18
Views
9
CrossRef citations to date
0
Altmetric
Original Article

Contributions of Hippocampal Cellular Damage and NMDA Receptor Dysfunction to Behavioral Markers of Schizophrenia

, , &
Pages 61-70 | Received 04 Jan 2001, Published online: 07 Jul 2009

References

  • Abi-Saab W. M., ĎSousa D. C., Moghaddam B., Krystal J. H. The NMDA antagonist model for schizophrenia: Promises and pitfalls. Pharmacopsychiatry 1998; 31: 104–109
  • Bakshi V. P., Geyer M. A. Multiple limbic regions mediate the disruption of prepulse inhibition produced in rats by the noncompetitive NMDA antagonist dizocilpine. Journal of Newoscience 1998; 18: 8394–8401
  • Banerjee S. P., Zuck L. G., Yablonski-Alter E., Lidsky T. I. Glutamate agonist activity: Implications for antipsychotic drug action and schizophrenia. Neuroreport 1995; 6: 2500–2504
  • Bardgett M. E., Jackson J. L., Taylor G. T., Csernansky J. G. Kainic acid decreases hippocampal neuronal number and increases dopamine receptor binding in the nucleus accumbens: An animal model of schizophrenia. Behavioural Brain Research 1995; 70: 153–164
  • Bardgett M. E., Jackson J. L., Taylor G. T., Csernansky J. G. The effects of kainic acid lesions on locomotor responses to haloperidol and clozapine. Psychopharmacology 1998; 133: 270–287
  • Bilder R. M., Bogerts B., Ashtari M., Wu H., Alvir J. M., Jody D., et al. Anterior hippocampal volume reductions predict frontal lobe dysfunction in first episode schizophrenia. Schizophrenia Research 1995; 17: 47–58
  • Braff D., Grillon C., Geyer M. A. Gating and habituation of the startle reflex in schizophrenic patients. Archives of General Psychiatry 1992; 49: 206–215
  • Braff D., Stone C, Callaway E., Geyer M., Glick I., Bali L. Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 1978; 15: 339–343
  • Breier A., Buchanan R. W., Elkashef A., Munson R. C., Kirkpatrick B., Gellad F. Brain morphology and schizophrenia: A magnetic resonance imaging study of limbic, prefrontal cortex and caudate structures. Archives of General Psychiatry 1992; 49: 921–926
  • Conrad A. J., Scheibel A. B. Schizophrenia and the hippocampus: The embryoiogical hypothesis extended. Schizophrenia Bulletin 1987; 13: 577–587
  • Duncan P. M., Duncan N. C. Free operant and T-maze avoidance performance by septal and hippocampal damaged rats. Physiology and Behavior 1971; 7: 687–693
  • Faustman W. O., Bardgett M., Faull K. F., Pfefferman A., Csernansky J. G. Cerebrospinal fluid glutamate inversely correlates with positive symptom severity in unmedicated male schizophrenic/schizoaffective patients. Biological Psychiatry 1999; 45: 68–75
  • Gray N. S., Hemsley D. R., Gray J. A. Abolition of latent inhibition in acute but not chronic schizophrenics. Neurological Psychiatry and Brain Research 1992; 1: 83–89
  • Grillon C, Ameli R., Charney D. S., Krystal J., Braff D. Startle gating deficits occur across prepulse intensities in schizophrenia patients. Biological Psychiatry 1992; 32: 939–943
  • Harris E. W., Ganong A. H., Cotman C. W. Long-term potentiation in the hippocampus involves activation of the N-methyl-d-aspartate receptors. Brain Research 1984; 323: 132–137
  • Heresco-Levy U., Javitt D. C. The role of N-Methyl-D-Aspartate receptor mediated neurotransmission in the pathophysiology and therapeutics of psychiatric syndromes. European Neuropsychopharmacology 1998; 8: 141–152
  • Ishimaru M. J., Toru M. The glutamate hypothesis of schizophrenia. CNS Drugs 1997; 7: 47–67
  • Judd L. L., McAdams L., Budnick B., Braff D. L. Sensory gating deficits in schizophrenia: New results. American Journal of Psychiatry 1992; 149: 488–493
  • Kline L., Dccena E., Hitzemann R., McCaughran J. Acoustic startle, prepulse inhibition, locomotion and latent inhibition in the neuroleptic-responsive (NR) and neuroleptic-nonresponsive (NNR) lines of mice. Psychopharmacology 1998; 139: 322–331
  • Kovelman J. A., Scheibel A. B. A neurohistological correlate of schizophrenia. Biological Psychiatry 1984; 19: 1601–1621
  • Mansbach R. S., Geyer M. A. Effects of phencyclidine and phencyclidine biologs on sensory gating in the rat. Neuropsychopharmacology 1989; 2: 299–308
  • Nelson M. D., Saykin A. J., Flashman L. A., Riordan H. J. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging. Archives of General Psychiatry 1998; 55: 433–440
  • Newcomer J. W., Farber N. B., Jcvtovic-Todorovic V., Selge G., Melson A. K., Hershey T., et al. Ketamine induced NMDA receptor hypofunction as a model of memory impairment and psychosis. Neuropsychopharmacology 1999; 20: 106–118
  • Port R. L., Sample J. A., Seybold K. A. Partial hippocampal pyramidal cell loss alters behavior in rats: Implications for an animal model of schizophrenia. Brain Research Bulletin 1991; 26: 993–996
  • Port R. L., Seybold K. S. Hippocampal synaptic plasticity as a biological substrate underlying episodic psychosis. Biological Psychiatry 1995; 37: 318–324
  • Robinson G. B., Port R. L., Stillwell E. J. Latent inhibition of the classically conditioned rabbit nictitating membrane response is unaffected by the NMDA antagonist MK.801. Psychobiohgy 1993; 21: 120–124
  • Scheibel A. B., Kovelman J. A. Disorientation of hippocampal pyramidal cells and its processes in the schizophrenic patient. Biological Psychiatry 1981; 16: 101–102
  • Schmaltz L. W., Theios J. Acquisition and extinction of a classically conditioned response in hippocampectomized rabbits. Journal of Comparative and Physiological Psychology 1972; 79: 328–333
  • Solomon P. R., Moore J. W. Latent inhibition and stimulus generalization of the classically conditioned nictitating membrane response in rabbit following dorsal hippocampal ablation. Journal of Comparative and Physiological Psychology 1975; 89: 1192–1203
  • Tamminga C. A. Schizophrenia and glutamatergic transmission. Critical Reviews in Neurobiology 1998; 12: 21–36
  • van Berckel B. N. M., Evenblij C. N., van Loon B. J. A.M., Maas M. F., van der Geld M. A. M., Wynne H. J., et al. D-cycloserine increases positive symptoms in chronic schizophrenic patients when administered in addition to antipsychotics: A double-blind parallel placebo-controlled study. Neuropsychopharmacology 1999; 21: 203–210
  • Vinogradova O. S. Functional organization of the limbic system in the process of registration ofinformation: Facts and hypotheses. The hippocampus, R. L. Isaacson, K. H. Pribram. Plenum Press, New York 1975; 3–69
  • Zihl J., Gron G., Brunnauer A. Cognitive deficits in schizophrenia and affective disorders: Evidence for a final common pathway disorder. Acta Psychiatrica Scandinavica 1998; 97: 351–357

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.