cell renal cell carcinoma. J Immunother Cancer. 2020;8(1):e000552. doi:10.1136/jitc-2020-000552
   PubMed Web of Science ®Google Scholar
• Bruni D, Angell HK, Galon J. The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy. Nat Rev Cancer. 2020;20(11):662–680. doi:10.1038/s41568-020-0285-7
   PubMed Web of Science ®Google Scholar
• Unterleuthner D, Neuhold P, Schwarz K, et al. Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer. Angiogenesis. 2020;23(2):159–177. doi:10.1007/s10456-019-09688-8
   PubMed Web of Science ®Google Scholar
• Zhuang J, Lu Q, Shen B, et al. TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT. Sci Rep. 2015;5(1):11924. doi:10.1038/srep11924
   PubMedGoogle Scholar
• Barrett RL, Puré E. Puré E: cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy. eLife. 2020;9. doi:10.7554/eLife.57243
   PubMed Web of Science ®Google Scholar
• Argraves WS, Greene LM, Cooley MA, Gallagher WM. Fibulins: physiological and disease perspectives. EMBO Rep. 2003;4(12):1127–1131. doi:10.1038/sj.embor.7400033
   PubMed Web of Science ®Google Scholar
• Albig AR, Schiemann WP. Fibulin-5 antagonizes vascular endothelial growth factor (VEGF) signaling and angiogenic sprouting by endothelial cells. DNA Cell Biol. 2004;23(6):367–379. doi:10.1089/104454904323145254
   PubMed Web of Science ®Google Scholar
• Heo JH, Song JY, Jeong JY, et al. Fibulin-5 is a tumour suppressor inhibiting cell migration and invasion in ovarian cancer. J Clin Pathol. 2016;69(2):109–116. doi:10.1136/jclinpath-2015-203129
   PubMed Web of Science ®Google Scholar
• Hu Z, Ai Q, Xu H, et al. Fibulin-5 is down-regulated in urothelial carcinoma of bladder and inhibits growth and invasion of human bladder cancer cell line 5637. Urol Oncol. 2011;29(4):430–435. doi:10.1016/j.urolonc.2009.06.004
   PubMed Web of Science ®Google Scholar
• Chen X, Song X, Yue W, et al. Fibulin-5 inhibits Wnt/β-catenin signaling in lung cancer. Oncotarget. 2015;6(17):15022–15034. doi:10.18632/oncotarget.3609
   PubMedGoogle Scholar
• Lee YH, Albig AR, Regner M, Schiemann BJ, Schiemann WP. Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism. Carcinogenesis. 2008;29(12):2243–2251. doi:10.1093/carcin/bgn199
   PubMed Web of Science ®Google Scholar
• Topalovski M, Hagopian M, Wang M, Brekken RA. Hypoxia and transforming growth factor β cooperate to induce fibulin-5 expression in pancreatic cancer. J Biol Chem. 2016;291(42):22244–22252. doi:10.1074/jbc.M116.730945
   PubMed Web of Science ®Google Scholar
• Wu A, Kunju LP, Cheng L, Shah RB. Renal cell carcinoma in children and young adults: analysis of clinicopathological, immunohistochemical and molecular characteristics with an emphasis on the spectrum of Xp11.2 translocation-associated and unusual clear cell subtypes. Histopathology. 2008;53(5):533–544. doi:10.1111/j.1365-2559.2008.03151.x
   PubMed Web of Science ®Google Scholar
• Furge KA, Dykema K, Petillo D, et al. Combining differential expression, chromosomal and pathway analyses for the molecular characterization of renal cell carcinoma. Can Urol Assoc J. 2007;1(2 Suppl):S21–S27. doi:10.5489/cuaj.64
   PubMed Web of Science ®Google Scholar
• Kochevar J. A renal cell carcinoma neoplastic antigen detectable by immunohistochemistry is defined by a murine monoclonal antibody. Cancer. 1987;59(12):2031–2036. doi:10.1002/1097-0142(19870615)59:12<2031::AID-CNCR2820591211>3.0.CO;2-0
   PubMed Web of Science ®Google Scholar
• Zhu D, Xu X, Zhang M, Wang T. TPX2 regulated by miR-29c-3p induces cell proliferation in osteosarcoma via the AKT signaling pathway. Oncol Lett. 2022;23(5):143. doi:10.3892/ol.2022.13262
   PubMed Web of Science ®Google Scholar
• Zhu D, Zhu Z, Qi H. NEAT1/microRNA 339-5p/SPI1 axis feedback loop contributes to osteogenic differentiation in acute suppurative osteomyelitis in children. J Inflamm Res. 2023;16:2675–2687. doi:10.2147/JIR.S410339
   PubMed Web of Science ®Google Scholar
• Rigoglio NN, Rabelo ACS, Borghesi J, et al. The tumor microenvironment: focus on extracellular matrix. Adv Exp Med Biol. 2020;1245:1–38. doi:10.1007/978-3-030-40146-7_1
   PubMed Web of Science ®Google Scholar
• Anderson NM, Simon MC. The tumor microenvironment. Curr Biol. 2020;30(16):R921–R925. doi:10.1016/j.cub.2020.06.081
   PubMed Web of Science ®Google Scholar
• Ashraf R, Shah NP. Immune system stimulation by probiotic microorganisms. Crit Rev Food Sci Nutr. 2014;54(7):938–956. doi:10.1080/10408398.2011.619671
   PubMed Web of Science ®Google Scholar
• Ren Z, He Y, Yang Q, et al. A comprehensive analysis of the glutathione peroxidase 8 (GPX8) in human cancer. Front Oncol. 2022;12:812811. doi:10.3389/fonc.2022.812811
   PubMed Web of Science ®Google Scholar
• Obaya AJ, Rua S, Moncada-Pazos A, Cal S. The dual role of fibulins in tumorigenesis. Cancer Lett. 2012;325(2):132–138. doi:10.1016/j.canlet.2012.06.019
   PubMed Web of Science ®Google Scholar