Effects of pregnenolone intervention on the cholinergic system and synaptic protein 1 in aged rats

References

• Wang F, Chen H, Sun X. Age-related spatial cognitive impairment is correlated with a decrease in ChAT in the cerebral cortex, hippocampus and forebrain of SAMP8 mice. Neurosci Lett 2009;454:212–7.
   PubMed Web of Science ®Google Scholar
• Babic M, Zinsmaier KE. Memory, synapse stability, and β-adducin. Neuron 2011;69:1039–41.
   Google Scholar
• Mellon SH. Neurosteroid regulation of central nervous system development. Pharmacol Ther 2007;116:107–24.
   PubMed Web of Science ®Google Scholar
• Foy MR, Akopian G,Thompson RF. Progesterone regulation of synaptic transmission and plasticity in rodent hippocampus. Learn Mem 2008;15:820–2.
   Google Scholar
• Frye CA, Duffy CK, Walf AA. Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task. Neurobiol Learn Mem 2007;88:208–16.
   PubMed Web of Science ®Google Scholar
• George O, Vallee M, Le Moal M, Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes. Psychopharmacology (Berl) 2006;186:402–13.
   Google Scholar
• van Wingen GA, van Broekhoven F, Verkes RJ, Progesterone selectively increases amygdala reactivity in women. Mol Psychiatry 2008;13:325–33.
   PubMed Web of Science ®Google Scholar
• Gill SK, Ishak M, Dobransky T, 82-kDa choline acetyltransferase is in nuclei of cholinergic neurons in human CNS and altered in aging and Alzheimer disease. Neurobiol Aging 2007;28:1028–40.
   Google Scholar
• Terry R, Katzman R. Life span and synapses: will there be a primary senile dementia? Neurobiol Aging 2001;22:347–8.
   PubMed Web of Science ®Google Scholar
• Bartus RT, Dean RL 3rd, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982;217:408–14.
   PubMed Web of Science ®Google Scholar
• Do Rego JL, Seong JY, Burel D, Neurosteroid biosynthesis: enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides. Front Neuroendocrinol 2009;30:259–301.
   PubMed Web of Science ®Google Scholar
• Do Rego JL, Tremblay Y, Repetto E, Immunohistochemical localization and biological activity of the steroidogenic enzyme cytochrome P450 17α‐hydroxylase/C17, 20‐lyase (P450C17) in the frog brain and pituitary. J Neurochem 2007;100:251–68.
   Google Scholar
• Shibuya K, Takata N, Hojo Y, Hippocampal cytochrome P450s synthesize brain neurosteroids which are paracrine neuromodulators of synaptic signal transduction. Biochimica et Biophysica Acta (BBA)-General Subjects 2003;1619:301–16.
   PubMed Web of Science ®Google Scholar
• Ishunina TA, van Beurden D, van der Meulen G, Diminished aromatase immunoreactivity in the hypothalamus, but not in the basal forebrain nuclei in Alzheimer's disease. Neurobiol Aging 2005;26:173–94.
   PubMedGoogle Scholar
• Specht CG, Triller A. The dynamics of synaptic scaffolds. Bioessays 2008;30:1062–74.
   PubMed Web of Science ®Google Scholar
• Fiumara F, Onofri F, Benfenati F, Intracellular injection of synapsin I induces neurotransmitter release in C1 neurons of Helix pomatia contacting a wrong target. Neurosci 2001;104:271–80.
   Google Scholar
• Baskerville KA, Kent C, Nicolle MM, Aging causes partial loss of basal forebrain but no loss of pontine reticular cholinergic neurons. Neuroreport 2006;17:1819–23.
   Google Scholar
• Geula C, Nagykery N, Nicholas A, Early cholinergic neuronal and axonal pathology in aging and Alzheimer's disease. J Neuropathol Exp Neurol 2008;67:309.
   Google Scholar
• Ferrari R, Pedrazzi P, Algeri S, Subunit and region-specific decreases in nicotinic acetylcholine receptor mRNA in the aged rat brain. Neurobiol Aging 1999;20:37–46.
   Google Scholar
• Ping SE, Trieu J, Wlodek ME, Effects of estrogen on basal forebrain cholinergic neurons and spatial learning. J Neurosci Res 2008;86:1588–98.
   PubMed Web of Science ®Google Scholar
• Dominguez R, Jalali C, de Lacalle S. Morphological effects of estrogen on cholinergic neurons in vitro involves activation of extracellular signal-regulated kinases. J Neurosci 2004;24:982–90.
   Google Scholar
• Rudick CN, Gibbs RB, Woolley CS. A role for the basal forebrain cholinergic system in estrogen-induced disinhibition of hippocampal pyramidal cells. J Neurosci 2003;23:4479– 90.
   PubMed Web of Science ®Google Scholar
• Kompoliti K, Chu Y, Polish A, Effects of estrogen replacement therapy on cholinergic basal forebrain neurons and cortical cholinergic innervation in young and aged ovariectomized rhesus monkeys. J Comparat Neurolo 2004;472:193–207.
   PubMed Web of Science ®Google Scholar
• Norbury R, Travis MJ, Erlandsson K, Estrogen therapy and brain muscarinic receptor density in healthy females: a SPET study. Horm Behav 2007;51:249–57.
   PubMedGoogle Scholar
• Zheng P. Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance. Progress Neurobiol 2009;89:134–52.
   PubMed Web of Science ®Google Scholar
• Darnaudéry M, Koehl M, Piazza PV, Pregnenolone sulfate increases hippocampal acetylcholine release and spatial recognition. Brain Res 2000;852:173–9.
   PubMed Web of Science ®Google Scholar