351
Views
5
CrossRef citations to date
0
Altmetric
Original Research

The Impact of an Antibiotic Stewardship Program on the Consumption of Specific Antimicrobials and Their Cost Burden: A Hospital-wide Intervention

ORCID Icon, , ORCID Icon & ORCID Icon
Pages 1701-1709 | Published online: 23 Sep 2020

References

  • Hulscher ME, Grol RP, van der Meer JW. Antibiotic prescribing in hospitals: a social and behavioural scientific approach. Lancet Infect Dis. 2010;10(3):167–175. doi:10.1016/S1473-3099(10)70027-X20185095
  • Gong J, Wang C, Shi S, et al. Highly drug-resistant Salmonella enterica serovar Indiana clinical isolates recovered from broilers and poultry workers with diarrhea in China. Antimicrob Agents Chemother. 2016;60(3):1943–1947. doi:10.1128/AAC.03009-1526824960
  • Byarugaba D. Antimicrobial resistance in developing countries and responsible risk factors. Int J Antimicrob Agents. 2004;24(2):105–110. doi:10.1016/j.ijantimicag.2004.02.01515288307
  • Bonnet V, Dupont H, Glorion S, et al. Influence of bacterial resistance on mortality in intensive care units: a registry study from 2000 to 2013 (IICU Study). J Hosp Infect. 2019;102(3):317–324. doi:10.1016/j.jhin.2019.01.01130659869
  • Smith RA, M’ikanatha NM, Read AF. Antibiotic resistance: a primer and call to action. Health Commun. 2015;30(3):309–314. doi:10.1080/10410236.2014.94363425121990
  • DiazGranados CA, Cardo DM, McGowan JE Jr. Antimicrobial resistance: international control strategies, with a focus on limited-resource settings. Int J Antimicrob Agents. 2008;32(1):1–9. doi:10.1016/j.ijantimicag.2008.03.00218550343
  • Laxminarayan R, Heymann DL. Challenges of drug resistance in the developing world. BMJ. 2012;344:e1567. doi:10.1136/bmj.e156722491075
  • Cox J, Vlieghe E, Mendelson M, et al. Antibiotic stewardship in low-and middle-income countries: the same but different? Clin Microbiol Infect. 2017;23(11):812–818. doi:10.1016/j.cmi.2017.07.01028712667
  • Abbasian H, Hajimolaali M, Yektadoost A, Zartab S. Antibiotic utilization in Iran 2000–2016: pattern analysis and benchmarking with organization for economic co-operation and development countries. J Res Pharm Pract. 2019;8(3):162. doi:10.4103/jrpp.JRPP_19_4231728348
  • Sadatsharifi A, Davarpanah M-A, Namazi S, Mottaghi S, Mahmoudi L. Economic burden of inappropriate empiric antibiotic therapy: a report from Southern Iran. Risk Manag Healthc Policy. 2019;12:339. doi:10.2147/RMHP.S22220031849550
  • O’neill J. Review on Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations. 2014. London: HM Government; 2016.
  • Founou RC, Founou LL, Essack SY, Butaye P. Clinical and economic impact of antibiotic resistance in developing countries: a systematic review and meta-analysis. PLoS One. 2017;12(12):e0189621. doi:10.1371/journal.pone.018962129267306
  • Organization WH. Global Action Plan on Antimicrobial Resistance. 2015:2017
  • Mahmoudi L, Ghouchani M, Mahi-Birjand M, Bananzadeh A, Akbari A. Optimizing compliance with surgical antimicrobial prophylaxis guidelines in patients undergoing gastrointestinal surgery at a referral teaching hospital in southern Iran: clinical and economic impact. Infect Drug Resist. 2019;12:2437. doi:10.2147/IDR.S21272831496756
  • Sharland M, Pulcini C, Harbarth S, et al. Classifying antibiotics in the WHO essential medicines list for optimal use—be AWaRe. Lancet Infect Dis. 2018;18(1):18–20. doi:10.1016/S1473-3099(17)30724-729303731
  • Firouzabadi D, Mahmoudi L. Knowledge, attitude, and practice of health care workers towards antibiotic resistance and antimicrobial stewardship programmes: a cross‐sectional study. J Eval Clin Pract. 2020;26(1):190–196. doi:10.1111/jep.1317731115129
  • CLSI. CLSI supplement M100. Performance Standards for Antimicrobial Susceptibility Testing. Wayne, PA: Clinical and Laboratory Standards Institute; 2017.
  • Wernli D, Jørgensen PS, Harbarth S, et al. Antimicrobial resistance: the complex challenge of measurement to inform policy and the public. PLoS Med. 2017;14(8):e1002378. doi:10.1371/journal.pmed.100237828817562
  • de Kraker MEA, Stewardson AJ, Harbarth S. Will 10 million people die a year due to antimicrobial resistance by 2050? PLoS Med. 2016;13(11):e1002184. doi:10.1371/journal.pmed.100218427898664
  • Simpson SA, Wood F, Butler CC. General practitioners’ perceptions of antimicrobial resistance: a qualitative study. J Antimicrob Chemother. 2006;59(2):292–296. doi:10.1093/jac/dkl46717110392
  • Ozkurt Z, Erol S, Kadanali A, Ertek M, Ozden K, Tasyaran MA. Changes in antibiotic use, cost and consumption after an antibiotic restriction policy applied by infectious disease specialists. Jpn J Infect Dis. 2005;58(6):338.16377863
  • Lemmen SW, Becker G, Frank U, Daschner FD. Influence of an infectious disease consulting service on quality and costs of antibiotic prescriptions in a university hospital. Scand J Infect Dis. 2001;33(3):219–221. doi:10.1080/0036554015106092311303814
  • Marquet K, Liesenborgs A, Bergs J, Vleugels A, Claes N. Incidence and outcome of inappropriate in-hospital empiric antibiotics for severe infection: a systematic review and meta-analysis. Crit Care. 2015;19(1):63. doi:10.1186/s13054-015-0795-y25888181
  • Barlam TF, Cosgrove SE, Abbo LM, et al. Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis. 2016;62(10):e51–e77. doi:10.1093/cid/ciw11827080992
  • White, Jr. AC, Atmar RL, Wilson J, Cate TR, Stager CE, Greenberg SB. Effects of requiring prior authorization for selected antimicrobials: expenditures, susceptibilities, and clinical outcomes. Clin Infect Dis. 1997;25(2):230–239. doi:10.1086/5145459332517
  • Kabbani S, Baggs J, Hicks LA, Srinivasan A. Potential impact of antibiotic stewardship programs on overall antibiotic use in adult acute-care hospitals in the United States. Infect Control Hosp Epidemiol. 2018;39(3):373–376. doi:10.1017/ice.2017.27329444725
  • Saxena S, Priyadarshi M, Saxena A, Singh R. Antimicrobial consumption and bacterial resistance pattern in patients admitted in ICU at a tertiary care center. J Infect Public Health. 2019;12(5):695–699. doi:10.1016/j.jiph.2019.03.01431000490
  • Scheetz MH, Knechtel SA, Malczynski M, Postelnick MJ, Qi C. Increasing incidence of linezolid-intermediate or-resistant, vancomycin-resistant Enterococcus faecium strains parallels increasing linezolid consumption. Antimicrob Agents Chemother. 2008;52(6):2256–2259. doi:10.1128/AAC.00070-0818391028
  • Ramírez E, Gómez-Gil R, Borobia AM, et al. Improving linezolid use decreases the incidence of resistance among Gram-positive microorganisms. Int J Antimicrob Agents. 2013;41(2):174–178. doi:10.1016/j.ijantimicag.2012.10.01723276501
  • Meyer E, Schwab F, Schroeren-Boersch B, Gastmeier P. Increasing consumption of MRSA-active drugs without increasing MRSA in German ICUs. Intensive Care Med. 2011;37(10):1628. doi:10.1007/s00134-011-2335-921858520
  • Bai B, Hu K, Zeng J, et al. Linezolid consumption facilitates the development of linezolid resistance in Enterococcus faecalis in a tertiary-care hospital: a 5-year surveillance study. Microb Drug Resist. 2019;25(6):791–798. doi:10.1089/mdr.2018.000530762463
  • Bizo PT, Dumitras D, Popa A. Evaluation of restricted antibiotic use in a hospital in Romania. Int J Clin Pharm. 2015;37(3):452–456. doi:10.1007/s11096-015-0096-125832678
  • Dik J-WH, Hendrix R, Friedrich AW, et al. Cost-minimization model of a multidisciplinary antibiotic stewardship team based on a successful implementation on a urology ward of an academic hospital. PLoS One. 2015;10(5):e0126106. doi:10.1371/journal.pone.012610625955494
  • Durvasula R, Kelly J, Schleyer A, Anawalt BD, Somani S, Dellit TH. Standardized review and approval process for high-cost medication use promotes value-based care in a large academic medical system. Am Health Drug Benefits. 2018;11(2):65.29915640
  • Lanbeck P, Tennvall GR, Resman F. A cost analysis of introducing an infectious disease specialist-guided antimicrobial stewardship in an area with relatively low prevalence of antimicrobial resistance. BMC Health Serv Res. 2016;16(1):311. doi:10.1186/s12913-016-1565-527464508
  • Hagiwara D, Sato K, Miyazaki M, et al. The impact of earlier intervention by an antimicrobial stewardship team for specific antimicrobials in a single weekly intervention. Int J Infect Dis. 2018;77:34–39. doi:10.1016/j.ijid.2018.09.02530292892
  • Kimura T, Uda A, Sakaue T, et al. Long-term efficacy of comprehensive multidisciplinary antibiotic stewardship programs centered on weekly prospective audit and feedback. Infection. 2018;46(2):215–224. doi:10.1007/s15010-017-1099-829134582
  • Stultz JS, Arnold SR, Shelton CM, Bagga B, Lee KR. Antimicrobial stewardship impact on Pseudomonas aeruginosa susceptibility to meropenem at a tertiary pediatric institution. Am J Infect Control. 2019;47(12):1513–1515. doi:10.1016/j.ajic.2019.05.00131253550
  • Fernández-Morato J, Moro L, Sancho J, et al. An antimicrobial stewardship program reduces antimicrobial therapy duration and hospital stay in surgical wards. Rev Esp Quimioter. 2016;29(3):119–122.27167764
  • Sepasian A The Impact of Infectious Disease Specialist’s Consultation on Antibiotic Prescribing in Shahid Faghihi Hospital [PharmD Thesis]. Shiraz: Shiraz University of Medical Sciences, Faculty of Pharmacy; 2019.