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Acta Obstetricia et Gynecologica Scandinavica Volume 64, 1985 - Issue 6
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Original Article

Maternal-Serum-Alphafetoprotein Screening for Fetal Malformations in 28062 Pregnancies: A four-year experience from a low-risk area

Bent Norgaard-Pedersen Hormone Department, Statens Seruminstitut, Copenhagen; Department of Clinical Chemistry, Sønderborg Hospital, Hvidovre; Department of Obstetrics and Cynecology, Københavns Kommunes Hospital, Hvidovre; Department of Obstetrics and Gynecology, Kolding Hospital, Copenhagen; Department of Obstetrics and Gynecology and Ultrasound Laboratory, Rigshospitalet, Copenhagen; Department of Obstetrics and Gynecology, Senderborg Hospital, Denmark
,
Peter Bagger Hormone Department, Statens Seruminstitut, Copenhagen; Department of Clinical Chemistry, Sønderborg Hospital, Hvidovre; Department of Obstetrics and Cynecology, Københavns Kommunes Hospital, Hvidovre; Department of Obstetrics and Gynecology, Kolding Hospital, Copenhagen; Department of Obstetrics and Gynecology and Ultrasound Laboratory, Rigshospitalet, Copenhagen; Department of Obstetrics and Gynecology, Senderborg Hospital, Denmark
,
Jens Bang Hormone Department, Statens Seruminstitut, Copenhagen; Department of Clinical Chemistry, Sønderborg Hospital, Hvidovre; Department of Obstetrics and Cynecology, Københavns Kommunes Hospital, Hvidovre; Department of Obstetrics and Gynecology, Kolding Hospital, Copenhagen; Department of Obstetrics and Gynecology and Ultrasound Laboratory, Rigshospitalet, Copenhagen; Department of Obstetrics and Gynecology, Senderborg Hospital, Denmark
,
Wiggo Fischer-Rasmussen Hormone Department, Statens Seruminstitut, Copenhagen; Department of Clinical Chemistry, Sønderborg Hospital, Hvidovre; Department of Obstetrics and Cynecology, Københavns Kommunes Hospital, Hvidovre; Department of Obstetrics and Gynecology, Kolding Hospital, Copenhagen; Department of Obstetrics and Gynecology and Ultrasound Laboratory, Rigshospitalet, Copenhagen; Department of Obstetrics and Gynecology, Senderborg Hospital, Denmark
,
Claus Gad Hormone Department, Statens Seruminstitut, Copenhagen; Department of Clinical Chemistry, Sønderborg Hospital, Hvidovre; Department of Obstetrics and Cynecology, Københavns Kommunes Hospital, Hvidovre; Department of Obstetrics and Gynecology, Kolding Hospital, Copenhagen; Department of Obstetrics and Gynecology and Ultrasound Laboratory, Rigshospitalet, Copenhagen; Department of Obstetrics and Gynecology, Senderborg Hospital, Denmark
,
Ernst Hasch Hormone Department, Statens Seruminstitut, Copenhagen; Department of Clinical Chemistry, Sønderborg Hospital, Hvidovre; Department of Obstetrics and Cynecology, Københavns Kommunes Hospital, Hvidovre; Department of Obstetrics and Gynecology, Kolding Hospital, Copenhagen; Department of Obstetrics and Gynecology and Ultrasound Laboratory, Rigshospitalet, Copenhagen; Department of Obstetrics and Gynecology, Senderborg Hospital, Denmark
,
Poul-Erik Helkjær Hormone Department, Statens Seruminstitut, Copenhagen; Department of Clinical Chemistry, Sønderborg Hospital, Hvidovre; Department of Obstetrics and Cynecology, Københavns Kommunes Hospital, Hvidovre; Department of Obstetrics and Gynecology, Kolding Hospital, Copenhagen; Department of Obstetrics and Gynecology and Ultrasound Laboratory, Rigshospitalet, Copenhagen; Department of Obstetrics and Gynecology, Senderborg Hospital, Denmark
,
Jens Christian Jacobsen Hormone Department, Statens Seruminstitut, Copenhagen; Department of Clinical Chemistry, Sønderborg Hospital, Hvidovre; Department of Obstetrics and Cynecology, Københavns Kommunes Hospital, Hvidovre; Department of Obstetrics and Gynecology, Kolding Hospital, Copenhagen; Department of Obstetrics and Gynecology and Ultrasound Laboratory, Rigshospitalet, Copenhagen; Department of Obstetrics and Gynecology, Senderborg Hospital, Denmark
,
Jens Kjeldsen Hormone Department, Statens Seruminstitut, Copenhagen; Department of Clinical Chemistry, Sønderborg Hospital, Hvidovre; Department of Obstetrics and Cynecology, Københavns Kommunes Hospital, Hvidovre; Department of Obstetrics and Gynecology, Kolding Hospital, Copenhagen; Department of Obstetrics and Gynecology and Ultrasound Laboratory, Rigshospitalet, Copenhagen; Department of Obstetrics and Gynecology, Senderborg Hospital, Denmark
,
Erik Kjærsgaard Hormone Department, Statens Seruminstitut, Copenhagen; Department of Clinical Chemistry, Sønderborg Hospital, Hvidovre; Department of Obstetrics and Cynecology, Københavns Kommunes Hospital, Hvidovre; Department of Obstetrics and Gynecology, Kolding Hospital, Copenhagen; Department of Obstetrics and Gynecology and Ultrasound Laboratory, Rigshospitalet, Copenhagen; Department of Obstetrics and Gynecology, Senderborg Hospital, Denmark
,
Peter Lund Petersen Hormone Department, Statens Seruminstitut, Copenhagen; Department of Clinical Chemistry, Sønderborg Hospital, Hvidovre; Department of Obstetrics and Cynecology, Københavns Kommunes Hospital, Hvidovre; Department of Obstetrics and Gynecology, Kolding Hospital, Copenhagen; Department of Obstetrics and Gynecology and Ultrasound Laboratory, Rigshospitalet, Copenhagen; Department of Obstetrics and Gynecology, Senderborg Hospital, Denmark
,
John Philip Hormone Department, Statens Seruminstitut, Copenhagen; Department of Clinical Chemistry, Sønderborg Hospital, Hvidovre; Department of Obstetrics and Cynecology, Københavns Kommunes Hospital, Hvidovre; Department of Obstetrics and Gynecology, Kolding Hospital, Copenhagen; Department of Obstetrics and Gynecology and Ultrasound Laboratory, Rigshospitalet, Copenhagen; Department of Obstetrics and Gynecology, Senderborg Hospital, Denmark
,
Jørgen Thisted Hormone Department, Statens Seruminstitut, Copenhagen; Department of Clinical Chemistry, Sønderborg Hospital, Hvidovre; Department of Obstetrics and Cynecology, Københavns Kommunes Hospital, Hvidovre; Department of Obstetrics and Gynecology, Kolding Hospital, Copenhagen; Department of Obstetrics and Gynecology and Ultrasound Laboratory, Rigshospitalet, Copenhagen; Department of Obstetrics and Gynecology, Senderborg Hospital, Denmark
&
Kim Toftager-Larsen Hormone Department, Statens Seruminstitut, Copenhagen; Department of Clinical Chemistry, Sønderborg Hospital, Hvidovre; Department of Obstetrics and Cynecology, Københavns Kommunes Hospital, Hvidovre; Department of Obstetrics and Gynecology, Kolding Hospital, Copenhagen; Department of Obstetrics and Gynecology and Ultrasound Laboratory, Rigshospitalet, Copenhagen; Department of Obstetrics and Gynecology, Senderborg Hospital, Denmark
 show all
Pages 511-514 | Received 19 Dec 1984, Accepted 08 Feb 1985, Published online: 03 Aug 2009

References

  • Burton B K., Sowere S G., Nelson L H. Maternal serum alpha-fetoprotein screening in North Carolina: Experience with more than twelve thousand pregnancies. Am J Obstet Gynecol 1983; 146: 439
  • Campell S, Pearce J M. Ultrasound visualization of congenital malformations. Br Med Bull 1983; 39: 322
  • Ferguson Smith M A. The reduction of anencephalic and spina bifida births by maternal serum alphafeto-protein screening. Br Med Bull 1983; 39: 365
  • Kjessler B, Johansson S GD. Monitoring of the development of early pregnancy by determination of alpha-fetoprotein in maternal serum and amniotic fluid samples. Acta Obstet Gynecol Scand (Suppl) 1977; 69: 5
  • Kjsersgaard E, Nørgaard-Pedersen B. Comparison of five different commercially available radioimmuno-assay kits for alpha-fetoprotein. Carcinoembryonic Proteins, vol. II, F-G Lehman. Elsevier Publ, Amsterdam, Oxford, New York 1979; 853–60
  • Nørgaard-Pedersen B. Human alpha-fetoprotein. Scand J Immunol (Suppl) 1976; 4: 1
  • Norgaard-Pedersen B, Jensen S, Wandrup J. Immuno-logical identification of acetylcholinesterase in amniotic fluid. Immune absorption technique. Prenatal Diagnosis 1982; 2: 257
  • Nergaard-Pedersen B, Hangaard J, Bjerrum O J. Quantitative enzyme antigen immunoassay of acetylcholinesterase in amniotic fluid. Clin Chem 1983; 29: 1061
  • Persson P H., Kullander S, Gennser G, Grennert L, Laurell C B. Screening for fetal malformations using ultrasound and measurements of alpha-fetoprotein in maternal serum. Br Med J 1983; 286: 747
  • Schnittger A. Alpha-fetoprotein screening in obstetric practice. Linköping: Linköping University Medical Dissertation 1983; 154: 1–826
  • Standing S J., Brindle M J., McDonald A P., Lacey R W. Maternal alpha-fetoprotein screening: two years experience in a low-risk district. Br Med J 1981; 283: 705
  • Toftager-Larsen K, Kjærsgaard E., Jacobsen J., Chr., Nargaard-Pedersen B. Reactivity of amniotic fluid alpha-fetoprotein with concanavalin A in relation to gestational age: Clinical implications. Clin Chem 1980; 26: 1656
  • UK collaboration study on alpha-fetoprotein in relation to neural tube defects: Maternal serum-alpha-fetopro-tein measurement in antenatal screening for anencepha-ly and spina bifida in early pregnancy. Lancet 1977; i: 1323

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