557
Views
40
CrossRef citations to date
0
Altmetric
Research Article

Ginseng in the treatment of fatigue in multiple sclerosis: a randomized, placebo-controlled, double-blind pilot study

, , , , , , & show all
Pages 480-486 | Received 23 Oct 2012, Accepted 04 Jan 2013, Published online: 11 Feb 2013

References

  • Wallin MT, Page WF, Kurtzke JF. Epidemiology of multiple sclerosis in US veterans. VIII. Long-term survival after onset of multiple sclerosis. Brain (a journal of neurology) 2000;123:1677–87.
  • Etemadifar M, Abtahi SH. Multiple sclerosis in Isfahan, Iran: past, present and future. Int J Prev Med 2012;3(5):301–2.
  • Flensner G, Ek AC, Landtblom AM, Fatigue in relation to perceived health: people with multiple sclerosis compared with people in the general population. Scandinavian J Caring Sci 2008;22(3):391–400.
  • Lintern TC, Beaumont JG, Kenealy PM, Quality of life (QoL) in severely disabled multiple sclerosis patients: comparison of three QoL measures using multi-dimensional scaling. Qual Life Res (an international journal of quality of life aspects of treatment, care and rehabilitation) 2001;10(4):371–8.
  • Foley J. Recommendations for the selection, treatment, and management of patients utilizing natalizumab therapy for multiple sclerosis. Am J Manag Care 2010;16(6):178–83.
  • Kim YK, Guo Q, Packer L. Free radical scavenging activity of red ginseng aqueous extracts. Toxicology 2002;172(2):149–56.
  • Hou JP. The chemical constituents of ginseng plants. Comp Med East West 1977;5(2):123–45.
  • Yip TT, Lau CN, But PP, Quantitative analysis of ginsenosides in fresh Panax ginseng. Am J Chin Med 1985;13(1–4):77–88.
  • Saito H, Morita M, Takagi K. Pharmacological studies of Panax ginseng leaves. Jpn J Pharmacol 1973;23(1):43–56.
  • Wang BX, Cui JC, Liu AJ. The action of ginsenosides extracted from the stems and leaves of Panax ginseng in promoting animal growth. Yao Xue Xue Bao (Acta pharmaceutica Sinica) 1982;17(12):899–904.
  • Wang BX, Cui JC, Liu AJ, Studies on the anti-fatigue effect of the saponins of stems and leaves of panax ginseng (SSLG). J Tradit Chin Med (Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine) 1983;3(2):89–94.
  • Sotaniemi EA, Haapakoski E, Rautio A. Ginseng therapy in non-insulin-dependent diabetic patients. Diabetes care 1995;18(10):1373–5.
  • Chung SH, Choi CG, Park SH. Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice. Arch Pharm Res 2001;24(3):214–8.
  • Davydov VV, Molokovskii DS, Limarenko A. Efficacy of ginseng drugs in experimental insulin-dependent diabetes and toxic hepatitis. Patologicheskaia fiziologiia i eksperimental'naia terapiia 1990;(5):49–52.
  • Xie JT, Wang CZ, Ni M, American ginseng berry juice intake reduces blood glucose and body weight in ob/ob mice. J Food Sci 2007;72(8):S590–4.
  • Xie JT, Aung HH, Wu JA, Effects of American ginseng berry extract on blood glucose levels in ob/ob mice. Am J Chin Med 2002;30(2–3):187–94.
  • Kitts DD, Popovich DG, Hu C. Characterizing the mechanism for ginsenoside-induced cytotoxicity in cultured leukemia (THP-1) cells. Can J Physiol Pharmacol 2007;85(11):1173–83.
  • Kitts DD, Wijewickreme AN, Hu C. Antioxidant properties of a North American ginseng extract. Mol Cell Biochem 2000;203(1–2):1–10.
  • Li J, Huang M, Teoh H, Panax quinquefolium saponins protects low density lipoproteins from oxidation. Life Sci 1999;64(1):53–62.
  • Zhou L, Hao R, Jiang L. Clinical study on retarding aging effect of tongbu recipe to traditional Chinese medicine. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi (Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban) 1999;19(4):218–20.
  • Elam JL, Carpenter JS, Shu XO, Methodological issues in the investigation of ginseng as an intervention for fatigue. Clin Nurse Spec 2006;20(4):183–9.
  • Tadano T, Aizawa T, Asao T, Pharmacological studies of nutritive and tonic crude drugs on fatigue in mice. Nihon yakurigaku zasshi Folia pharmacologica Japonica1992;100(5):423–31.
  • Bahrke MS, Morgan WP, Stegner A. Is ginseng an ergogenic aid? Int J Sport Nutr Exerc Metab 2009;19(3):298–322.
  • Singh B, Chandan BK, Gupta DK. Adaptogenic activity of a novel with anolide-free aqueous fraction from the roots of Withania somnifera Dun. (Part II) 2003;17(5):531–6.
  • Siegel RK. Ginseng abuse syndrome. Problems with the panacea. JAMA (the journal of the American Medical Association) 1979;241(15):1614–5.
  • Ang-Lee MK, Moss J, Yuan CS. Herbal medicines and perioperative care. JAMA (the journal of the American Medical Association) 2001;286(2):208–16.
  • Kim E, Cameron M, Lovera J, American ginseng does not improve fatigue in multiple sclerosis: a single center randomized double-blind placebo-controlled crossover pilot study. Mult Scler 2011;17(12):1523–6.
  • McDonald WI, Compston A, Edan G, Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001 Jul;50(1):121–7.
  • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33(11):1444–52.
  • Saghaei M. Random allocation software for parallel group randomized trials. BMC Med Res Methodol 2004;4:26.
  • Guidelines MSCfCP. Fatigue and multiple sclerosis: evidence-based management strategies for fatigue in multiple sclerosis. Washington, DC: Paralyzed Veterans of America; 1998. 33 p.
  • Ghaem H, Borhani Haghighi A, Jafari P, Validity and reliability of the Persian version of the multiple sclerosis quality of life questionnaire. Neurol India 2007;55(4):369–75.
  • Rammohan KW, Rosenberg JH, Lynn DJ, Efficacy and safety of modafinil (Provigil) for the treatment of fatigue in multiple sclerosis: a two centre phase 2 study. J Neurol Neurosurg Psychiatry 2002;72(2):179–83.
  • Krupp LB, Coyle PK, Doscher C, Fatigue therapy in multiple sclerosis: results of a double-blind, randomized, parallel trial of amantadine, pemoline, and placebo. Neurology 1995;45(11):1956–61.
  • Tomassini V, Pozzilli C, Onesti E, Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomised, double-blind, crossover trial. J Neurol Sci 2004;218(1–2):103–8.
  • Ziemssen T, Hoffman J, Apfel R, Effects of glatiramer acetate on fatigue and days of absence from work in first-time treated relapsing-remitting multiple sclerosis. Health Qual Life Outcomes 2008;6:67–72.
  • Barton DL, Soori GS, Bauer BA, Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA. Support Care Cancer (official journal of the Multinational Association of Supportive Care in Cancer) 2010;18(2):179–87.
  • Hartz AJ, Bentler S, Noyes R, Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 2004 Jan;34(1):51–61.
  • Fischer MT, Sharma R, Lim JL, NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury. Brain 2012;135(Pt 3):886–99.
  • Powell T, Sussman JG, Davies-Jones GA. MR imaging in acute multiple sclerosis: ringlike appearance in plaques suggesting the presence of paramagnetic free radicals. Am J Neuroradiol 1992;13(6):1544–6.
  • Lian XY, Zhang Z, Stringer JL. Protective effects of ginseng components in a rodent model of neurodegeneration. Ann Neurol 2005;57(5):642–8.
  • Yuan CS, Attele AS, Wu JA, Liu D. Modulation of American ginseng on brainstem GABAergic effects in rats. J Ethnopharmacol 1998;62(3):215–22.
  • Iarlori C, Gambi D, Lugaresi A, Reduction of free radicals in multiple sclerosis: effect of glatiramer acetate (Copaxone). Mult Scler 2008;14(6):739–48.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.