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Research Article

Development of Erlotinib-Loaded Nanotransferosomal Gel for the Topical Treatment of Ductal Carcinoma in Situ

ORCID Icon, , ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 855-874 | Received 13 Sep 2023, Accepted 08 Feb 2024, Published online: 05 Mar 2024

References

  • Kumar P , ManglaB , JavedSet al. A review of nanomaterials from synthetic and natural molecules for prospective breast cancer nanotherapy. Front. Pharmacol.14, 1149554 (2023).
  • Łukasiewicz S , CzeczelewskiM , FormaAet al. Breast cancer –epidemiology, risk factors, classification, prognostic markers, and current treatment strategies – an updated review. Cancers13(17), 4287 (2021).
  • Mansour HH , ShalloufFA , NajimAAet al. Knowledge and practices of female nurses at primary health care clinics in Gaza strip – Palestine regarding early detection of breast Cancer. Asian Pac. J. Cancer Prev.22(11), 3679 (2021).
  • Seijen MV , LipsEH , ThompsonAMet al. Ductal carcinoma in situ: to treat or not to treat, that is the question. Br. J. Cancer121(4), 285–292 (2019).
  • Bijker N , DonkerM , WesselingJet al. Is DCIS breast cancer, and how do I treat it? Curr. Treat. Options Oncol. 14, 75–87 (2013).
  • Ward EM , DeSantisCE , LinCCet al. Cancer statistics: breast cancer in situ. CA. Cancer J. Clin.65(6), 481–495 (2015).
  • Bergholtz H , LienTG , SwansonDMet al. Contrasting DCIS and invasive breast cancer by subtype suggests basal-like DCIS as distinct lesions. NPJ Breast Cancer6(1), 26 (2020).
  • Zheng J , YuJ , ZhouT. Clinical characteristics of breast ductal carcinoma in situ with microinvasion: a narrative review. J. Int. Med. Res.48(11), 0300060520969304 (2020).
  • Kalwaniya DS , GairolaM , GuptaSet al. Ductal carcinoma in situ: a detailed review of current practices. Cureus15(4), e37932 (2023).
  • Magkou C , NakopoulouL , ZoubouliCet al. Expression of the epidermal growth factor receptor (EGFR) and the phosphorylated EGFR in invasive breast carcinomas. Breast Cancer Res.10, 1–8 (2008).
  • Kumar P , ManglaB , JavedSet al. Gefitinib: an updated review of its role in the cancer management, its nanotechnological interventions, recent patents and clinical trials. Recent Pat. Anticancer Drug Discov.18(4), 448–469 (2023).
  • Bareschino MA , SchettinoC , TroianiT , MartinelliE , MorgilloF , CiardielloF. Erlotinib in cancer treatment. Ann. Oncol.18, vi35–vi41 (2007).
  • Dowell J , MinnaJD , KirkpatrickP. Erlotinib hydrochloride. Nat. Rev. Drug Discov.4(1), 13–14 (2007).
  • Kim MK , YeeJ , ChoYSet al. Risk factors for erlotinib-induced hepatotoxicity: a retrospective follow-up study. BMC Cancer18(1), 1–7 (2018).
  • Suri SS , FenniriH , SinghB. Nanotechnology-based drug delivery systems. J. Occup. Med. Toxicol.2, 1–6 (2007).
  • Fernández-García R , LalatsaA , StattsLet al. Transferosomes as nanocarriers for drugs across the skin: quality by design from lab to industrial scale. Int. J. Appl. Pharm.573, 118817 (2020).
  • Sundralingam U , ChakravarthiS , RadhakrishnanAKet al. Efficacy of emu oil transfersomes for local transdermal delivery of 4-OH tamoxifen in the treatment of breast cancer. Pharmaceutics12(9), 807 (2020).
  • Omar MM , HasanOA , ElSisi AM. Preparation and optimization of lidocaine transferosomal gel containing permeation enhancers: a promising approach for enhancement of skin permeation. Int. J. Nanomed.14, 1551–1562 (2019).
  • Mangla B , NeupaneYR , SinghAet al. Lipid-nanopotentiated combinatorial delivery of tamoxifen and sulforaphane: ex vivo, in vivo and toxicity studies. Nanomedicine15(26), 2563–2583 (2020).
  • Uwaezuoke O , DuToit LC , KumarPet al. Linoleic acid-based transferosomes for topical ocular delivery of cyclosporine A. Pharmaceutics14(8), 1695 (2022).
  • Khan MI , YaqoobS , MadniAet al. Development and in vitro/ex vivo evaluation of lecithin-based deformable transfersomes and transfersome-based gels for combined dermal delivery of meloxicam and dexamethasone. BioMed Res. Int.2022, 8170318 (2022).
  • Kumari SD , ChevalaNT , JittaSRet al. Design and development of naringin-loaded proposomal gel for wound healing. J. Cosmet. Dermatol.21(10), 5187–5202 (2022).
  • Gayathri H , SangeethaS. Pharmaceutical development of methotrexate loaded transferosomal gel for skin cancer by DoE approach. J. Pharm. Negat.59, 2456–2468 (2022).
  • Chitkara A , ManglaB , KumaPet al. Design-of-experiments (DoE)-assisted fabrication of quercetin-loaded nanoemulgel and its evaluation against human skin cancer cell lines. Pharmaceutics14(11), 2517 (2022).
  • Sethuraman N , ShanmuganathanS , SandhyaK. Design, development and characterization of nano structured lipid carrier for topical delivery of aceclofenac. Indian J. Pharm. Educ. Res.52(4), 581–586 (2018).
  • Shao B , SunL , XuNet al. Development and evaluation of topical delivery of microemulsions containing adapalene (MEs-Ap) for acne. AAPS PharmSciTech.22(3), 125 (2021).
  • Shiehzadeh F , MohebiD , ChavoshianOet al. Formulation, characterization, and optimization of a topical gel containing tranexamic acid to prevent superficial bleeding: in vivo and in vitro evaluations. Turk. J. Pharm. Sci.20(4), 261–269 (2023).
  • Badhwar R , ManglaB , NeupaneYRet al. Quercetin loaded silver nanoparticles in hydrogel matrices for diabetic wound healing. Nanotechnology32(50), 505102 (2021).
  • Aqil M , SultanaY , AliA. Matrix type transdermal drug delivery systems of metoprolol tartrate: in vitro characterization. Acta Pharm.53(2), 119–126 (2023).
  • Ahmed TA . Preparation of transfersomes encapsulating sildenafil aimed for transdermal drug delivery: Plackett–Burman design and characterization. J. Liposome Res.25(1), 1–10 (2015).
  • Paiva-Santos AC , SilvaAL , GuerraCet al. Ethosomes as nanocarriers for the development of skin delivery formulations. Pharm. Res.8, 947–970 (2021).
  • Meng S , ChenZ , YangLet al. Enhanced transdermal bioavailability of testosterone propionate via surfactant-modified ethosomes. Int. J. Nanomed.8, 3051–3060 (2013).
  • Mekonnen A , TesfayeS , ChristosSGet al. Evaluation of skin irritation and acute and subacute oral toxicity of Lavandula angustifolia essential oils in rabbit and mice. J. Toxicol.2019, 5979546 (2019).
  • Siddique MI , KatasH , AminMCet al. In-vivo dermal pharmacokinetics, efficacy, and safety of skin targeting nanoparticles for corticosteroid treatment of atopic dermatitis. Int. J. Pharm.507(1–2), 72–82 (2016).
  • Gupta A , PrajapatiSK , BalamuruganMet al. Design and development of a proniosomal transdermal drug delivery system for captopril. Trop. J. Pharm. Res.6(2), 687–693 (2007).
  • Mahmood S , TaherM , MandalUK. Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application. Int. J. Nanomed.9, 4331–4346 (2014).
  • Dong W , YeJ , WangWet al. Self-assembled lecithin/chitosan nanoparticles based on phospholipid complex: a feasible strategy to improve entrapment efficiency and transdermal delivery of poorly lipophilic drug. Int. J. Nanomed.15, 5629–5643 (2020).
  • Abdallah MH , AbuLila AS , ShawkySMet al. Experimental design and optimization of nano-transfersomal gel to enhance the hypoglycemic activity of silymarin. Polymers14(3), 508 (2022).
  • Khan MA , PanditJ , SultanaYet al. Novel carbopol-based transfersomal gel of 5-fluorouracil for skin cancer treatment: in vitro characterization and in vivo study. Drug Deliv.22(6), 795–802 (2015).
  • Akram MW , JamshaidH , RehmanFUet al. Transfersomes: a revolutionary nanosystem for efficient transdermal drug delivery. AAPS PharmSciTech.23, 7 (2022).
  • Sah SK , BadolaA , MukhopadhyayS. Development and evaluation of tioconazole loaded emulgel. Int. J. Appl. Pharm.9(5), 83–90 (2017).
  • Pande VV , KadnorNA , KadamRNet al. Fabrication and characterization of sertaconazole nitrate microsponge as a topical drug delivery system. Indian J. Pharm. Sci.77(6), 675 (2015).
  • Singh A , NeupaneYR , ShafiSet al. PEGylated liposomes as an emerging therapeutic platform for oral nanomedicine in cancer therapy: in vitro and in vivo assessment. J. Mol. Liq.303, 112649 (2020).
  • Imam SS , AhadA , AqilMet al. Formulation by design based risperidone nano soft lipid vesicle as a new strategy for enhanced transdermal drug delivery: in-vitro characterization, and in-vivo appraisal. Mater. Sci. Eng. C.75, 1198–1205 (2017).
  • Khatoon K , RizwanullahMD , AminSet al. Cilnidipine loaded transfersomes for transdermal application: formulation optimization, in-vitro and in-vivo study. J. Drug Deliv. Sci. Technol.54, 101303 (2019).
  • Zhang G , SunJ. Lipid in chips: a brief review of liposomes formation by microfluidics. Int. J. Nanomed.16, 7391–7416 (2021).
  • Danaei M , DehghankholdM , AtaeiSet al. Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems. Pharmaceutics10(2), 57 (2018).
  • Vasanth S , DubeyA , GSRet al. Development and investigation of vitamin C-enriched adapalene-loaded transfersome gel: a collegial approach for the treatment of acne vulgaris. AAPS PharmSciTech.21, 1–17 (2020).
  • Ahad A , Al-SalehAA , Al-MohizeaAMet al. Formulation and characterization of novel soft nanovesicles for enhanced transdermal delivery of eprosartan mesylate. Saudi Pharm. J.25(7), 1040–1046 (2017).
  • Duangjit S , OpanasopitP , RojanarataTet al. Evaluation of meloxicam-loaded cationic transfersomes as transdermal drug delivery carriers. AAPS Pharmscitech.14, 133–140 (2013).
  • Sinico C , ManconiM , PeppiMet al. Liposomes as carriers for dermal delivery of tretinoin: in vitro evaluation of drug permeation and vesicle–skin interaction. J. Control. Rel.103(1), 123–136 (2005).
  • Ascenso A , RaposoS , BatistaCet al. Development, characterization, and skin delivery studies of related ultradeformable vesicles: transfersomes, ethosomes, and transethosomes. Int. J. Nanomed.10, 5837–5851 (2015).
  • Bnyan R , KhanI , EhtezaziTet al. Formulation and optimisation of novel transfersomes for sustained release of local anaesthetic. J. Pharm. Pharmacol.71(10), 1508–1519 (2019).
  • Dora CP , KushwahV , KatiyarSSet al. Improved oral bioavailability and therapeutic efficacy of erlotinib through molecular complexation with phospholipid. Int. J. Pharm.534(1–2), 1–13 (2017).
  • Yusuf M , SharmaV , PathakK. Nanovesicles for transdermal delivery of felodipine: development, characterization, and pharmacokinetics. Int. J. Pharm. Investig.4(3), 119 (2014).
  • Jin Y , WenJ , GargSet al. Development of a novel niosomal system for oral delivery of Ginkgo biloba extract. Int. J. Nanomed.8, 421–430 (2013).
  • Kumar M , SolankiP , KumarPet al. Formulation development, optimization by box-behnken design, and in vitro characterization of gefitinib phospholipid complex based nanoemulsion drug delivery system. Int. J. Innov. Pharm.18, 952–964 (2023).
  • Balata GF , FaisalMM , ElghamryHAet al. Preparation and characterization of ivabradine HCl transfersomes for enhanced transdermal delivery. J. Drug Deliv. Sci. Technol.60, 101921 (2020).
  • Jahangiri A , KhalilzadF , BarghiL. Dissolution improvement of binary solid dispersions of erlotinib prepared by one-step electrospray method. Biol. Methods Protoc.7(1), bpac001 (2022).
  • Kuligowski J , QuintásG , Esteve-TurrillasFAet al. On-line gel permeation chromatography–attenuated total reflectance–Fourier transform infrared determination of lecithin and soybean oil in dietary supplements. J. Chromatogr. A.1185(1), 71–77 (2008).
  • Pramod K , SuneeshCV , ShanavasSet al. Unveiling the compatibility of eugenol with formulation excipients by systematic drug-excipient compatibility studies. J. Anal. Sci. Technol.6(1), 1–14 (2015).
  • Rajan R , JoseS , MukundVPBet al. Transferosomes – a vesicular transdermal delivery system for enhanced drug permeation. J. Adv. Pharm. Technol. Res.2(3), 138–143 (2011).
  • Osborne DW , WardAJI , O’NeillKJ. Microemulsions as topical drug delivery vehicles: in-vitro transdermal studies of a model hydrophilic drug. J. Pharm. Pharmacol.43(6), 451–454 (1991).
  • Nguyen HX , BozorgBD , KimYet al. Poly (vinyl alcohol) microneedles: Fabrication, characterization, and application for transdermal drug delivery of doxorubicin. Eur. J. Pharm. Biopharm.129, 88–103 (2018).
  • Kaur H , GhoshS , KumarPet al. Ellagic acid-loaded, tween 80-coated, chitosan nanoparticles as a promising therapeutic approach against breast cancer: in-vitro and in-vivo study. Life Sci.284, 119927 (2021).

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