Comparison of single and multiple dose methotrexate therapy for unruptured tubal ectopic pregnancy: a prospective randomized study

References

• Centers for Disease Control and Prevention. Current trends ectopic pregnancy-United States, 1990–1992. MMWR Morb Mortal Wkly Rep. 1995;44:46–8.
   PubMedGoogle Scholar
• Coste J, Bouyer J, Ughetto S, Gerbaud L, Fernandez H, Pouly JL, Ectopic pregnancy is again on the increase. Recent trends in the incidence of ectopic pregnancies in France (1992–2002). Hum Reprod. 2004;19:2014–18.
   PubMed Web of Science ®Google Scholar
• Fylstra DL. Tubal pregnancy: a review of current diagnosis and treatment. Obstet Gynecol Surv. 1998;53:320–8.
   PubMedGoogle Scholar
• Ankum WM, Van der Veen F, Hamerlynck JV, Lammes FB. Transvaginal sonography and human chorionic gonadotrophin measurements in suspected ectopic pregnancy: a detailed analysis of a diagnostic approach. Hum Reprod. 1993;8:1307–11.
   PubMed Web of Science ®Google Scholar
• Mol BW, Hajenius PJ, Engelsbel S, Ankum WM, Van der Veen F, Hemrika DJ, Serum human chorionic gonadotropin measurement in the diagnosis of ectopic pregnancy when transvaginal sonography is inconclusive. Fertil Steril. 1998;70:972–81.
   PubMed Web of Science ®Google Scholar
• Shalev E, Yarom I, Bustan M, Weiner E, Ben-Shlomo I. Transvaginal sonography as the ultimate diagnostic tool for the management of ectopic pregnancy: experience with 840 cases. Fertil Steril. 1998;69:62–5.
   PubMed Web of Science ®Google Scholar
• Rantala M, Makinen J. Tubal patency and fertility outcome after expectant management of ectopic pregnancy. Fertil Steril. 1997;68:1043–6.
   PubMed Web of Science ®Google Scholar
• Lipscomb GH, Givens VM, Meyer NL, Bran D. Comparison of multidose and single-dose methotrexate protocols for the treatment of ectopic pregnancy. Am J Obstet Gynecol. 2005;192:1844–7; discussion 7–8.
   PubMed Web of Science ®Google Scholar
• Barnhart KT, Gosman G, Ashby R, Sammel M. The medical management of ectopic pregnancy: a meta-analysis comparing “single dose” and “multidose” regimens. Obstet Gynecol. 2003;101:778–84.
   PubMed Web of Science ®Google Scholar
• Stovall TG, Kellerman AL, Ling FW, Buster JE. Emergency department diagnosis of ectopic pregnancy. Ann Emerg Med. 1990;19:1098–103.
   PubMed Web of Science ®Google Scholar
• Barnhart K, Hummel AC, Sammel MD, Menon S, Jain J, Chakhtoura N. Use of “2-dose” regimen of methotrexate to treat ectopic pregnancy. Fertil Steril. 2007;87:250–6.
   PubMed Web of Science ®Google Scholar
• Silva C, Sammel MD, Zhou L, Gracia C, Hummel AC, Barnhart K. Human chorionic gonadotropin profile for women with ectopic pregnancy. Obstet Gynecol. 2006;107:605–10.
   PubMedGoogle Scholar
• Lipscomb GH, Bran D, McCord ML, Portera JC, Ling FW. Analysis of three hundred fifteen ectopic pregnancies treated with single-dose methotrexate. Am J Obstet Gynecol. 1998;178:1354–8.
   PubMed Web of Science ®Google Scholar
• Alleyassin A, Khademi A, Aghahosseini M, Safdarian L, Badenoosh B, Hamed EA. Comparison of success rates in the medical management of ectopic pregnancy with single-dose and multiple-dose administration of methotrexate: a prospective, randomized clinical trial. Fertil Steril. 2006;85:1661–6.
   PubMed Web of Science ®Google Scholar
• Condous G, Okaro E, Khalid A, Lu C, Van Huffel S, Timmerman D, The accuracy of transvaginal ultrasonography for the diagnosis of ectopic pregnancy prior to surgery. Hum Reprod. 2005;20:1404–9.
   PubMed Web of Science ®Google Scholar
• Guvendag Guven ES, Dilbaz S, Dilbaz B, Guven S, Sahin Ozdemir D, Haberal A. Serum biochemistry correlates with the size of tubal ectopic pregnancy on sonography. Ultrasound Obstet Gynecol. 2006;28:826–30.
   PubMed Web of Science ®Google Scholar
• Mol BW, Lijmer JG, Ankum WM, van der Veen F, Bossuyt PM. The accuracy of single serum progesterone measurement in the diagnosis of ectopic pregnancy: a meta-analysis. Hum Reprod. 1998;13:3220–7.
   PubMed Web of Science ®Google Scholar
• Elito J Jr, Han KK, Camano L. Tubal patency after clinical treatment of unruptured ectopic pregnancy. Int J Gynaecol Obstet. 2005;88:309–13.
   PubMed Web of Science ®Google Scholar
• Dilbaz S, Caliskan E, Dilbaz B, Degirmenci O, Haberal A. Predictors of methotrexate treatment failure in ectopic pregnancy. J Reprod Med. 2006;51:87–93.
   PubMed Web of Science ®Google Scholar
• Hajenius PJ, Mol F, Mol BW, Bossuyt PM, Ankum WM, van der Veen F. Interventions for tubal ectopic pregnancy. Cochrane Database Syst Rev. 2007:CD000324.
   PubMed Web of Science ®Google Scholar
• Sowter MC, Farquhar CM. Ectopic pregnancy: an update. Curr Opin Obstet Gynecol. 2004;16:289–93.
   PubMed Web of Science ®Google Scholar
• Rau R, Herborn G. Benefit and risk of methotrexate treatment in rheumatoid arthritis. Clin Exp Rheumatol. 2004;22:S83–94.
   Google Scholar