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Research Article

Systematic Review and Meta-Analysis of the Efficacy of Sphingosine-1-Phosphate (S1P) Receptor Agonist FTY720 (Fingolimod) in Animal Models of Stroke

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Pages 163-169 | Received 30 Jul 2012, Published online: 21 Dec 2012

REFERENCES

  • Singh IN, Hall ED. Multifaceted roles of sphingosine-1-phosphate: how does this bioactive sphingolipid fit with acute neurological injury? J Neurosci. 2008;86(7):1419–33.
  • Brinkmann V, Michael MD, Heise CE, Albert R, Cottens S, Hof R, Bruns C, Prieshcl E, Baumruker T, Hiestand P, Foster CA, Zollienger M, Lynch KR. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem. 2002;277(24):21453–7.
  • Yagi H, Kamba R, Chiba K, Soga H, Yaguchi K, Nakamura M, Itoh T. Immunosuppressant FTY720 inhibits thymocyte emigration. Eur J Immunol. 2000;30(5):1435–44.
  • Brinkmann V, Pinschewer DD, Feng L, Chen S. FTY720: altered lymphocyte traffic results in allograft protection. Transplantation. 2001;72(5):764–9.
  • Jung CG, Kim HJ, Miron VE, Cook S, Kennedy TE, Foster CA, Antel JP, Soliven B. Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells. Glia. 2007;55(16):1656–67.
  • Wacker BK, Park TS, Gidday JM. Hypoxic preconditioning-induced cerebral ischemic tolerance role of microvascular sphingosine kinase 2. Stroke. 2009;40(10):3342–8.
  • Kappos L, Antel J, Comi G, Montalban X, O'Connor P, Polman CH, Haas T, Korn AA, Karlsson G, Radue EW. FTY720 D2201 study group, oral fingolimod FTY720 for relapsing multiple sclerosis. N. Engl J Med. 2006;355(11):1124–40.
  • Sandercock P, Roberts I. Systematic reviews of animal experiments. Lancet. 2002;360(9333):586.
  • Macleod M, Sandercock P. Can systematic reviews help animal experimental work? RDS News winter 2005.
  • Egger M, Smith GD, Altman D. Systematic reviews in health care: meta-analysis in context. London: BMJ Books, 2001.
  • Macleod MR, O'Collins T, Howells DW, Donnan GA. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke, 2004, 35(5):1203–8.
  • Macleod MR, Vander Worp HB, Sena ES, Howells DW, Dirnagl U, Donnan GA. Evidence for the efficacy of NXY-059 in experimental focal cerebral ischemia is confounded by study quality. Stroke. 2008;39(10):2824–9.
  • Minnerup J, Heidrich J, Wellmann J, Rogalewski A, Schneider A, Schabitz WR. Meta-analysis of the efficacy of granulocyte-colony stimulating factor in animal models of focal cerebral ischemia. Stroke. 2008;39(6):1855–61.
  • Frantzias J, Sena ES, Macleod MR, Salman AR. Treatment of intra cerebral hemorrhage in animal models: meta-analysis Ann Neurol. 2011;69(2):389–99.
  • Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH, STAIR Group. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke. 2009;40(6):2244–50.
  • Liesz A, Sun L, Zhou W, Schwarting S, Mracsko E, Zorn M, Bauer H, Sommer C, Veltkamp R. FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia. PLoS ONE. June 2011; 6(6):e21312. DOI:10.1371/journal.pone.0021312.
  • Wei S, Su ZQ, Song L, Wang B, Yao M. Expression of S1P1 in focal brain ischemia-reperfusion rat. JA Poplexy and Nervous Diseases. 2011;28(2):347–51.
  • Hasegawa Y, Suzuki H, Sozen T, Rolland W, Zhang JH. Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats. Stroke. 2010;41(2):368–74.
  • Wei Y, Yemisci M, Kimm HH, Yung LM, Shin HK, Hwang SK, Guo S, Qin T, Alsharif N, Brinkmann V, Liao JK, Lo EH, Waeber C. Fingolimod provides long-term protection in rodent models of cerebral ischemia. Ann Neurol. 2010;69(1):119–29.
  • Shichita T, Sugiyama Y, Ooboshi H, Sugimori H, Nakagawa R, Takada I, Iwaki T, Okada Y, Lida M, Cua DJ, Iwakura Y, Yoshimura A. Pivotal role of cerebral interleukin-17–producing T cells in the delayed phase of ischemic brain injury. Nat Med. 2009;15(8):946–50.
  • Czech B, Pfeilschifter W, Mazaheri-Omrani N, Strobel MA, Kahles T, Neumann-Haefelin T, Rami A, Huwiler A, Pfeilschifter J. The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. Biochem Biophys Res Commun. 2009;389(2): 251–6.
  • Pfeilschifter W, Czech-Zechmeister B, Sujak M, Foerch C, Wichelhaus TA, Pfeilschifter J. Treatment with the immunomodulator FTY720 does not promote spontaneous bacterial infections after experimental stroke in mice. Exp Transl Stroke Med. 2011;3(2):2040–2046.
  • Pfeilschifter W, Czech-Zechmeister B, Sujak M, Mirceska A, Koch A, Rami A, Steinmetz H, Foerch C, Huwiler A, Pfeilschifter J. Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia. Biochem Biophys Res Commun. 2011;413(2):212–7.
  • Van der Worp HB, Sena ES, Donnan GA, Howells DW, Macleod MR. Hypothermia in animal models of acute ischemic stroke: a systematic review and meta-analysis. Brain. 2007;130(12):3063–74.
  • Andaluz N, Zuccarello M, Wagner KR. Experimental animal models of intracerebral hemorrhage. Neurosurg Clin NAm. 2002;13(3):385–93.
  • Al-Shahi SR, Labovitz DL, Stapf C. Spontaneous intracerebral hemorrhage. BMJ. 2009;339:b2586.

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