The histopathological and morphometric investigation of the effects of systemically administered boric acid on alveolar bone loss in ligature-induced periodontitis in diabetic rats

References

• Karima M, Kantarci A, Ohira T, Hasturk H, Jones VL, Nam BH, et al. Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: association with periodontitis. J Leukoc Biol 2005;78:862–70.
   PubMed Web of Science ®Google Scholar
• Mealey BL, Ocampo GL. Diabetes mellitus and periodontal disease. Periodontol 2000 44:127–53.
   PubMedGoogle Scholar
• Nassar H, Kantarci A, van Dyke TE. Diabetic periodontitis: a model for activated innate immunity and impaired resolution of inflammation. Periodontol 2000 43:233–44.
   PubMedGoogle Scholar
• Lusis AJ. Atherosclerosis. Nature 2000;407:233–41.
   PubMed Web of Science ®Google Scholar
• Shlossman M, Knowler WC, Pettitt DJ, Genco RJ. Type 2 diabetes mellitus and periodontal disease. J Am Dent Assoc 1990;121:532–6.
   PubMed Web of Science ®Google Scholar
• Loots MA, Lamme EN, Zeegelaar J, Mekkes JR, Bos JD, Middelkoop E. Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds. J Invest Dermatol 1998;111:850–7.
   PubMed Web of Science ®Google Scholar
• Holzhausen M, Garcia DF, Pepato MT, Marcantonio E. Jr. The influence of short-term diabetes mellitus and insulin therapy on alveolar bone loss in rats. J Periodontal Res 2004;39:188–93.
   PubMed Web of Science ®Google Scholar
• Skamagas M, Breen TL, LeRoith D. Update on diabetes mellitus: prevention, treatment, and association with oral diseases. Oral Dis 2008;14:105–14.
   PubMed Web of Science ®Google Scholar
• Nishimura F, Iwamoto Y, Soga Y. The periodontal host response with diabetes. Periodontol 2000 43:245–53.
   PubMedGoogle Scholar
• Gumus P, Buduneli N, Cetinkalp S, Hawkins SI, Renaud D, Kinane DF, et al. Salivary antioxidants in patients with type 1 or 2 diabetes and inflammatory periodontal disease: a case-control study. J Periodontol 2009;80:1440–6.
   PubMedGoogle Scholar
• Dandona P, Thusu K, Cook S, Snyder B, Makowski J, Armstrong D, et al. Oxidative damage to DNA in diabetes mellitus. Lancet 1996;347:444–5.
   PubMed Web of Science ®Google Scholar
• Konopka T, Krol K, Kopec W, Gerber H. Total antioxidant status and 8-hydroxy-2'-deoxyguanosine levels in gingival and peripheral blood of periodontitis patients. Arch Immunol Ther Exp (Warsz) 2007;55:417–22.
   PubMed Web of Science ®Google Scholar
• Chapple IL. Reactive oxygen species and antioxidants in inflammatory diseases. J Clin Periodontol 1997;24:287–96.
   PubMed Web of Science ®Google Scholar
• Sakallioglu U, Aliyev E, Eren Z, Aksimsek G, Keskiner I, Yavuz U. Reactive oxygen species scavenging activity during periodontal mucoperiosteal healing: an experimental study in dogs. Arch Oral Biol 2005;50:1040–6.
   PubMedGoogle Scholar
• Sutherland B, Strong P, King JC. Determining human dietary requirements for boron. Biol Trace Elem Res 1998;66:193–204.
   PubMed Web of Science ®Google Scholar
• Chapin RE, Ku WW, Kenney MA, McCoy H. The effects of dietary boric acid on bone strength in rats. Biol Trace Elem Res 1998;66:395–9.
   PubMed Web of Science ®Google Scholar
• Devirian TA, Volpe SL. The physiological effects of dietary boron. Crit Rev Food Sci Nutr 2003;43:219–31.
   PubMed Web of Science ®Google Scholar
• Ince S, Kucukkurt I, Cigerci IH, Fatih Fidan A, Eryavuz A. The effects of dietary boric acid and borax supplementation on lipid peroxidation, antioxidant activity, and DNA damage in rats. J Trace Elem Med Biol 2010;24:161–4.
   PubMed Web of Science ®Google Scholar
• Hakki SS, Bozkurt BS, Hakki EE. Boron regulates mineralized tissue-associated proteins in osteoblasts (MC3T3-E1). J Trace Elem Med Biol 2010;24:243–50.
   PubMed Web of Science ®Google Scholar
• Fry RS, Brown TT Jr, Lloyd KE, Hansen SL, Legleiter LR, Robarge WP, et al. Effect of dietary boron on physiological responses in growing steers inoculated with bovine herpesvirus type-1. Res Vet Sci 2011;90:78–83.
   PubMed Web of Science ®Google Scholar
• Armstrong TA, Spears JW, Lloyd KE. Inflammatory response, growth, and thyroid hormone concentrations are affected by long-term boron supplementation in gilts. J Anim Sci 2001;79:1549–56.
   PubMed Web of Science ®Google Scholar
• Demirer S, Kara MI, Erciyas K, Ozdemir H, Ozer H, Ay S. Effects of boric acid on experimental periodontitis and alveolar bone loss in rats. Arch Oral Biol 2012;57:60–5.
   PubMed Web of Science ®Google Scholar
• Toker H, Ozdemir H, Balci H, Ozer H. N-acetylcysteine decreases alveolar bone loss on experimental periodontitis in streptozotocin-induced diabetic rats. J Periodontal Res 2012;47:793–9.
   PubMed Web of Science ®Google Scholar
• Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005;38:1103–11.
   PubMed Web of Science ®Google Scholar
• Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 2004;37:112–19.
   PubMed Web of Science ®Google Scholar
• Ozturk E, Balat O, Acilmis YG, Ozcan C, Pence S, Erel O. Measurement of the placental total antioxidant status in preeclamptic women using a novel automated method. J Obstet Gynaecol Res 2011;37:337–42.
   PubMedGoogle Scholar
• Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 2001;50:537–46.
   PubMed Web of Science ®Google Scholar
• Toker H, Ozdemir H, Balci H, Ozer H. N-acetylcysteine decreases alveolar bone loss on experimental periodontitis in streptozotocin-induced diabetic rats. J Periodontal Res 2012;47:793–9.
   PubMed Web of Science ®Google Scholar
• Nishikawa T, Naruse K, Kobayashi Y, Miyajima S, Mizutani M, Kikuchi T, et al. Involvement of nitrosative stress in experimental periodontitis in diabetic rats. J Clin Periodontol 2012;39:342–9.
   PubMed Web of Science ®Google Scholar
• Ozdemir SP, Kurtis B, Tuter G, Bozkurt S, Gultekin SE, Senguven B, et al. Effects of low-dose doxycycline and bisphosphonate clodronate on alveolar bone loss and gingival levels of matrix metalloproteinase-9 and interleukin-1beta in rats with diabetes: a histomorphometric and immunohistochemical study. J Periodontol 2012;83:1172–82.
   PubMedGoogle Scholar
• Sakallioglu EE, Ayas B, Lutfioglu M, Keles GC, Acikgoz G, Firatli E. Gingival levels of monocyte chemoattractant protein-1 (MCP-1) in diabetes mellitus and periodontitis: an experimental study in rats. Clin Oral Investig 2008;12:83–9.
   PubMed Web of Science ®Google Scholar
• Silva JA, Lorencini M, Reis JR, Carvalho HF, Cagnon VH, Stach-Machado DR. The influence of type I diabetes mellitus in periodontal disease induced changes of the gingival epithelium and connective tissue. Tissue Cell 2008;40:283–92.
   PubMed Web of Science ®Google Scholar
• Kuhr A, Popa-Wagner A, Schmoll H, Schwahn C, Kocher T. Observations on experimental marginal periodontitis in rats. J Periodontal Res 2004;39:101–6.
   PubMedGoogle Scholar
• Di Paola R, Mazzon E, Zito D, Maiere D, Britti D, Genovese T, et al. Effects of Tempol, a membrane-permeable radical scavenger, in a rodent model periodontitis. J Clin Periodontol 2005;32:1062–8.
   PubMedGoogle Scholar
• Hunt CD. Boron. In Macrae R, Robinson RK, Sadler MJ, editor. Encyclopedia of food science, food technology and nutrition. London: Academic Press; 1993. p 440–7.
   Google Scholar
• Saygı DS. Toxicity Testings and the importance of test results in experimental toxicology. Gulhane Med J 2003;45:291–8; Turkish.
   Google Scholar
• Hunt CD, Herbel JL, Idso JP. Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick. J Bone Miner Res 1994;9:171–82.
   PubMed Web of Science ®Google Scholar
• Dzondo-Gadet M, Mayap-Nzietchueng R, Hess K, Nabet P, Belleville F, Dousset B. Action of boron at the molecular level: effects on transcription and translation in an acellular system. Biol Trace Elem Res 2002;85:23–33.
   PubMedGoogle Scholar
• Uysal T, Ustdal A, Sonmez MF, Ozturk F. Stimulation of bone formation by dietary boron in an orthopedically expanded suture in rabbits. Angle Orthod 2009;79:984–90.
   PubMed Web of Science ®Google Scholar
• Benderdour M, Hess K, Dzondo-Gadet M, Nabet P, Belleville F, Dousset B. Boron modulates extracellular matrix and TNF alpha synthesis in human fibroblasts. Biochem Biophys Res Commun 1998;246:746–51.
   PubMed Web of Science ®Google Scholar
• Naghii MR, Mofid M, Asgari AR, Hedayati M, Daneshpour MS. Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. J Trace Elem Med Biol 2011;25:54–8.
   PubMed Web of Science ®Google Scholar
• Armstrong TA, Spears JW. Effect of boron supplementation of pig diets on the production of tumor necrosis factor-alpha and interferon-gamma. J Anim Sci 2003;81:2552–61.
   PubMed Web of Science ®Google Scholar
• Cao J, Jiang L, Zhang X, Yao X, Geng C, Xue X, et al. Boric acid inhibits LPS-induced TNF-alpha formation through a thiol-dependent mechanism in THP-1 cells. J Trace Elem Med Biol 2008;22:189–95.
   PubMed Web of Science ®Google Scholar
• Toker H, Akpinar A, Aydin H, Poyraz O. Influence of smoking on interleukin-1beta level, oxidant status and antioxidant status in gingival crevicular fluid from chronic periodontitis patients before and after periodontal treatment. J Periodontal Res 2012;47:572–7.
   PubMedGoogle Scholar
• Esen C, Alkan BA, Kirnap M, Akgul O, Isikoglu S, Erel O. The effects of chronic periodontitis and rheumatoid arthritis on serum and gingival crevicular fluid total antioxidant/oxidant status and oxidative stress index. J Periodontol 2012;83:773–9.
   PubMed Web of Science ®Google Scholar
• Abou Sulaiman AE, Shehadeh RM. Assessment of total antioxidant capacity and the use of vitamin C in the treatment of non-smokers with chronic periodontitis. J Periodontol 2010;81:1547–54.
   PubMed Web of Science ®Google Scholar
• Akalin FA, Baltacioglu E, Alver A, Karabulut E. Total antioxidant capacity and superoxide dismutase activity levels in serum and gingival crevicular fluid in pregnant women with chronic periodontitis. J Periodontol 2009;80:457–67.
   PubMedGoogle Scholar
• Sezer U, Erciyas K, Ustun K, Pehlivan Y, Ziya Senyurt S, Aksoy N, et al. Effect of chronic periodontitis on oxidative status in patients with rheumatoid arthritis. J Periodontol 2013;84:785–92.
   PubMedGoogle Scholar
• Pawa S, Ali S. Boron ameliorates fulminant hepatic failure by counteracting the changes associated with the oxidative stress. Chem Biol Interact 2006;160:89–98.
   PubMed Web of Science ®Google Scholar
• Turkez H, Geyikoglu F, Tatar A, Keles S, Ozkan A. Effects of some boron compounds on peripheral human blood. Z Naturforsch C 2007;62:889–96.
   PubMed Web of Science ®Google Scholar