Neuroprotective Agents in Brain Injury: A Partial Failure?

REFERENCES

• Group EAIS. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis. 2003;15:222–9.
   PubMedGoogle Scholar
• Itoh T, Satou T, Nishida S, Tsubaki M, Hashimoto S, Ito H. The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury. Neurotox Res. 2009;16:378–89.
   PubMedGoogle Scholar
• Itoh T, Satou T, Nishida S, Tsubaki M, Imano M, Hashimoto S, Ito H. Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats. Neurochem Res. 2010;35:348–55.
   PubMedGoogle Scholar
• Abrahamson EE, Ikonomovic MD, Dixon CE, DeKosky ST. Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels. Ann Neurol. 2009;66:407–14.
   PubMedGoogle Scholar
• Chauhan NB, Gatto R. Synergistic benefits of erythropoietin and simvastatin after traumatic brain injury. Brain Res. 2010;1360:177–92.
   PubMedGoogle Scholar
• Mahmood A, Goussev A, Kazmi H, Qu C, Lu D, Chopp M. Long-term benefits after treatment of traumatic brain injury with simvastatin in rats. Neurosurgery. 2009;65:187–91; discussion 91-2.
   Google Scholar
• Chung RS, Penkowa M, Dittmann J, King CE, Bartlett C, Asmussen JW, Hidalgo J, Carrasco J, Leung YK, Walker AK, Fung SJ, Dunlop SA, Fitzgerald M, Beazley LD, Chuah MI, Vickers JC, West AK. Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury. J Biol Chem. 2008;283:15349–58.
   PubMedGoogle Scholar
• Leung YK, Pankhurst M, Dunlop SA, Ray S, Dittmann J, Eaton ED, Palumaa P, Sillard R, Chuah MI, West AK, Chung RS. Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways. Exp Neurol. 2010;221:98–106.
   PubMedGoogle Scholar
• Penkowa M, Giralt M, Lago N, Camats J, Carrasco J, Hernández J, Molinero A, Campbell IL, Hidalgo J. Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury. Exp Neurol. 2003;181:130–48.
   PubMedGoogle Scholar
• Ivanova T, Karolczak M, Beyer C. Estrogen stimulates the mitogen-activated protein kinase pathway in midbrain astroglia. Brain Res. 2001;889:264–9.
   PubMedGoogle Scholar
• Zhang L, Li B, Zhao W, Chang YH, Ma W, Dragan M, Barker JL, Hu Q, Rubinow DR. Sex-related differences in MAPKs activation in rat astrocytes: effects of estrogen on cell death. Brain Res Mol Brain Res. 2002;103:1–11.
   PubMedGoogle Scholar
• Dhandapani KM, Wade FM, Mahesh VB, Brann DW. Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: involvement of nonclassical genomic signaling pathways. Endocrinology. 2005;146:2749–59.
   PubMedGoogle Scholar
• Arnold S. Estrogen suppresses the impact of glucose deprivation on astrocytic calcium levels and signaling independently of the nuclear estrogen receptor. Neurobiol Dis. 2005;20: 82–92.
   PubMedGoogle Scholar
• Chaban VV, Lakhter AJ, Micevych P. A membrane estrogen receptor mediates intracellular calcium release in astrocytes. Endocrinology. 2004;145:3788–95.
   PubMedGoogle Scholar
• Micevych P, Bondar G, Kuo J. Estrogen actions on neuroendocrine glia. Neuroendocrinology. 2010;91:211–22.
   PubMedGoogle Scholar
• Barreto G, Santos-Galindo M, Diz-Chaves Y, Pernía O, Carrero P, Azcoitia I, Garcia-Segura LM. Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones. Endocrinology. 2009;150:5010–5.
   PubMedGoogle Scholar
• Barreto G, Veiga S, Azcoitia I, Garcia-Segura LM, Garcia-Ovejero D. Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone. Eur J Neurosci. 2007;25:3039–46.
   PubMedGoogle Scholar
• Barreto GE. Neuroprotection by estradiol: some important considerations. Hum Exp Toxicol. 2011;30:1737–9.
   PubMedGoogle Scholar
• Sayeed I, Stein DG. Progesterone as a neuroprotective factor in traumatic and ischemic brain injury. Prog Brain Res. 2009;175:219–37.
   PubMedGoogle Scholar
• Stein DG. Progesterone in the treatment of acute traumatic brain injury: a clinical perspective and update. Neuroscience. 2011;191:101–6.
   PubMedGoogle Scholar
• Ouyang YB, Voloboueva LA, Xu LJ, Giffard RG. Selective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia. J Neurosci. 2007;27:4253–60.
   PubMedGoogle Scholar
• Tsuru-Aoyagi K, Potts MB, Trivedi A, Pfankuch T, Raber J, Wendland M, Claus CP, Koh SE, Ferriero D, Noble-Haeusslein LJ. Glutathione peroxidase activity modulates recovery in the injured immature brain. Ann Neurol. 2009;65:540–9.
   PubMedGoogle Scholar
• Wu O, Christensen S, Hjort N, Dijkhuizen RM, Kucinski T, Fiehler J, Thomalla G, Röther J, Østergaard L. Characterizing physiological heterogeneity of infarction risk in acute human ischaemic stroke using MRI. Brain. 2006;129:2384–93.
   PubMedGoogle Scholar
• Hampton DW, Seitz A, Chen P, Heber-Katz E, Fawcett JW. Altered CNS response to injury in the MRL/MpJ mouse. Neuroscience. 2004;127:821–32.
   PubMedGoogle Scholar
• Bush TG, Puvanachandra N, Horner CH, Polito A, Ostenfeld T, Svendsen CN, Mucke L, Johnson MH, Sofroniew MV. Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron. 1999;23:297–308.
   PubMedGoogle Scholar