127
Views
0
CrossRef citations to date
0
Altmetric
FERTILITY

Androgen receptor epigenetic variations influence early follicular phase gonadotropin levels

, , , , , & show all
Pages 1557-1563 | Received 16 Mar 2010, Accepted 13 Sep 2010, Published online: 05 Nov 2010

References

  • Batista MC, Cartledge TP, Zellmer AW, Merino MJ, Axiotis C, Bremner WJ, Effects of aging on menstrual cycle hormones and endometrial maturation. Fertil Steril. 1995;64:492–9.
  • Sharara FI, Beatse SN, Leonardi MR, Navot D, Scott Jr RT. Cigarette smoking accelerates the development of diminished ovarian reserve as evidenced by the clomiphene citrate challenge test. Fertil Steril. 1994;62:257–62.
  • Sherman BM, Korenman SG. Hormonal characteristics of the human menstrual cycle throughout reproductive life. J Clin Invest. 1975;55:699–706.
  • Meskhi A, Seif MW. Premature ovarian failure. Curr Opin Obstet Gynecol. 2006;18:418–26.
  • Fassnacht W, Mempel A, Strowitzki T, Vogt PH. Premature ovarian failure (POF) syndrome: towards the molecular clinical analysis of its genetic complexity. Curr Med Chem. 2006;13:1397–410.
  • Dunaif A. Hyperandrogenic anovulation (PCOS): a unique disorder of insulin action associated with an increased risk of non-insulin-dependent diabetes mellitus. Am J Med. 1995;98:33S–39S.
  • Franks S. Polycystic ovary syndrome. N Engl J Med. 1995;333:853–61.
  • Jonard S, Dewailly D. The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrest. Hum Reprod Update. 2004;10:107–17.
  • Chamberlain NL, Driver ED, Miesfeld RL. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res. 1994;22:3181–6.
  • Puck JM, Willard HF. X inactivation in females with X-linked disease. N Engl J Med. 1998;338:325–8.
  • The Rotterdam ESHRE/ASRM-sponsored PCOS workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19:41–7.
  • Vrbikova J, Bendlova B, Hill M, Vankova M, Vondra K, Starka L. Insulin sensitivity and beta-cell function in women with polycystic ovary syndrome. Diabetes Care. 2002;25:1217–22.
  • Saare M, Belousova A, Punab M, Peters M, Haller K, Ausmees K, Androgen receptor gene haplotype is associated with male infertility. Int J Androl. 2008;31:395–402.
  • Sugawa F, Wada Y, Maruyama T, Uchida H, Ishizuka B, Ogata T. Premature ovarian failure and androgen receptor gene CAG repeat lengths weighted by X chromosome inactivation patterns. Fertil Steril. 2009;91:649–52.
  • Billig H, Furuta I, Hsueh AJ. Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis. Endocrinology. 1993;133:2204–12.
  • Sato K, Uehara S, Hashiyada M, Nabeshima H, Sugawara J, Terada Y, Genetic significance of skewed X-chromosome inactivation in premature ovarian failure. Am J Med Genet A. 2004;130A:240–4.
  • Yoon SH, Choi YM, Hong MA, Kang BM, Kim JJ, Min EG, X chromosome inactivation patterns in patients with idiopathic premature ovarian failure. Hum Reprod. 2008;23:688–92.
  • Bione S, Benedetti S, Goegan M, Menditto I, Marozzi A, Ferrari M, Skewed X-chromosome inactivation is not associated with premature ovarian failure in a large cohort of Italian patients. Am J Med Genet A. 2006;140:1349–51.
  • Pu D, Wu J, Liu J. Skewed X chromosome inactivation may be not associated with premature ovarian failure. Gynecol Endocrinol. 2010;26:423–8.
  • Hickey T, Chandy A, Norman RJ. The androgen receptor CAG repeat polymorphism and X-chromosome inactivation in Australian Caucasian women with infertility related to polycystic ovary syndrome. J Clin Endocrinol Metab. 2002;87:161–5.
  • Mifsud A, Ramirez S, Yong EL. Androgen receptor gene CAG trinucleotide repeats in anovulatory infertility and polycystic ovaries. J Clin Endocrinol Metab. 2000;85:3484–8.
  • Hickey TE, Legro RS, Norman RJ. Epigenetic modification of the X chromosome influences susceptibility to polycystic ovary syndrome. J Clin Endocrinol Metab. 2006;91:2789–91.
  • Burger LL, Haisenleder DJ, Aylor KW, Dalkin AC, Prendergast KA, Marshall JC. Regulation of luteinizing hormone-beta and follicle-stimulating hormone (FSH)-beta gene transcription by androgens: testosterone directly stimulates FSH-beta transcription independent from its role on follistatin gene expression. Endocrinology. 2004;145:71–8.
  • Zitzmann M, Depenbusch M, Gromoll J, Nieschlag E. X-chromosome inactivation patterns and androgen receptor functionality influence phenotype and social characteristics as well as pharmacogenetics of testosterone therapy in Klinefelter patients. J Clin Endocrinol Metab. 2004;89:6208–17.
  • Otsuka F, Yao Z, Lee T, Yamamoto S, Erickson GF, Shimasaki S. Bone morphogenetic protein-15. Identification of target cells and biological functions. J Biol Chem. 2000;275:39523–8.
  • Otsuka F, Shimasaki S. A novel function of bone morphogenetic protein-15 in the pituitary: selective synthesis and secretion of FSH by gonadotropes. Endocrinology. 2002;143:4938–41.
  • Kline J, Kinney A, Levin B, Kelly A, Yu CY, Brown S, X-chromosome inactivation and ovarian age during the reproductive years. Fertil Steril. 2006;85:1488–95.
  • Calvo RM, Asuncion M, Sancho J, San Millan JL, Escobar-Morreale HF. The role of the CAG repeat polymorphism in the androgen receptor gene and of skewed X-chromosome inactivation, in the pathogenesis of hirsutism. J Clin Endocrinol Metab. 2000;85:1735–40.
  • Chang RJ, Katz SE. Diagnosis of polycystic ovary syndrome. Endocrinol Metab Clin North Am. 1999;28:397–408.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.