Reduced Intellectual Ability in Offspring Born from Preeclamptic Mothers: A Prospective Cohort Study

References

• Abalos E, Cuesta C, Grosso AL, Chou D, Say L. Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol. 2013;170:1–7. doi:10.1016/j.ejogrb.2013.05.00523746796
   PubMed Web of Science ®Google Scholar
• Eiriksdottir VH, Valdimarsdottir UA, Asgeirsdottir TL, et al. Pregnancy-induced hypertensive disorders before and after a national economic collapse: a population based cohort study. PLoS One. 2015;10:e0138534.26379126
   PubMed Web of Science ®Google Scholar
• Ozeki A, Tani K, Takahashi H, et al. Preeclamptic patient-derived circulating cell-free DNA activates the production of inflammatory cytokines via toll-like receptor 9 signalling in the human placenta. J Hypertens. 2019;37:2452–2460. doi:10.1097/HJH.000000000000220831385869
   PubMed Web of Science ®Google Scholar
• Lv LJ, Wu LL, Wen JY, et al. Excessive umbilical cord coiling confers risk of elevated nocturnal blood pressure and severe/early-onset preeclampsia. J Hypertens. 2019;37:187–196.30015757
   PubMed Web of Science ®Google Scholar
• Debbie AL, Corrie M-W, Abigail F, et al. Cardiovascular biomarkers and vascular function during childhood in the offspring of mothers with hypertensive disorders of pregnancy: findings from the Avon Longitudinal Study of Parents and Children. Eur Heart J. 2012;33:335–345.21862461
   PubMed Web of Science ®Google Scholar
• Byberg KK, Øymar K, Eide GE, Forman MR, Júlíusson PB. Exposure to preeclampsia in utero affects growth from birth to late childhood dependent on child’s sex and severity of exposure: follow-up of a nested case-control study. PLoS One. 2017;12:e0176627. doi:10.1371/journal.pone.017662728486480
   PubMed Web of Science ®Google Scholar
• Heikura U, Hartikainen AL, Nordstrom T, Pouta A, Taanila A, Jarvelin MR. Maternal hypertensive disorders during pregnancy and mild cognitive limitations in the offspring. Paediatr Perinat Epidemiol. 2013;27:188–198.23374064
   PubMed Web of Science ®Google Scholar
• Rätsep MT, Hickman AF, Croy BA. Impacts of placental growth factor and preeclampsia on brain development, behavior, and cognition. Placenta. 2016;48:S40–D46. doi:10.1016/j.placenta.2016.02.00126880207
   PubMed Web of Science ®Google Scholar
• Rätsep MT, Hickman AF, Maser B, et al. Impact of preeclampsia on cognitive function in the offspring. Behav Brain Res. 2016;302:175–181. doi:10.1016/j.bbr.2016.01.03026784561
   PubMed Web of Science ®Google Scholar
• Leversen KT, Sommerfelt K, Ronnestad A, et al. Prediction of neurodevelopmental and sensory outcome at 5 years in Norwegian children born extremely preterm. Pediatrics. 2011;127:e630–638. doi:10.1542/peds.2010-100121321031
   PubMed Web of Science ®Google Scholar
• Ehrenstein V, Rothman KJ, Pedersen L, Hatch EE, Sorensen HT. Pregnancy-associated hypertensive disorders and adult cognitive function among Danish conscripts. Am J Epidemiol. 2009;170(8):1025–1031. doi:10.1093/aje/kwp22319726495
   PubMed Web of Science ®Google Scholar
• Tuovinen S, Eriksson JG, Kajantie E, et al. Maternal hypertensive disorders in pregnancy and self-reported cognitive impairment of the offspring 70 years later: the Helsinki Birth Cohort Study. Am J Obstet Gynecol. 2013;208:200.e201–209. doi:10.1016/j.ajog.2012.12.017
   Web of Science ®Google Scholar
• Gudnadottir TA, Bateman BT, Hernadez-Diaz S, Luque-Fernandez MA, Valdimarsdottir U, Zoega H. Body mass index, smoking and hypertensive disorders during pregnancy: a population based case-control study. PLoS One. 2016;11:e0152187. doi:10.1371/journal.pone.015218727010734
   PubMed Web of Science ®Google Scholar
• Maher GM, O’Keeffe GW, Kearney PM, et al. Association of hypertensive disorders of pregnancy with risk of neurodevelopmental disorders in offspring: a systematic review and meta-analysis. JAMA Psychiat. 2018;75:809–819. doi:10.1001/jamapsychiatry.2018.0854
   PubMed Web of Science ®Google Scholar
• Roberts JM. Endothelial dysfunction in preeclampsia. Semin Reprod Endocrinol. 1998;16(01):5–15. doi:10.1055/s-2007-10162489654603
   PubMedGoogle Scholar
• Chau K, Hennessy A, Makris A. Placental growth factor and pre-eclampsia. J Hum Hypertens. 2017;31(12):782–786. doi:10.1038/jhh.2017.6129115294
   PubMed Web of Science ®Google Scholar
• Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: pathophysiology, challenges, and perspectives. Circ Res. 2019;124:1094–1112.30920918
   PubMed Web of Science ®Google Scholar
• Finkelstein JD, Martin JJ. Homocysteine. Int J Biochem Cell Biol. 2000;32(4):385–389. doi:10.1016/S1357-2725(99)00138-710762063
   PubMed Web of Science ®Google Scholar
• Dubchenko EA, Ivanov AV, Boiko AN, Spirina NN, Gusev EI, Kubatiev AA. Hyperhomocysteinemia and endothelial dysfunction in patients with cerebral vascular and autoimmune diseases. Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119:133–138. doi:10.17116/jnevro2019119111133
   Google Scholar
• Lentz SR, Rodionov RN, Dayal S. Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk: the potential role of ADMA. Atheroscler Suppl. 2003;4:61–65. doi:10.1016/S1567-5688(03)00035-714664904
   PubMed Web of Science ®Google Scholar
• Musolino PL, Gong Y, Snyder JM, et al. Brain endothelial dysfunction in cerebral adrenoleukodystrophy. Brain. 2015;138:3206–3220.26377633
   PubMed Web of Science ®Google Scholar
• Deng F, Wang S, Xu R, Yu W, Wang X, Zhang L. Endothelial microvesicles in hypoxic hypoxia diseases. J Cell Mol Med. 2018;22(8):3708–3718. doi:10.1111/jcmm.13671
   Web of Science ®Google Scholar
• Picker JD, Coyle JT. Do maternal folate and homocysteine levels play a role in neurodevelopmental processes that increase risk for schizophrenia? Harv Rev Psychiatry. 2005;13:197–205. doi:10.1080/1067322050024337216126606
   PubMed Web of Science ®Google Scholar
• Huseynova SA, Panakhova NF, Hajiyeva AS, Orujova PA, Mukhtarova SN, Agayeva GT. Endothelial dysfunction and developmental outcomes of very low birth weight newborns with hypoxic encephalopathy. J Pak Med Assoc. 2017;67:1857–1863.29256530
   PubMed Web of Science ®Google Scholar
• Mol BWJ, Roberts CT, Thangaratinam S, Magee LA, de Groot CJM, Hofmeyr GJ. Pre-eclampsia. Lancet. 2016;387:999–1011. doi:10.1016/S0140-6736(15)00070-726342729
   PubMed Web of Science ®Google Scholar
• Li HT, Ye RW, Pei LJ, Ren AG, Zheng XY, Liu JM. Cesarean delivery on maternal request and childhood intelligence: a cohort study. Chin Med J (Engl). 2011;124:3982–3987.22340328
   PubMed Web of Science ®Google Scholar
• Small HY, Currie GE, Delles C. Prostasin, proteases, and preeclampsia. J Hypertens. 2016;34:193–195. doi:10.1097/HJH.000000000000082826682786
   PubMed Web of Science ®Google Scholar
• Duley L. The global impact of pre-eclampsia and eclampsia. Semin Perinatol. 2009;33:130–137.19464502
   PubMed Web of Science ®Google Scholar
• Phipps EA, Thadhani R, Benzing T, Karumanchi SA. Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol. 2019;15:275–289.30792480
   PubMed Web of Science ®Google Scholar
• Chaiworapongsa T, Chaemsaithong P 1, Yeo L, Romero R. Pre-eclampsia part 1: current understanding of its pathophysiology. Nat Rev Nephrol. 2014;10:466–480.25003615
   PubMed Web of Science ®Google Scholar
• Tomimatsu T, Mimura K, Endo M, Kumasawa K, Kimura T. Pathophysiology of preeclampsia: an angiogenic imbalance and long-lasting systemic vascular dysfunction. Hypertens Res. 2017;40:305–310.27829661
   PubMed Web of Science ®Google Scholar
• Welch GN, Upchurch GR Jr, Loscalzo J. Homocysteine, oxidative stress, and vascular disease. Hosp Pract. 1997;32:81–2,85, 88–92. doi:10.1080/21548331.1997.11443510
   Web of Science ®Google Scholar
• Sun LJ, Xu GF, Lv M, Zhou H, Huang HF, Luo Q. Predictive value of maternal serum biomarkers for preeclampsia and birth weight: a case-control study in Chinese pregnant women. J Womens Health (Larchmt). 2018;27:1519–1524. doi:10.1089/jwh.2017.679329920141
   PubMed Web of Science ®Google Scholar
• Maged AM, Saad H, Meshaal H, et al. Maternal serum homocysteine and uterine artery doppler as predictors of preeclampsia and poor placentation. Arch Gynecol Obstet. 2017;296:475–482. doi:10.1007/s00404-017-4457-y28689278
   PubMed Web of Science ®Google Scholar
• Bernardi FC, Felisberto F, Vuolo F, et al. Oxidative damage, inflammation, and toll-like receptor 4 pathway are increased in preeclamptic patients: a case-control study. Oxid Med Cell Longev. 2012;2012:636419. doi:10.1155/2012/63641922792416
   PubMed Web of Science ®Google Scholar
• Tawakol A, Omland T, Gerhard M, Wu JT, Creager MA. Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation. 1997;95:1119–1121. doi:10.1161/01.CIR.95.5.11199054838
   PubMed Web of Science ®Google Scholar
• Woo KS, Chook P, Lolin YI, et al. Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans. Circulation. 1997;96:2542–2544. doi:10.1161/01.CIR.96.8.25429355891
   PubMed Web of Science ®Google Scholar
• Massy ZA, Ceballos I, Chadefaux-Vekemens B, et al. Homocyst(e)ine, oxidative stress, and endothelium function in uremic patients. Kidney Int Suppl. 2001;78:S243–S245. doi:10.1046/j.1523-1755.2001.59780243.x11169019
   PubMed Web of Science ®Google Scholar
• Zeng Y, Li M, Chen Y, Wang S. Homocysteine, endothelin-1 and nitric oxide in patients with hypertensive disorders complicating pregnancy. Int J Clin Exp Pathol. 2015;8:15275–15279.26823880
   PubMed Web of Science ®Google Scholar
• Wang XC, Sun WT, Yu CM, et al. ER stress mediates homocysteine-induced endothelial dysfunction: modulation of IKCa and SKCa channels. Atherosclerosis. 2015;242:191–198. doi:10.1016/j.atherosclerosis.2015.07.02126204495
   PubMed Web of Science ®Google Scholar
• Sengupta A, Das U, Manna K, et al. An association study of severity of intellectual disability with peripheral biomarkers of disabled children in a rehabilitation home, Kolkata, India. Sci Rep. 2019;9:13652.31541143
   PubMed Web of Science ®Google Scholar
• Smith AD, Refsum H. Homocysteine, B vitamins, and cognitive impairment. Annu Rev Nutr. 2016;36:211–239. doi:10.1146/annurev-nutr-071715-05094727431367
   PubMed Web of Science ®Google Scholar
• Sachdev PS. Homocysteine and brain atrophy. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29:1152–1161. doi:10.1016/j.pnpbp.2005.06.02616102882
   PubMed Web of Science ®Google Scholar
• Murphy MM, Fernandez-Ballart JD, Molloy AM, Canals J. Moderately elevated maternal homocysteine at preconception is inversely associated with cognitive performance in children 4 months and 6 years after birth. Matern Child Nutr. 2017;13:e12289.
   Web of Science ®Google Scholar
• Dayan N, Kaur A, Elharram M, Rossi AM, Pilote L. Impact of preeclampsia on long-term cognitive function. Hypertension. 2018;72:1374–1380. doi:10.1161/HYPERTENSIONAHA.118.1132030571227
   PubMed Web of Science ®Google Scholar
• Sverrisson FA, Bateman BT, Aspelund T, Skulason S, Zoega H. Preeclampsia and academic performance in children: a nationwide study from Iceland. PLoS One. 2018;13:e0207884.30462738
   PubMed Web of Science ®Google Scholar
• Javadi EHS, Ghorbali F, Sarookhani M, Javadi A, Mashrabi O. The relationship between the level of homocysteine in mother’s serum and the intensity of preeclampsia. Life Sci J. 2012;9:1247–1249.
   Google Scholar