Celastrol Suppresses Morphological and Transcriptional Responses in Microglial Cells Upon Stimulation with Double-Stranded RNA

REFERENCES

• Akira, S., & Hemmi, H. (2003). Recognition of pathogen-associated molecular patterns by TLR family. Immunology Letters, 85, 85–95.
   PubMed Web of Science ®Google Scholar
• Allison, A. C., Cacabelos, R., Lombardi, V. R., Alvarez, X. A., & Vigo, C. (2001). Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease. Progress in Neuro-psychopharmacology & Biological Psychiatry, 25, 1341–1357.
   PubMed Web of Science ®Google Scholar
• Aloisi, F. (2001). Immune function of microglia. Glia, 36, 165–179.
   PubMed Web of Science ®Google Scholar
• Cleren, C., Calingasan, N. Y., Chen, J., & Beal, M. F. (2005). Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity. Journal of Neurochemistry, 94, 995–1004.
   PubMed Web of Science ®Google Scholar
• Fenteany, G., & Glogauer, M. (2004). Cytoskeletal remodeling in leukocyte function. Current Opinion in Hematology, 11, 15–24.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Scarano, F., & Baltuch, G. (1999). Microglia as mediators of inflammatory and degenerative diseases. Annual Review of Neuroscience, 22, 219–240.
   PubMed Web of Science ®Google Scholar
• He, W., Huang, F. C., Gavai, A., Chan, W. K., Amato, G., Yu, K. T., (1998). Novel cytokine release inhibitors. Part III: Truncated analogs of tripterine. Bioorganic & Medicinal Chemistry Letters, 8, 3659–3664.
   PubMedGoogle Scholar
• Jin, H. Z., Hwang, B. Y., Kim, H. S., Lee, J. H., Kim, Y. H., & Lee, J. J. (2002). Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production. Journal of Natural Products, 65, 89–91.
   PubMed Web of Science ®Google Scholar
• Jung, H. W., Chung, Y. S., Kim, Y. S., & Park, Y. K. (2007). Celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells. Experimental & Molecular Medicine, 39, 715–721.
   PubMed Web of Science ®Google Scholar
• Mogensen, T. H., & Paludan, S. R. (2001). Molecular pathways in virus-induced cytokine production. Microbiology and Molecular Biology Reviews, 65, 131–150.
   PubMed Web of Science ®Google Scholar
• Nakamichi, K., Inoue, S., Takasaki, T., Morimoto, K., & Kurane, I. (2004). Rabies virus stimulates nitric oxide production and CXC chemokine ligand 10 expression in macrophages through activation of extracellular signal-regulated kinases 1 and 2. Journal of Virology, 78, 9376–9388.
   Google Scholar
• Nakamichi, K., Saiki, M., Kitani, H., Kuboyama, Y., Morimoto, K., Takayama-Ito, M., (2007). Roles of NF-kappaB and MAPK signaling pathways in morphological and cytoskeletal responses of microglia to double-stranded RNA. Neuroscience Letters, 414, 222–227.
   Google Scholar
• Nakamichi, K., Saiki, M., Sawada, M., Yamamuro, Y., Morimoto, K., & Kurane, I. (2005). Double-stranded RNA stimulates chemokine expression in microglia through vacuolar pH-dependent activation of intracellular signaling pathways. Journal of Neurochemistry, 95, 273–283.
   Google Scholar
• Ngassapa, O., Soejarto, D. D., Pezzuto, J. M., & Farnsworth, N. R. (1994). Quinone-methide triterpenes and salaspermic acid from Kokoona ochracea. Journal of Natural Products, 57, 1–8.
   PubMed Web of Science ®Google Scholar
• Pinna, G. F., Fiorucci, M., Reimund, J. M., Taquet, N., Arondel, Y., & Muller, C. D. (2004). Celastrol inhibits pro-inflammatory cytokine secretion in Crohn's disease biopsies. Biochemical and Biophysical Research Communications, 322, 778–786.
   PubMed Web of Science ®Google Scholar
• Ransohoff, R. M. (2002). The chemokine system in neuroinflammation: An update. The Journal of Infectious Diseases, 186, S152–S156.
   Google Scholar
• Spencer, D. C., & Price, R. W. (1992). Human immunodeficiency virus and the central nervous system. Annual Review of Microbiology, 46, 655–693.
   PubMed Web of Science ®Google Scholar
• Takenouchi, T., Iwamaru, Y., Sugama, S., Sato, M., Hashimoto, M., & Kitani, H. (2008). Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway. Journal of Immunology, 180, 7827–7839.
   Google Scholar
• Takenouchi, T., Nakai, M., Iwamaru, Y., Sugama, S., Tsukimoto, M., Fujita, M., (2009). The activation of P2×7 receptor impairs lysosomal functions and stimulates the release of autophagolysosomes in microglial cells. Journal of Immunology, 182, 2051–2062.
   PubMedGoogle Scholar
• Takenouchi, T., Ogihara, K., Sato, M., & Kitani, H. (2005). Inhibitory effects of U73122 and U73343 on Ca2+ influx and pore formation induced by the activation of P2×7 nucleotide receptors in mouse microglial cell line. Biochimica et Biophysica Acta, 1726, 177–186.
   Google Scholar
• Vilhardt, F. (2005). Microglia: Phagocyte and glia cell. The International Journal of Biochemistry & Cell Biology, 37, 17–21.
   PubMed Web of Science ®Google Scholar