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Research Article

Mouse model of experimental Eustachian tube occlusion: a surgical technique

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Pages 12-17 | Received 10 May 2015, Accepted 31 Jul 2015, Published online: 18 Sep 2015

References

  • Bluestone CD, Doyle WJ. Anatomy and physiology of eustachian tube and middle ear related to otitis media. J Allergy Clin Immunol 1988;81:997–1003.
  • Vicente J, Trinidad A, Ramirez-Camacho R, Garcia-Berrocal JR, Gonzalez-Garcia JA, Ibanez A, et al. Evolution of middle ear changes after permanent eustachian tube blockage. Arch Otolaryngol Head Neck Surg 2007;133:587–92.
  • Tos M, Wiederhold M, Larsen P. Experimental long-term tubal occlusion in cats. A quantitative histopathological study. Acta Otolaryngol 1984;97:580–92.
  • Trinidad A, Ramirez-Camacho R, Garcia-Berrocal JR, Verdaguer JM, Vicente J, Pinilla MT. Pseudomonas aeruginosa infection in the hypoventilated middle ear: an experimental model. Acta Otolaryngol 2005;125:266–9.
  • Piltcher OB, Swarts JD, Magnuson K, Alper CM, Doyle WJ, Hebda PA. A rat model of otitis media with effusion caused by eustachian tube obstruction with and without Streptococcus pneumoniae infection: methods and disease course. Otolaryngol Head Neck Surg 2002;126:490–8.
  • Johnson MD, Contrino A, Contrino J, Maxwell K, Leonard G, Kreutzer D. Murine model of otitis media with effusion: immunohistochemical demonstration of IL-1 alpha antigen expression. Laryngoscope 1994;104:1143–9.
  • Maeda K, Hirano T, Ichimiya I, Kurono Y, Suzuki M, Mogi G. Cytokine expression in experimental chronic otitis media with effusion in mice. Laryngoscope 2004;114:1967–72.
  • Kuijpers W, Van der Beek JM, Jap PH. Experimental model for the study of otitis media with effusion. Acta Otorhinolaryngol Belg 1983;37:135–7.
  • Kawano H, Haruta A, Tsuboi Y, Kim Y, Schachern PA, Paparella MM, et al. Induction of mucous cell metaplasia by tumor necrosis factor alpha in rat middle ear: the pathological basis for mucin hyperproduction in mucoid otitis media. Ann Otol Rhinol Laryngol 2002;111:415–22.
  • von Unge M, Bagger-Sjoback D. Tympanic membrane changes in experimental otitis media with effusion. Am J Otol 1994;15:663–9.
  • von Unge M, Decraemer WF, Dirckx JJ, Bagger-Sjoback D. Shape and displacement patterns of the gerbil tympanic membrane in experimental otitis media with effusion. Hear Res 1995;82:184–96.
  • Russell JD, Giles SJ. Persistent otitis media with effusion: a new experimental model. Laryngoscope 1998;108:1181–4.
  • Lazaridis E, Saunders JC. Can you hear me now? A genetic model of otitis media with effusion. J Clin Invest 2008;118:471–4.
  • Song JJ, Kown SK, Kim EJ, Lee YS, Kim BY, Chae SW. Mucosal expression of ENaC and AQP in experimental otitis media induced by Eustachian tube obstruction. Int J Pediatr Otorhinolaryngol 2009;73:1589–93.
  • Hellstrom S, Salen B, Stenfors LE. The site of initial production and transport of effusion materials in otitis media serosa. A study on rat middle ear cavity. Acta Otolaryngol 1982;93:435–40.
  • Eriksson PO, Mattsson C, Hellstrom S. First forty-eight hours of developing otitis media: an experimental study. Ann Otol Rhinol Laryngol 2003;112:558–66.
  • Tsuboi Y, Kim Y, Giebink GS, Le C, Paparella MM, Chen N, et al. Induction of mucous cell metaplasia in the middle ear of rats using a three-step method: an improved model for otitis media with mucoid effusion. Acta Otolaryngol 2002;122:153–60.
  • Hellstrom S, Salen B, Stenfors LE, Soderberg O. Appearance of effusion material in the attic space correlated to an impaired Eustachian tube function. Int J Pediatr Otorhinolaryngol 1983;6:127–34.
  • Widemar L, Hellstrom S, Stenfors LE. Different structural changes in membrana Shrapnelli in serous and purulent otitis media. An experimental study in the rat. Acta Otolaryngol 1986;102:266–73.
  • Santa Maria PL, Kim S, Varsak YK, Yang YP. Heparin binding-epidermal growth factor-like growth factor for the regeneration of chronic tympanic membrane perforations in mice. Tissue Eng A 2015;21:1483–94.

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