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Acta Oto-Laryngologica Volume 94, 1982 - Issue 1-6
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Original Article

Individual Variation and Mechanism of Kanamycin Ototoxicity in Rabbits

Iwao Ohtani ORL Department, Fukushinta Medical College, Fukushima, Japan; Department of Pathology, Tohoku Dental University, Koriyama, Japan
,
Kohsei Ohtsuki ORL Department, Fukushinta Medical College, Fukushima, Japan; Department of Pathology, Tohoku Dental University, Koriyama, Japan
,
Tohru Aikawa ORL Department, Fukushinta Medical College, Fukushima, Japan; Department of Pathology, Tohoku Dental University, Koriyama, Japan
,
Takeo Omata ORL Department, Fukushinta Medical College, Fukushima, Japan; Department of Pathology, Tohoku Dental University, Koriyama, Japan
,
Jin Ouchi ORL Department, Fukushinta Medical College, Fukushima, Japan; Department of Pathology, Tohoku Dental University, Koriyama, Japan
&
Takeo Saito ORL Department, Fukushinta Medical College, Fukushima, Japan; Department of Pathology, Tohoku Dental University, Koriyama, Japan
Pages 413-419 | Received 22 Sep 1981, Published online: 08 Jul 2009

References

  • Banck G., Belfrage S., Juhlin I., Nordström L., Tjern-ström Ö., Toremalm N. G. Retrospective study of the ototoxicity of gentamicin. Acta Path Mi-crobiol Scand, Section B81, Suppl. 1973; 241: 54
  • Brummett R. E., Fox K. E., Bendrick T. W., Himes D. L. Ototoxicity of tobramycin, gentamicin. amikacin and sisomicin in the guinea pig. J Antimicroh Chemother 1978; 4, Suppl. A 73
  • Brunelle P. The toxic effect of kanamycin on the inner ear. Canad MAJ 1959; 81: 381
  • Johnsonbaugh R. E., Drexler H. G., Light I. J., Sutherland J. M. Familial occurrence of drug-induced hearing loss. Am J Dis Child 1974; 127: 245
  • Jørgensen M. J., Schmidt M. R. The ototoxic effect of kanamycin. Acta Otolarynnol (Stockhl 1962; 55: 537
  • Koide Y., Stern R., Roesler H. K., Daly J. F. Studies on susceptibility to kanamycin. Laryngoscope 1966; 76: 1769
  • Naunton R. F., Ward P. H. The ototoxicity of kanamycin sulfate in the presence of compromised renal function. Arch Otoluryngol 1959; 69: 398
  • Ohtani I., Ohtsuki K., Aikawa T., Ouchi J., Nakayoshi T. A comparative study on the ototoxicity of dibekacin and tobramycin administered by intravenous infusion. Jap J Antibiotics 1979; 32: 990
  • Ohtani I., Ohtsuki K., Aikawa T., Takenaka M., Omata T., Ouchi J., Saito T., Nakayoshi T., Kikai S., Abe M. Ototoxicity and nephrotoxicity of aminoglycoside antibiotics administered by intravenous infusion in rabbits. Chemotherapy (Tokyo) 1980; 28: 129
  • Ohtani I., Ohtsuki K., Omata T., Ouchi J., Saito T. Potentiation and its mechanism of cochlear damage resulting from furosemide and aminoglycoside antibiotics. ORL 1978a; 40: 53
  • Ohtani I., Ohtsuki K., Omata T., Ouchi J., Saito T. Interaction of bumetanide and kanamycin. ORL 1978b; 40: 216
  • Ouchi J., Ohtani I. Studies on the ototoxicity of kanamycin. Pract Otorhinolaryngol 1969; 31: 218
  • Prazic M., Subotic R. Familial sensitivity to streptomycin. J Laryng Olol 1964; 78: 1037
  • Sataloff J., Wagner S., Menduke H. Kanamycin ototoxicity in healthy men. Arch Otolaryngol 1964; 80: 413
  • Tsuiki T., Murai S. Familial incidence of streptomycin hearing loss and hereditary weakness of the cochlea. Audiology 1971; 10: 315

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