References
- Youdim MB, Ben-Shachar D, Yehuda S, The role of iron in the basal ganglion. Adv Neurol 1990;53:155–62.
- Kissel K, Hamm S, Schulz M, Immunohistochemical localization of the murine transferrin receptor (TfR) on blood-tissue barriers using a novel anti-TfR monoclonal antibody. Histochem Cell Biol 1998;110:63–72.
- Crichton RR, Ward RJ. Metal-based neurodegeneration: from molecular mechanisms to therapeutic strategies. Chichester: Wiley; c2006.
- Connor JR, Menzies SL, Burdo JR, Iron and iron management proteins in neurobiology. Pediatr Neurol 2001;25:118–29.
- Stankiewicz JM, Brass SD. Role of iron in neurotoxicity: a cause for concern in the elderly? Curr Opin Clin Nutr Metab Care 2009;12:22–9.
- Qian ZM, Wang Q. Expression of iron transport proteins and excessive iron accumulation of iron in the brain in neurodegenerative disorders. Brain Res Rev 1998;27:257–67.
- Samudralwer DL, Diprete CC, Ni B-F, Elemental imbalances in the olfactory pathway in Alzheimer's disease. J Neurol Sci 1995;130:139–45.
- Deibel MA, Ehmann WD, Markesbery WR. Copper, iron and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: Possible relation to oxidative stress. J Neurol Sci 1996;143:137–42.
- Dexter DT, Carayon A, Agid AF, Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. Brain 1991;114:1953–75.
- Jellinger K, Kienzl E, Rumpelmaier G, Iron and ferritin in substantia nigra in Parkinson's disease. Adv Neurol 1993;60:267–72.
- Mochizuki H, Imai H, Endo K, Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced hemiparkinsonian monkeys. Neurosci Lett 1994;168:251–53.
- Temlett JA, Landsberg P, Watt F, Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian green monkey: evidence from proton microprobe elemental microanalysis. J Neurochem 1994;62:134–46.
- Wu J, Hua Y, Keep RF, Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke 2003;34:2964–69.
- Wan S, Hua Y, Keep RF, Deferoxamine reduces CSF free iron levels following intracerebral hemorrhage. Acta Neurochir Suppl 2006;96:199–202.
- Wagner KR, Sharp FR, Ardizzone TD, Heme and iron metabolism: role in cerebral hemorrhage. J Cereb Blood Flow Metab 2003;23:629–52.
- Hidalgo C, Nunez MT. Calcium, iron and neuronal function. IUBMB Life 2007;59:280–5.
- Berridge MJ. Neuronal calcium signaling. Neuron 1998;21:13–26.
- Baba A, Yasui T, Fujisawa S, Activity-evoked capacitative Ca2+ entry: implications in synaptic plasticity. J Neurosci 2003;23:7737–41.
- Oheim M, Kirchhoff F, Stuhmer W. Calcium microdomains in regulated exocytosis. Cell Calcium 2006;40:423–39.
- Nicotera P, McConkey D, Svensson SA, Correlation between cytosolic Ca2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress. Toxicology 1988;52:55–63.
- Farber JL. The role of calcium in cell death. Life Sci 1981;29:1289–95.
- Schanne FAX, Kane AB, Young EE, Calcium dependence of toxic cell death: a final common pathway. Science 1979;206:700–2.
- Hansen AK, Zeuthen T. Extracellular ion concentrations during spreading depression and ischemia in the rat brain cortex. Acta Physiol Scand 1981;113:437–45.
- Guzman JN, Sanchez-Padilla J, Wokosin D, Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 2010;468:696–700.
- Bostanci MO, Bagirici F, Canan S. A calcium channel blocker flunarizine attenuates the neurotoxic effects of iron. Cell Biol Toxicol 2006;22:119–25.
- Akaike N, Kostyuk PG, Osipchuk YV. Dihydropyridine-sensitive low-threshold calcium channels in isolated rat hypothalamic neurones. J Physiol 1989;412:181–95.
- Paxinos G, Watson C, eds. The rat brain in the stereotaxic coordinates. 4th ed. London: Academic Pres; c1998.
- Bostanci MO, Bagirici F. Nitric oxide synthesis inhibition attenuates iron-induced neurotoxicity: a stereological study. Neurotoxicology 2008;29:130–35.
- Bostanci MO, Bagirici F, Bas O. Role of nitric oxide synthesis inhibitors in iron-induced nigral neurotoxicity: a mechanistic exploration. Toxicol Mech Methods 2008;116:379–84.
- Schmitz C, Hof PR. Design-based stereology in neuroscience. Neuroscience 2005;130:813–31.
- Moos T. Brain iron homeostasis. Dan Med Bull 2002;49:279–301.
- Willmore LJ, Hiramatsu M, Kochi H, Formation of superoxide radicals after FeCl3 injection into rat isocortex. Brain Res 1983;277:393–96.
- Aust SD, Morehouse LA, Thomas CE. Role of metals in oxygen radicals reactions. J Free Rad Biol Med 1985;1:3–25.
- Braughler JM, Duncan LA, Chase RL. The involvement of iron in lipid peroxidation. J Biol Chem 1986;261:10282–9.
- Link G, Saada A, Pinson A, Mitochondrial respiratory enzymes are a major target of iron toxicity in rat heart cells. J Lab Clin Med 1998;131:466–74.
- Calabrese V, Lodi R, Tonon C, Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia. J Neurol Sci 2005;233:145–62.
- Deng X, Vidal R, Englander EW. Accumulation of oxidative DNA damage in brain mitochondria in mouse model of hereditary ferritinopathy. Neurosci Lett 2010;479:44–8.
- Nunez-Millacura C, Tapia V, Munoz P, An oxidative stress-mediated positive-feedback iron uptake loop in neuronal cells. J Neurochem 2002;82:240–48.
- Porter NA, Caldwell SE, Mills KA. Mechanisms of free radical oxidation of unsaturated lipids. Lipids 1995;30:277–90.
- Robb SJ, Robb-Gaspers LD, Scaduto RC, Influence of calcium and iron on cell death and mitochondrial function in oxidatively stressed astrocytes. J Neurosci Res 1999;55:674–86.
- Beal MF. Aging, energy and oxidative stress in neurodegenerative disease. Ann Neurol 1995;38:357–66.
- Orrenius S, Ankarcrona M, Nicotera P. Mechanism of calcium related cell death. Adv Neurol 1996;71:137–51.
- Wang R, Ma Z, Wang J, L-type Cav1.2 calcium channel is involved in 6-hydroxydopamine-induced neurotoxicity in rats. Neurotox Res 2012;21:266–70.
- Albers GW, Goldberg MP, Choi DW. Do NMDA antagonists prevent neuronal injury? Yes Arch Neurol 1992;49:418–20.
- Pellegrini-Giampietro DE, Cherici G, Alesiani M, Excitatory amino acid release from rat hippocampal slices as a consequence of free radical formation. J Neurochem 1988;51:1960–63.
- Izumi Y, Benz AM, Clifford DB, Nitric oxide inhibitors attenuate N-methyl-D-aspartate excitotoxicity in rat hippocampal slices. Neurosci Let 1992;135:227–30.
- Ma Z, Zhou Y, Xie J. Nifedipine prevents iron accumulation and reverses iron-overload-induced dopamine neuron degeneration in the substantia nigra of rats. Neurotox Res 2012;22:274–9.
- Lipscombe D, Helton TD, Xu W. L-type calcium channels: the low down. J Neurophysiol 2004;92:2633–41.
- Das SK, Oudit GY. Voltage-gated Ca2+ channels as key mediators of iron-transport and iron-overload cardiomyopathy: L-type vs. T-type Ca+ channels. Eur J Haematol 2012;88:476–7.
- Gaasch JA, Geldenhuys WJ, Lockman PR, Voltage-gated calcium channels provide an alternate route for iron uptake in neuronal cell cultures. Neurochem Res 2007;32:1686–93.
- Pelizzoni I, Macco R, Morini MF, Iron handling in hippocampal neurons: activitydependent iron entry and mitochondria-mediated neurotoxicity. Aging Cell 2011;10:172–83.
- Lockman JA, Geldenhuys WJ, Bohn KA, Differential effect of nimodipine in attenuating iron-induced toxicity in brain- and blood-brain barrier-associated cell types. Neurochem Res 2012;37:134–42.