224
Views
12
CrossRef citations to date
0
Altmetric
Research Article

Factors associated with medication non-adherence in patients suffering from schizophrenia: a cross-sectional study in a universal coverage health-care system

, , , , &
Pages 921-928 | Received 12 Feb 2010, Accepted 11 May 2010, Published online: 10 Oct 2010

References

  • Davis JM, Maintenance therapy and the natural course of schizophrenia. J Clin Psychiatry 1985; 46:18–21.
  • Hui CL, Chen EY, Kan CS, Yip KC, Law CW, Chiu CP. Detection of non-adherent behaviour in early psychosis. Aust N Z J Psychiatry 2006; 40:446–451.
  • Robinson D, Woerner MG, Alvir JM . Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder. Arch Gen Psychiatry 1999; 56:241–247.
  • Leucht S, Heres S. Epidemiology, clinical consequences, and psychosocial treatment of nonadherence in schizophrenia. J Clin Psychiatry 2006; 67 Suppl 5:3–8.
  • Masand PS, Roca M, Turner MS, Kane JM. Partial adherence to antipsychotic medication impacts the course of illness in patients with schizophrenia: a review. Prim Care Companion J Clin Psychiatry 2009; 11:147–154.
  • Velligan DI, Weiden PJ, Sajatovic M . The Expert Consensus Guideline Series: adherence problems in patients with serious and persistent mental illness. J Clin Psych 2009; 70:1–46.
  • Sibitz I, Katschnig H, Goessler R, Unger A, Amering M. Pharmacophilia and pharmacophobia: determinants of patients’ attitudes towards antipsychotic medication. Pharmacopsychiatry 2005; 38:107–112.
  • Perkins DO. Predictors of noncompliance in patients with schizophrenia. J Clin Psychiatry 2002; 63:1121–1128.
  • Mojtabai R, Fochtmann L, Chang SW, Kotov R, Craig TJ, Bromet E. Unmet need for mental health care in schizophrenia: an overview of literature and new data from a first-admission study. Schizophr Bull 2009; 35:679–695.
  • Sorgaard KW, Sandlund M, Heikkila J . Schizophrenia and contact with health and social services: a Nordic multi-centre study. Nord J Psychiatry 2003; 57:253–261.
  • McCann TV, Boardman G, Clark E, Lu S. Risk profiles for non-adherence to antipsychotic medications. J Psychiatr Ment Health Nurs 2008; 15:622–629.
  • Diagnostic and Statistical Manual of Mental Disorders: Fourth. Washington DC: American Psychiatric Association, 1994.
  • Appelberg B, Tuisku K, Joffe G. Is it worth while changing clinically stable schizophrenic out-patients with mild to moderate residual symptoms and/or side effects from conventional to atypical antipsychotics? A prospective, randomised study with olanzapine. Eur Psychiatry 2004; 19:516–518.
  • World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. Seoul, World Medical Association, General Assembly, Oct 2008.
  • Act n°78-17 of 6 January 1978 on Data Processing, Data Files and Individual Liberties (amended by the Act of 6 August 2004 relating to the protection of individuals with regard to the processing of personal data). Journal officiel de la République Française. Assemblée Nationale et Sénat, France, 1978.
  • Awad AG. Subjective response to neuroleptics in schizophrenia. Schizophr Bull 1993; 19:609–618.
  • Hogan TP, Awad AG, Eastwood R. A self-report scale predictive of drug compliance in schizophrenics: reliability and discriminative validity. Psychol Med 1983; 13:177–183.
  • Petersen L, Thorup A, Oqhlenschlaeger J . Predictors of remission and recovery in a first-episode schizophrenia spectrum disorder sample: 2-year follow-up of the OPUS trial. Can J Psychiatry 2008; 53:660–670.
  • Endicott J, Spitzer RL, Fleiss JL, Cohen J. The global assessment scale. A procedure for measuring overall severity of psychiatric disturbance. Arch Gen Psychiatry 1976; 33:766–771.
  • Amador XF, Strauss DH. The Scale to Assess Unawareness of Mental Disorder. New York: Columbia University and New York Psychiatric Institute, 1990.
  • Amador XF, Strauss DH. Poor insight in schizophrenia. Psychiatr Q 1993; 64:305–318.
  • Amador XF, Strauss DH, Yale SA, Flaum MM, Endicott J, Gorman JM. Assessment of insight in psychosis. Am J Psychiatry 1993; 150:873–879.
  • Wittorf A, Jakobi U, Bechdolf A . The influence of baseline symptoms and insight on the therapeutic alliance early in the treatment of schizophrenia. Eur Psychiatry 2009; 24:259–267.
  • Velligan DI, Lam YW, Glahn DC . Defining and assessing adherence to oral antipsychotics: a review of the literature. Schizophr Bull 2006; 32:724–742.
  • Ahn J, McCombs JS, Jung C . Classifying patients by antipsychotic adherence patterns using latent class analysis: characteristics of nonadherent groups in the California Medicaid (Medi-Cal) program. Value Health 2008; 11:48–56.
  • Cooper C, Bebbington P, King M . Why people do not take their psychotropic drugs as prescribed: results of the 2000 National Psychiatric Morbidity Survey. Acta Psychiatr Scand 2007; 116: 47–53.
  • Valenstein M, Blow FC, Copeland LA . Poor antipsychotic adherence among patients with schizophrenia: medication and patient factors. Schizophr Bull 2004; 30:255–264.
  • Mojtabai R, Olfson M. Medication costs, adherence, and health outcomes among Medicare beneficiaries. Health Aff (Millwood) 2003; 22:220–229.
  • Piette JD, Heisler M. Problems due to medication costs among VA and non-VA patients with chronic illnesses. Am J Manag Care 2004; 10:861–868.
  • Ascher-Svanum H, Zhu B, Faries D, Lacro JP, Dolder CR. A prospective study of risk factors for nonadherence with antipsychotic medication in the treatment of schizophrenia. J Clin Psychiatry 2006; 67:1114–1123.
  • Rocca P, Crivelli B, Marino F, Mongini T, Portaleone F, Bogetto F. Correlations of attitudes toward antipsychotic drugs with insight and objective psychopathology in schizophrenia. Compr Psychiatry 2008; 49:170–176.
  • Norman RM, Malla AK. Duration of untreated psychosis: a critical examination of the concept and its importance. Psychol Med 2001; 31:381–400.
  • Perkins D, Lieberman J, Gu H . Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders. Br J Psychiatry 2004; 185:18–24.
  • Norman RM, Malla AK. Examining adherence to medication and substance use as possible confounds of duration of untreated psychosis. J Nerv Ment Dis 2002; 190:331–334.
  • Verdoux H, Lengronne J, Liraud F . Medication adherence in psychosis: predictors and impact on outcome. A 2-year follow-up of first-admitted subjects. Acta Psychiatr Scand 2000; 102:203–210.
  • Young JL, Spitz RT, Hillbrand M, Daneri G. Medication adherence failure in schizophrenia: a forensic review of rates, reasons, treatments, and prospects. J Am Acad Psychiatry Law 1999; 27:426–444.
  • Fenton WS, Blyler CR, Heinssen RK. Determinants of medication compliance in schizophrenia: empirical and clinical findings. Schizophr Bull 1997; 23:637–651.
  • Fujikawa M, Togo T, Yoshimi A . Evaluation of subjective treatment satisfaction with antipsychotics in schizophrenia patients. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32:755–760.
  • Newcomer JW, Haupt DW. The metabolic effects of antipsychotic medications. Can J Psychiatry 2006; 51:480–491.
  • Atkinson MJ, Sinha A, Hass SL . Validation of a general measure of treatment satisfaction, the Treatment Satisfaction Questionnaire for Medication (TSQM), using a national panel study of chronic disease. Health Qual Life Outcomes 2004; 2:12.
  • Lacro JP, Dunn LB, Dolder CR, Leckband SG, Jeste DV. Prevalence of and risk factors for medication nonadherence in patients with schizophrenia: a comprehensive review of recent literature. J Clin Psychiatry 2002; 63:892–909.
  • Weiss KA, Smith TE, Hull JW, Piper AC, Huppert JD. Predictors of risk of nonadherence in outpatients with schizophrenia and other psychotic disorders. Schizophr Bull 2002; 28:341–349.
  • Kikkert MJ, Schene AH, Koeter MW . Medication adherence in schizophrenia: exploring patients’, carers’ and professionals’ views. Schizophr Bull 2006; 32:786–794.
  • Day JC, Bentall RP, Roberts C . Attitudes toward antipsychotic medication: the impact of clinical variables and relationships with health professionals. Arch Gen Psychiatry 2005; 62:717–724.
  • Hamann J, Cohen R, Leucht S, Busch R, Kissling W. Do patients with schizophrenia wish to be involved in decisions about their medical treatment? Am J Psychiatry 2005; 162:2382–2384.
  • Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987; 13:261–276.
  • Levine SZ, Rabinowitz J, Engel R, Etschel E, Leucht S. Extrapolation between measures of symptom severity and change: an examination of the PANSS and CGI. Schizophr Res 2008; 98: 318–322.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.