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Research Article

Role of Melatonin in the Prevention of Morphine-Induced Hyperalgesia and Spinal Glial Activation in Rats: Protein Kinase C Pathway Involved

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Pages 154-163 | Received 26 Jul 2011, Published online: 02 Dec 2011

REFERENCES

  • Angst MS, Clark JD. Opioid-induced hyperalgesia: a qualitative systematic review. Anesthesiology. 2006;104:570–87.
  • Guntz E, Talla G, Roman A, Dumont H, Segers B, Sosnowski M. Opioid-induced hyperalgesia. Eur J Anaesthesiol. 2007;24:205–7.
  • Chang G, Chen L, Mao J. Opioid tolerance and hyperalgesia. Med Clin North Am. 2007;91:199–211.
  • Zhao M, Joo DT. Enhancement of spinal N-methyl-D-aspartate receptor functions by remifentanil action at delta-opioid receptors as a mechanism for acute opioid-induced hyperalgesia or tolerance. Anesthesiology. 2008;109:308–17.
  • Jellinger KA. Neuropathological aspects of Alzheimer disease, Parkinson disease and frontotemporal dementia. Neurodegener Dis. 2008;5:118–21.
  • Watkins LR, Hutchinson MR, Ledeboer A Wieseler-Frank J, Milligan ED, Maier SF. Glia as the “bad guys”: implications for improving clinical pain control and the clinical utility of opioids. Brain Behav Immun. 2007;21:131–46.
  • Hulsebosch CE. Gliopathy ensures persistent inflammation and chronic pain after spinal cord injury. Exp Neurol. 2008;214: 6–9.
  • Raghavendra V, Tanga FY, DeLeo JA. Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats. Neuropsychopharmacology. 2004;29:327–34.
  • Song P, Zhao Z-Q. The involvement of glial cells in the development of morphine tolerance. Neurosci Res. 2001;39:281–6.
  • Lu CH, Chao PC, Borel CO Yang CP, Yeh CC, Wong CS, Wu CT. Preincisional intravenous pentoxifylline attenuating perioperative cytokine response, reducing morphine consumption, and improving recovery of bowel functions in patients undergoing colorectal cancer surgery. Anesth Analg. 2004;99:1465–71.
  • Norton WT, Aquino DA, Hozumi I, Chiu FC, Brosnan CF. Quantitative aspects of reactive gliosis: a review. Neurochem Res. 1992;17:877–85.
  • Lazriev IL, Kiknadze GI, Kutateladze II Nebieridze MI. Effect of morphine on the number and branching of astrocytes in various regions of rat brain. Bull Exp Biol Med. 2001;131:248–50.
  • Narita M, Suzuki M, Narita M, Neuronal protein kinase C-dependent proliferation and hypertrophy of spinal cord astrocytes following repeated in vivo administration of morphine. Eur J Neurosci. 2004;19:479–84.
  • Reiter RJ, Tan DX, Fuentes-Broto L. Melatonin: a multitasking molecule.Prog Brain Res. 2010;181:127-151.
  • Naguib M, Gottumukkala V, Goldstein PA. Melatonin and anesthesia: a clinical perspective. J Pineal Res. 2007;42:12–21.
  • Shavali S, Ho B, Govitrapong P, Sawlom S, Ajjimaporn A, Klongpanichapak S, Ebadi M. Melatonin exerts its analgesic actions not by binding to opioid receptor subtypes but by increasing the release of beta-endorphin an endogenous opioid. Brain Res Bull. 2005;64:471–9.
  • Yu CX, Wu GC, Xu SF, Chen CH. Melatonin influences the release of endogenous opioid peptides in rat periaqueductal gray. Sheng Li Xue Bao. 2000;52:207–10.
  • Raghavendra V, Kulkarni SK. Possible mechanisms of action in melatonin reversal of morphine tolerance and dependence in mice.Eur J Pharmacol. 2000;409: 279–89.
  • Zhou YH, Huo ZY, Qiu XC. Inhibitory effect of melatonin on morphine withdrawal syndromes and the content of NO in plasma and brain tissue in morphine dependent mice. Yao Xue Xue Bao. 2002;37:175–7.
  • Baydas G, Reiter RJ, Yasar A, Tuzcu M, Akdemir I, Nedzvetskii VS. Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats. Free Radic Biol Med. 2003;35:797–804.
  • Baydas G, Reiter RJ, Nedzvetskii VS, Nerush PA, Kirichenko SV. Altered glial fibrillary acidic protein content and its degradation in the hippocampus, cortex and cerebellum of rats exposed to constant light: reversal by melatonin. J Pineal Res. 2002;33:134–9.
  • Baydas G, Tuzcu M. Protective effects of melatonin against ethanol-induced reactive gliosis in hippocampus and cortex of young and aged rats. Exp Neurol. 2005;194:175–81.
  • Baydas G, Ozer M, Yasar A, Koz ST, Tuzcu M. Melatonin prevents oxidative stress and inhibits reactive gliosis induced by hyperhomocysteinemia in rats. Biochemistry (Mosc). 2006;71 Suppl 1:S91–95.
  • Jesudason EP, Baben B, Ashok BS, Masilamoni JG, Kirubagaran R, Jebaraj WC, Jayakumar R. Anti-inflammatory effect of melatonin on A beta vaccination in mice. Mol Cell Biochem. 2007;298:69–81.
  • Reddy DS, Kulkarni SK. Chronic neurosteroid treatment prevents the development of morphine tolerance and attenuates abstinence behavior in mice. Eur J Pharmacol. 1997;337:19–25.
  • Bernard S, Macedo N, Malpaux B, Chemineau P. Comparison of immune parameters of sheep with naturally high or low plasma concentrations of melatonin. J Pineal Res. 2001;31:248–55.
  • Steiner AL, Pagliara AS, Chase LR, Kipnis DM. Radioimmunoassay for cyclic nucleotides. II. Adenosine 3′, 5′-monophosphate and guanosine 3′,5′-monophosphate in mammalian tissues and body fluids. J Biol Chem. 1972;247:1114–20.
  • Galeotti N, Stefano GB, Guarna M, Bianchi E, Ghelardini C. Signaling pathway of morphine induced acute thermal hyperalgesia in mice. Pain. 2006;123:294–305.
  • Shy M, Chakrabarti S, Gintzler AR. Plasticity of adenylyl cyclase-related signaling sequelae after long-term morphine treatment. Mol Pharmacol. 2008;73:868–79.
  • Rubovitch V, Gafni M, Sarne Y. The mu opioid agonist DAMGO stimulates cAMP production in SK-N-SH cells through a PLC-PKC-Ca2+ pathway. Brain Res Mol Brain Res. 2003;110:261–6.
  • Mao J, Price DD, Phillips LL, Lu J, Mayer DJ. Increases in protein kinase C gamma immunoreactivity in the spinal cord dorsal horn of rats with painful mononeuropathy. Neurosci Lett. 1995;198:75–8.
  • Celerier E, Laulin JP, Corcuff JB, Le Moal M, Simonnet G. Progressive enhancement of delayed hyperalgesia induced by repeated heroin administration: A sensitization process, J. Nerosci. 2001;21:4074–80.
  • Ingram SL, Traynor JR. Role of protein kinase C in functional selectivity for desensitization at the mu-opioid receptor: from pharmacological curiosity to therapeutic potential. Br J Pharmacol. 2009;158:154–6.
  • Dong Y, Benveniste EN. Immune function of astrocytes. Glia. 2001;36:180–90.
  • Narita M, Suzuki M, Kuzumaki N, Miyatake M, Suzuki T. Implication of activated astrocytes in the development of drug dependence: differences between methamphetamine and morphine.Ann N Y Acad Sci. 2008;1141:96–104.
  • Dubocovich ML, Markowska M. Functional MT1 and MT2 melatonin receptors in mammals.Endocrine. 2005;27:101–10.
  • Wan Q, Pang SF. Segmental, coronal and subcellular distribution of 2-[125I] iodomelatonin binding sites in the chicken spinal cord. Neurosci Lett. 1994;180:253–6.
  • Williams LM, Hannah LT, Hastings MH, Maywood ES. Melatonin receptors in the rat brain and pituitary. J Pineal Res. 1995;19:173–7.
  • Weaver DR, Rivkees SA, Reppert SM. Localization and characterization of melatonin receptors in rodent brain by in vitro autoradiography. J Neurosci. 1989;9:2581–90.
  • Zahn PK, Lansmann T, Berger E, Speckmann EJ, Musshoff U. Gene expression and functional characterization of melatonin receptors in the spinal cord of the rat: implications for pain modulation. J Pineal Res. 2003;35:24–31.
  • Laurido C, Pelissie T, Soto-Moyano R, Valladares L, Flores F, Hernández A. Effect of melatonin on rat spinal cord nociceptive transmission. Neuroreport. 2002;13:89–91.
  • Ruzicka BB, Fox CA, Thompson RC, Meng F, Watson S J, Akil H. Primary astroglial cultures derived from several rat brain regions differentially express μ, ä and ê opioid receptor mRNA. Molec Brain Res. 1995;34:209–20.
  • Kong X, Li X, Cai Z, Yang N, Liu Y, Shu J, Pan L, Zuo P. Melatonin regulates the viability and differentiation of rat midbrain neural stem cells. Cell Mol Neurobiol. 2008;28:569–79.
  • Adachi A, Natesan AK, Whitfield-Rucker MG, Functional melatonin receptors and metabolic coupling in cultured chick astrocytes. Glia. 2002;39:268–78.
  • Noseda R, Hernández A, Valladares L, Mondaca M, Laurido C, Soto-Moyano R. Melatonin-induced inhibition of spinal cord synaptic potentiation in rats is MT2 receptor-dependent. Neurosci Lett. 2004;360:41–4.
  • Soto VE, Meza I, Ramírez RG, Benitez KG. Melatonin stimulates calmodulin phosphorylation by protein kinase C. J Pineal Res. 2004;37:98–106.
  • Baydas G, Tuzcu M, Yasar A, Baydas B. Early changes in glial reactivity and lipid peroxidation in diabetic rat retina: effects of melatonin. Acta Diabetol. 2004;41:123–8.
  • Martín V, Herrera F, García-Santos G, Antolín I, Rodriguez-Blanco J, Medina M, Rodriguez C. Involvement of protein kinase C in melatonin's oncostatic effect in C6 glioma cells. J Pineal Res. 2007;43:239–44.
  • Yeleswaram K, McLaughlin LG, Knipe JO, Schabdach D. Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implications. J Pineal Res. 1997;22:45–51.

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