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Acta Obstetricia et Gynecologica Scandinavica Volume 52, 1973 - Issue 2
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Original Article

The Transfer of Diazepam Across the Placenta During Labour

R. Erkkola Department of Obstetrics and Gynaecology, Turku University, Turku, Finland; Department of Pharmacology, Turku University, Turku, Finland
,
L. Kangas Department of Obstetrics and Gynaecology, Turku University, Turku, Finland; Department of Pharmacology, Turku University, Turku, Finland
&
A. Pekkarinen Department of Obstetrics and Gynaecology, Turku University, Turku, Finland; Department of Pharmacology, Turku University, Turku, Finland
Pages 167-170 | Received 19 Aug 1972, Published online: 09 Jul 2009

References

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  • Cavanagh D., Condo D. S. Diazepam–a pilot study of drug concentrations in maternal blood, amniotic fluid and cord blood. Curr Ther Res 1964; 6: 122
  • DeSilva J. A. F., d'Arconte L., Kaplan J. The determination of blood levels and the placental transfer of diazepam in humans. Curr Ther Res 1964; 6: 115
  • Ernebo E., Agurell S., Jalling B., Borens L. O. Age differences in drug binding by plasma proteins. Studies on human foetuses, neonates and adults. Eur J Clin Pharmacol 1971; 3: 169
  • Flowers C. E., Rudolph A. J., Murdina M. M. Diazepam (Valium) as an adjunct in obstetrical analgesia. Obstet Gynec 1969; 34: 68
  • Friedman E. A., Niswander K. R., Sachtleben M. R. Effect of diazepam on labour. Obstet Gynec 1969; 34: 82
  • Idänpään-Heikkilä J. E., Jouppila P. I., Puolakka J. O., Verne M. S. Placental transfer and fetal metabolism of diazepam in early human pregnancy. Am J Obstet Gynecol 1971; 109: 1011
  • Idänpään-Heikkilä J. E., Taska R. J., Allen H. A., Schoolar J. G. Placental transfer of diazepam-14 C in mice, hamsters and monkeys. J Pharmacol Exp Ther 1971; 176: 152
  • Marcucci F., Fanelli R., Mussini E. A method for gas chromatographic determination of benzodiazepines. J Chromatogr 1968; 37: 318
  • Moya F., Smith B. E. Placental transport of drugs and anesthetics. Anesthesiology 1965; 26: 465
  • Nisbet R., Boulas S. H., Kantor H. I. Diazepam (Valium) during labor. Obstet Gynec 1967; 29: 726
  • Page E. W. Transfer of materials across the human placenta. Am J Obstet Gynecol 1957; 74: 705
  • Schubert B., Malmgren G. Diazepam–en klinisk-analytisk undersökning. Opuscula Med 1969; 8: 288
  • Timonen S., Hagner M. Benzodiazepines in an unselected obstetrical series. Ann Chir Gynecol Fenn 1966; 55: 5
  • van der Kleijn E. Kinetics of distribution and metabolism of diazepam in animals and humans. Arch Int Pharmacydon Ther 1969; 182: 433
  • Villee C. A. Placental transfer of drugs. Ann NY Acad Sci 1965; 123: 237

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