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Review

Intersection of chronic pain treatment and opioid analgesic misuse: causes, treatments, and policy strategies

, , , , &
Pages 145-162 | Published online: 18 Aug 2011

References

  • GilsonAMRyanKMJoransonDEDahlJLA reassessment of trends in the medical use and abuse of opioid analgesics and implications for diversion control: 1997–2002J Pain Symptom Manage20042817618815276196
  • ComptonWMVolkowNDMajor increases in opioid analgesic abuse in the United States: concerns and strategiesDrug Alcohol Depend20068110310716023304
  • Drug Abuse Warning NetworkHealth and Human Services (DHHS)National Estimates of Drug-related Emergency Department VisitsWashington, DCdepartment of Health and Human Services2004
  • ElliottAMSmithBHPennyKISmithWCChambersWAThe epidemiology of chronic pain in the communityLancet19993541248125210520633
  • SchappertSMNational Ambulatory Medical Care Survey: 1989-summaryVital Health Stat 1319921101801376543
  • StewartWFRicciJACheeEMorgansteinDLiptonRLost productive time and cost due to common pain conditions in the US workforceJAMA20032902443245414612481
  • TurkDCClinical effectiveness and cost-effectiveness of treatments for patients with chronic painClin J Pain20021835536512441829
  • JoransonDERyanKMGilsonAMDahlJLTrends in medical use and abuse of opioid analgesicsJAMA20002831710171410755497
  • IvesTJChelminskiPRHammett-StablerCAPredictors of opioid misuse in patients with chronic pain: a prospective cohort studyBMC Health Serv Res200664616595013
  • ReigerDAFarmerMERaeDSComorbidity of mental disorders with alcohol and other drug abuseJAMA1990264251125182232018
  • FishbainDAColeBLewisJRosomoffHLRosomoffRSWhat percentage of chronic nonmalignant pain patients exposed to chronic opioid analgesic therapy develop abuse/addiction and/or aberrant drug-related behaviors? A structured evidence-based reviewPain Med2008944445918489635
  • RosenblumAJosephHFongCKipnisSClelandCPortenoyRKPrevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilitiesJAMA20032892370237812746360
  • LarsonMJPaasche-OrlowMChengDMPersistent pain is associated with substance use after detoxification: a prospective cohort analysisAddiction200710275276017506152
  • OkieSA food of opioids, a rising tide of deathsN Engl J Med20103631981198521083382
  • MelzackRFrom the gate to the neuromatrixPain19996S121S12610491980
  • TurkDCOkifujiAPsychological factors in chronic pain: evolution and revolutionJ Consult Clin Psychol20027067869012090376
  • EisenbergerNILiebermanMDWilliamsKDDoes rejection hurt? An fMRI study of social exclusionScience200330229029214551436
  • WachholtzABPearceMJKoenigHGExploring the relationship between spirituality, coping, and painJ Behav Med20073031131817541817
  • BairMRobinsonRKatonWKroenkeKDepression and pain comorbidity: a literature reviewArch Intern Med20031632433244514609780
  • ZelmanDCHowlandEWNicholsSNCleelandCSThe effects of induced mood on laboratory painPain1991461051111896201
  • EdwardsRRHaythornthwaiteJASullivanMJFillingimRBCatastrophizing as a mediator of sex differences in pain: differential effects for daily pain versus laboratory-induced painPain200411133534115363877
  • KeefeFJLefebvreJCMaixnerWJrANS, Caldwell DS. Self-efficacy for arthritis pain: relationship to perception of thermal laboratory pain stimuliArthritis Care Res1997101771849335629
  • AdamsEHBreinerSCiceroTJA comparison of the abuse liability of tramadol, NSAIDs, and hydrocodone in patients with chronic painJ Pain Symptom Manage20063146547616716877
  • MartellBAO’ConnorPGKernsRDSystematic review: opioid treatment for chronic back pain: prevalence, efficacy, and association with addictionAnn Intern Med200714611612717227935
  • HojstedJSjogrenPAddiction to opioids in chronic pain patients: a literature reviewEur J Pain20071149051817070082
  • MiottoKComptonPLingWConollyMDiagnosing addictive disease in chronic pain patientsPsychosomatics1996372232358849499
  • ComptonPDarakjianJMiottoKScreening for addiction in patients with chronic pain and “problematic” substance use: evaluation of a pilot assessment toolJ Pain Symptom Manage1998163553639879160
  • PortenoyRKHagenNABreakthrough pain: definition, prevalence and characteristicsPain1990412732811697056
  • BrodnerRATaubAChronic pain exacerbated by long-term narcotic use in patients with nonmalignant disease: clinical syndrome and treatmentMt Sinai J Med19784523323726869
  • MathewNTKurmanRPerezFDrug induced refractory headache – clinical features and managementHeadache1990306346382272811
  • PortenoyRKChronic opioid therapy in nonmalignant painJ Pain Symptom Manage19905S46S621969892
  • DunbarSAKatzNPChronic opioid therapy for nonmalignant pain in patients with a history of substance abuse: report of 20 casesJ Pain Symptom Manage1996111631718851374
  • Perdue PharmaDrug Safety and Risk Management Advisory Committee2009 Available from: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/Drug-SafetyandRiskManagementAdvisoryCommittee/UCM164897.pdfAccessed July 12, 2011
  • LeeSParkYHanEThebaine in hair as a marker for chronic use of illegal opium poppy substancesForensic Sci Int201120411511820558018
  • HahmETKimYLeeJJChoYWGABAergic synaptic response and its opioidergic modulation in periaqueductal gray neurons of rats with neuropathic painBMC Neurosci2011124121569381
  • CorbettADHendersonGMcKnightATPatersonSJ75 years of opioid research: the exciting but vain quest for the Holy GrailBr J Pharmacol2006147Suppl 1S153S16216402099
  • OssipovMHLaiJKingTAntinociceptive and nociceptive actions of opioidsJ Neurobiol20046112614815362157
  • MollereauCParmentierMMailleuxPORL1, a novel member of the opioid receptor family. Cloning, functional expression and localizationFEBS Lett199434133388137918
  • ChevillardLMechanisms of respiratory insufficiency induced by methadone overdose in ratsAddict Biol200915628020002023
  • ArvidssonURiedlMChakrabartiSDistribution and targeting of a mu-opioid receptor (MOR1) in brain and spinal cordJ Neurosci1995155 Pt 1332833417751913
  • HolzerPOpioid receptors in the gastrointestinal tractRegul Pept2009155111719345246
  • FurlanADSandovalJAMailis-GagnonATunksEOpioids for chronic noncancer pain: a meta-analysis of effectiveness and side effectsCMAJ20061741589159416717269
  • GlassPSJhaveriRMSmithLRComparison of potency and duration of action of nalmefene and naloxoneAnesth Analg1994785365418109774
  • MooreRAMcQuayHJPrevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioidsArthritis Res Ther20057R1046R105116207320
  • EisenbergEMcNicolEDCarrDBEfficacy of mu-opioid agonists in the treatment of evoked neuropathic pain: systematic review of randomized controlled trialsEur J Pain20061066767616337151
  • DaniellHWOpioid endocrinopathy in women consuming prescribed sustained-action opioids for control of nonmalignant painJ Pain20089283617936076
  • AngstMSClarkJDOpioid-induced hyperalgesia: a qualitative systematic reviewAnesthesiology200610457058716508405
  • VadiveluNMitraSHinesRLPeripheral opioid receptor agonists for analgesia: a comprehensive reviewJ Opioid Manag20117556821434585
  • SamWJMacKeySCLotschJDroverDRMorphine and its metabolites after patient-controlled analgesia: considerations for respiratory depressionJ Clin Anesth20112310210621377072
  • HerveraANegreteRLeanezSMartin-CamposJMPolOPeripheral effects of morphine and expression of mu-opioid receptors in the dorsal root ganglia during neuropathic pain: nitric oxide signalingMol Pain201172521486477
  • KirchheinerJSchmidtHTzvetkovMPharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplicationPharmacogenomics J2007725726516819548
  • FosterDUptonRChristrupLPopperLPharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgeryAnn Pharmacother2008421380138718728103
  • JumbelicMIDeaths with transdermal fentanyl patchesAm J Forensic Med Pathol201031182119918162
  • DhallaIAMamdaniMMSivilottiMLKoppAQureshiOJuurlinkDNPrescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodoneCMAJ200918189189619969578
  • WardJBellJMattickRPMethadone maintenance treatment and other opioid replacement therapiesMethadone Maintenance Therapy for Opioid Dependence: A Guide to Appropriate UseWardJMattickRPHallWSydney, AustraliaHarwood Academic Publishers1996
  • BrownRKrausCFlemingMReddySMethadone: applied pharmacology and use as adjunctive treatment in chronic painPostgrad Med J20048065465915537850
  • BlindermanCDSekineRZhangBNillsonMShaiovaLMethadone as an analgesic for patients with chronic pain in methadone maintenance treatment programs (MMTPs)J Opioid Manag2009510711419507807
  • RhodinAGronbladhLNilssonLHGordhTMethadone treatment of chronic non-malignant pain and opioid dependence – a long-term follow-upEur J Pain20061027127815972261
  • KrantzMJHeterogeneous impact of methadone on the QTc interval: what are the practical implications?J Addict Dis2008275919042586
  • KrantzMJMartinJStimmelBMehtaDHaigneyMCQTc interval screening in methadone treatmentAnn Intern Med200915038739519153406
  • MartellBAArnstenJHRayBGourevitchMNThe impact of methadone induction on cardiac conduction in opiate usersAnn Intern Med200313915415512859171
  • CrucianiRASekineRHomelPMeasurement of QTc in patients receiving chronic methadone therapyJ Pain Symptom Manage20052938539115857742
  • BruceRDPharmacokinetic drug interactions between opioid agonist therapy and antiretroviral medications: implications and management for clinical practiceJ Acquir Immune Defic Syndr20064156357216652030
  • PerretGDeglonJJKreekMJHoALaHRLethal methadone intoxications in Geneva, Switzerland, from 1994 to 1998Addiction2000951647165311219368
  • MattickRPBreenCKimberJDavoliMMethadone maintenance therapy versus no opioid replacement therapy for opioid dependenceCochrane Database Syst Rev20032CD00220912804430
  • CooperJRIncluding narcotic addiction treatment in an office-based practiceJAMA1995273161916207745777
  • NovickDMJosephHSalsitzEAOutcomes of treatment of socially rehabilitated methadone maintenance patients in physicians’ offices (medical maintenance): follow-up at three and a half to nine and a fourth yearsJ Gen Intern Med199491271308195910
  • NovickDMPascarelliEFJosephHMethadone maintenance patients in general medical practice. A preliminary reportJAMA1988259329933023373662
  • GrahamNAMerloLJGoldbergerBAGoldMSMethadone- and heroin-related deaths in FloridaAm J Drug Alcohol Abuse20083434735318428077
  • FudalaPJYuEMacfaddenWBoardmanCChiangCNEffects of buprenorphine and naloxone in morphine-stabilized opioid addictsDrug Alcohol Depend199850189589267
  • KuhlmanJJJrLevineBJohnsonREFudalaPJConeEJRelationship of plasma buprenorphine and norbuprenorphine to withdrawal symptoms during dose induction, maintenance and withdrawal from sublingual buprenorphineAddiction1998935495599684393
  • AmassLKamienJBMikulichSKThrice-weekly supervised dosing with the combination buprenorphine-naloxone tablet is preferred to daily supervised dosing by opioid-dependent humansDrug Alcohol Depend20016117318111137282
  • PetryNMBickelWKBadgerGJExamining the limits of the buprenorphine interdosing interval: daily, every-third-day and every-fifth-day dosing regimensAddiction20019682383411399214
  • WalshSLPrestonKLStitzerMLConeEJBigelowGEClinical pharmacology of buprenorphine: ceiling effects at high dosesClin Pharmacol Ther1994555695808181201
  • WalshSLPrestonKLBigelowGEStitzerMLAcute administration of buprenorphine in humans: partial agonist and blockade effectsJ Pharmacol Exp Ther19952743613727542336
  • LangeWRFudalaPJDaxEMJohnsonRESafety and side-effects of buprenorphine in the clinical management of heroin addictionDrug Alcohol Depend19902619282209411
  • HuestisMAUmbrichtAPrestonKLSafety of buprenorphine: no clinically relevant cardio-respiratory depression at high IV dosesProblems of Drug DependenceHarrisLSWashington, DCUS Government Printing Office1999
  • PergolizziJBogerRHBuddKOpioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone)Pain Pract2008828731318503626
  • BallantyneJCLaForgeKSOpioid dependence and addiction during opioid treatment of chronic painPain200712923525517482363
  • JohnsonREFudalaPJPayneRBuprenorphine: considerations for pain managementJ Pain Symptom Manage20052929732615781180
  • LingWCharuvastraCCollinsJFBuprenorphine maintenance treatment of opiate dependence: a multicenter, randomized clinical trialAddiction1998934754869684386
  • FiellinDAPantalonMVPakesJPO’ConnorPGChawarskiMSchottenfeldRSTreatment of heroin dependence with buprenorphine in primary careAm J Drug Alcohol Abuse20022823124112014814
  • McDiarmidTMacklerLSchneiderDMClinical inquiries. What is the addiction risk associated with tramadol?J Fam Pract200554727315623411
  • KroenkeKKrebsEEBairMJPharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviewsGen Hosp Psychiatry20093120621919410099
  • GonzalezGOlivetoAKostenTRCombating opiate dependence: a comparison among the available pharmacological optionsExpert Opin Pharmacother2004571372515102558
  • SilvermanSMOpioid induced hyperalgesia: clinical implications for the pain practitionerPain Physician20091267968419461836
  • KasimcanOKaptanHEfficacy of gabapentin for radiculopathy caused by lumbar spinal stenosis and lumbar disk herniaNeurol Med Chir (Tokyo)2010501070107321206180
  • UcakAOnanBSenHSelcukITuranAYilmazATThe effects of gabapentin on acute and chronic postoperative pain after coronary artery bypass graft surgeryJ Cardiothorac Vasc Anesth1112011 [Epub ahead of print]
  • FolkessonAHonorePHAndersenLMKristensenPBjerrumOJLow dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studiesJ Neural Transm20101171377138520890617
  • CroffordLJRowbothamMCMeasePJPregabalin for the treatment of fibromyalgia syndrome: results of a randomized, doubleblind, placebo-controlled trialArthritis Rheum2005521264127315818684
  • ArnoldLMRussellIJDiriEWA 14-week, randomized, double-blinded, placebo-controlled monotherapy trial of pregabalin in patients with fibromyalgiaJ Pain2008979280518524684
  • CroffordLJMeasePJSimpsonSLFibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): a 6-month, double-blind, placebo-controlled trial with pregabalinPain200813641943118400400
  • MeasePJRussellIJArnoldLMA randomized, double-blind, placebo-controlled, phase III trial of pregabalin in the treatment of patients with fibromyalgiaJ Rheumatol20083550251418278830
  • ReclaJMNew and emerging therapeutic agents for the treatment of fibromyalgia: an updateJ Pain Res201038910321197313
  • PDR Network LLCAvailable from: http://www.pdr.net/drugpages/productlabeling.aspx?mpcode=62950900Accessed July 13, 2011
  • FilipettoFAZippCPCorenJSPotential for pregabalin abuse or diversion after past drug-seeking behaviorJ Am Osteopath Assoc201011060560721068226
  • ArnoldLMLuYCroffordLJA double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorderArthritis Rheum2004502974298415457467
  • ArnoldLMRosenAPritchettYLA randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorderPain200511951516298061
  • ChappellASBradleyLAWiltseCDetkeMJD’SouzaDNSpaethMA six-month double-blind, placebo-controlled, randomized clinical trial of duloxetine for the treatment of fibromyalgiaInt J Gen Med200919110220428412
  • MeasePJRussellIJKajdaszDKLong-term safety, tolerability, and efficacy of duloxetine in the treatment of fibromyalgiaSemin Arthritis Rheum20103945446419152958
  • RussellIJMeasePJSmithTREfficacy and safety of duloxetine for treatment of fibromyalgia in patients with or without major depressive disorder: results from a 6-month, randomized, double-blind, placebo-controlled, fixed-dose trialPain200813643244418395345
  • ArnoldLMClauwDJWohlreichMMEfficacy of duloxetine in patients with fibromyalgia: pooled analysis of 4 placebo-controlled clinical trialsPrim Care Companion J Clin Psychiatry20091123724419956462
  • GredenJFDuloxetine and milnacipranSchatzbergAFNemeroffCBEssentials of Clinical Psychopharmacology2nd edArlington, VAAmerican Psychiatric Publishing Inc2006
  • ShutoSOnoSHaseYSynthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide, an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonistJ Med Chem199639484448528941398
  • NebelMBGracelyRHNeuroimaging of fibromyalgiaRheum Dis Clin North Am20093531332719647145
  • NagaokaSOhnoMSekiguchiAAn open-label clinical trial of milnacipran in fibromyalgia syndrome with co-morbid depressive symptomsInt Clin Psychiatry Clin Pract200484751
  • BrancoJCZachrissonOPerrotSMainguyYA European multicenter randomized double-blind placebo-controlled monotherapy clinical trial of milnacipran in treatment of fibromyalgiaJ Rheumatol20103785185920156949
  • VittonOGendreauMGendreauJKranzlerJRaoSGA double-blind placebo-controlled trial of milnacipran in the treatment of fibromyalgiaHum Psychopharmacol200419Suppl 1S27S3515378666
  • DharmshaktuPTayalVKalraBSEfficacy of antidepressants as analgesics: a reviewJ Clin Pharmacol3172011 [Epub ahead of print]
  • McQuayHJTramérMNyeBACarrollDWiffenPJMooreRAA systematic review of antidepressants in neuropathic painPain1996682172279121808
  • MeliefEJMiyatakeMBruchasMRChavkinCLigand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signalingProc Natl Acad Sci U S A2010107116081161320534436
  • ChavkinCThe therapeutic potential of kappa-opioids for treatment of pain and addictionNeuropsychopharmacology20113636937021116263
  • LiXYKoHGChenTAlleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortexScience20103301400140421127255
  • ProchaskaJODiClementeCCToward a comprehensive model of changeMillerWHeatherNTreating Addictive Behavior: Processes of ChangeNew York, NYPlenum Press1986
  • SavageSAssessment for addiction in pain-treatment settingsClin J Pain200218S28S3812479252
  • EcclestonCRole of psychology in pain managementBr J Anaesth20018714415211460803
  • RounsavilleBJCarrollKMIndividual psychotherapy for drug abusersLowinsohnJRuizPMillerRComprehensive Textbook of Substance AbuseNew York, NYWilliams and Wilkins1997
  • CheatleMDGallagherRMChronic pain and comorbid mood and substance use disorders: a biopsychosocial treatment approachCurr Psychiatry Rep2006837137616968617
  • FordyceWEBehavioral Methods for Chronic Pain and IllnessSaint Louis, MOMosby1976
  • MoltonIRGStoelbCJensenBLCurrent psychological approaches to the management of chronic painCurr Opin Anasthesiol200720485489
  • StitzerMPetryNContingency management for treatment of substance abuseAnnu Rev Clin Psychol2006241143417716077
  • MayetSFarrellMFerriMMFAmatoLDavoliMPsychosocial treatment for opiate abuse and dependenceCochrane Database Syst Rev20051CD00433015744796
  • SeyboldKPhysiological mechanisms involved in religiosity/spirituality and healthJ Behav Med20073030330917549618
  • National Institutes of HealthNIH Consensus Development Conference on AcupunctureJAMA1998280151815249809733
  • EzzoJBermanBHadhazyVAJadadARLaoLSinghBBIs acupuncture effective for the treatment of chronic pain? A systematic reviewPain20008621722510812251
  • ArnoldRMAvantsSKMargolinAMarcotteDPatient attitudes concerning the inclusion of spirituality into addiction treatmentJ Subst Abuse Treat20022331932612495793
  • BarryDTBeitelMCutterCJJoshiDFalcioniJSchottenfeldRConventional and nonconventional pain treatment utilization among opioid dependent individuals with pain seeking methadone maintenance treatment: a needs assessment studyJ Addict Med200918379385
  • CarsonJKeefeFLynchTLoving-kindness meditation for chronic low back pain: results from a pilot trialJ Holist Nurs20052328730416049118
  • MoroneNEGrecoCMMind-body interventions for chronic pain in older adults: a structured reviewPain Med2007835937517610459
  • WachholtzAPargamentKMigraines and meditation: does spirituality matter?J Behav Med20083135136618551362
  • DaleyDCMarlattGARelapse prevention: cognitive and behavioral interventionsLowinsonJHRuizPMillmanRBLangrodJGSubstance Abuse: A Comprehensive Textbook2nd edBaltimore, MDWilliams and Wilkins1992
  • VallejoZAmaroHAdaptation of mindfulness-based stress reduction program for addiction relapse preventionThe Humanistic Psychologist200937192206
  • Kabat-ZinnJLipworthLBurneyRSellersWFour-year follow-up of a meditation based program for the self-regulation of chronic pain: treatment outcomes and complianceClin J Pain19862159173
  • RosenzweigSGreesonJMReibelDKGreenJSJasserSABeasleyDMindfulness-based stress reduction for chronic pain conditions: variation in treatment outcomes and role of home meditation practiceJ Psychosom Res201068293620004298
  • ZgierskaARabagoDChawlaNKushnerKKoehlerRMarlattAMindfulness meditation for substance use disorders: a systematic reviewSubst Abuse200930266294
  • ZiedonisDMBermanJLehnMDCoamecoSSupport groups and twelve-step programs in the treatment of the chronic pain patientPain and Chemical DependencySmithHSPassikSDNew York, NYOxford University Press2008
  • MartelliMLiljedahlENicholsonKZaslerNA brief introductory guide to chronic pain resources on the InternetNeuroRehabilitation20001410512111455073
  • American Chronic Pain AssociationTen Steps2011 Available from: http://www.theacpa.org/21/TenSteps.aspxAccessed May 6, 2011
  • DavisWJohnsonBPrescription opioid use, misuse, and diversion among street drug users in New York CityDrug Alcohol Depend2008922677617913395
  • EzykBPrescription drug monitoring programs2008 Available from: http://www.codrugfreeworkplace.org/files/documents/White%20paper%20-PDMP%207-08%20with%20logos.pdfAccessed March 2, 2011